FB2025_05 , released December 11, 2025
Gene: Dmel\Atf3
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General Information
Symbol
Dmel\Atf3
Species
D. melanogaster
Name
Activating transcription factor 3
Annotation Symbol
CG11405
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028550
Gene Model Status
Current
Stock Availability
39 publicly available
Gene Summary
Activating transcription factor 3 (Atf3) encodes a transcription factor whose levels are tightly controlled during development. It forms homodimers or heterodimerizes with the product of Jra. It contributes to abdominal morphogenesis, and immune system and metabolic homeostasis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

A3-3, EG:33C11.1 , dATF3

Key Links
Genomic Location
Cytogenetic map
1E5-1F1
Sequence location
Recombination map
1-0.1
RefSeq locus
NC_004354 REGION:1242740..1275284
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Jra; FB:FBgn0001291
(Sekyrova et al., 2010)
enables sequence-specific DNA binding
inferred from direct assay
(Sekyrova et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR000837
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001156258
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR000837, InterPro:IPR004827, InterPro:IPR046347
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001156258
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in immune response
inferred from mutant phenotype
(Rynes et al., 2012)
involved_in lipid homeostasis
inferred from mutant phenotype
(Rynes et al., 2012)
involved_in regulation of lipid storage
inferred from mutant phenotype
(Chakrabarti et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR046347
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from electronic annotation with InterPro:IPR000837
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN001156258
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Rynes et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001156258
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the bZIP family. ATF subfamily. (Q9XZS8)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Activating transcription factor 3 (Atf3) encodes a transcription factor whose levels are tightly controlled during development. It forms homodimers or heterodimerizes with the product of Jra. It contributes to abdominal morphogenesis, and immune system and metabolic homeostasis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
BASIC LEUCINE ZIPPER TRANSCRIPTION FACTORS -
The basic leucine zipper (bZIP) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60-80 amino acid bZIP domain: a basic DNA binding domain followed by a leucine zipper dimerization domain. (Adapted from FBrf0152056).
Protein Function (UniProtKB)
Transcription factor which binds to the cAMP response element (CRE) (PubMed:20023169). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut (PubMed:22851689). Required for the expression of odorant receptors Or43b and Or47b (PubMed:26848073).
(UniProt, Q9XZS8)
Summary (Interactive Fly)

basic leucine-zipper transcription factor - partner of Jun in preventing extrusion and replacement of epidermal cells with histoblasts during larval morphogenesis

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Atf3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9XZS8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Atf3-RA
FBtr0070244
NM_138988
7025
613
Atf3-RB
FBtr0330391
NM_001272196
7025
688
Atf3-RC
FBtr0345507
NM_001297840
6975
613
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Atf3-PA
FBpp0070234
65.2
613
6.17
Q9XZS8
NP_620473
AAF45599
Atf3-PB
FBpp0303417
73.7
688
5.24
M9PIP2
NP_001259125
AGB94971
Atf3-PC
FBpp0311616
65.2
613
6.17
Q9XZS8
NP_001284769
AHN59240
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

613 aa isoforms: Atf3-PA, Atf3-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Jra/jun; the interaction enhances the DNA-binding activity of Atf3.

(UniProt, Q9XZS8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atf3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.40

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
gonad
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
larval stage
epidermis of abdomen
(Sekyrova et al., 2010)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism

Comment: higest

(Sekyrova et al., 2010)
first instar larval stage -- second instar larval stage
organism
(Sekyrova et al., 2010)
early third instar larval stage
organism

Comment: low

(Sekyrova et al., 2010)
pharate adult stage P8
organism

Comment: lowest

(Sekyrova et al., 2010)
adult stage
organism
(Sekyrova et al., 2010)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
early third instar larval stage
organism

Comment: low

(Sekyrova et al., 2010)
prepupal stage P3
epidermis | subset

Comment: isolated abdominal integuments

(Sekyrova et al., 2010)
prepupal stage P3 -- P4
organism

Comment: reference states 4h, 6h, and 8h APF timepoints

(Sekyrova et al., 2010)
pharate adult stage P9
organism

Comment: reference states 61h, 66h, and 72h APF timepoints

(Sekyrova et al., 2010)
Additional Descriptive Data

Atf3 mRNA as assayed by northen blot is expressed highly in embryos and first instar larvae, then tapers off to no expression by wandering third instar larval stage. Faint expression is again seen in pupae at 48h APF, which is increased to moderate expression in adults. Atf3 mRNA was also assayed by RT-PCR at 15 timepoints in third instar larvae and pupae, showing an early peak at 6h APF, then minimal expression until 61h APF. Tissue-specific RT-PCR showed expression in isolated integuments but not in fat body.

