FB2026_02 , released June 18, 2026
Gene: Dmel\Marf
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General Information
Symbol
Dmel\Marf
Species
D. melanogaster
Name
Mitochondrial assembly regulatory factor
Annotation Symbol
CG3869
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029870
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dMfn, Mfn, Mfn2, mitofusin

Key Links
Genomic Location
Cytogenetic map
5F4-5F4
Sequence location
Recombination map
1-16
RefSeq locus
NC_004354 REGION:6365949..6370924
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR030381
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from sequence or structural similarity with UniProtKB:O18412
(Hwa et al., 2002)
inferred from biological aspect of ancestor with PANTHER:PTN002573358
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006884, InterPro:IPR027094
(InterPro Project Members, 2004-)
Biological Process (12 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in adult locomotory behavior
inferred from mutant phenotype
(Debattisti et al., 2014)
involved_in axonal transport of mitochondrion
inferred from mutant phenotype
(Sandoval et al., 2014)
involved_in ecdysone biosynthetic process
inferred from mutant phenotype
(Sandoval et al., 2014)
involved_in endoplasmic reticulum organization
inferred from mutant phenotype
(Debattisti et al., 2014)
involved_in lipid droplet organization
inferred from mutant phenotype
(Sandoval et al., 2014)
acts_upstream_of_negative_effect lymph gland crystal cell differentiation
inferred from mutant phenotype
(Ray et al., 2021)
inferred from genetic interaction with FLYBASE:asrij; FB:FBgn0034793
(Ray et al., 2021)
involved_in mitochondrial fusion
inferred from mutant phenotype
(Nag et al., 2023, Ray et al., 2021, Sandoval et al., 2014, Deng et al., 2008)
inferred from mutant phenotype
(Senyilmaz et al., 2015)
inferred from genetic interaction with FLYBASE:Trabd; FB:FBgn0283438
(Zhou et al., 2024)
involved_in mitochondrion organization
inferred from mutant phenotype
(Debattisti et al., 2014, Eschenbacher et al., 2012, Dorn et al., 2011)
involved_in positive regulation of mitochondrial fusion
inferred from mutant phenotype
(Bhandari et al., 2014)
inferred from mutant phenotype
(Ziviani et al., 2010)
involved_in regulation of mitochondrial fission
inferred from mutant phenotype
(Ratnaparkhi, 2013)
involved_in response to endoplasmic reticulum stress
inferred from mutant phenotype
(Debattisti et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mitochondrial fusion
inferred from biological aspect of ancestor with PANTHER:PTN002573358
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006884
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:O18412
(Hwa et al., 2002)
involved_in mitochondrion localization
inferred from biological aspect of ancestor with PANTHER:PTN002573358
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrial outer membrane
inferred from direct assay
(Senyilmaz et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR006884
(InterPro Project Members, 2004-)
located_in mitochondrial envelope
inferred from sequence or structural similarity with UniProtKB:O18412
(Hwa et al., 2002)
is_active_in mitochondrial outer membrane
inferred from biological aspect of ancestor with PANTHER:PTN002573358
(GO Reference Genome Project, 2011-)
located_in mitochondrial outer membrane
inferred from electronic annotation with InterPro:IPR006884
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (Q7YU24)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
DYNAMIN-LIKE GTPASES -
The Dynamin-like GTPases are a family of GTPases that undergo nucleotide-dependent dimerization and dimer-dependent GTP hydrolysis. They are implicated in membrane remodelling and endocytic membrane fission events. (Adapted from PMID:22233676).
Protein Function (UniProtKB)
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:18799731, PubMed:20869429, PubMed:22396657, PubMed:24192653, PubMed:26214738). Mitochondrial fusion is the physical merging of mitochondria that gives rise to mitochondrial networks, and this process is counterbalanced by mitochondrial fission which fragments networks (PubMed:20869429, PubMed:22396657, PubMed:24192653). Promotes, but is not required for park recruitment to dysfunctional mitochondria (PubMed:20194754).
(UniProt, Q7YU24)
Summary (Interactive Fly)

target of the Yorkie pathway - regulation of mitochondrial fusion, organ size, steroid synthesis in the ring gland and ovarian follicle cell differentiation - modulates endoplasmic reticulum function, Reaper binds Marf to induce mitochondrial fragmentation

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Marf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7YU24)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Marf-RB
FBtr0070909
NM_206635
3444
810
Marf-RC
FBtr0070910
NM_206634
3605
810
Marf-RD
FBtr0343373
NM_132092
3617
814
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Marf-PB
FBpp0089222
91.4
810
6.69
Q7YU24
NP_996358
AAS65267
Marf-PC
FBpp0089221
91.4
810
6.69
Q7YU24
NP_996357
AAS65268
Marf-PD
FBpp0310030
91.8
814
6.69
NP_572320
AAF46162
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

810 aa isoforms: Marf-PB, Marf-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Mul1.

