FB2022_02, released March 29, 2022

Gene: Dmel\DAT

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General Information
Symbol
Dmel\DAT
Species
D. melanogaster
Name
Dopamine transporter
Annotation Symbol
CG8380
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034136
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Dopamine transporter (DAT) encodes a dopamine transporter that mediates uptake of dopamine from the synaptic cleft. Its loss increases extracellular dopamine and is associated with behavioral phenotypes including increased activity and decreased sleep. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

fumin, fmn, dDAT, DmDAT

Key Links
Genomic Location
Cytogenetic map
53C7-53C8
Sequence location
Recombination map
2-80
RefSeq locus
NT_033778 REGION:16558567..16565238
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables cocaine binding
inferred from direct assay
(Porzgen et al., 2001)
enables dopamine:sodium symporter activity
inferred from direct assay
(Porzgen et al., 2001)
inferred from direct assay
(assigned by UniProt )
(Wu and Gu, 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables dopamine:sodium symporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000746001
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in adult locomotory behavior
inferred from mutant phenotype
(van der Voet et al., 2016)
involved_in circadian sleep/wake cycle
inferred from mutant phenotype
(assigned by UniProt )
(Ueno and Kume, 2014)
inferred from direct assay
(Kume et al., 2005)
involved_in dopamine transport
inferred from direct assay
(assigned by UniProt )
(Wu and Gu, 2003)
inferred from direct assay
(Porzgen et al., 2001)
involved_in regulation of presynaptic cytosolic calcium ion concentration
inferred from mutant phenotype
(Cohn et al., 2015)
involved_in response to odorant
inferred from mutant phenotype
(Cohn et al., 2015)
involved_in sleep
inferred from mutant phenotype
(Wu et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in dopamine uptake involved in synaptic transmission
inferred from biological aspect of ancestor with PANTHER:PTN000746001
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in norepinephrine transport
inferred from biological aspect of ancestor with PANTHER:PTN000746001
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in sodium ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(assigned by UniProt )
(Wang et al., 2015, Penmatsa et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of plasma membrane
inferred from sequence model
(Porzgen et al., 2001)
is_active_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000746001
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in neuronal cell body membrane
inferred from biological aspect of ancestor with PANTHER:PTN000746001
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in presynaptic membrane
inferred from biological aspect of ancestor with PANTHER:PTN000746001
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (Q7K4Y6)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Dopamine transporter (DAT) encodes a dopamine transporter that mediates uptake of dopamine from the synaptic cleft. Its loss increases extracellular dopamine and is associated with behavioral phenotypes including increased activity and decreased sleep. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS -
Solute carrier family 6 (SLC6) members are Na+/Cl--dependent transporters of extracellular neurotransmitters, amino acids and osmolytes across the plasma membrane into the cytosol. (Adapted from FBrf0193583).
Protein Function (UniProtKB)
Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:11125028, PubMed:12606774, PubMed:24037379, PubMed:25970245). Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin (PubMed:11125028, PubMed:12606774). Plays a role in the regulation of the rest/activity cycle (PubMed:16093388, PubMed:25232310).
(UniProt, Q7K4Y6)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\DAT for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7K4Y6)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
DAT-RA
FBtr0087125
NM_079039
3040
631
DAT-RB
FBtr0330002
NM_001274097
3040
644
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
DAT-PA
FBpp0086271
70.3
631
6.31
NP_523763
AAF57986
DAT-PB
FBpp0303037
71.9
644
6.70
NP_001261026
AGB93558
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\DAT using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
embryonic stage 14
H-cell
(Stagg et al., 2011)
embryonic stage 17
H-cell
(Wheeler et al., 2006)
third instar larval stage
dopaminergic neuron
(Porzgen et al., 2001)
dopaminergic neuron
(Porzgen et al., 2001)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Romero-Calderon et al., 2007)
adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Porzgen et al., 2001)
embryonic stage 1 -- 9
organism | faint