(Sekyrova et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Rynes et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Atf3 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Atf3
Transgenic constructs containing regulatory region of Atf3
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal - all die before end of larval stage
lethal - all die before end of larval stage | partially | recessive
lethal - all die before end of P-stage, with Scer\GAL4ppl.PP
lethal - all die before end of pupal stage, with Scer\GAL4MsrA.657
Sterility
Allele
female semi-fertile
Other Phenotypes
Allele
abnormal developmental rate | larval stage
decreased body size | male
short lived | male
some die during larval stage
some die during larval stage | recessive
some die during pharate adult stage, with Scer\GAL4ppl.PP
some die during pupal stage, with Scer\GAL4MsrA.657
visible, with Scer\GAL4arm.PS
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4MsrA.657
visible, with Scer\GAL4ppl.PP
visible | somatic clone, with Scer\GAL4Act5C.PI
Phenotype manifest in
Allele
adult abdomen | dorsal, with Scer\GAL4arm.PS
adult abdomen | dorsal, with Scer\GAL4MsrA.657
adult abdomen | dorsal, with Scer\GAL4ppl.PP
adult abdomen | somatic clone, with Scer\GAL4Act5C.PI
adult cuticle | dorsal, with Scer\GAL4arm.PS
adult cuticle | dorsal, with Scer\GAL4MsrA.657
adult cuticle | dorsal, with Scer\GAL4ppl.PP
adult cuticle | somatic clone, with Scer\GAL4Act5C.PI
embryonic/larval fat body
eye, with Scer\GAL4GMR.PF
lipid droplet
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (26)
Hsap\ATF3
6 of 14
Yes
Yes
 