(UniProt, Q7YU24)
Post Translational Modification

Ubiquitinated by park and Mul1 (PubMed:20194754, PubMed:24898855). Ubiquitinated, probably by HUWE1, when dietary stearate ( C18:0 ) levels are low; ubiquitination inhibits mitochondrial fusion (PubMed:26214738).

(UniProt, Q7YU24)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Marf using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally contributed

(Hwa et al., 2002)
embryonic stage 8 -- 10
organism

Comment: zygotically expressed; pattern not described

(Hwa et al., 2002)
embryonic stage 11
mesoderm
(Hwa et al., 2002)
posterior midgut primordium
(Hwa et al., 2002)
anterior midgut primordium
(Hwa et al., 2002)
embryonic stage 13
embryonic/larval gut
(Hwa et al., 2002)
embryonic stage 13 -- 15
embryonic/larval midgut primordium

Comment: strong expression

(Hwa et al., 2002)
embryonic somatic muscle cell

Comment: weak expression

(Hwa et al., 2002)
pharyngeal muscle cell

Comment: weak expression

(Hwa et al., 2002)
adult stage | female & oogenesis
nurse cell

Comment: NOT follicle cell

(Hwa et al., 2002)
oocyte
(Hwa et al., 2002)
adult stage | male & spermatogenesis
primary gonial cell
(Hwa et al., 2002)
spermatogenesis & adult stage | male
primary spermatocyte
(Hwa et al., 2002)
spermatid
(Hwa et al., 2002)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
organism
(Hwa et al., 2002)
adult stage | female
organism

Comment: expressed more strongly in males

(Hwa et al., 2002)
Additional Descriptive Data

Maternally-expressed Marf transcript is present in early embryos, but has degraded before blastoderm stage. Zygotic expression begins at embryonic stage 8. By stage 11,expression is primarily observed in the invaginating midgut and in the mesoderm. During germ band retraction, expression is observed in the developing gut, with strong expression in the midgut. Expression is also observed in somatic muscle and in pharyngeal muscle. In adult females, Marf is expressed in nurse cells and oocytes, but not in follicle cells. In adult males, Marf is expressed in premeiotic spermaticytes, primary spermatocytes, and early-stage spermatids.