Comment: residual maternal transcript

(Porzgen et al., 2001)
embryonic stage 15 -- 17

Comment: 12-24 hr AEL; not expressed 4-12 hr AEL

(Porzgen et al., 2001)
first instar larval stage -- adult stage
organism
(Porzgen et al., 2001)
adult stage | male
adult head
(Porzgen et al., 2001)
adult thorax & adult abdomen

Comment: reference states "body"

(Porzgen et al., 2001)
adult stage | female
adult head
(Porzgen et al., 2001)
adult thorax | faint & adult abdomen | faint

Comment: reference states "body"

(Porzgen et al., 2001)
Additional Descriptive Data

In situ hybridization in third instar larvae show that DAT is expressed in dopaminergic (DA) neurons. In the brain, it is observed in three DA neuron cell groups in each lobe. In the ventral nerve cord, it is seen in eight unpaired medial DA neurons along the midline and in two rows of seven dorsal lateral DA neurons. A developmental profile done by RT-PCR show robust expression in late embryos and larvae, a dip in expression in pupae and an increase in adults, with heads showing enhanced signal over bodies.

(Porzgen et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(assigned by UniProt )
(Wang et al., 2015, Penmatsa et al., 2013)
Expression Deduced from Reporters
Reporter: P{DAT-B-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
dopaminergic PAL neuron | subset
(Xie et al., 2018)
dopaminergic PPL1 neuron | subset
(Xie et al., 2018)
dopaminergic PPL2ab neuron | subset
(Xie et al., 2018)
dopaminergic PPM3 neuron | subset
(Xie et al., 2018)
Reporter: P{DAT-GAL4.L}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
dopaminergic neuron
(Bang et al., 2011)
Reporter: P{GMR55C10-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult crepine | faint | restricted
(Jenett and Svirskas, 2012.9.24)
adult antennal lobe | faint | restricted
(Jenett and Svirskas, 2012.9.24)
bulb | intense | restricted
(Jenett and Svirskas, 2012.9.24)
vest | faint | restricted
(Jenett and Svirskas, 2012.9.24)
inferior clamp | intense | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body | intense | restricted
(Jenett and Svirskas, 2012.9.24)
gall | faint | restricted
(Jenett and Svirskas, 2012.9.24)
adult optic lobe | intense | restricted
(Jenett and Svirskas, 2012.9.24)
superior medial protocerebrum | restricted
(Jenett and Svirskas, 2012.9.24)
superior intermediate protocerebrum | faint | restricted
(Jenett and Svirskas, 2012.9.24)
dopaminergic PAL neuron | subset
(Xie et al., 2018)
dopaminergic PPL1 neuron | subset
(Xie et al., 2018)
dopaminergic PPL2ab neuron | subset
(Xie et al., 2018)
dopaminergic PPM1 neuron | subset
(Xie et al., 2018)
dopaminergic PPM2 neuron | subset
(Xie et al., 2018)
dopaminergic PPM3 neuron | subset
(Xie et al., 2018)
dopaminergic GNG neuron | subset
(Xie et al., 2018)
Reporter: P{GMR58E02-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval mushroom body dopaminergic neuron h1
(Saumweber et al., 2018, Rohwedder et al., 2016)
larval mushroom body dopaminergic neuron i1
(Saumweber et al., 2018, Rohwedder et al., 2016)
larval mushroom body dopaminergic neuron j1
(Saumweber et al., 2018, Rohwedder et al., 2016)
larval mushroom body dopaminergic neuron k1
(Rohwedder et al., 2016)
adult stage
mushroom body medial lobe | restricted
(Riemensperger et al., 2013)
dopaminergic PAM neuron
(Yamagata et al., 2015, Vogt et al., 2014, Perisse et al., 2013, Riemensperger et al., 2013, Liu et al., 2012)
adult brain | restricted
(Shuai et al., 2015, Yamagata et al., 2015)
mushroom body extrinsic neuron
(Shuai et al., 2015)
mushroom body gamma lobe slice 1
(Shuai et al., 2015)
mushroom body gamma lobe slice 2
(Shuai et al., 2015)
mushroom body gamma lobe slice 3
(Shuai et al., 2015)
mushroom body gamma lobe slice 4
(Shuai et al., 2015)
mushroom body gamma lobe slice 5
(Shuai et al., 2015)
mushroom body beta lobe slice 1
(Shuai et al., 2015)
mushroom body beta lobe slice 2
(Shuai et al., 2015)
mushroom body beta' lobe slice 1
(Shuai et al., 2015)
mushroom body beta' lobe slice 2
(Shuai et al., 2015)
mushroom body alpha lobe slice 1
(Shuai et al., 2015)
dopaminergic PAM neuron 13
(Shuai et al., 2015)
dopaminergic PAM neuron 14
(Shuai et al., 2015)
adult optic lobe glial cell
(Liu et al., 2012)
dopaminergic PAM neuron | subset
(Meissner et al., 2019, Huetteroth et al., 2015)
medial lobe of adult mushroom body
(Huetteroth et al., 2015)
Reporter: P{GMR58E02-lexA}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
dopaminergic PAM neuron
(Dag et al., 2019, Owald et al., 2015, Yamagata et al., 2015, Liu et al., 2012)
adult optic lobe glial cell
(Liu et al., 2012)
adult brain | restricted
(Yamagata et al., 2015)
dopaminergic PAM neuron 1
(Dag et al., 2019)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\DAT in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of DAT
Transgenic constructs containing regulatory region of DAT
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene not disrupted in
Df(2R)Sema2b-C4
(Wu et al., 2011)
Gene disrupted in
Df(2R)A15
(Wu et al., 2011)
Df(2R)B65
(Wu et al., 2011)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC6A2
14 of 15
Yes
Yes
Hsap\SLC6A3
10 of 15
No
Yes
 
