controls brain growth through lineage-specific interactions with master mitotic signaling kinase Aurora A - glial lineage-specific WDR62 depletion significantly decreases brain volume - JNK interacts with Wdr62 at the spindle and transcriptionally represses the kinesin Kif1a to promote planar spindle orientation - required to maintain centrosome asymmetry in Drosophila neuroblasts by directly or indirectly stabilizing the interphase MTs necessary to accumulate and maintain pericentriolar matrix-associated Polo - control of intestinal cell fate
Gene model reviewed during 5.41
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Wdr62 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Wdr62 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Wdr62 CG7337
Gene is named "Wdr62" based on orthology with the human WDR62 gene.