FB2021_01, released Feb 18, 2021

Gene: Dmel\Rpn11

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General Information
Symbol
Dmel\Rpn11
Species
D. melanogaster
Name
Regulatory particle non-ATPase 11
Annotation Symbol
CG18174
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028694
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

p37B, DmS13, 37B, S13

Key Links
Genomic Location
Cytogenetic map
25C3-25C3
Sequence location
2L:5,058,404..5,059,790 [-]
Recombination map

2-15

RefSeq locus
NT_033779 REGION:5058404..5059790
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables Lys63-specific deubiquitinase activity
inferred from electronic annotation with InterPro:IPR035299
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables metallopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000045368
(assigned by GO_Central )
(Gaudet et al., 2011)
enables proteasome binding
inferred from biological aspect of ancestor with PANTHER:PTN000045438
(assigned by GO_Central )
(Gaudet et al., 2011)
enables thiol-dependent ubiquitin-specific protease activity
inferred from biological aspect of ancestor with PANTHER:PTN000045438
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:P43588
(FlyBase Curators, 2008--)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Lőw et al., 2013, Tonoki et al., 2009, Lundgren et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000045438
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred by curator from GO:0005838
(Sumegi et al., 2003)
involved_in protein deubiquitination
inferred from sequence or structural similarity with UniProtKB:P43588
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000045438
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of proteasome complex
inferred from direct assay
(Nickell et al., 2009)
part_of proteasome regulatory particle
inferred from direct assay
(Tonoki et al., 2009, Sumegi et al., 2003, Holzl et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of proteasome regulatory particle, lid subcomplex
inferred from sequence or structural similarity with UniProtKB:P43588
(Holzl et al., 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000045438
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase M67A family. PSMD14 subfamily. (Q9V3H2)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
JAMM DEUBIQUITINASES -
The JAMM (JAB1/MPN/MOV34) sub-family of deubiquitinases are Zn[2+]-binding metalloproteases. In general, JAMMs are components of larger assemblies such as the proteasome. JAMM deubiquitinases belong to MEROPS family M67. (Adapted from FBrf0224141).
PROTEASOME REGULATORY PARTICLE NON-ATPASES -
The 26S proteasome degrades polyubiquitinated proteins in the cytoplasm and nucleus. It is formed from a cylindrical catalytic core 20S proteasome capped at each end by a regulatory 19S particle. The 19S regulatory particle recognizes, unfolds, and translocates ubiquitinated proteins into the catalytic core particle in an ATP-dependent manner. 'Rpn' subunits are non-ATPase subunits located in the base and lid subcomplexes of the regulatory particle (Adapted from FBrf0215459 and PMID:28583440.)
Protein Function (UniProtKB)
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).
(UniProt, Q9V3H2)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rpn11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rpn11-RA
FBtr0079027
NM_135061
1208
308
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Rpn11-PA
FBpp0078664
34.4
308
6.05
NP_608905
AAF52215
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the 19S regulatory cap of the 26S proteasome.