19  
Hsap\SLC6A4
5 of 15
No
No
1  
Hsap\SLC6A1
3 of 15
No
No
Hsap\SLC6A6
3 of 15
No
No
Hsap\SLC6A7
3 of 15
No
No
Hsap\SLC6A8
3 of 15
No
No
Hsap\SLC6A9
3 of 15
No
No
Hsap\SLC6A11
3 of 15
No
No
Hsap\SLC6A12
3 of 15
No
No
Hsap\SLC6A13
3 of 15
No
No
Hsap\SLC6A15
3 of 15
No
No
Hsap\SLC6A16
3 of 15
No
No
Hsap\SLC6A17
3 of 15
No
No
Hsap\SLC6A5
2 of 15
No
No
1  
Hsap\SLC6A14
2 of 15
No
No
Hsap\SLC6A18
2 of 15
No
No
Hsap\SLC6A19
2 of 15
No
No
1  
Hsap\SLC6A20
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc6a2
13 of 15
Yes
Yes
Mmus\Slc6a3
10 of 15
No
Yes
Mmus\Slc6a4
5 of 15
No
No
Mmus\Slc6a6
3 of 15
No
No
Mmus\Slc6a7
3 of 15
No
No
Mmus\Slc6a8
3 of 15
No
No
Mmus\Slc6a9
3 of 15
No
No
Mmus\Slc6a11
3 of 15
No
No
Mmus\Slc6a12
3 of 15
No
No
Mmus\Slc6a13
3 of 15
No
No
Mmus\Slc6a15
3 of 15
No
No
Mmus\Slc6a21
3 of 15
No
No
Mmus\Slc6a1
2 of 15
No
No
Mmus\Slc6a5
2 of 15
No
No
Mmus\Slc6a14
2 of 15
No
No
Mmus\Slc6a16
2 of 15
No
No
Mmus\Slc6a17
2 of 15
No
No
Mmus\Slc6a18
2 of 15
No
No
Mmus\Slc6a19
2 of 15
No
No
Mmus\Slc6a20a
2 of 15
No
No
Mmus\Slc6a20b
2 of 15
No
No
Mmus\Wdr76
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (21)
Rnor\Slc6a3
9 of 13
Yes
Yes
Rnor\Slc6a2
8 of 13
No
Yes
Rnor\Slc6a4
5 of 13
No
No
Rnor\RGD1562492
3 of 13
No
No
Rnor\Slc6a1
3 of 13
No
No
Rnor\Slc6a6
3 of 13
No
No
Rnor\Slc6a7
3 of 13
No
No
Rnor\Slc6a9
3 of 13
No
No
Rnor\Slc6a11
3 of 13
No
No
Rnor\Slc6a12
3 of 13
No
No
Rnor\Slc6a13
3 of 13
No
No
Rnor\Slc6a16
3 of 13
No
No
Rnor\Slc6a17
3 of 13
No
No
Rnor\Slc6a5
2 of 13
No
No
Rnor\Slc6a8
2 of 13
No
No
Rnor\Slc6a14
2 of 13
No
No
Rnor\Slc6a15
2 of 13
No
No
Rnor\Slc6a18
2 of 13
No
No
Rnor\Slc6a19
2 of 13
No
No
Rnor\Slc6a20
2 of 13
No
No
Rnor\LOC103690061
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (23)
Xtro\slc6a2
8 of 12
Yes
Yes
Xtro\slc6a3
6 of 12
No
Yes
Xtro\slc6a4
4 of 12
No
No
Xtro\LOC100127682
3 of 12
No
No
Xtro\slc6a1
3 of 12
No
No
Xtro\slc6a6
3 of 12
No
No
Xtro\slc6a7
3 of 12
No
No
Xtro\slc6a8
3 of 12
No
No
Xtro\slc6a8
3 of 12
No
No
Xtro\slc6a9
3 of 12
No
No
Xtro\slc6a12
3 of 12
No
Yes
Xtro\slc6a13
3 of 12
No
No
Xtro\slc6a15
3 of 12
No
No
Xtro\slc6a17
3 of 12
No
No
Xtro\slc6a4
2 of 12
No
Yes
Xtro\slc6a5
2 of 12
No
No
Xtro\slc6a14.2
2 of 12
No
No
Xtro\slc6a16
2 of 12
No
No
Xtro\slc6a19
2 of 12
No
No
Xtro\LOC100490052
1 of 12
No
Yes
Xtro\LOC100497766
1 of 12
No
Yes
