FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Fit1
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General Information
Symbol
Dmel\Fit1
Species
D. melanogaster
Name
Fermitin 1
Annotation Symbol
CG14991
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035498
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
Probably involved in cell adhesion. (UniProt, Q9VZI3)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Fit 1

Key Links
Genomic Location
Cytogenetic map
64A6-64A6
Sequence location
Recombination map
3-10
RefSeq locus
NT_037436 REGION:4103564..4107116
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables cell adhesion molecule binding
inferred from sequence or structural similarity with UniProtKB:Q18685
(Gene Ontology Curators, 2002-)
enables integrin binding
inferred from biological aspect of ancestor with PANTHER:PTN001043969
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in cardiac muscle tissue development
inferred from genetic interaction with FLYBASE:Fit2; FB:FBgn0036688
(Catterson et al., 2013)
involved_in defense response to Gram-negative bacterium
inferred from mutant phenotype
(Berkey et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cell-matrix adhesion
inferred from biological aspect of ancestor with PANTHER:PTN001043969
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q18685
(Gene Ontology Curators, 2002-)
involved_in integrin-mediated signaling pathway
inferred from electronic annotation with InterPro:IPR037837, InterPro:IPR037843
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cell-substrate junction
inferred from biological aspect of ancestor with PANTHER:PTN001043969
(GO Reference Genome Project, 2011-)
located_in cytoplasm
inferred from sequence or structural similarity with UniProtKB:Q18685
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the kindlin family. (Q9VZI3)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Probably involved in cell adhesion.
(UniProt, Q9VZI3)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Fit1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VZI3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.39

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Fit1-RA
FBtr0073209
NM_168060
3119
708
Fit1-RB
FBtr0073210
NM_139601
3469
708
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Fit1-PA
FBpp0073065
80.5
708
7.81
Q9VZI3
NP_728936
AAF47838
Fit1-PB
FBpp0073066
80.5
708
7.81
Q9VZI3
NP_647858
AAG22245
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

708 aa isoforms: Fit1-PA, Fit1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Domain

The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.

(UniProt, Q9VZI3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fit1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.92

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fit1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Fit1
Transgenic constructs containing regulatory region of Fit1
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel6100
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (8)
Hsap\FERMT2
14 of 14
Yes
Yes
1  
Hsap\FERMT1
13 of 14
No
Yes
Hsap\FERMT3
12 of 14
No
Yes
Hsap\EPB41L5
1 of 14
No
No
Hsap\PTPN3
1 of 14
No
No
Hsap\PTPN4
1 of 14
No
No
Hsap\TLN1
1 of 14
No
No
Hsap\TLN2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (6)
Rnor\Fermt2
14 of 14
Yes
Yes
Rnor\Fermt1
13 of 14
No
Yes
Rnor\Fermt3
12 of 14
No
Yes
Rnor\Rdx
1 of 14
No
No
Rnor\Tln1
1 of 14
No
No
Rnor\Tln2
1 of 14
No
No
Mus musculus (laboratory mouse) (9)
Mmus\Fermt2
14 of 14
Yes
Yes
Mmus\Fermt1
12 of 14
No
Yes
Mmus\Fermt3
12 of 14
No
Yes
Mmus\Epb41l5
1 of 14
No
No
Mmus\Frmd3
1 of 14
No
No
Mmus\Ptpn3
1 of 14
No
No
Mmus\Ptpn4
1 of 14
No
No
Mmus\Tln1
1 of 14
No
No
Mmus\Tln2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\fermt2
7 of 13
Yes
Yes
Xtro\fermt3
7 of 13
Yes
Yes
Xtro\fermt1
6 of 13
No
Yes
Xtro\pdcl
6 of 13
No
No
Xtro\pik3r5
1 of 13
No
Yes
Xtro\stard7
1 of 13
No
No
Danio rerio (Zebrafish) (8)
Drer\fermt1
13 of 14
Yes
Yes
Drer\fermt2
13 of 14
Yes
Yes
Drer\fermt3b
12 of 14
No
Yes
Drer\im:7154036
12 of 14
No
Yes
Drer\ptpn4a
1 of 14
No
No
Drer\ptpn4b
1 of 14
No
No
Drer\tln1
1 of 14
No
No
Drer\tln2a
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\unc-112
14 of 14
Yes
Yes
Cele\tln-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP002054
12 of 12
Yes
Yes
Agam\AgaP_AGAP007130
1 of 12
No
No
Agam\AgaP_AGAP007474
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Fit1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (4)
Fit2
13 of 13
Bili
1 of 13
Ptpmeg
1 of 13
rhea
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
Fit1GD17050
exacerbates  tauopathy
modeled by Hsap\MAPTV337M.UAS
(Shulman et al., 2014)
Fit1UAS.GFP
ameliorates  tauopathy
modeled by Hsap\MAPTV337M.UAS
(Shulman et al., 2014)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
FERMT2; FERM domain containing kindlin 2
14 of 14
FERM DOMAIN-CONTAINING KINDLIN 2; FERMT2
       
      FERMT1; FERM domain containing kindlin 1
      13 of 14
      607900
      FERMT3; FERM domain containing kindlin 3
      12 of 14
      607901
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Fit1 - Fit2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Fit1
      enhanceable
      Fit2
      (Catterson et al., 2013)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      pbl
      suppressible
      Fit1
      (Gregory et al., 2007)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-10
      Cytogenetic map
      64A6-64A6
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      64A6-64A6
      Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-10

      (FlyBase, 2016)

      3-8.9

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (17)
      Genomic Clones (15)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (135)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            The Fit1 and Fit2 genes are partially redundant during development. Elimination of both Fit1 and Fit2 results in embryonic lethality marked by severe developmental defects.

            (Devenport and Brown, 2005)

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            (Kiger et al., 2003)

            Area matching Drosophila EST AA697191. This EST forms a 1002bp EST contig with AA392404 and AA438791.

            (Davies, 2001.3.15)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: Fit1 anon-WO0118547.421

            (FlyBase, 1996-)
            Additional comments

            The Fit1 and Fit2 genes share at least 50% identity.

            (Langille and Clark, 2007)

            Source for merge of Fit1 anon-WO0118547.421 was sequence comparison ( date:051113 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: Fit1 CG14991

            (Devenport, 2005.3.2)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (9)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 51 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (66)