(Hwa et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrial outer membrane
inferred from direct assay
(Senyilmaz et al., 2015)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Marf in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Marf
Transgenic constructs containing regulatory region of Marf
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4Mef2.PU
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4Tub.PU
lethal - all die before end of P-stage, with Scer\GAL4insc.PU
lethal - all die before end of P-stage, with Scer\GAL4pros.PU
lethal - all die before end of P-stage, with Scer\GAL4wor.PU
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
lethal - all die during pupal stage, with Scer\GAL4elav.PLu
lethal - all die during second instar larval stage, with Scer\GAL4Tub.PU
lethal - all die during third instar larval stage (with Df(1)Exel6239)
lethal - all die during third instar larval stage | recessive
partially lethal, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4elav-C155
partially lethal - majority die, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mhc.PU
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal adult locomotory behavior, with Scer\GAL4Mef2.PR
abnormal cell cycle | oogenesis, with Scer\GAL4nanos.PG
abnormal cell death, with Scer\GAL4elav.PU
abnormal developmental rate
abnormal developmental rate, with Scer\GAL4phtm.PU
abnormal eclosion, with Scer\GAL4elav.PU
abnormal flight, with Scer\GAL4Mhc.PW
abnormal locomotor behavior | adult stage, with Scer\GAL4elav.PU
abnormal locomotor behavior | adult stage, with Scer\GAL4Mhc.PU
abnormal locomotor behavior | adult stage, with Scer\GAL4nSyb.PS
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4tin.CΔ4
abnormal locomotor behavior | third instar larval stage, with Scer\GAL4Mef2.PR
abnormal neuroanatomy, with Scer\GAL4elav.PU
abnormal neuroanatomy | adult stage, with Scer\GAL4ple.PF
abnormal neuroanatomy | adult stage, with Scer\GAL4VGlut1-OK371
abnormal neuroanatomy | adult stage | progressive
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | larval stage, with Scer\GAL4pnt-14-94
abnormal neurophysiology, with Scer\GAL4Toll-6-D42
abnormal neurophysiology | adult stage | somatic clone
abnormal neurophysiology | larval stage
abnormal neurophysiology | larval stage (with MarfB)
abnormal neurophysiology | larval stage (with MarfE)
abnormal size | larval stage
abnormal size | larval stage, with Scer\GAL4elav.PU
abnormal size | larval stage, with Scer\GAL4VGlut1-OK371
abnormal size | third instar larval stage, with Scer\GAL4Cg.PA
abnormal stress response | larval stage, with Scer\GAL4Act.PU
abnormal stress response | larval stage, with Scer\GAL4Tub.PU
abnormal stress response | oogenesis, with Scer\GAL4nanos.PG
chemical resistant | adult stage, with Scer\GAL4ple.PF
decreased body size | larval stage
decreased cell number | adult stage, with Scer\GAL4VGlut1-OK371
decreased cell number | larval stage, with Scer\GAL4pnt-14-94
decreased occurrence of cell division | larval stage, with Scer\GAL4pnt-14-94
decreased rate of movement | adult stage, with Scer\GAL4pnt-14-94
decreased rate of movement | adult stage, with Scer\GAL4sca.PU
decreased rate of movement | adult stage, with Scer\GAL4wor.PU
decreased size, with Scer\GAL4Mef2.PR
decreased size | adult stage, with Scer\GAL4Mhc.PW
decreased size | larval stage, with Scer\GAL4Toll-6-D42
flightless, with Scer\GAL4Mef2.PR
increased body size | P-stage, with Scer\GAL4phtm.PU
increased cell number | third instar larval stage, with Scer\GAL4Antp-10
increased cell number | third instar larval stage, with Scer\GAL4dome-PG14
increased cell number | third instar larval stage, with Scer\GAL4e33C
increased cell size | larval stage, with Scer\GAL4unspecified
increased occurrence of cell division | larval stage, with Scer\GAL4pnt-14-94
increased occurrence of cell division | larval stage, with Scer\GAL4wor.PU
increased size | larval stage, with Scer\GAL4ap.PU