Xtro\LOC101731472
1 of 12
No
Yes
Xtro\slc6a14.1
1 of 12
No
Yes
Danio rerio (Zebrafish) (36)
Drer\slc6a2
13 of 15
Yes
Yes
Drer\slc6a4a
5 of 15
No
No
Drer\slc6a4b
5 of 15
No
No
Drer\slc6a3
4 of 15
No
Yes
Drer\si:ch211-117c9.5
3 of 15
No
No
Drer\si:ch211-132b12.1
3 of 15
No
No
Drer\si:ch211-132b12.2
3 of 15
No
No
Drer\si:ch211-132b12.3
3 of 15
No
No
Drer\slc6a1b
3 of 15
No
No
Drer\slc6a1l
3 of 15
No
No
Drer\slc6a6a
3 of 15
No
No
Drer\slc6a7
3 of 15
No
No
Drer\slc6a8
3 of 15
No
No
Drer\slc6a9
3 of 15
No
No
Drer\slc6a11a
3 of 15
No
No
Drer\slc6a11b
3 of 15
No
No
Drer\slc6a13
3 of 15
No
No
Drer\slc6a15
3 of 15
No
No
Drer\slc6a16a
3 of 15
No
No
Drer\slc6a17
3 of 15
No
No
Drer\slc6a22.1
3 of 15
No
No
Drer\slc6a22.2
3 of 15
No
No
Drer\si:ch211-132b12.6
2 of 15
No
No
Drer\si:ch211-225b11.1
2 of 15
No
No
Drer\si:ch211-283g2.1
2 of 15
No
No
Drer\slc6a1a
2 of 15
No
No
Drer\slc6a5
2 of 15
No
No
Drer\slc6a6b
2 of 15
No
No
Drer\slc6a14
2 of 15
No
No
Drer\slc6a18
2 of 15
No
No
Drer\slc6a19a.1
2 of 15
No
No
Drer\slc6a19a.2
2 of 15
No
No
Drer\slc6a19b
2 of 15
No
No
Drer\zgc:158427
2 of 15
No
No
Drer\si:ch211-132b12.4
1 of 15
No
No
Drer\slc6a16b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\dat-1
15 of 15
Yes
Yes
Cele\mod-5
4 of 15
No
No
Cele\snf-2
2 of 15
No
No
Cele\snf-3
2 of 15
No
No
Cele\snf-6
2 of 15
No
No
Cele\snf-7
2 of 15
No
No
Cele\snf-9
2 of 15
No
No
Cele\snf-10
2 of 15
No
No
Cele\snf-11
2 of 15
No
No
Cele\snf-12
2 of 15
No
No
Cele\Y43D4A.1
2 of 15
No
No
Cele\C09E8.1
1 of 15
No
No
Cele\F56F4.3
1 of 15
No
No
Cele\snf-1
1 of 15
No
No
Cele\snf-5
1 of 15
No
No
Cele\snf-8
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (22)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
SerT
6 of 10
CG1698
4 of 10
CG4476
4 of 10
CG8850
4 of 10
CG13796
4 of 10
CG15279
4 of 10
Gat
4 of 10
ine
4 of 10
List
4 of 10
NAAT1
4 of 10
CG13793
3 of 10
CG13794
3 of 10
CG13795
3 of 10
CG33296
3 of 10
CG43066
3 of 10
GlyT
3 of 10
Ntl
3 of 10
bdg
2 of 10
blot
2 of 10
CG10804
2 of 10
CG31904
2 of 10
natalisin
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
DATfmn
model of  autism spectrum disorder
is ameliorated by Hsap\SLC6A3UAS.cHa
(Cartier et al., 2015)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SLC6A2; solute carrier family 6 member 2
14 of 15
163970
SLC6A3; solute carrier family 6 member 3
10 of 15
126455
     
