FlyBase Gene Report: Dmel\feo

General Information

Symbol

Dmel\feo

Species

D. melanogaster

Name

fascetto

Annotation Symbol

CG11207

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030241

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

l(1)BP1, l(1)9Fe, Q54, PRC1

Key Links

Genomic Location

Cytogenetic map

9F5-9F5

Sequence location

X:10,852,446..10,854,869 [-]

Recombination map

1-33

RefSeq locus

NC_004354 REGION:10852446..10854869

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables microtubule binding

inferred from biological aspect of ancestor with PANTHER:PTN000448589

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in mitotic spindle organization

inferred from mutant phenotype

(Verni et al., 2004)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in microtubule bundle formation

inferred from electronic annotation with InterPro:IPR032921

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in microtubule cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN000448589

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in mitotic spindle midzone assembly

inferred from biological aspect of ancestor with PANTHER:PTN000448590

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of cytokinesis

inferred from electronic annotation with InterPro:IPR032921

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Verni et al., 2004)

located_in spindle midzone

inferred from direct assay

(Verni et al., 2004)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000448589

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in mitotic spindle midzone

inferred from biological aspect of ancestor with PANTHER:PTN000448590

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in spindle

inferred from biological aspect of ancestor with PANTHER:PTN000448589

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\feo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VZ62)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

feo-RA

FBtr0073410

NM_132430

2424

671

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

feo-PA

FBpp0073266

78.2

671

9.44

NP_572658

AAF47965

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\feo using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

feo_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

• cytoplasm | basal

Comment: apically cleared

(Fisher et al., 2012)

pole plasm

(Fisher et al., 2012)

yolk

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain glial cell

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

lateral cord glial cell

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Verni et al., 2004)

located_in spindle midzone

inferred from direct assay

(Verni et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\feo in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\feo

View exonic expression by tissue for Dmel\feo

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030241

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32015/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030241

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030241

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030241

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11207

Flygut - An atlas of the Drosophila adult midgut

FBgn0030241

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\feo

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of feo

Transgenic constructs containing regulatory region of feo

Aberrations (Deficiencies and Duplications) ( 43 )

Inferred from experimentation ( 43 )

Gene disrupted in

Df(1)59D3

(Kozlova et al., 1994, Zhimulev et al., 1987)

Df(1)203C10

(Kozlova et al., 1994, Zhimulev et al., 1987)

Df(1)ras-v17

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)ras-v-P26

(Zhimulev et al., 1987)

Df(1)sbr1

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)sbr8

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)sbr9

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)sbr10

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v64f

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-B151

(Zhimulev et al., 1987)

Df(1)v-L3

(Verni et al., 2004, Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Kramers et al., 1983, Zhimulev et al., 1981)

Df(1)v-L4

(Kozlova et al., 1994, Zhimulev et al., 1987, Kramers et al., 1983, Zhimulev et al., 1981)

Df(1)v-L7

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-L11

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-L15

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-M1

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-M7

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-P5

(Zhimulev et al., 1987, Zhimulev et al., 1981)

In(1)w^m4hrx500

(Kozlova et al., 1994)

Gene not disrupted in

Df(1)HC133

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)HM456

(Kramers et al., 1983)

Df(1)KA7

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Df(1)N71

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Df(1)RA37

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1981)

Df(1)ras-P14

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)sev-P1

(Kozlova et al., 1994)

Df(1)v65b

(Verni et al., 2004, Kozlova et al., 1994, Zhimulev et al., 1981)

Df(1)v-L1

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Geer et al., 1983, Kramers et al., 1983, Zhimulev et al., 1981)

Df(1)v-L2

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Df(1)v-L3

(Geer et al., 1983)

Df(1)v-M5

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-M6

(Verni et al., 2004, Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-P16

(Kozlova et al., 1994, Zhimulev et al., 1987)

Df(1)v-P22

(Kozlova et al., 1994, Zhimulev et al., 1987)

Gene not duplicated in

Dp(1;2)v⁺65b

(Zhimulev et al., 1987, Geer et al., 1983, Kramers et al., 1983)