paralytic | adult stage, with Scer\GAL4elav.PU
short lived, with Scer\GAL4nSyb.PS
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during larval stage, with Scer\GAL4Tub.PU
some die during pupal stage, with Scer\GAL4Mef2.PR
visible, with Scer\GAL4ey.3.5.Exel
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
A band | adult stage | progressive, with Scer\GAL4Mhc.PW
adult anterior midgut epithelium | conditional, with Scer\GAL4NP3084
adult brain, with Scer\GAL4elav.PU
adult heart, with Scer\GAL4tin.CΔ4
adult optic lobe glial cell
adult optic lobe glial cell | cell non-autonomous
axon | adult stage, with Scer\GAL4GMR15B07
axon | adult stage, with Scer\GAL4VGlut1-OK371
axon | adult stage | somatic clone
axon | third instar larval stage, with Scer\GAL4RapGAP1-OK6
cardial cell, with Scer\GAL4tin.CΔ4
cardial cell | adult stage, with Scer\GAL4tin.CΔ4
cell body | adult stage | somatic clone
dopaminergic PPL1 neuron | adult stage, with Scer\GAL4ple.PF
dorsal longitudinal indirect flight muscle cell | adult stage | progressive, with Scer\GAL4Mhc.PW
embryonic/larval crystal cell | increased number | third instar larval stage, with Scer\GAL4dome-PG14
embryonic/larval crystal cell | increased number | third instar larval stage, with Scer\GAL4e33C
embryonic/larval fat body | early third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval hypodermal muscle cell | third instar larval stage, with Scer\GAL4Mef2.PU
embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4dome-PG14
embryonic/larval motor neuron | larval stage
embryonic/larval motor neuron | larval stage, with Scer\GAL4elav.PU
embryonic/larval motor neuron | larval stage, with Scer\GAL4ple.PF
embryonic/larval motor neuron | larval stage, with Scer\GAL4VGlut1-OK371
embryonic/larval neuromuscular junction, with Scer\GAL4Feb36
embryonic/larval neuromuscular junction, with Scer\GAL4Tub.PU
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval plasmatocyte | increased number | third instar larval stage, with Scer\GAL4dome-PG14
endoplasmic reticulum
endoplasmic reticulum | larval stage, with Scer\GAL4elav.PLu
endoplasmic reticulum | larval stage, with Scer\GAL4Tub.PU
epithelium, with Scer\GAL4Gug-AGiR
eye, with Scer\GAL4ey.3.5.Exel
eye, with Scer\GAL4GMR.PU
eye photoreceptor cell, with Scer\GAL4VGlut1-OK371
eye photoreceptor cell | somatic clone
fat body, with Scer\GAL4Cg.PU
female germline stem cell, with Scer\GAL4nanos.PG
flight muscle cell | adult stage, with Scer\GAL4Mef2.247
gustatory receptor neuron of the wing, with Scer\GAL4GMR15B07
gut | prepupal stage, with Scer\GAL4NP0001
gut | prepupal stage | somatic clone, with Scer\GAL4Act5C.PP
indirect flight muscle | adult stage, with Scer\GAL4Mef2.PR
indirect flight muscle cell, with Scer\GAL4fln.IFM
indirect flight muscle cell, with Scer\GAL4Mef2.PR
indirect flight muscle cell, with Scer\GAL4Mhc.PU
indirect flight muscle cell | adult stage, with Scer\GAL4Mef2.PR
indirect flight muscle cell | adult stage, with Scer\GAL4Mhc.PU
indirect flight muscle cell | adult stage, with Scer\GAL4Mhc.PW
indirect flight muscle cell | P-stage, with Scer\GAL4Mef2.PR
intermediate neuronal progenitor | larval stage, with Scer\GAL4pnt-14-94
interommatidial bristle, with Scer\GAL4GMR.PU
lamellocyte | third instar larval stage, with Scer\GAL4Antp-10
larval brain | larval stage, with Scer\GAL4pnt-14-94
larval brain | larval stage, with Scer\GAL4wor.PU
larval neuroblast, with Scer\GAL4unspecified
larval neuron | decreased number | larval stage, with Scer\GAL4pnt-14-94
larval ventral nerve cord
lipid droplet
lipid droplet, with Scer\GAL4Feb36
lipid droplet | adult stage
lipid droplet | adult stage | cell non-autonomous
lipid droplet | adult stage | increased number
mitochondrial crista, with Scer\GAL4Cg.PU
mitochondrial crista, with Scer\GAL4Mef2.PR
mitochondrial crista | adult stage, with Scer\GAL4Mhc.PU
mitochondrial membrane | adult stage, with Scer\GAL4Mhc.PU
mitochondrion