    SLC6A4; solute carrier family 6 member 4
    5 of 15
    182138
     
    SLC6A1; solute carrier family 6 member 1
    3 of 15
    137165
      SLC6A6; solute carrier family 6 member 6
      3 of 15
      186854
        SLC6A7; solute carrier family 6 member 7
        3 of 15
        606205
            SLC6A8; solute carrier family 6 member 8
            3 of 15
            300036
            SLC6A9; solute carrier family 6 member 9
            3 of 15
            601019
              SLC6A11; solute carrier family 6 member 11
              3 of 15
              607952
                  SLC6A12; solute carrier family 6 member 12
                  3 of 15
                  603080
                      SLC6A13; solute carrier family 6 member 13
                      3 of 15
                      615097
                          SLC6A15; solute carrier family 6 member 15
                          3 of 15
                          607971
                              SLC6A16; solute carrier family 6 member 16
                              3 of 15
                              607972
                                  SLC6A17; solute carrier family 6 member 17
                                  3 of 15
                                  610299
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Dmel gene
                                    Ortholog showing functional complementation
                                    Supporting References
                                    DAT
                                    Hsap\SLC6A3
                                    (Hamilton et al., 2014, Hamilton et al., 2013)
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Interactions Browser
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    External Data
                                    Linkouts
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    2R
                                    Recombination map
                                    2-80
                                    Cytogenetic map
                                    53C7-53C8
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    53C7-53C8
                                    Limits computationally determined from genome sequence between P{PZ}Sema-2a03021&P{PZ}Cdk405428 and P{EP}BEST:SD02913EP2148&P{lacW}Dekk09907
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    53C7-53C14
                                    (Porzgen, 2000.4.26)
                                    Experimentally Determined Recombination Data
                                    Location

                                    2-80

                                    (FlyBase, 2016)

                                    2-83.1

                                    (Comeron et al., 2012)

