FB2021_01, released Feb 18, 2021

Gene: Dmel\feo

Open Close
General Information
Symbol
Dmel\feo
Species
D. melanogaster
Name
fascetto
Annotation Symbol
CG11207
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030241
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Snapshot
fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

l(1)BP1, l(1)9Fe, Q54, PRC1

Key Links
Genomic Location
Cytogenetic map
9F5-9F5
Sequence location
X:10,852,446..10,854,869 [-]
Recombination map

1-33

RefSeq locus
NC_004354 REGION:10852446..10854869
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables microtubule binding
inferred from biological aspect of ancestor with PANTHER:PTN000448589
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in mitotic spindle organization
inferred from mutant phenotype
(Verni et al., 2004)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in microtubule bundle formation
inferred from electronic annotation with InterPro:IPR032921
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in microtubule cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN000448589
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in mitotic spindle midzone assembly
inferred from biological aspect of ancestor with PANTHER:PTN000448590
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of cytokinesis
inferred from electronic annotation with InterPro:IPR032921
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Verni et al., 2004)
located_in spindle midzone
inferred from direct assay
(Verni et al., 2004)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000448589
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in mitotic spindle midzone
inferred from biological aspect of ancestor with PANTHER:PTN000448590
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in spindle
inferred from biological aspect of ancestor with PANTHER:PTN000448589
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\feo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
feo-RA
FBtr0073410
NM_132430
2424
671
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
feo-PA
FBpp0073266
78.2
671
9.44
NP_572658
AAF47965
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\feo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous

Comment: apically cleared

(Fisher et al., 2012)
pole plasm
(Fisher et al., 2012)
yolk
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Verni et al., 2004)
located_in spindle midzone
inferred from direct assay
(Verni et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\feo in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of feo
Transgenic constructs containing regulatory region of feo
Aberrations (Deficiencies and Duplications) ( 43 )
Inferred from experimentation
Gene duplicated in
Dp(1;2)v+63i
(Zhimulev et al., 1987, Kramers et al., 1983, Lefevre, 1981, Zhimulev et al., 1981)
Dp(1;2)v+65b
(Lefevre, 1981)
Dp(1;2)v+75d
(Geer et al., 1983)
Dp(1;Y)v+y+366
(Zhimulev et al., 1987)
Dp(1;Y)v+y+
(Zhimulev et al., 1987, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1981)
Dp(1;Y)v+y+U15
(Zhimulev et al., 1987)
Dp(1;Y)y+v+BS#1
Dp(1;Y)y+v+BS#2
Dp(1;Y)y+v+BS#3
(Schalet, 1969)
Gene disrupted in
Df(1)59D3
(Kozlova et al., 1994, Zhimulev et al., 1987)
Df(1)203C10
(Kozlova et al., 1994, Zhimulev et al., 1987)
Df(1)ras-v17
(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)ras-v-P26
(Zhimulev et al., 1987)
Df(1)sbr1
(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)sbr8
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)sbr9
(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)sbr10
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v64f
(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-B151
(Zhimulev et al., 1987)
Df(1)v-L3
(Verni et al., 2004, Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Kramers et al., 1983, Zhimulev et al., 1981)
Df(1)v-L4
(Kozlova et al., 1994, Zhimulev et al., 1987, Kramers et al., 1983, Zhimulev et al., 1981)
Df(1)v-L7
(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-L11
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-L15
(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-M1
(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-M7
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-P5
(Zhimulev et al., 1987, Zhimulev et al., 1981)
In(1)wm4hrx500
(Kozlova et al., 1994)
Gene not disrupted in
Df(1)HC133
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)HM456
(Kramers et al., 1983)
Df(1)KA7
(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)
Df(1)N71
(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)
Df(1)RA37
(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1981)
Df(1)ras-P14
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)sev-P1
(Kozlova et al., 1994)
Df(1)v65b
(Verni et al., 2004, Kozlova et al., 1994, Zhimulev et al., 1981)
Df(1)v-L1
(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1981)
Df(1)v-L2
(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)
Df(1)v-L3
(Geer et al., 1983)
Df(1)v-M5
(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-M6
(Verni et al., 2004, Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-P16
(Kozlova et al., 1994, Zhimulev et al., 1987)
Df(1)v-P22
(Kozlova et al., 1994, Zhimulev et al., 1987)
Gene not duplicated in
Dp(1;2)v+65b
(Zhimulev et al., 1987, Geer et al., 1983, Kramers et al., 1983)
Dp(1;Y)dsh+y+
(Zhimulev et al., 1987)
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | germline clone
lethal
lethal, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage | recessive
partially lethal - majority die
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4αTub84B.PL
Other Phenotypes
Allele
abnormal cytokinesis
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4αTub84B.PL
decreased occurrence of cell division | spermatogenesis
some die during pupal stage
some die during pupal stage | recessive
visible
visible, with Scer\GAL4pnr-MD237
visible | cold sensitive
Phenotype manifest in
Allele
embryonic/larval brain | larval stage, with Scer\GAL4αTub84B.PL
epithelium, with Scer\GAL4NP1624
female germline cyst, with Scer\GAL4NP1624
ganglion mother cell | larval stage
larval neuroblast | larval stage
mesothoracic tergum, with Scer\GAL4pnr-MD237
mitotic telophase & contractile ring
mitotic telophase & spindle
posterior supraalar bristle | cold sensitive
spermatocyte
testis
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PRC1
12 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Prc1
12 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Prc1
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\prc1.2
8 of 12
Yes
Yes
Xtro\prc1
6 of 12
No
Yes
Xtro\jakmip3
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\prc1a
8 of 15
Yes
Yes
Drer\prc1b
8 of 15
Yes
Yes
Drer\zgc:86764
8 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\spd-1
8 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (9)
Atha\MAP65-1
6 of 9
Yes
No
Atha\MAP65-2
6 of 9
Yes
No
Atha\MAP65-4
6 of 9
Yes
No
Atha\MAP65-9
6 of 9
Yes
Yes
Atha\MAP65-5
5 of 9
No
Yes
Atha\MAP65-8
5 of 9
No
Yes
Atha\ATMAP65-6
4 of 9
No
Yes
Atha\MAP65-7
4 of 9
No
No
Atha\PLE
4 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ASE1
7 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ase1
10 of 12
Yes
Yes
Spom\mcp1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905B9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006878
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006877
Drosophila simulans
Dsim\GD29459
Drosophila simulans
Dsim\GD29554
Drosophila sechellia
Dsec\GM11282
Drosophila sechellia
Dsec\GM11280
Drosophila erecta
Dere\GG18895
Drosophila erecta
Dere\GG18896
Drosophila yakuba
Dyak\GE15365
Drosophila yakuba
Dyak\GE15366
Drosophila ananassae
Dana\GF20258
Drosophila ananassae
Dana\GF20260
Drosophila pseudoobscura pseudoobscura
Dpse\GA22612
Drosophila pseudoobscura pseudoobscura
Dpse\GA26369
Drosophila pseudoobscura pseudoobscura
Dpse\GA10841
Drosophila persimilis
Dper\GL21681
Drosophila persimilis
Dper\GL21682
Drosophila persimilis
Dper\GL12872
Drosophila persimilis
Dper\GL14295
Drosophila persimilis
Dper\GL15749
Drosophila willistoni
Dwil\GK16121
Drosophila virilis
Dvir\GJ19495
Drosophila virilis
Dvir\GJ18655
Drosophila mojavensis
Dmoj\GI15801
Drosophila grimshawi
Dgri\GH24191
Drosophila grimshawi
Dgri\GH24767
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02DK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008467
Danaus plexippus
Monarch butterfly
Dple\DPOGS211351-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004396
Apis florea
Little honeybee
Aflo\4011867140
Apis mellifera
Western honey bee
Amel\GB41422
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23556
Bombus terrestris
Buff-tailed bumblebee
Bter\15210075
Linepithema humile
Argentine ant
Lhum\LH19857
Linepithema humile
Argentine ant
Lhum\LH19852
Linepithema humile
Argentine ant
Lhum\LH19853
Linepithema humile
Argentine ant
Lhum\LH22012
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001099
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010487
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12450
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05748
Tribolium castaneum
Red flour beetle
Tcas\TC009312
Tribolium castaneum
Red flour beetle
Tcas\TC005107
Pediculus humanus
Human body louse
Phum\PHUM174370
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005449
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14700
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05549
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14701
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12120
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02B5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW011459
Ixodes scapularis
Black-legged tick
Isca\ISCW019129
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64165.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82249.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g09170
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306019
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
sofe
10 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PRC1; protein regulator of cytokinesis 1
    12 of 15
    603484
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        feo - Klp3A
        anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
        (D'Avino et al., 2007)
        feo - neb
        pull down, autoradiography
        (Bassi et al., 2013)
        feo - pav
        pull down, autoradiography
        (Bassi et al., 2013)
        feo - sip2
        two hybrid, anti tag coimmunoprecipitation, anti tag western blot
        (Swider et al., 2019)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        feo
        enhanceable
        sip2
        (Swider et al., 2019)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        sip2
        enhanceable
        feo
        (Swider et al., 2019)
        sip2
        suppressible
        feo
        (Swider et al., 2019)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map