mitochondrion, with Scer\GAL4Cg.PA
mitochondrion, with Scer\GAL4Cg.PU
mitochondrion, with Scer\GAL4elav.PU
mitochondrion, with Scer\GAL4fln.IFM
mitochondrion, with Scer\GAL4Gug-AGiR
mitochondrion, with Scer\GAL4Mef2.PR
mitochondrion, with Scer\GAL4Mhc.PW
mitochondrion, with Scer\GAL4tin.CΔ4
mitochondrion & dopaminergic neuron, with Scer\GAL4ple.PF
mitochondrion | adult stage, with Scer\GAL4GMR15B07
mitochondrion | adult stage, with Scer\GAL4Mef2.247
mitochondrion | adult stage, with Scer\GAL4Mef2.PR
mitochondrion | adult stage, with Scer\GAL4Mhc.PU
mitochondrion | adult stage, with Scer\GAL4ple.PF
mitochondrion | adult stage, with Scer\GAL4tin.CΔ4
mitochondrion | adult stage, with Scer\GAL4VGlut1-OK371
mitochondrion | adult stage | conditional, with Scer\GAL4NP3084
mitochondrion | adult stage | increased number, with Scer\GAL4Mef2.PR
mitochondrion | adult stage | increased number, with Scer\GAL4Mhc.PW
mitochondrion | adult stage | progressive, with Scer\GAL4Mhc.PW
mitochondrion | adult stage | somatic clone
mitochondrion | decreased number | larval stage, with Scer\GAL4Toll-6-D42
mitochondrion | early third instar larval stage, with Scer\GAL4Cg.PA
mitochondrion | increased number | prepupal stage, with Scer\GAL4NP0001
mitochondrion | increased number | prepupal stage | somatic clone, with Scer\GAL4Act5C.PP
mitochondrion | larval stage
mitochondrion | larval stage, with Scer\GAL4elav.PLu
mitochondrion | larval stage, with Scer\GAL4elav.PU
mitochondrion | larval stage, with Scer\GAL4Mef2.PR
mitochondrion | larval stage, with Scer\GAL4Mhc.PW
mitochondrion | larval stage, with Scer\GAL4ple.PF
mitochondrion | larval stage, with Scer\GAL4pnt-14-94
mitochondrion | larval stage, with Scer\GAL4Tub.PU
mitochondrion | larval stage, with Scer\GAL4VGlut1-OK371
mitochondrion | P-stage, with Scer\GAL4Mef2.PR
mitochondrion | P-stage, with Scer\GAL4phtm.PU
mitochondrion | somatic clone
mitochondrion | third instar larval stage, with Scer\GAL4Cg.PA
mitochondrion | third instar larval stage, with Scer\GAL4dome-PG14
mitochondrion | third instar larval stage, with Scer\GAL4Mef2.PU
mitochondrion | third instar larval stage, with Scer\GAL4RapGAP1-OK6
motor neuron | larval stage, with Scer\GAL4Toll-6-D42
motor neuron | third instar larval stage, with Scer\GAL4RapGAP1-OK6
muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage, with Scer\GAL4Mhc.PW
muscle cell of A1-7 ventral longitudinal muscle 4 | larval stage, with Scer\GAL4Mhc.PW
myotube | adult stage | progressive, with Scer\GAL4Mhc.PW
NMJ bouton
NMJ bouton, with Scer\GAL4Feb36
NMJ bouton, with Scer\GAL4Tub.PU
NMJ bouton | larval stage, with Scer\GAL4VGlut1-OK371
ommatidium, with Scer\GAL4ey.3.5.Exel
ommatidium, with Scer\GAL4GMR.long
ommatidium, with Scer\GAL4GMR.PU
ommatidium | adult stage
peripodial epithelium, with Scer\GAL4Gug-AGiR
photoreceptor | adult stage | progressive
primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4dome-PG14
primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4e33C
prohemocyte | increased number | third instar larval stage, with Scer\GAL4dome-PG14
prohemocyte | third instar larval stage, with Scer\GAL4dome-PG14
prothoracic gland | P-stage, with Scer\GAL4phtm.PU
ring gland
ring gland, with Scer\GAL4Feb36
sarcomere, with Scer\GAL4Mef2.PR
sarcomere | adult stage | progressive, with Scer\GAL4Mhc.PW
sarcoplasmic reticulum | larval stage, with Scer\GAL4Mef2.PR
secondary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4dome-PG14
skeletal muscle myofibril, with Scer\GAL4Mef2.PR
tertiary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4dome-PG14
trichogen cell, with Scer\GAL4pnr-MD237
type II neuroblast | larval stage, with Scer\GAL4pnt-14-94
type II neuroblast | larval stage, with Scer\GAL4wor.PU
wing disc, with Scer\GAL4Gug-AGiR
wing disc | larval stage, with Scer\GAL4ap.PU
Z disc | adult stage | progressive, with Scer\GAL4Mhc.PW
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\MFN2
13 of 14
Yes
Yes
 