                                    2-

                                    (Wu et al., 2008)
                                    Left of (cM)
                                    (Kume et al., 2005)
                                    Right of (cM)
                                    (Wu et al., 2008)
                                    (Kume et al., 2005)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (15)
                                    Genomic Clones (20)
                                    cDNA Clones (7)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                      Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      DRSC - Results frm RNAi screens
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       

                                      monoclonal

                                      (Pidathala et al., 2021, Penmatsa et al., 2013)
                                      Commercially Available Antibodies
                                       
                                      Other Information
                                      Relationship to Other Genes
                                      Source for database identify of
                                      Source for database merge of

                                      Source for merge of: DAT CG8380

                                      (FlyBase, 1996-)
                                      Additional comments

                                      Source for merge of DAT CG8380 was sequence comparison ( date:000622 ).

                                      (FlyBase, 1996-)
                                      Other Comments

                                      The elimination of DAT activity generates a dramatic increase in the length of the active (waking) phase and a corresponding reduction of the inactive phase (sleep or rest), resulting a a nearly sleepless phenotype.

                                      (Kume et al., 2005)
                                      Origin and Etymology
                                      Discoverer
                                      Etymology

                                      Called 'fumin' (fmn), meaning 'sleepless' in Japanese.

                                      (Kume et al., 2005)
                                      Identification
                                      External Crossreferences and Linkouts ( 43 )
                                      Sequence Crossreferences
                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                      Other crossreferences
                                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                      Flygut - An atlas of the Drosophila adult midgut
                                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                      InterPro - A database of protein families, domains and functional sites
                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                      MARRVEL_MODEL - MARRVEL (model organism gene)
                                      modMine - A data warehouse for the modENCODE project
                                      Linkouts
                                      DroID - A comprehensive database of gene and protein interactions.
                                      DRSC - Results frm RNAi screens
                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                      FlyMine - An integrated database for Drosophila genomics
                                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                      Synonyms and Secondary IDs (11)
                                      Reported As
                                      Symbol Synonym
                                      CG8380
                                      (Frenkel et al., 2017, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Miller et al., 2008, Ni et al., 2008, Romero-Calderon et al., 2007, Porzgen, 2001.2.22)
                                      DAT
                                      (Aguilar et al., 2021, Bhat et al., 2021, Herborg et al., 2021, Hill et al., 2020, Lathen et al., 2020, Mariano et al., 2020, Naz et al., 2020, Öztürk-Çolak et al., 2020, Petruccelli et al., 2020, Rojas et al., 2020, Roy et al., 2020, Xu and Chen, 2020, Bellosta and Soldano, 2019, Campbell et al., 2019, Deng et al., 2019, Meissner et al., 2019, Rao and Deng, 2019.10.23, Ueoka et al., 2019, Aboudhiaf et al., 2018, Gene Disruption Project members, 2018-, Ugrankar et al., 2018, Kline et al., 2017, Mohandas et al., 2017, Shekar et al., 2017, Transgenic RNAi Project members, 2017-, Crocker et al., 2016, King et al., 2016, Landgraf et al., 2016, Petruccelli et al., 2016, Rohde et al., 2016, Sarov et al., 2016, Slade and Staveley, 2016, Sucic et al., 2016, van der Voet et al., 2016, Afonso et al., 2015, Cartier et al., 2015, Grotewiel and Bettinger, 2015, Pathak et al., 2015, Sakloth et al., 2015, Shankar et al., 2015, Bjordal et al., 2014, Kayser et al., 2014, Hamilton et al., 2013, Joiner et al., 2013, Penmatsa et al., 2013, Wiemerslage et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kaun et al., 2012, Pfeiffenberger and Allada, 2012, Featherstone, 2011, Jungreis et al., 2011, Stagg et al., 2011, Wakabayashi-Ito et al., 2011, Wu et al., 2011, Kong et al., 2010, Wu et al., 2010, Wheeler et al., 2009, Wu et al., 2008, Thimgan et al., 2006, Wheeler et al., 2006, Kume et al., 2005)
