FlyBase Gene Report: Dmel\mthl10

General Information

Symbol

Dmel\mthl10

Species

D. melanogaster

Name

methuselah-like 10

Annotation Symbol

CG17061

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035132

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

Growth-blocking peptides initiate signaling in surrounding epithelial cells through the G-protein-coupled receptor Mthl10 - activation of tissue repair through activation of calcium signaling (Interactive Fly, mthl10 )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

61C1-61C1

Sequence location

3L:332,801..342,915 [-]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:332801..342915

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables G protein-coupled peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002932399

(GO Reference Genome Project, 2011-)

enables G protein-coupled receptor activity

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(Gene Ontology Curators, 2002-, Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000832, InterPro:IPR010596, InterPro:IPR036272

(InterPro Project Members, 2004-)

enables transmembrane signaling receptor activity

inferred from electronic annotation with InterPro:IPR017981

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cell surface receptor signaling pathway

inferred from electronic annotation with InterPro:IPR017981

(InterPro Project Members, 2004-)

involved_in determination of adult lifespan

inferred from sequence or structural similarity with UniProtKB:O97148

(Gene Ontology Curators, 2002-)

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000832

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(Gene Ontology Curators, 2002-, Brody and Cravchik, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN002932399

(GO Reference Genome Project, 2011-)

involved_in response to starvation

inferred from sequence or structural similarity with UniProtKB:O97148

(Gene Ontology Curators, 2002-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(Gene Ontology Curators, 2002-, Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000832, InterPro:IPR017981

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002932399

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

METHUSELAH-TYPE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (Q9W0R5)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

METHUSELAH-TYPE RECEPTORS -: Methuselah GPCRs are Class B GPCRs, forming the B3 subgroup. The gene family's founding member methuselah (mth) was identified as a Drosophila GPCR involved in the modulation of life span and stress response. No counterpart for the methuselah gene family have been identified in vertebrates. (Adapted from FBrf0129744 and FBrf0218628).

Summary (Interactive Fly)

Growth-blocking peptides initiate signaling in surrounding epithelial cells through the G-protein-coupled receptor Mthl10 - activation of tissue repair through activation of calcium signaling

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mthl10 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0R5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mthl10-RA

FBtr0072572

NM_138186

1844

577

mthl10-RB

FBtr0072573

NM_176268

2457

585

mthl10-RC

FBtr0306564

NM_001259603

2415

584

mthl10-RD

FBtr0306565

NM_001259604

2316

557

mthl10-RE

FBtr0306566

NM_001259605

3020

575

mthl10-RF

FBtr0333903

NM_001274276

2942

575

mthl10-RG

FBtr0333904

NM_001274277

2512

575

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

mthl10-PA

FBpp0072471

66.4

577

8.37

NP_612030

AAF47378

mthl10-PB

FBpp0072472

67.4

585

8.41

FBpp0297519

67.1

584

8.52

FBpp0297520

64.1

557

8.07

FBpp0297521

66.0

575

8.16

FBpp0306034

66.0

575

8.16

FBpp0306035

66.0

575

8.16

M9PGK2

NP_001261206

AGB93901

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

575 aa isoforms: mthl10-PE, mthl10-PF, mthl10-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mthl10 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.23

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 13

eye-antennal disc

(Patel et al., 2012)

labial disc

(Patel et al., 2012)

humeral disc

(Patel et al., 2012)

wing disc

(Patel et al., 2012)

haltere disc

(Patel et al., 2012)

leg disc

(Patel et al., 2012)

embryonic stage 11 -- 16

embryonic/larval crystal cell

(Patel et al., 2012)

embryonic stage 16

sensory neuron

(Patel et al., 2012)

chordotonal organ

(Patel et al., 2012)

histoblast

(Patel et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval central nervous system

(Sung et al., 2017)

embryonic/larval epidermis

(Sung et al., 2017)

embryonic/larval fat body

(Sung et al., 2017)

embryonic/larval gut

(Sung et al., 2017)

adult stage

adult central nervous system

(Sung et al., 2017)

adult abdomen

(Sung et al., 2017)

adult gut

(Sung et al., 2017)

Additional Descriptive Data

mthl10 expression is detected at stages 15 and 16 in the midgut with later expression at the foregut-midgut border and most posterior regions of the midgut. It is expressed in two bilateral clusters in the posterior portion of the the embryonic head that remain on either side of the proventriculus through stages 11-16. These cells are likely to be crystal cells. Expression is also observed in the head region and along the dorso-lateral edge of the abdomen. Dissection of 22C10-stained embryos shows expression in the eye-antennal disc, in two sets of thoracic discs, in a neuron within the chordotonal organ, and in presumptive histoblasts. mthl10 expression is also observed in third instar larvae in the CNS and in imaginal discs. Expression is seen in the morphogenetic furrow as well as in the adjacent vertex that develops into ocelli and neighboring head epidermal tissue. Isoform-specific expression is observed in some tissues.