5  
Hsap\MFN1
12 of 14
No
Yes
 
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Mfn2
13 of 14
Yes
Yes
Rnor\Mfn1
12 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Mfn2
13 of 14
Yes
Yes
Mmus\Mfn1
11 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\mfn2
8 of 13
Yes
Yes
Xtro\mfn1
7 of 13
No
Yes
Xtro\serpine3
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\mfn2
13 of 14
Yes
Yes
Drer\mfn1b
12 of 14
No
Yes
Drer\mfn1a
6 of 14
No
Yes
Drer\nuggc.1
1 of 14
No
Yes
Drer\nuggc.3
1 of 14
No
Yes
Drer\si:dkey-242h9.3
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\fzo-1
12 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP001802
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\FZL
2 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\FZO1
6 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\fzo1
5 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Marf. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
fzo
7 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 9 )
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 11 )
Allele
Disease
Interaction
References
MarfUAS.cSa.Tag:HA
ameliorates  amyotrophic lateral sclerosis type 10
modeled by Hsap\TARDBPG298S.UAS.Tag:FLAG
(Khalil et al., 2017)
modeled by Hsap\TARDBPUAS.cKa.Tag:FLAG
(Khalil et al., 2017)
MarfJF01650
ameliorates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Duboff et al., 2012)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis 2
modeled by Chchd2S81L.UAS
(Baek et al., 2021)
MarfUAS.cDa
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Duboff et al., 2012)
MarfGD11094
exacerbates  Machado-Joseph disease
modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
(Voßfeldt et al., 2012)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis 2
modeled by Chchd2S81L.UAS
(Baek et al., 2021)
MarfKK105681
ameliorates  Parkinson's disease
modeled by park25
(Celardo et al., 2016)
modeled by Pink1B9
(Celardo et al., 2016)
model of  Charcot-Marie-Tooth disease type 2A2A
is ameliorated by NmdmcUAS.Tag:HA
(Garrido-Maraver et al., 2019)
ameliorates  Parkinson's disease 2
modeled by parkΔ21, park1
(Valadas et al., 2018)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis 2
modeled by Chchd2S81L.UAS
(Baek et al., 2021)
ameliorates  Huntington's disease
modeled by Hsap\HTTQ93.ex1.UAS
(Campesan et al., 2023)
MarfHMC03883
ameliorates  Friedreich ataxia 1
modeled by fhRNAi.UAS.cAa
(Edenharter et al., 2018)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis 2
modeled by Chchd2S81L.UAS
(Baek et al., 2021)
ameliorates  Parkinson's disease 6
modeled by Pink1B9
(Li et al., 2023)
ameliorates  cancer
modeled by HipkUAS.Tag:HA
(Wong et al., 2020)
MarfUAS.cUa
ameliorates  amyotrophic lateral sclerosis
modeled by Hsap\TAF15UAS.cCa
(Altanbyek et al., 2016)
ameliorates  amyotrophic lateral sclerosis type 10
modeled by Hsap\TARDBPUAS.cEa
(Altanbyek et al., 2016)
ameliorates  amyotrophic lateral sclerosis type 6
modeled by Hsap\FUSUAS.cUa
(Altanbyek et al., 2016)
ameliorates  frontotemporal dementia and/or amyotrophic lateral sclerosis 2
modeled by Chchd2S81L.UAS
(Baek et al., 2021)
MarfL76Plike.UAS
model of  Charcot-Marie-Tooth disease type 2
is ameliorated by Drp1UAS.Tag:HA
(El Fissi et al., 2018)
MarfR94Qlike.UAS
model of  Charcot-Marie-Tooth disease type 2
is NOT exacerbated by Drp1K38A.UAS.Tag:HA
(El Fissi et al., 2018)
is NOT ameliorated by Drp1UAS.Tag:HA
(El Fissi et al., 2018)
is NOT ameliorated by Opa1RNAi.CDS.UAS
(El Fissi et al., 2018)
MarfR364Wlike.UAS
model of  Charcot-Marie-Tooth disease type 2
is exacerbated by Drp1K38A.UAS.Tag:HA
(El Fissi et al., 2018)
is ameliorated by Drp1UAS.Tag:HA
(El Fissi et al., 2018)
is ameliorated by Opa1RNAi.CDS.UAS
(El Fissi et al., 2018)
MarfRNAi.UAS.cUa
ameliorates  Parkinson's disease 6
modeled by Pink1RNAi.UAS.cYa
(Liu and Lu, 2010)
modeled by Pink1B9
(Liu and Lu, 2010)
exacerbates  amyotrophic lateral sclerosis type 6
modeled by Hsap\FUSUAS.cUa
(Altanbyek et al., 2016)
exacerbates  amyotrophic lateral sclerosis type 10
modeled by Hsap\TARDBPUAS.cEa
(Altanbyek et al., 2016)
exacerbates  amyotrophic lateral sclerosis
modeled by Hsap\TAF15UAS.cCa
(Altanbyek et al., 2016)
model of  Charcot-Marie-Tooth disease type 2
is exacerbated by CG13551UAS.cKa
(Kandul et al., 2016)
ameliorates  Parkinson's disease
modeled by MiroUAS.Tag:MYC
(Lee et al., 2018)
ameliorates  Friedreich ataxia 1
modeled by fhRNAi.UAS.cAa
(Edenharter et al., 2018)
ameliorates  cardiomyopathy
modeled by parkHMS01651
(Bhandari et al., 2014)
modeled by parkHMS01800
(Bhandari et al., 2014)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MFN2; mitofusin 2
13 of 14
MITOFUSIN 2; MFN2
 
