FB2021_02, released April 13, 2021

Gene: Dmel\ergic53

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General Information
Symbol
Dmel\ergic53
Species
D. melanogaster
Name
ergic53
Annotation Symbol
CG6822
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035909
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(3)s1760, dERGIC53, rhea

Key Links
Genomic Location
Cytogenetic map
66D6-66D6
Sequence location
3L:8,534,977..8,538,013 [+]
Recombination map
3-26
RefSeq locus
NT_037436 REGION:8534977..8538013
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables mannose binding
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum organization
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in Golgi organization
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in COPII-coated ER to Golgi transport vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in endoplasmic reticulum-Golgi intermediate compartment
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in Golgi membrane
inferred from biological aspect of ancestor with PANTHER:PTN000259611
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ergic53 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ergic53-RA
FBtr0301629
NM_080037
2031
512
ergic53-RB
FBtr0076626
NM_176301
2463
512
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ergic53-PA
FBpp0290843
57.6
512
5.96
NP_524776
AAF50400
ergic53-PB
FBpp0076352
57.6
512
5.96
NP_788479
AAO41269
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

512 aa isoforms: ergic53-PA, ergic53-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ergic53 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ergic53 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ergic53
Transgenic constructs containing regulatory region of ergic53
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene not disrupted in
Df(3L)h-i22
(BDGP Project Members, 1994-1999)
Inferred from location ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LMAN1
14 of 15
Yes
Yes
Hsap\LMAN1L
6 of 15
No
Yes
Hsap\LMAN2
2 of 15
No
No
1  
Hsap\LMAN2L
2 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lman1
14 of 15
Yes
Yes
Mmus\Lman1l
6 of 15
No
Yes
Mmus\Lman2
2 of 15
No
No
Mmus\Lman2l
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Lman1
12 of 13
Yes
Yes
Rnor\Lman1l
6 of 13
No
Yes
Rnor\Lman2
2 of 13
No
No
Rnor\Lman2l
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\lman1
8 of 12
Yes
Yes
Xtro\cplx3
7 of 12
No
Yes
Xtro\lman2l
2 of 12
No
No
Xtro\lman2
2 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\lman1
9 of 15
Yes
Yes
Drer\lman2
2 of 15
No
No
Drer\lman2la
2 of 15
No
No
Drer\lman2lb
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ile-1
13 of 15
Yes
Yes
Cele\ile-2
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (8)
Atha\AT1G53060
1 of 9
Yes
Yes
Atha\AT1G70110
1 of 9
Yes
Yes
Atha\AT3G16530
1 of 9
Yes
Yes
Atha\AT3G59730
1 of 9
Yes
Yes
Atha\AT3G59740
1 of 9
Yes
Yes
Atha\AT4G29050
1 of 9
Yes
Yes
Atha\AT5G06740
1 of 9
Yes
Yes
Atha\HLECRK
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\EMP46
6 of 15
Yes
Yes
Scer\EMP47
5 of 15
No
Yes
Scer\UIP5
2 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPCC126.08c
4 of 12
Yes
No
Spom\SPBC4F6.05c
2 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906W7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD14102
Drosophila sechellia
Dsec\GM25064
Drosophila erecta
Dere\GG14323
Drosophila yakuba
Dyak\GE20751
Drosophila ananassae
Dana\GF24333
Drosophila pseudoobscura pseudoobscura
Dpse\GA27650
Drosophila persimilis
Dper\GL22531
Drosophila willistoni
Dwil\GK13314
Drosophila virilis
Dvir\GJ13048
Drosophila mojavensis
Dmoj\GI12907
Drosophila grimshawi
Dgri\GH22518
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504FO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021151
Glossina morsitans
Tsetse fly
Gmor\GMOY004668
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010901
Anopheles darlingi
American malaria mosquito
Adar\ADAC003354
Anopheles gambiae
Malaria mosquito
Agam\AGAP005404
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017989
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05XN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001352
Bombyx mori
Silkmoth
Bmor\BGIBMGA001353
Danaus plexippus
Monarch butterfly
Dple\DPOGS201735-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015888
Apis florea
Little honeybee
Aflo\2408700916
Apis mellifera
Western honey bee
Amel\GB49871
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24858
Bombus terrestris
Buff-tailed bumblebee
Bter\15210008
Linepithema humile
Argentine ant
Lhum\LH17466
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001866
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002131
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_13007
Tribolium castaneum
Red flour beetle
Tcas\TC009540
Pediculus humanus
Human body louse
Phum\PHUM035550
Rhodnius prolixus
Kissing bug
Rpro\RPRC013331
Rhodnius prolixus
Kissing bug
Rpro\RPRC002463
Cimex lectularius
Bed bug
Clec\CLEC004112
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000278
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01320
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05TA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007028
Ixodes scapularis
Black-legged tick
Isca\ISCW016179
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60991.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g06120
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_191157
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08WZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lman1
Gallus gallus
Domestic chicken
Ggal\LMAN1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG5510
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LMAN1; lectin, mannose binding 1
    14 of 15
    601567
      LMAN1L; lectin, mannose binding 1 like
      6 of 15
      609548
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          ergic53 - CG11911
          experimental knowledge based
          (Guruharsha et al., 2011)
          ergic53 - NTPase
          experimental knowledge based
          (Guruharsha et al., 2011)
          ergic53 - yellow-f
          experimental knowledge based
          (Guruharsha et al., 2011)
          Summary of Genetic Interactions
          esyN Network Diagram
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-26
          Cytogenetic map
          66D6-66D6
          Sequence location
          3L:8,534,977..8,538,013 [+]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          66D6-66D6
          Limits computationally determined from genome sequence between P{lacW}foij8E8 and P{PZ}SrpRβrK561&P{lacW}l(3)j5B6j5B6
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          66D5-66D6
          (Prout, 2000.1.11, BDGP Project Members, 1994-1999)
          Experimentally Determined Recombination Data
          Location

          3-26

          (FlyBase, 2016)

          3-20.1

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (6)
          Genomic Clones (18)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (170)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of
            Additional comments

            FlyBase curator comment: the gene referred to as "rhea" in FBrf0131052 is not the same gene as the one referred to as "rhea" in FlyBase (FBgn0020254), but actually corresponds to FBgn0035909 (referred to as "ergic53" in FlyBase).

            (Hauri et al., 2000)

            FlyBase curator comment: the gene referred to as "rhea" in FBrf0128021 is not the same gene as the one referred to as "rhea" in FlyBase (FBgn0020254), but actually corresponds to FBgn0035909 (referred to as "ergic53" in FlyBase).

            (Prout, 2000.1.11)
            Other Comments
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 42 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (9)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (46)