1  
Hsap\JDP2
6 of 14
Yes
Yes
Hsap\BATF2
4 of 14
No
Yes
Hsap\BATF3
4 of 14
No
Yes
Hsap\BATF
4 of 14
No
Yes
Hsap\FOSB
3 of 14
No
No
Hsap\FOS
3 of 14
No
No
Hsap\FOSL1
3 of 14
No
No
Hsap\FOSL2
3 of 14
No
No
1  
Hsap\ATF2
2 of 14
No
No
Hsap\ATF7
2 of 14
No
No
1  
Hsap\CREB5
2 of 14
No
No
Hsap\ATF4
1 of 14
No
No
Hsap\ATF5
1 of 14
No
No
Hsap\ATF7-NPFF
1 of 14
No
Yes
Hsap\BACH1
1 of 14
No
Yes
Hsap\CEBPG
1 of 14
No
No
Hsap\CREB3L1
1 of 14
No
No
3  
Hsap\CREB3L4
1 of 14
No
No
1  
Hsap\DBP
1 of 14
No
No
Hsap\HLF
1 of 14
No
No
1  
Hsap\JUNB
1 of 14
No
No
Hsap\JUND
1 of 14
No
No
Hsap\JUN
1 of 14
No
No
Hsap\NFE2L1
1 of 14
No
No
Hsap\TEF
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (21)
Rnor\Atf3
6 of 14
Yes
Yes
Rnor\Jdp2
6 of 14
Yes
Yes
Rnor\Batf2
4 of 14
No
Yes
Rnor\Batf3
4 of 14
No
Yes
Rnor\Batf
4 of 14
No
Yes
Rnor\Fosb
3 of 14
No
Yes
Rnor\Fosl1
3 of 14
No
No
Rnor\Fos
3 of 14
No
No
Rnor\Atf2
2 of 14
No
No
Rnor\Atf7
2 of 14
No
No
Rnor\Creb5
2 of 14
No
No
Rnor\Atf4
1 of 14
No
No
Rnor\Atf5
1 of 14
No
No
Rnor\Cebpg
1 of 14
No
No
Rnor\Creb3l1
1 of 14
No
No
Rnor\Dbp
1 of 14
No
No
Rnor\Fosl2
1 of 14
No
No
Rnor\Hlf
1 of 14
No
No
Rnor\Junb
1 of 14
No
No
Rnor\Jun
1 of 14
No
No
Rnor\Tef
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Jdp2
6 of 14
Yes
Yes
Mmus\Atf3
5 of 14
No
Yes
Mmus\Batf2
4 of 14
No
Yes
Mmus\Batf3
4 of 14
No
Yes
Mmus\Batf
4 of 14
No
Yes
Mmus\Fosb
3 of 14
No
No
Mmus\Fosl1
3 of 14
No
No
Mmus\Fosl2
3 of 14
No
No
Mmus\Fos
3 of 14
No
No
Mmus\Atf2
2 of 14
No
No
Mmus\Atf4
1 of 14
No
No
Mmus\Atf5
1 of 14
No
No
Mmus\Atf7
1 of 14
No
No
Mmus\Cebpg
1 of 14
No
No
Mmus\Creb3l1
1 of 14
No
No
Mmus\Creb5
1 of 14
No
No
Mmus\Dbp
1 of 14
No
No
Mmus\Hlf
1 of 14
No
No
Mmus\Junb
1 of 14
No
No
Mmus\Jun
1 of 14
No
No
Mmus\Tef
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\atf3
2 of 13
Yes
Yes
Xtro\batf
2 of 13
Yes
Yes
Xtro\add2
1 of 13
No
No
Xtro\atf4
1 of 13
No
No
Xtro\atf5.2
1 of 13
No
No
Xtro\atf5
1 of 13
No
No
Xtro\atf6
1 of 13
No
No
Xtro\cebpg
1 of 13
No
No
Xtro\creb3l1
1 of 13
No
No
Xtro\flrt1
1 of 13
No
Yes
Xtro\fosb
1 of 13
No
No
Xtro\fosl2
1 of 13
No
No
Xtro\hlf
1 of 13
No
No
Xtro\ifitm5
1 of 13
No
Yes
Xtro\junb
1 of 13
No
No
Xtro\nfe2
1 of 13
No
No
Xtro\npc1
1 of 13
No
No
Xtro\nsf
1 of 13
No
No
Xtro\ptgfr
1 of 13
No
No
Xtro\slc6a16
1 of 13
No
No
Xtro\tef
1 of 13
No
No
Danio rerio (Zebrafish) (31)
Drer\jdp2a
6 of 14
Yes
Yes
Drer\jdp2b
6 of 14
Yes
Yes
Drer\atf3
5 of 14
No
Yes
Drer\batf3
4 of 14
No
Yes
Drer\batf
4 of 14
No
Yes
Drer\fosl2l
4 of 14
No
No
Drer\fosaa
3 of 14
No
No
Drer\fosab
3 of 14
No
No
Drer\fosb
3 of 14
No
No
Drer\fosl1a
3 of 14
No
No
Drer\si:ch211-153j24.3
3 of 14
No
No
Drer\atf2
2 of 14
No
No
Drer\atf7a
2 of 14
No
No
Drer\batf2
2 of 14
No
Yes
Drer\creb5b
2 of 14
No
No
Drer\fosl1b
2 of 14
No
No
Drer\fosl2
2 of 14
No
No
Drer\atf5b
1 of 14
No
No
Drer\atf7b
1 of 14
No
No
Drer\cebpd
1 of 14
No
No
Drer\cebpg
1 of 14
No
No
Drer\creb3l1
1 of 14
No
No
Drer\creb5a
1 of 14
No
No
Drer\crebzf
1 of 14
No
Yes
Drer\dbpa
1 of 14
No
No
Drer\dbpb
1 of 14
No
No
Drer\hlfa
1 of 14
No
No
Drer\hlfb
1 of 14
No
No
Drer\jun
1 of 14
No
No
Drer\tefa
1 of 14
No
No
Drer\tefb
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\fos-1
2 of 14
Yes
No
Cele\atf-8
1 of 14
No
No
Cele\zip-8
1 of 14
No
Yes
Cele\zip-11
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP001536
9 of 12
Yes
Yes
Agam\AgaP_AGAP001093
1 of 12
No
No
Agam\AgaP_AGAP001464
1 of 12
No
No
Agam\AgaP_AGAP006376
1 of 12
No
No
Agam\AgaP_AGAP006386
1 of 12
No
No
Agam\AgaP_AGAP008416
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (13)
Atha\ABF1
1 of 13
Yes
Yes
Atha\ABI5
1 of 13
Yes
Yes
Atha\AT5G07160
1 of 13
Yes
Yes
Atha\bZIP5
1 of 13
Yes
Yes
Atha\bZIP16
1 of 13
Yes
Yes
Atha\BZIP28
1 of 13
Yes
No
Atha\bZIP68
1 of 13
Yes
Yes
Atha\bZIP70
1 of 13
Yes
Yes
Atha\GBF1
1 of 13
Yes
Yes
Atha\GBF2
1 of 13
Yes
Yes
Atha\GBF3
1 of 13
Yes
Yes
Atha\HY5
1 of 13
Yes
No
Atha\HYH
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\ACA1
2 of 13
Yes
Yes
Scer\CST6
1 of 13
No
Yes
Scer\SKO1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\atf1
2 of 12
Yes
No
Spom\atf21
2 of 12
Yes
Yes
Spom\atf31
1 of 12
No
No
Spom\pcr1
1 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Atf3. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
kay
3 of 13
CrebB
1 of 13
gt
1 of 13
Jra
1 of 13
Pdp1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ATF3; activating transcription factor 3
    6 of 14
    603148
         