Dp(1;Y)dsh⁺y⁺

(Zhimulev et al., 1987)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | germline clone

feo^EA86

lethal

lethal, with Scer\GAL4^pnr-MD237

feo^GD1603

lethal | recessive

lethal - all die before end of pupal stage

feo¹⁴

lethal - all die before end of pupal stage | recessive

partially lethal - majority die

feo⁸

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

feo^GD1603

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

feo^GD1603

viable, with Scer\GAL4^tin.CΔ4

feo^GD1603

viable, with Scer\GAL4^αTub84B.PL

feo^GL00393

Other Phenotypes

Allele

abnormal cytokinesis

abnormal neuroanatomy | larval stage

feo^GD1603

abnormal neuroanatomy | larval stage, with Scer\GAL4^αTub84B.PL

feo^GL00393

decreased occurrence of cell division | spermatogenesis

feo^unspecified

some die during pupal stage

feo¹⁴

some die during pupal stage | recessive

visible

feo¹²

visible, with Scer\GAL4^pnr-MD237

feo^GD1603

visible | cold sensitive

feo¹²

Phenotype manifest in

Allele

embryonic/larval brain | larval stage, with Scer\GAL4^αTub84B.PL

feo^GL00393

epithelium, with Scer\GAL4^NP1624

feo^KK108553

female germline cyst, with Scer\GAL4^NP1624

feo^KK108553

ganglion mother cell | larval stage

feo^GD1603

larval neuroblast | larval stage

feo^GD1603

mesothoracic tergum, with Scer\GAL4^pnr-MD237

feo^GD1603

mitotic telophase & contractile ring

feo^unspecified

mitotic telophase & spindle

feo^unspecified

posterior supraalar bristle | cold sensitive

feo¹²

spermatocyte

feo^unspecified

testis

feo^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PRC1

12 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Prc1

12 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Prc1

10 of 13

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\prc1.2

8 of 12

Yes

Xtro\prc1

6 of 12

Yes

Xtro\jakmip3

1 of 12

Yes

Danio rerio (Zebrafish) (3)

Drer\prc1a

8 of 15

Yes

Drer\prc1b

8 of 15

Yes

Drer\zgc:86764

8 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\spd-1

8 of 15

Yes

Arabidopsis thaliana (thale-cress) (9)

Atha\MAP65-1

6 of 9

Yes

Atha\MAP65-2

6 of 9

Yes

Atha\MAP65-4

6 of 9

Yes

Atha\MAP65-9

6 of 9

Yes

Atha\MAP65-5

5 of 9

Yes

Atha\MAP65-8

5 of 9

Yes

Atha\ATMAP65-6

4 of 9

Yes

Atha\MAP65-7

4 of 9

Atha\PLE

4 of 9

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ASE1

7 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\ase1

10 of 12

Yes

Spom\mcp1

1 of 12

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

10 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRC1; protein regulator of cytokinesis 1

12 of 15

603484

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

feo - Klp3A

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(D'Avino et al., 2007)

feo - neb

pull down, autoradiography

(Bassi et al., 2013)

feo - pav

pull down, autoradiography

(Bassi et al., 2013)

feo - sip2

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Swider et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

feo

enhanceable

sip2

(Swider et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

sip2

enhanceable

feo

(Swider et al., 2019)

sip2

suppressible

feo

(Swider et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58432

DroID - A comprehensive database of gene and protein interactions.

FBgn0030241

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030241

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RHO GTPases activate CIT

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-33

Cytogenetic map

9F5-9F5

Sequence location

X:10,852,446..10,854,869 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

9F5-9F5

Limits computationally determined from genome sequence between P{EP}sesB^EP319&P{EP}Imp^EP760 and P{EP}EP1321^EP1321&P{EP}CG2061^EP1537

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-33

(FlyBase, 2016)

1-33.8

(Comeron et al., 2012)

1-32.88

(Geer et al., 1983)

Left of (cM)

(Zhimulev et al., 1981)

