FlyBase Gene Report: Dmel\Dscam1

1 of 13

fred

1 of 13

hbs

1 of 13

InR

1 of 13

nkt

1 of 13

Nrg

1 of 13

otk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Pxn

1 of 13

Dscam1^{ΔC.UAS.1.30.30.1.GFP}

1 of 13

robo2

1 of 13

robo3

1 of 13

sev

1 of 13

side

1 of 13

side-VII

1 of 13

sls

1 of 13

sns

1 of 13

Tehao

1 of 13

tei

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Down syndrome, DSCAM-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 9 )

Allele

Disease

Evidence

References

Dscam1⁰⁵⁵¹⁸

model of Down syndrome

CEA with fra⁴

(Hernández et al., 2023)

Dscam1¹⁸

model of Down syndrome

CEA

(Huang et al., 2011)

Dscam1²¹

model of Down syndrome

CEA with Dscam1^B17-1

(Huang et al., 2011)

Dscam1^+t73.3

model of Down syndrome

CEA

(Lowe et al., 2018, Cvetkovska et al., 2013)

Dscam1^{UAS.1.30.30.2}

model of Down syndrome

CEA with Dscam1^{ΔC.UAS.1.30.30.1.GFP}

(Hernández et al., 2023)

Dscam1^GD2596

model of autism spectrum disorder

CEA

(Stessman et al., 2017)

Dscam1^B17-1

model of Down syndrome

CEA with Dscam1²¹

(Huang et al., 2011)

Dscam1^{4.3-6.36-9.25-17.2}

model of Down syndrome

CEA

(Pizzano et al., 2023)

model of Down syndrome

CEA with Dscam1^{UAS.1.30.30.2}

(Hernández et al., 2023)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 11 )

Allele

Disease

Interaction

References

Dscam1¹⁸

model of Down syndrome

is ameliorated by Dscam1^{C2.4.2-6.14-9.24-17.2}

(Huang et al., 2011)

Dscam1^unspecified

ameliorates Down syndrome

modeled by Fmr1^unspecified

(Cvetkovska et al., 2013)

modeled by Fmr1^RNAi.UAS.cUa

(Cvetkovska et al., 2013)

ameliorates fragile X syndrome

modeled by Fmr1^unspecified

(Cvetkovska et al., 2013)

modeled by Fmr1^RNAi.UAS.cUa

(Cvetkovska et al., 2013)

Dscam1^{UAS.1.30.30.2}

ameliorates Down syndrome

modeled by Dscam1⁰⁵⁵¹⁸, fra⁴

(Hernández et al., 2023)

Dscam1^{4.3-6.36-9.25-17.2}

model of Down syndrome

is exacerbated by Appl^{UAS.cPa.Tag:V5}

(Pizzano et al., 2023)

Dscam1^{7.27.25.1.UAS.cZa}

ameliorates Down syndrome

modeled by Dscam1⁰⁵⁵¹⁸, fra⁴

(Hernández et al., 2023)

Dscam1^{A1.4.3-6.36-9.25-17.1}

ameliorates Down syndrome

modeled by Dscam1²¹, Dscam1^B17-1

(Huang et al., 2011)

Dscam1^{A2.4.3-6.36-9.25-17.2}

ameliorates Down syndrome

modeled by Dscam1²¹, Dscam1^B17-1

(Huang et al., 2011)

Dscam1^{B1.4.2-6.18-9.22-17.1}

ameliorates Down syndrome

modeled by Dscam1²¹, Dscam1^B17-1

(Huang et al., 2011)

Dscam1^{B2.4.2-6.18-9.22-17.2}

ameliorates Down syndrome

modeled by Dscam1²¹, Dscam1^B17-1

(Huang et al., 2011)

Dscam1^{C1.4.2-6.14-9.24-17.1}

ameliorates Down syndrome

modeled by Dscam1²¹, Dscam1^B17-1

(Huang et al., 2011)

Dscam1^{C2.4.2-6.14-9.24-17.2}

ameliorates Down syndrome

modeled by Dscam1²¹, Dscam1^B17-1

(Huang et al., 2011)

modeled by Dscam1¹⁸

(Huang et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DSCAM; DS cell adhesion molecule

11 of 14

DOWN SYNDROME CELL ADHESION MOLECULE; DSCAM

DSCAML1; DS cell adhesion molecule like 1

11 of 14

611782

KIRREL2; kirre like nephrin family adhesion molecule 2

3 of 14

607762

KIRREL3; kirre like nephrin family adhesion molecule 3

3 of 14

607761

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Hsap\DSCAM

(Huang et al., 2011)

anti bait coimmunoprecipitation, full identification by DNA sequencing, primer specific pcr