        JDP2; Jun dimerization protein 2
        6 of 14
        608657
            BATF2; basic leucine zipper ATF-like transcription factor 2
            4 of 14
            614983
                BATF3; basic leucine zipper ATF-like transcription factor 3
                4 of 14
                612470
                    BATF; basic leucine zipper ATF-like transcription factor
                    4 of 14
                    612476
                        FOSB; FosB proto-oncogene, AP-1 transcription factor subunit
                        3 of 14
                        164772
                            FOS; Fos proto-oncogene, AP-1 transcription factor subunit
                            3 of 14
                            164810
                                FOSL1; FOS like 1, AP-1 transcription factor subunit
                                3 of 14
                                136515
                                    FOSL2; FOS like 2, AP-1 transcription factor subunit
                                    3 of 14
                                    601575
                                       
                                      Functional Complementation Data
                                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                      Dmel gene
                                      Ortholog showing functional complementation
                                      Supporting References
                                      Atf3
                                      Hsap\ATF3
                                      (Rynes et al., 2012)
                                      Interactions
                                      Summary of Physical Interactions
                                      Summary of Genetic Interactions
                                      Interaction Browsers
                                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                                      Please look at the allele data for full details of the genetic interactions
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      Atf3
                                      suppressible
                                      Jra
                                      (Sekyrova et al., 2010)
                                      Atf3
                                      enhanceable
                                      Jra
                                      (Sekyrova et al., 2010)
                                      Atf3
                                      suppressible
                                      kay
                                      (Sekyrova et al., 2010)
                                      Atf3
                                      suppressible
                                      Rel
                                      (Rynes et al., 2012)
                                      Atf3
                                      enhanceable
                                      Rho1
                                      (Sekyrova et al., 2010)
                                      Atf3
                                      suppressible
                                      Rho1
                                      (Sekyrova et al., 2010)
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      Rho1
                                      enhanceable
                                      Atf3
                                      (Sekyrova et al., 2010)
                                      External Data
                                      Subunit Structure (UniProtKB)
                                      Interacts with Jra/jun; the interaction enhances the DNA-binding activity of Atf3.
                                      (UniProt, Q9XZS8 )
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      DroID - A comprehensive database of gene and protein interactions.
                                      MIST (genetic) - An integrated Molecular Interaction Database
                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                      Pathways
                                      Signaling Pathways (FlyBase)
                                      Metabolic Pathways
                                      FlyBase
                                      External Links
                                      External Data
                                      Linkouts
                                      Class of Gene
                                      Genomic Location and Detailed Mapping Data
                                      Chromosome (arm)
                                      X
                                      Recombination map
                                      1-0.1
                                      Cytogenetic map
                                      1E5-1F1
                                      Sequence location
                                      FlyBase Computed Cytological Location
                                      Cytogenetic map
                                      Evidence for location
                                      1E5-1F1
                                      Experimentally Determined Cytological Location
                                      Cytogenetic map
                                      Notes
                                      References
                                      1F-1F
                                      (Heitzeberg, 1999.9.15)
                                      Experimentally Determined Recombination Data
                                      Location