MFN1; mitofusin 1
12 of 14
608506
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Marf
      Hsap\MFN1
      (Dorn et al., 2011)
      Marf
      Hsap\MFN2
      (Debattisti et al., 2014, Sandoval et al., 2014, Eschenbacher et al., 2012, Dorn et al., 2011)
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Marf
      enhanceable
      Arl6IP1
      (Fowler and O'Sullivan, 2016)
      Marf
      enhanceable
      asrij
      (Ray et al., 2021)
      Marf
      suppressible
      Bsg
      (Liu et al., 2017)
      Marf
      suppressible
      Chchd2
      (Liu et al., 2020)
      Marf
      enhanceable
      clu
      (Wang et al., 2016)
      Marf
      suppressible
      Cs1
      (Liu et al., 2017)
      Marf
      enhanceable
      Dhpr
      (Zhou et al., 2019)
      Marf
      suppressible
      Drp1
      (Dubal et al., 2022, El Fissi et al., 2018)
      Marf
      enhanceable
      Drp1
      (El Fissi et al., 2018)
      Marf
      suppressible
      Fatp1
      (Liu et al., 2017)
      Marf
      suppressible
      Gdap1
      (López Del Amo et al., 2015)
      Marf
      suppressible
      gfzf
      (Smith et al., 2019)
      Marf
      suppressible
      GLaz
      (Liu et al., 2017)
      Marf
      suppressible
      Miga
      (Zhang et al., 2016)
      Marf
      enhanceable
      Mtx2
      (Zhang et al., 2025)
      Marf
      suppressible
      Mul1
      (Yun et al., 2014)
      Marf
      suppressible
      Opa1
      (El Fissi et al., 2018)
      Marf
      suppressible
      out
      (Liu et al., 2017)
      Marf
      suppressible
      park
      (Bhandari et al., 2014, Yun et al., 2014)
      Marf
      suppressible
      Pdha1
      (Liu et al., 2017)
      Marf
      suppressible
      Sln
      (Liu et al., 2017)
      Marf
      suppressible
      Sod1
      (Dorn et al., 2011)
      Marf
      suppressible
      tau
      (Goodman et al., 2024)
      Marf
      suppressible
      Trabd
      (Zhou et al., 2024)
      Marf
      enhanceable
      Trabd
      (Zhou et al., 2024)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      asrij
      suppressible
      Marf
      (Ray et al., 2021)
      asrij
      enhanceable
      Marf
      (Ray et al., 2021)
      Baldspot
      suppressible
      Marf
      (Senyilmaz et al., 2015)
      Chchd2
      enhanceable
      Marf
      (Baek et al., 2021)
      Cisd
      enhanceable
      Marf
      (Chen et al., 2020)
      clu
      suppressible
      Marf
      (Wang et al., 2016)
      Dhpr
      enhanceable
      Marf
      (Zhou et al., 2019)
      Drp1
      suppressible
      Marf
      (Uttekar et al., 2024, El Fissi et al., 2018, Rival et al., 2011)
      egr
      enhanceable
      Marf
      (Yang et al., 2013)
      fog
      suppressible
      Marf
      (Ratnaparkhi, 2013)
      fog
      enhanceable
      Marf
      (Ratnaparkhi, 2013)
      fwd
      suppressible
      Marf
      (Terriente-Felix et al., 2020)
      gfzf
      suppressible
      Marf
      (Smith et al., 2019)
      LamC
      suppressible
      Marf
      (Li et al., 2016)
      N
      suppressible
      Marf
      (Dubal et al., 2022, Lee et al., 2013)
      N
      suppressible
      Myc|Marf
      (Lee et al., 2013)
      park
      suppressible
      Marf
      (Celardo et al., 2016, Bhandari et al., 2014, Deng et al., 2008)
      park|Mul1
      suppressible
      Marf
      (Yun et al., 2014)
      Pink1
      suppressible
      Marf
      (Li et al., 2023, Celardo et al., 2016, Park et al., 2009, Deng et al., 2008)
      Pink1
      enhanceable
      Marf
      (Li et al., 2023, Poole et al., 2008)
      Pink1|trc
      suppressible
      Marf
      (Wu et al., 2013)
      porin
      suppressible
      Marf
      (Park et al., 2010)
      rictor|Pink1
      suppressible
      Marf
      (Wu et al., 2013)
      srl|yki
      enhanceable
      Marf
      (Sew et al., 2025)
      Ssrp
      suppressible
      Marf
      (Lou et al., 2024)
      Tango5
      suppressible
      Marf
      (Shen et al., 2021)
      Vps13D
      suppressible
      Marf
      (Shen et al., 2021, Anding et al., 2018)
      yki
      enhanceable
      Marf
      (Sew et al., 2025)
      yki|srl
      suppressible
      Marf
      (Sew et al., 2025)
      αCOP
      suppressible
      Marf
      (Maddison et al., 2023)
      External Data
      Subunit Structure (UniProtKB)
      Interacts with Mul1.
      (UniProt, Q7YU24 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-16
      Cytogenetic map
      5F4-5F4
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      5F4-5F4
      Limits computationally determined from genome sequence between P{EP}EP1402&P{EP}CG15893EP1634 and P{EP}Ctr1AEP1364&P{EP}EP1445
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      1-16

