target of the Hippo-Warts pathway - ortholog of the mammalian transcriptional coactivator yes-associated protein - transcriptional coactivator that negatively regulates cell-cycle and cell-death regulators - fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis
Gene model reviewed during 5.40
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
Gene model reviewed during 6.14
Interacts (via WW domains) with wts (PubMed:16096061). Interacts (via N-terminus) with sd (via C-terminus) and this interaction enhances the transcriptional activity of sd (PubMed:18313299). The phosphorylated form interacts with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Interacts with Ack and ex (PubMed:27462444).
Its activity is regulated by multiple phosphorylation events. Phosphorylation at Ser-88, Ser-145 and Ser-227 negatively regulate its activity and restrict its nuclear localization. Wts-mediated phosphorylation at Ser-145 promotes interaction with 14-3-3epsilon and 14-3-3zeta. Phosphorylation at Ser-88 and Ser-227 regulate nuclear localization and activity independent of 14-3-3 association.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\yki using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\yki in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
This gene is named "yorkie" after Yorkshire Terriers, one of the World's smallest breeds of pet dogs, according to its loss-of-function phenotype.