                                      1-0.1

                                      (FlyBase, 2016, Comeron et al., 2012)
                                      Left of (cM)
                                      Right of (cM)
                                      Notes
                                      Stocks and Reagents
                                      Stocks (39)
                                      Genomic Clones (27)
                                      cDNA Clones (30)
                                       

                                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                      cDNA clones, fully sequenced
                                      BDGP DGC clones
                                        Other clones
                                          Drosophila Genomics Resource Center cDNA clones

                                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                          cDNA Clones, End Sequenced (ESTs)
                                          BDGP DGC clones
                                            Other clones
                                              RNAi and Array Information
                                              Linkouts
                                              DRSC - Results frm RNAi screens
                                              Antibody Information
                                              Laboratory Generated Antibodies
                                               
                                              Commercially Available Antibodies
                                               
                                              Cell Line Information
                                              Publicly Available Cell Lines
                                               
                                                Other Stable Cell Lines
                                                 
                                                  Other Comments

                                                  RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                                                  (Boutros et al., 2004)
                                                  Relationship to Other Genes
                                                  Source for database merge of

                                                  Source for merge of: A3-3 EG:33C11.1

                                                  (Gatt and Ashburner, 2000.2.3)
                                                  Additional comments
                                                  Nomenclature History
                                                  Source for database identify of
                                                  Nomenclature comments
                                                  Etymology
                                                  Synonyms and Secondary IDs (9)
                                                  Reported As
                                                  Symbol Synonym
                                                  A3-3
                                                  (Yao et al., 2017, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Wilczynski et al., 2012, Abruzzi et al., 2011, Jungreis et al., 2011, Grieder et al., 2007, Koizumi et al., 2007, Manak et al., 2006)
                                                  ATF3
                                                  (Kwon et al., 2020, Toprak et al., 2020, Zhou et al., 2017, Atkins et al., 2016, Sekyrova et al., 2006)
                                                  Atf3
                                                  (Meyer et al., 2024, Raicu et al., 2024, Zhang et al., 2024, Floc'hlay et al., 2023, Pan et al., 2023, Stanković et al., 2023, Logeay et al., 2022, Onur et al., 2021, Wang et al., 2021, Cho et al., 2020, Csordás et al., 2020, Fujisawa et al., 2020, Jevitt et al., 2020, La Marca and Richardson, 2020, Port et al., 2020, Rust et al., 2020, Shokri et al., 2019, Bischof et al., 2018, La Fortezza et al., 2018, Transgenic RNAi Project members, 2017-, Atkins et al., 2016, Clandinin and Owens, 2016-, Schertel et al., 2015, Sen et al., 2013, Rynes et al., 2012, Spokony and White, 2012.11.14, Levis et al., 2011.12.16, Sekyrova et al., 2010)
                                                  CG11405
                                                  (Meadows, 2017.1.11, Reinke et al., 2013, Castillo et al., 2011, Sekyrova et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Grieder et al., 2007, Benos, 2000.12.13)
                                                  DM11
                                                  (Reinke et al., 2013)
                                                  EG:33C11.1
                                                  (Benos et al., 2001, Benos, 2000.12.13, Benos, 1999.12.28)
                                                  atf3
                                                  (Donohoe et al., 2018, Chakrabarti et al., 2014, Sekyrova et al., 2010)
                                                  dATF3
                                                  (Sekyrova et al., 2007, Sekyrova et al., 2006)
                                                  Name Synonyms
                                                  A3-3
                                                  Activating transcription factor 3
                                                  (Sekyrova et al., 2010)
                                                  Secondary FlyBase IDs
                                                  • FBgn0026877
                                                  Datasets (0)
                                                  Study focus (0)
                                                  Experimental Role
                                                  Project
                                                  Project Type
                                                  Title
                                                  Study result (0)
                                                  Result
                                                  Result Type
                                                  Title
                                                  External Crossreferences and Linkouts ( 47 )
                                                  Sequence Crossreferences
                                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                  Other crossreferences
                                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                  FlyMine - An integrated database for Drosophila genomics
                                                  InterPro - A database of protein families, domains and functional sites
                                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                                  Linkouts
                                                  BioGRID - A database of protein and genetic interactions.
                                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                  DroID - A comprehensive database of gene and protein interactions.
                                                  DRSC - Results frm RNAi screens
                                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                  Flygut - An atlas of the Drosophila adult midgut
                                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                                  MIST (genetic) - An integrated Molecular Interaction Database
                                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                                  References (93)