                                      Dat
                                      (Ceder et al., 2021, Liang et al., 2021, Matsumura et al., 2020, Croset et al., 2018)
                                      DmDAT
                                      (Arancibia et al., 2019, Miller et al., 2008)
                                      Fumin
                                      (Potdar and Sheeba, 2013)
                                      dDAT
                                      (Dvořáček and Kodrík, 2021, Steele et al., 2021, Xu and Chen, 2021, Belhassan et al., 2019, Campbell et al., 2019, Nielsen et al., 2019, Yuan et al., 2018, Zeppelin et al., 2018, Asjad et al., 2017, Karam et al., 2017, Freyberg et al., 2016, Haddad et al., 2016, Koenig et al., 2016, Cohn et al., 2015, Koldsø et al., 2015, Pathak et al., 2015, Penmatsa et al., 2015, Privman and Venton, 2015, Wang et al., 2015, Romero-Calderon et al., 2007, Suh and Jackson, 2007, Porzgen et al., 2001)
                                      dat
                                      (Chen et al., 2015)
                                      fmn
                                      (Belfer et al., 2021, Filošević Vujnović et al., 2021, Huang et al., 2020, Petruccelli et al., 2020, Vaccaro et al., 2020, Filošević et al., 2018, Shin and Venton, 2018, Shin et al., 2018, Koenig et al., 2016, Slade and Staveley, 2016, Tomita et al., 2015, Karuppudurai et al., 2014, Liu et al., 2014, Griffith, 2013, Kumar et al., 2012, Sorribes et al., 2011, Keene et al., 2010, Makos et al., 2010, Makos et al., 2009, Andretic et al., 2008, Zhang et al., 2008, Suh and Jackson, 2007, Wang et al., 2006, Kume et al., 2005)
                                      fumin
                                      (Hill et al., 2018, Kottler et al., 2013, Sorribes et al., 2011)
                                      Name Synonyms
                                      Dopamine transporter
                                      (van der Voet et al., 2016, Sambandan et al., 2008, Porzgen, 2000.4.26)
                                      Fumin
                                      (Branco et al., 2017)
                                      dopamine transporter
                                      (Slade and Staveley, 2016, Malinauskaite et al., 2014, Penmatsa et al., 2013, Kaun et al., 2012, Seugnet et al., 2011, Makos et al., 2009, Thimgan et al., 2006, Kume et al., 2005)
                                      fumin
                                      (Belfer et al., 2021, Funato, 2020, Hill et al., 2020, Filošević et al., 2018, Shin and Venton, 2018, Shin et al., 2018, Tomita et al., 2017, Koenig et al., 2016, Slade and Staveley, 2016, Donelson and Sanyal, 2015, Faville et al., 2015, Tomita et al., 2015, Liu et al., 2014, Shi et al., 2014, Singh et al., 2014, Griffith, 2013, Robertson and Keene, 2013, Kumar et al., 2012, Van Swinderen and Andretic, 2011, Keene et al., 2010, Makos et al., 2010, Andretic et al., 2008, Suh and Jackson, 2007, Kume et al., 2005)
                                      Secondary FlyBase IDs
                                        Datasets (7)
                                        Study focus (0)
                                        Experimental Role
                                        Project
                                        Project Type
                                        Title
                                        Study result (7)
                                        Result
                                        Result Type
                                        Title
                                        scRNAseq_2020_Cattenoz_WI_seq_clustering
                                        Clustering analysis of hemocytes from wasp-infested third instar larvae
                                        scRNAseq_2020_Cho_NI72LG_seq_clustering
                                        Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
                                        scRNAseq_2020_Cho_NI96LG_seq_clustering
                                        Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
                                        scRNAseq_2020_Cho_NI120LG_seq_clustering
                                        Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
                                        scRNAseq_2020_Cho_WI96LG_seq_clustering
                                        Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
                                        scRNAseq_2020_Cho_NI96HL_seq_clustering
                                        Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
                                        scRNAseq_2020_Cho_NI120HL_seq_clustering
                                        Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
                                        References (180)