Hsap\DSCAML1

(Huang et al., 2011)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Dscam1 - Fmr1

(Cvetkovska et al., 2013, Kim et al., 2013)

Dscam1 - Hrb27C

anti bait coimmunoprecipitation, nucleotide sequence identification

(Olson et al., 2007)

Dscam1 - Hrb87F

electrophoretic mobility shift assay, autoradiography, anti bait coimmunoprecipitation, nucleotide sequence identification

(Olson et al., 2007)

Dscam1 - Hrb98DE

anti bait coimmunoprecipitation, nucleotide sequence identification

(Olson et al., 2007)

Dscam1 - elav

clip-seq, electrophoretic mobility shift assay, autoradiography, anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Carrasco et al., 2020, Zhang et al., 2019)

Dscam1 - pAbp

pull down, anti tag western blot

(Singh et al., 2022)

Dscam1 - sqd

anti bait coimmunoprecipitation, nucleotide sequence identification

(Olson et al., 2007)

protein-protein

Physical Interaction

Assay

References

enzyme linked immunosorbent assay, cosedimentation, molecular weight, bead aggregation assay, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, anti tag western blot, affinity technology, x-ray crystallography

(Li et al., 2016, Ozkan et al., 2013, Wu et al., 2012, Meijers et al., 2007, Millard et al., 2007, Wojtowicz et al., 2004)

Dscam1 - Abl

anti tag coimmunoprecipitation, anti tag western blot

(Sterne et al., 2015)

Dscam1 - NetB

affinity technology, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, anti tag western blot

(Alavi et al., 2016, Andrews et al., 2008)

Dscam1 - Ptp69D

anti tag coimmunoprecipitation, western blot

(Dascenco et al., 2015)

Dscam1 - SH3PX1

two hybrid

(Worby et al., 2001)

Dscam1 - Src42A

enzymatic study, autoradiography

(Muda et al., 2002)

Dscam1 - Strip

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Sakuma et al., 2015)

Dscam1 - Tbcd

two hybrid, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Okumura et al., 2015)

Dscam1 - Ubi-p63E

anti tag coimmunoprecipitation, peptide massfingerprinting

(Yang et al., 2012)

Dscam1 - Vap33

anti bait coimmunoprecipitation, western blot, pull down, anti tag coimmunoprecipitation, peptide massfingerprinting

(Yang et al., 2012)

Dscam1 - dock

anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, edman degradation, autoradiography, western blot, anti bait coimmunoprecipitation, two hybrid, anti tag western blot, far western blotting

(Liu et al., 2020, Yang et al., 2012, Huang et al., 2011, Worby et al., 2001, Schmucker et al., 2000)

Dscam1 - robo1

anti bait coimmunoprecipitation, anti tag western blot

(Alavi et al., 2016)

Dscam1 - sli

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, affinity technology, fluorescence microscopy

(Alavi et al., 2016, Dascenco et al., 2015)

Dscam1 - vap

anti tag coimmunoprecipitation, peptide massfingerprinting

(Rowshanravan et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Abl

(Sterne et al., 2015)

enhanceable

dock

(Schmucker et al., 2000)

enhanceable

(Raza and Jacobs, 2016)

Spt-I|Dscam1

enhanceable

lace

(Goyal et al., 2019)

suppressible

Pak

(Kamiyama et al., 2015)

enhanceable

Pak

(Schmucker et al., 2000)

enhanceable

(Raza and Jacobs, 2016)

suppressible

(Raza and Jacobs, 2016)

suppressible

Strip

(Sakuma et al., 2015)

suppressible

Tbcd

(Okumura et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Appl

enhanceable

(Pizzano et al., 2023)

Appl

suppressible

(Pizzano et al., 2023)

dock

enhanceable

(Schmucker et al., 2000)

Fmr1

suppressible

(Cvetkovska et al., 2013, Kim et al., 2013)

enhanceable

Dscam1|Dscam3

(Andrews et al., 2008)

enhanceable

(Raza and Jacobs, 2016)

suppressible

(Kim et al., 2013)

enhanceable

(Goyal et al., 2019)

lace

suppressible

(Goyal et al., 2019)

Pak

enhanceable

(Schmucker et al., 2000)

enhanceable

(Raza and Jacobs, 2016)

suppressible

(Raza and Jacobs, 2016)

Tbcd

enhanceable

(Okumura et al., 2015)

wnd

suppressible