        1-33

        Cytogenetic map
        9F5-9F5
        Sequence location
        X:10,852,446..10,854,869 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        9F5-9F5
        Limits computationally determined from genome sequence between P{EP}sesBEP319&P{EP}ImpEP760 and P{EP}EP1321EP1321&P{EP}CG2061EP1537
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-33

        (FlyBase, 2016)

        1-33.8

        (Comeron et al., 2012)

        1-32.88

        (Geer et al., 1983)
        Left of (cM)
        (Zhimulev et al., 1981)
        Right of (cM)
        (Zhimulev et al., 1981)
        Notes
        Stocks and Reagents
        Stocks (15)
        Genomic Clones (9)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (96)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Wang et al., 2015)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: feo CG11207

          (Gatti, 2003.2.19)
          Source for database merge of

          Source for merge of: feo l(1)9Fe

          (Verni et al., 2004)
          Additional comments
          Other Comments

          dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

          (Echard et al., 2004)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.

          (Eggert et al., 2004)

          Mutant larval neuroblasts show severe defects in the assembly of both the central spindle and the contractile ring.

          (Gatti et al., 2003)
          Origin and Etymology
          Discoverer
          Etymology

          The gene is named "fascetto" (which means "thin bundle" in Italian) after the mutant phenotype; cells lacking feo function have thin central spindles during telophase.

          (Verni et al., 2004)
          Identification
          External Crossreferences and Linkouts ( 35 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (11)
          Reported As
          Symbol Synonym
          CG11207
          (Hosono et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Chen et al., 2012, Ni et al., 2011.7.19, Müller et al., 2010, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Molnar et al., 2006, Verni et al., 2004, Asha et al., 2003, Giot et al., 2003, Tomancak et al., 2002)
          EA86
          (Kramers et al., 1983)
          Feo
          (Costa and Ohkura, 2019, Jana et al., 2016, Sechi et al., 2014, Wang et al., 2013, Crest et al., 2012, Fabian and Brill, 2012, Giansanti and Fuller, 2012, Giansanti et al., 2012, Wainman et al., 2012, Szafer-Glusman et al., 2011, Gwack et al., 2007, D'Avino et al., 2005)
          PRC1
          (DeBruhl et al., 2016, Liu et al., 2014, Wainman et al., 2012)
          Q54
          (Lefevre and Watkins, 1986, Schalet, 1986, Lefevre, 1981)
          feo
          (Brust-Mascher and Scholey, 2015.2.12, Kitazawa et al., 2014, Bonke et al., 2013, Schertel et al., 2013, Giansanti et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Joyce et al., 2012, Lesch and Page, 2012, Szafer-Glusman et al., 2011, Blanco et al., 2010, Müller et al., 2010, Müller et al., 2010, Popodi et al., 2010-, Gao et al., 2008, Somma et al., 2008, D'Avino et al., 2007, Georlette et al., 2007, Molnar et al., 2006, Somma, 2006.8.30)
          l(1)9Fe
          (Verni et al., 2004, Kozlova et al., 1994, Perrimon et al., 1989, Geer et al., 1983)
          l(1)BP1
          (Verni et al., 2004, Pokholkova et al., 1991, Pokholkova and Solov'eva, 1989, Zhimulev et al., 1987, Bgatov et al., 1986, Pokholkova and Zhimulev, 1984, Zhimulev, 1982, Zhimulev et al., 1981)
          Name Synonyms
          Fascetto
          (Crest et al., 2012, Fabian and Brill, 2012, Giansanti and Fuller, 2012, Giansanti et al., 2012, Wainman et al., 2012, Szafer-Glusman et al., 2011, Gao et al., 2008, Cesario et al., 2006, D'Avino et al., 2005)
          fascetto
          (Peiris et al., 2018, DeBruhl et al., 2016, Berns et al., 2014, Debruhl et al., 2013, Lesch and Page, 2012, Somma et al., 2008, Foglietti et al., 2006, Gatti et al., 2003)
          lethal(1)9Fe
          Secondary FlyBase IDs
          • FBgn0001477
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (97)