(UniProt, Q9V3H2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rpn11 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of proteasome complex
inferred from direct assay
(Nickell et al., 2009)
part_of proteasome regulatory particle
inferred from direct assay
(Tonoki et al., 2009, Sumegi et al., 2003, Holzl et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rpn11 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rpn11
Transgenic constructs containing regulatory region of Rpn11
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PSMD14
15 of 15
Yes
Yes
Hsap\COPS5
2 of 15
No
No
1  
Hsap\BRCC3
1 of 15
No
Yes
Hsap\COPS6
1 of 15
No
No
Hsap\MPND
1 of 15
No
No
Hsap\MYSM1
1 of 15
No
No
Hsap\PSMD7
1 of 15
No
No
Hsap\STAMBP
1 of 15
No
No
1  
Hsap\STAMBPL1
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Psmd14
15 of 15
Yes
Yes
Mmus\Brcc3
1 of 15
No
Yes
Mmus\Cops5
1 of 15
No
No
Mmus\Cops6
1 of 15
No
No
Mmus\Eif3f
1 of 15
No
No
Mmus\Mpnd
1 of 15
No
No
Mmus\Mysm1
1 of 15
No
No
Mmus\Psmd7
1 of 15
No
No
Mmus\Stambpl1
1 of 15
No
No
Mmus\Stambp
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Psmd14
10 of 13
Yes
Yes
Rnor\Cops5
2 of 13
No
No
Rnor\Brcc3
1 of 13
No
Yes
Rnor\Cops6
1 of 13
No
No
Rnor\Eif3f
1 of 13
No
No
Rnor\Mpnd
1 of 13
No
No
Rnor\Mysm1
1 of 13
No
No
Rnor\Psmd7
1 of 13
No
No
Rnor\Stambpl1
1 of 13
No
No
Rnor\Stambp
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\psmd14
13 of 12
Yes
Yes
Xtro\cops5
2 of 12
No
No
Xtro\brcc3
1 of 12
No
Yes
Xtro\cops6
1 of 12
No
No
Xtro\eif3f
1 of 12
No
No
Xtro\mpnd
1 of 12
No
No
Xtro\mysm1
1 of 12
No
No
Xtro\psmd7
1 of 12
No
No
Xtro\stambpl1
1 of 12
No
No
Xtro\stambp
1 of 12
No
No
Danio rerio (Zebrafish) (9)
Drer\psmd14
10 of 15
Yes
Yes
Drer\cops5
2 of 15
No
No
Drer\brcc3
1 of 15
No
Yes
Drer\eif3f
1 of 15
No
No
Drer\mpnd
1 of 15
No
No
Drer\mysm1
1 of 15
No
No
Drer\stambpa
1 of 15
No
No
Drer\stambpb
1 of 15
No
No
Drer\stambpl1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\rpn-11
14 of 15
Yes
Yes
Cele\F37A4.5
3 of 15
No
Yes
Cele\csn-5
2 of 15
No
No
Cele\csn-6
1 of 15
No
No
Cele\eif-3.F
1 of 15
No
No
Cele\rpn-8
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\AT5G23540
9 of 9
Yes
Yes
Atha\CSN5A
1 of 9
No
No
Atha\CSN5B
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\RPN11
14 of 15
Yes
Yes
Scer\RRI1
2 of 15
No
No
Scer\RPN8
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rpn11
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BRM )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000263
Drosophila simulans
Dsim\GD22663
Drosophila sechellia
Dsec\GM18036
Drosophila erecta
Dere\GG24318
Drosophila yakuba
Dyak\Rpn11
Drosophila ananassae
Dana\GF14156
Drosophila pseudoobscura pseudoobscura
Dpse\GA14824
Drosophila persimilis
Dper\GL26475
Drosophila willistoni
Dwil\GK23790
Drosophila virilis
Dvir\GJ10111
Drosophila mojavensis
Dmoj\GI15638
Drosophila grimshawi
Dgri\GH10267
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507E5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016070
Glossina morsitans
Tsetse fly
Gmor\GMOY002328
Glossina morsitans
Tsetse fly
Gmor\GMOY005522
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09452
Mayetiola destructor
Hessian fly
Mdes\Mdes016374
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004733
Anopheles darlingi
American malaria mosquito
Adar\ADAC008431
Anopheles gambiae
Malaria mosquito
Agam\AGAP008617
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007692
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0892 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009010
Danaus plexippus
Monarch butterfly
Dple\DPOGS207376-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012235
Apis florea
Little honeybee
Aflo\2159461476
Apis mellifera
Western honey bee
Amel\Rpn11
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23988
Bombus terrestris
Buff-tailed bumblebee
Bter\15215238
Linepithema humile
Argentine ant
Lhum\LH24373
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001fb1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010548
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010539
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010540
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05689
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05690
Tribolium castaneum
Red flour beetle
Tcas\TC005869
Pediculus humanus
Human body louse
Phum\PHUM129240
Rhodnius prolixus
Kissing bug
Rpro\RPRC008832
Cimex lectularius
Bed bug
Clec\CLEC011828
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001186
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04509
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X084N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003005
Strigamia maritima
European centipede
Smar\SMAR011550
Ixodes scapularis
Black-legged tick
Isca\ISCW017120
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72629.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g00610
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304982
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CMC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_019232gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Psmd14
Ciona intestinalis
Vase tunicate
Cint\LOC100179683
Gallus gallus
Domestic chicken
Ggal\PSMD14
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CSN5
4 of 10
eIF3h
2 of 10
CG2224
1 of 10
CG4751
1 of 10
CSN6
1 of 10
eIF3f1
1 of 10
eIF3f2
1 of 10
Rpn8
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PSMD14; proteasome 26S subunit, non-ATPase 14
    15 of 15
    607173
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Rpn11 - Prosα2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosα3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosα4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosα5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosα6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosα7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosβ1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosβ2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosβ3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosβ4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosβ5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosβ6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Prosβ7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn13
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn8
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpn9
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpt1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpt2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpt3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpt4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpt5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Rpt6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - Spindly
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpn11 - sima
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Txl
        suppressible
        Rpn11
        (Uechi et al., 2018)
        External Data
        Subunit Structure (UniProtKB)
        Component of the 19S regulatory cap of the 26S proteasome.
        (UniProt, Q9V3H2 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-15

        Cytogenetic map
        25C3-25C3
        Sequence location
        2L:5,058,404..5,059,790 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        25C3-25C3
        Limits computationally determined from genome sequence between P{lacW}vkgk16721&P{lacW}Cg25Ck00405 and P{lacW}l(2)k11206k11206
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-15

        (FlyBase, 2016)

        2-16.5

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (10)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (46)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Tonoki et al., 2009)

        monoclonal

        (Tonoki et al., 2009)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments

        The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms.