Right of (cM)

sbr
fliG

(Zhimulev et al., 1981)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4688

feo^EA86/FM7a

59276

w^* P{Ubi-p63E-feo.GFP}1

59273

w^*; P{Ubi-p63E-feo.GFP}2

59278

w^*; P{Ubi-p63E-feo.mCherry}2/CyO

59274

w^*; P{Ubi-p63E-feo.GFP}3/TM3, Sb¹

59277

w^*; P{Ubi-p63E-feo.mCherry}3/TM3, Sb¹

28926

y¹ v¹; P{TRiP.HM05137}attP2/TM3, Sb¹

35467

y¹ sc^* v¹ sev²¹; P{TRiP.GL00393}attP2

FlyORF

F001412

M{UAS-feo.ORF}ZH-86Fb

Kyoto

100969

Dp(1;Y)y⁺v⁺#3 / Df(1)m259-4, feo¹ v¹ / FM6

VDRC

v107824

P{KK108553}VIE-260B

v7834

w¹¹¹⁸; P{GD1603}v7834

More stocks available...

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (96)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030241

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030241

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32015

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wang et al., 2015)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: feo CG11207

(Gatti, 2003.2.19)

Source for database merge of

Source for merge of: feo l(1)9Fe

(Verni et al., 2004)

Additional comments

Other Comments

dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

(Echard et al., 2004)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc₁₆₇ cells.

(Eggert et al., 2004)

Mutant larval neuroblasts show severe defects in the assembly of both the central spindle and the contractile ring.

(Gatti et al., 2003)

Origin and Etymology

Discoverer

Etymology

The gene is named "fascetto" (which means "thin bundle" in Italian) after the mutant phenotype; cells lacking feo function have thin central spindles during telophase.

(Verni et al., 2004)

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32015

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VZ62

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VZ62

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030241

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030241

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32015/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030241

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

feo_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030241

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030241

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11207

Flygut - An atlas of the Drosophila adult midgut

FBgn0030241

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030241

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32015

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005107

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG11207

MARRVEL_MODEL - MARRVEL (model organism gene)

32015

modMine - A data warehouse for the modENCODE project

FBgn0030241

Linkouts

BioGRID - A database of protein and genetic interactions.

58432

DroID - A comprehensive database of gene and protein interactions.

FBgn0030241

DRSC - Results frm RNAi screens

FBgn0030241

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030241

FlyMine - An integrated database for Drosophila genomics

FBgn0030241

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RHO GTPases activate CIT

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG11207

(Hosono et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Chen et al., 2012, Ni et al., 2011.7.19, Müller et al., 2010, Zhang et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Molnar et al., 2006, Verni et al., 2004, Asha et al., 2003, Giot et al., 2003, Tomancak et al., 2002)

EA86

(Kramers et al., 1983)

Feo

(Costa and Ohkura, 2019, Jana et al., 2016, Sechi et al., 2014, Wang et al., 2013, Crest et al., 2012, Fabian and Brill, 2012, Giansanti and Fuller, 2012, Giansanti et al., 2012, Wainman et al., 2012, Szafer-Glusman et al., 2011, Gwack et al., 2007, D'Avino et al., 2005)

PRC1

(DeBruhl et al., 2016, Liu et al., 2014, Wainman et al., 2012)

Q54

(Lefevre and Watkins, 1986, Schalet, 1986, Lefevre, 1981)

fascetto

(Kim et al., 2021)

l(1)9Fe

(Verni et al., 2004, Kozlova et al., 1994, Perrimon et al., 1989, Geer et al., 1983)

l(1)BP1

(Verni et al., 2004, Pokholkova et al., 1991, Pokholkova and Solov'eva, 1989, Zhimulev et al., 1987, Bgatov et al., 1986, Pokholkova and Zhimulev, 1984, Zhimulev, 1982, Zhimulev et al., 1981)

Name Synonyms

Fascetto

(Crest et al., 2012, Fabian and Brill, 2012, Giansanti and Fuller, 2012, Giansanti et al., 2012, Wainman et al., 2012, Szafer-Glusman et al., 2011, Gao et al., 2008, Cesario et al., 2006, D'Avino et al., 2005)

fascetto

(Peiris et al., 2018, DeBruhl et al., 2016, Berns et al., 2014, Debruhl et al., 2013, Lesch and Page, 2012, Somma et al., 2008, Foglietti et al., 2006, Gatti et al., 2003)

lethal(1)9Fe

Secondary FlyBase IDs

FBgn0001477

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (102)

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