(Patel et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mthl10 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mthl10

View exonic expression by tissue for Dmel\mthl10

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38057/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035132

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035132

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035132

Flygut - An atlas of the Drosophila adult midgut

FBgn0035132

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mthl10

Transgenic constructs containing regulatory region of mthl10

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6084

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mthl10^GD633

Other Phenotypes

Allele

abnormal cell adhesion | oogenesis, with Scer\GAL4^slbo.2.6

mthl10^HMC03304

abnormal cell migration | oogenesis, with Scer\GAL4^slbo.2.6

mthl10^HMC03304

abnormal immune response | adult stage, with Scer\GAL4^hs.PB

mthl10^NIG.17061R

increased mortality | conditional, with Scer\GAL4^hs.PB

mthl10^NIG.17061R

long lived | female, with Scer\GAL4^Act5C.PI

mthl10^NIG.17061R

long lived | male, with Scer\GAL4^Act5C.PI

mthl10^NIG.17061R

Phenotype manifest in

Allele

border follicle cell, with Scer\GAL4^slbo.2.6

mthl10^HMC03304

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (32)

Hsap\ADGRB1

1 of 14

Yes

Hsap\ADGRB2

1 of 14

Yes

Hsap\ADGRB3

1 of 14

Yes

Hsap\ADGRD1

1 of 14

Yes

Hsap\ADGRD2

1 of 14

Yes

Hsap\ADGRE1

1 of 14

Yes

Hsap\ADGRE2

1 of 14

Yes

Hsap\ADGRE3

1 of 14

Yes

Hsap\ADGRE4P

1 of 14

Yes

Hsap\ADGRE5

1 of 14

Yes

Hsap\ADGRF3

1 of 14

Yes

Hsap\ADGRF4

1 of 14

Yes

Hsap\ADGRF5

1 of 14

Yes

Hsap\ADGRG1

1 of 14

Yes

Hsap\ADGRG2

1 of 14

Yes

Hsap\ADGRG3

1 of 14

Yes

Hsap\ADGRG4

1 of 14

Yes

Hsap\ADGRG5

1 of 14

Yes

Hsap\ADGRG6

1 of 14

Yes

Hsap\ADGRG7

1 of 14

Yes

Hsap\ADGRL1

1 of 14

Yes

Hsap\ADGRL2

1 of 14

Yes

Hsap\ADGRL3

1 of 14

Yes

Hsap\ADGRL4

1 of 14

Yes

Hsap\ADGRV1

1 of 14

Yes

Hsap\CALCR

1 of 14

Yes

Hsap\CELSR1

1 of 14

Yes

Hsap\CELSR2

1 of 14

Yes

Hsap\GCGR

1 of 14

Yes

Hsap\GPR143

1 of 14

Yes

Hsap\MTNR1B

1 of 14

Yes

Hsap\VIPR1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Adgra3

1 of 14

Yes

Rnor\Adgrb1

1 of 14

Yes

Rnor\Adgrb2

1 of 14

Yes

Rnor\Adgrb3

1 of 14

Yes

Rnor\Adgrd1

1 of 14

Yes

Rnor\Adgre1

1 of 14

Yes

Rnor\Adgre4

1 of 14

Yes

Rnor\Adgre5

1 of 14

Yes

Rnor\Adgrf2

1 of 14

Yes

Rnor\Adgrf3

1 of 14

Yes

Rnor\Adgrf4

1 of 14

Yes

Rnor\Adgrf5

1 of 14

Yes

Rnor\Adgrg2

1 of 14

Yes

Rnor\Adgrg3

1 of 14

Yes

Rnor\Adgrg6

1 of 14

Yes

Rnor\Adgrg7

1 of 14

Yes

Rnor\Adgrl1

1 of 14

Yes

Rnor\Adgrl2

1 of 14

Yes

Rnor\Adgrl3

1 of 14

Yes

Rnor\Adgrl4

1 of 14

Yes

Rnor\Adgrv1

1 of 14

Yes

Rnor\Celsr2

1 of 14

Yes

Rnor\Celsr3

1 of 14

Yes

Mus musculus (laboratory mouse) (24)

Mmus\Adgrb1

1 of 14

Yes

Mmus\Adgrb2

1 of 14

Yes

Mmus\Adgrb3

1 of 14

Yes

Mmus\Adgrd1

1 of 14

Yes

Mmus\Adgre1

1 of 14

Yes

Mmus\Adgre4

1 of 14

Yes

Mmus\Adgre5

1 of 14

Yes

Mmus\Adgrf2

1 of 14

Yes

Mmus\Adgrf3

1 of 14

Yes

Mmus\Adgrf4

1 of 14

Yes

Mmus\Adgrf5

1 of 14

Yes

Mmus\Adgrg1

1 of 14

Yes

Mmus\Adgrg2

1 of 14

Yes

Mmus\Adgrg3

1 of 14

Yes

Mmus\Adgrg4

1 of 14

Yes

Mmus\Adgrg6

1 of 14

Yes

Mmus\Adgrl1

1 of 14

Yes

Mmus\Adgrl2

1 of 14

Yes

Mmus\Adgrl3

1 of 14

Yes

Mmus\Adgrl4

1 of 14

Yes

Mmus\Calcr

1 of 14

Yes

Mmus\Celsr2

1 of 14

Yes

Mmus\Celsr3

1 of 14

Yes

Mmus\Taar4

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (5)