        (FlyBase, 2009-)
        Other Comments

        Rpn11 overexpression suppresses the age-related reduction of the 26S proteasome activity, resulting in the extension of flies' life spans with suppression of the age-dependent accumulation of ubiquitinated proteins.

        (Tonoki et al., 2009)

        The loss of Rpn11 causes an early onset of reduced 26S proteasome activity and a premature age-dependent accumulation of ubiquitinated proteins. It also causes a shorter life span and an enhanced neurodegenerative phenotype.

        (Tonoki et al., 2009)

        RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

        (Boutros et al., 2004)

        RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

        (Boutros et al., 2004)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 88 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (14)
        Reported As
        Symbol Synonym
        37B
        (Lundgren et al., 2005, Ma et al., 2002)
        CG18174
        (Hosono et al., 2015, Rosa-Ferreira et al., 2015, Tsou et al., 2015, Fukuoh et al., 2014, Wang et al., 2014, Schertel et al., 2013, Tsou et al., 2012, Yano et al., 2012, Zhang et al., 2012, Zhang et al., 2012, Monzo et al., 2010, Ni et al., 2010.12.1, Belote and Zhong, 2009, Hughes et al., 2008, Barbash and Lorigan, 2007, Gandhi et al., 2007, Dorer et al., 2006, Lundgren et al., 2005, Ma et al., 2002)
        DmS13
        (Sathyanarayanan et al., 2008, Lundgren et al., 2003)
        PSMD14
        (Tsou et al., 2015)
        Q9V3H2
        (Clague et al., 2013)
        RPN11
        (Cheng and Chiang, 2018, Dorer et al., 2006, Gemmill et al., 2005)
        RPn11
        (Hoopfer et al., 2008)
        Rpn11
        (Gao et al., 2020, Lin et al., 2020, Wei et al., 2020, Bouska et al., 2019, Evangelakou et al., 2019, Gumeni et al., 2019, Manola et al., 2019, Tang et al., 2019, Tsakiri et al., 2019, Zhou et al., 2019, Augustin et al., 2018, Blount et al., 2018, Grobler et al., 2018, Liu et al., 2018, Nath et al., 2018, Uechi et al., 2018, Augustin et al., 2017, Sap et al., 2017, Sekiya et al., 2017, Tain et al., 2017, Ashton-Beaucage et al., 2016, Wang et al., 2016, Yu et al., 2016, Hudson et al., 2015, Kovacs et al., 2015, Wang et al., 2015, Chen et al., 2014, Wang et al., 2014, Lőw et al., 2013, McPhee et al., 2013, Schertel et al., 2013, Zuo et al., 2013, Gurudatta et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Peng et al., 2012, Tsou et al., 2012, Yano et al., 2012, Zhang et al., 2012, Zuo et al., 2012, Grimberg et al., 2011, Guruharsha et al., 2011, Peng et al., 2011, Monzo et al., 2010, Belote and Zhong, 2009, Nickell et al., 2009, Nie et al., 2009, Tonoki et al., 2009, Sathyanarayanan et al., 2008, Zhou et al., 2008, Barbash and Lorigan, 2007, Georlette et al., 2007, Latouche et al., 2007, Stuart et al., 2007, Liebl et al., 2006, Lundgren et al., 2005, Lundgren et al., 2003, Ma et al., 2002)
        S13
        (Lundgren et al., 2005)
        p37B
        (Sumegi et al., 2003, Kurucz et al., 2002, Holzl et al., 2000)
        rpn11
        (Nguyen et al., 2019, Tsakiri et al., 2017, Ristic et al., 2016, Tsakiri et al., 2013, Guest et al., 2011)
        yip5
        (Roxstrom-Lindquist, 1999.10.15)
        Name Synonyms
        Regulatory particle non-ATPase 11
        Rpn11
        yippee interacting protein 5
        (Roxstrom-Lindquist, 1999.10.15)
        Secondary FlyBase IDs
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (119)