Sterile 20 family kinase - a component of the Hippo pathway - restricts cell proliferation in imaginal discs - controls of epithelial morphogenesis by promoting Fasciclin 2 endocytosis - negative regulator of microtubule plus-end growth - regulation of apoptosis in pole cells
Gene model reviewed during 5.56
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
Gene model reviewed during 5.40
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 5.55
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 6.02
Interacts with Schip1; the interaction enhances Tao kinase activity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tao using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tao in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.
Ubiquitous RNAi-mediated knockdown of Tao-1 specifically affects the survival and proper migration behaviour of the pole cells/primordial germ cells, but embryos develop to viable adults. Ectopic expression of a GFP-tagged version of Tao-1long leads to viable adults with the fusion protein localised at cell membranes.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.