      (FlyBase, 2016)

      1-16.6

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (18)
      Genomic Clones (12)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (133)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Banerjee and Chinthapalli, 2014, Debattisti et al., 2014, Shiba-Fukushima et al., 2014, Poole et al., 2010, Ziviani et al., 2010)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Marf mutants exhibit lipid droplet accumulation in glia, but this does not lead to premature neurodegeneration.

            (Liu et al., 2015)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: Marf anon-WO0125274.3

            (FlyBase, 1996-)
            Additional comments

            Source for identity of Marf CG3869 was sequence comparison ( date:020416 ).

            (FlyBase, 1996-)

            Source for merge of Marf anon-WO0125274.3 was sequence comparison ( date:051113 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: Marf CG3869

            (FlyBase, 1996-)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (30)
            Reported As
            Symbol Synonym
            CG3869
            (Metwally et al., 2019, Yamaguchi and Takashima, 2018, Hallier et al., 2015, Hosono et al., 2015, Debattisti and Scorrano, 2013, Owusu-Ansah et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Poole et al., 2008, Bonacum et al., 2001)
            CG38869
            (Banerjee and Chinthapalli, 2014)
            MARF
            (Toprak et al., 2020, Valadas et al., 2018, Bhandari et al., 2015, Bhandari et al., 2014, Dorn, 2013, Melkani et al., 2013, Chen et al., 2012, Duboff et al., 2012, Eschenbacher et al., 2012, Abdelwahid et al., 2011, Fergestad et al., 2006)
            MARF1
            (Salgania et al., 2024)
            MFN
            (von Stockum et al., 2019)
            MFN2
            (Xiu et al., 2025, Mendez et al., 2016)
            Marf
            (Gandara et al., 2026, Li et al., 2026, Couto-Lima et al., 2025, Gundberg and Nance, 2025, Guo et al., 2025, Matsuo et al., 2025, Murray-Cors et al., 2025, Zhang et al., 2025, Au et al., 2024, Lou et al., 2024, Sood et al., 2024, Taylor et al., 2024, Vedelek et al., 2024, Zhou et al., 2024, Campesan et al., 2023, Cheon et al., 2023, Maddison et al., 2023, Mauri et al., 2023, Nag et al., 2023, Nemtsova et al., 2023, Taslim et al., 2023, Ecovoiu et al., 2022, Huang et al., 2022, Katti et al., 2022, Petridi et al., 2022, Anoar et al., 2021, Avellaneda et al., 2021, Baek et al., 2021, Kim et al., 2021, Layalle et al., 2021, Lee et al., 2021, Manola et al., 2021, Pang et al., 2021, Pant et al., 2021, Tapia et al., 2021, Yamaguchi et al., 2021, Yamaguchi et al., 2021, Abtahi et al., 2020, Cerqueira et al., 2020, Cha et al., 2020, Chen et al., 2020, Couly et al., 2020, Garrido-Maraver et al., 2020, Graves et al., 2020, Kankel et al., 2020, Kitani-Morii and Noto, 2020, Li et al., 2020, Liu et al., 2020, Ponte et al., 2020, Xu et al., 2020, Forgiarini et al., 2019, Ge et al., 2019, Gumeni et al., 2019, Lieber et al., 2019, Meltzer et al., 2019, Metwally et al., 2019, Smith et al., 2019, Tsakiri et al., 2019, von Stockum et al., 2019, Yadav and Srikrishna, 2019, Zhou et al., 2019, Anding et al., 2018, Ding et al., 2018, El Fissi et al., 2018, Gene Disruption Project members, 2018-, Lee et al., 2018, Lee et al., 2018, Liu et al., 2018, Şentürk and Bellen, 2018, Shaltouki et al., 2018, Yamaguchi and Takashima, 2018, Bussmann and Storkebaum, 2017, Cao et al., 2017, Housden et al., 2017, Liu et al., 2017, Transgenic RNAi Project members, 2017-, Ugur et al., 2017, Altanbyek et al., 2016, Deng et al., 2016, Fowler and O'Sullivan, 2016, Kandul et al., 2016, Lee et al., 2016, Lee et al., 2016, Ugur et al., 2016, Wang et al., 2016, Zhang et al., 2016, Foriel et al., 2015, Liu et al., 2015, López Del Amo et al., 2015, Senyilmaz et al., 2015, Banerjee and Chinthapalli, 2014, Debattisti et al., 2014, Hwang et al., 2014, Luck et al., 2014, Pogson et al., 2014, Sandoval et al., 2014, Debattisti and Scorrano, 2013, Lee et al., 2013, Ratnaparkhi, 2013, Wu et al., 2013, Yamamoto et al., 2013-, Japanese National Institute of Genetics, 2012.5.21, Liu et al., 2012, Nagaraj et al., 2012, Schmidt et al., 2012, Boyd et al., 2011, Dorn et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Thomenius et al., 2011, Liu and Lu, 2010, Ziviani et al., 2010, Deng et al., 2008, Bakal et al., 2007, Juhász et al., 2007)
            Marf-1
            (Mitra et al., 2012)
            Mfn
            (Sew et al., 2025, Qu et al., 2022, Yang et al., 2022, Panchal and Tiwari, 2020, Bouska et al., 2019, Zhang et al., 2017, Kandul et al., 2016, López Del Amo et al., 2015, Mulakkal et al., 2014, Shiba-Fukushima et al., 2014, Thomas et al., 2014, Burchell et al., 2013, Fabian and Brill, 2012, Nezis, 2012, Ziviani et al., 2010)
            Mfn-2
            (Banerjee and Chinthapalli, 2014)
            Mfn2
            (Parvez and Rahul, 2026, Taslim et al., 2023, Vos and Klein, 2021, Xu et al., 2019, Chen and Dorn, 2013, Laslo et al., 2013)
            anon-WO0125274.3
            dMARF
            (Geng et al., 2023)
            dMFN
            (Thomenius et al., 2011)
            dMarf
            (Gupta et al., 2022)
            dMfn
            (Liu et al., 2026, Tiwari and Mandal, 2021, Rodriguez-Fernandez et al., 2020, Garrido-Maraver et al., 2019, Sênos Demarco et al., 2019, Basso et al., 2018, Rana et al., 2017, Celardo et al., 2016, Senyilmaz et al., 2015, Shiba-Fukushima et al., 2014, Dorn, 2013, Kim et al., 2013, Rana et al., 2013, Chen et al., 2012, Eschenbacher et al., 2012, Abdelwahid et al., 2011, Poole et al., 2010)
            dMfn2
            (Hao et al., 2010)
            dmfn
            (Hwa et al., 2002)
            marf
            (Dark et al., 2024, Goodman et al., 2024, Haddadi et al., 2024, Liao et al., 2024, Li et al., 2023, Dai et al., 2020, Gonzalez and Wang, 2020, Wong et al., 2020, Khalil et al., 2017, Li et al., 2016, Wang et al., 2016, Gehrke et al., 2015, Gupte, 2015, Khalil et al., 2015, Wang et al., 2015, Banerjee and Chinthapalli, 2014, Bhandari et al., 2014, Mulakkal et al., 2014, Nezis, 2012, Rival et al., 2011, Park et al., 2010, Park et al., 2009)
            mfn
            (Joy et al., 2021, Ma et al., 2018, Mulakkal et al., 2014, Yun et al., 2014, Rival et al., 2011, Imai et al., 2010)
            mfn2
            (Mendez et al., 2016, Rival et al., 2011, Poole et al., 2008)
            Name Synonyms
            Drosophila mitofusin
            (Hwa et al., 2002)
            Mitochondrial assembly regulatory factor
            (Graves et al., 2020, Debattisti and Scorrano, 2013, Sinenko et al., 2011)
            Mitofusin
            (Imai, 2020, Zhang et al., 2016, Poole et al., 2010, Ziviani et al., 2010)
            mitochondria assembly regulatory factor
            (Nagaraj et al., 2012)
            mitochondrial assembly
            (Hallier et al., 2015)
            mitochondrial assembly regulatory factor
            (Boyd et al., 2011, Dorn et al., 2011)
            mitofusin
            (Liguori et al., 2021, Kandul et al., 2016, Yun et al., 2014, Nezis, 2012, Martinou and Youle, 2011, Rival et al., 2011)
            mitofusin/MARF
            (Bhandari et al., 2015)
            regulatory factor
            (Hallier et al., 2015)
            Secondary FlyBase IDs
            • FBgn0044368
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 55 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (281)