Xtro\gpr157

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (42)

Drer\adgre14

2 of 14

Yes

Drer\adgrb1a

1 of 14

Drer\adgrb1b

1 of 14

Yes

Drer\adgrb3

1 of 14

Yes

Drer\adgrd1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\adgre15

1 of 14

Drer\adgre16

1 of 14

Yes

Drer\adgrf3a

1 of 14

Drer\adgrf3b

1 of 14

Drer\adgrf6

1 of 14

Yes

Drer\adgrf7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC103909395

1 of 14

Drer\LOC103911493

1 of 14

Yes

Drer\LOC108181087

1 of 14

Yes

Drer\LOC108182851

1 of 14

Yes

Drer\LOC110439896

1 of 14

Yes

Drer\LOC110439897

1 of 14

Yes

Drer\si:dkey-100n23.5

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\lat-2

2 of 14

Yes

Cele\lat-1

1 of 14

Cele\ser-7

1 of 14

Anopheles gambiae (African malaria mosquito) (12)

Agam\GPRMTH4

9 of 12

Yes

Agam\GPRMTH2

8 of 12

Yes

5 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\GCR1

2 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mthl10. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (24)

7 of 13

7 of 13

7 of 13

7 of 13

7 of 13

mth

7 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

mthl10 - Gbp1

fluorescence polarization spectroscopy, predetermined participant

(Sung et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mthl10

suppressible

Gbp1

(Sung et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Gbp1

suppressible

mthl10

(Sung et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0035132

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

61C1-61C1

Sequence location

3L:332,801..342,915 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61C1-61C1

Limits computationally determined from genome sequence between P{PZ}trh¹⁰⁵¹² and P{EP}EP3104^EP3104

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-0.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

84656

TI{2A-GAL4}mthl10^2A-GAL4

51753

y¹ v¹; P{TRiP.HMC03304}attP2

62315

y¹ v¹; P{TRiP.HMJ23672}attP40/CyO

97819

w¹¹¹⁸; P{UAS-mthl10.gRNAx3.pCFD6}attP1/CyO

44358

y¹ w^*; Mi{MIC}Ptpmeg^MI08056

84657

TI{2A-GAL4}mthl10^2A-BEF.GAL4/TM3, Sb¹

NIG-Fly

17061R-2

P{NIG.17061R}2

17061R-3

P{NIG.17061R}3

HMC03304

y¹ v¹; P{TRiP.HMC03304}attP2

HMJ23672

y¹ v¹; P{TRiP.HMJ23672}attP40/CyO

VDRC

v51425

P{GD633}v51425

v100829

P{KK103159}VIE-260B

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035132

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035132

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: mthl10 anon-WO0170980.166 anon-WO0170980.167

(FlyBase, 1996-)

Additional comments

Source for merge of mthl10 anon-WO0170980.166 anon-WO0170980.167 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG17061

(Mao et al., 2024, Friedrich and Jones, 2016, Li et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Harmar, 2001)

Mthl10

(Ono et al., 2024, Bossen et al., 2023, Stevens et al., 2023, Worley and Hariharan, 2022, Sciambra and Chtarbanova, 2021, Texada et al., 2020, Sung et al., 2017)

anon-WO0170980.166

anon-WO0170980.167

mth2

(Duvernell et al., 2003)

mthl-10

(Kim et al., 2006)

mthl10

(Hultmark and Andó, 2022, Schlichting et al., 2022, Liu et al., 2021, O'Connor et al., 2021, Rao and Deng, 2019.10.23, Raza et al., 2019, Clandinin and Owens, 2016-, Friedrich and Jones, 2016, Gene Disruption Project members, 2015-, Araújo et al., 2013, Li et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Patel et al., 2012, FlyBase Curators, 2008-)

Name Synonyms

Methuselah-like 10

(Saad and Hipfner, 2021)

Methuselah-like10

(Fernandez-Gonzalez and Harris, 2023)

Mth-like 10

(West et al., 2001)

methuselah-like 10

mth-like 10

(Brody and Cravchik, 2000)

Secondary FlyBase IDs

FBgn0046574
FBgn0046575

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 123 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38057

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0R5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W0R5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0R5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38057/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035132

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035132

FlyMine - An integrated database for Drosophila genomics

FBgn0035132

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17061

MARRVEL_MODEL - MARRVEL (model organism gene)

38057

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035132

DroID - A comprehensive database of gene and protein interactions.

FBgn0035132

DRSC - Results frm RNAi screens

FBgn0035132

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035132

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035132

Flygut - An atlas of the Drosophila adult midgut

FBgn0035132

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030964

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (64)

The following external sites may use different assemblies or annotations than FlyBase.

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