FlyBase Gene Report: Dmel\Srrm1

General Information

Symbol

Dmel\Srrm1

Species

D. melanogaster

Name

Serine-arginine repetitive matrix 1

Annotation Symbol

CG11274

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036340

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

SRm160 (SRm160) encodes a conserved RNA-binding protein that participates in the exon junction complex and is involved in pre-mRNA splicing and 3' end formation. It participates in somatic sex determination, cell death, retinal development and the control of circadian rhythm. Direct targets include rl. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

SRm160

Key Links

Genomic Location

Cytogenetic map

69F6-69F6

Sequence location

3L:13,036,821..13,040,976 [+]

Recombination map

3-39

RefSeq locus

NT_037436 REGION:13036821..13040976

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000567596

(GO Reference Genome Project, 2011-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in compound eye development

inferred from mutant phenotype

(Fan et al., 2014)

involved_in genitalia development

inferred from mutant phenotype

(Fan et al., 2014)

involved_in positive regulation of programmed cell death

inferred from mutant phenotype

(Fan et al., 2014)

involved_in regulation of alternative mRNA splicing, via spliceosome

inferred from direct assay

(Beckwith et al., 2017)

involved_in regulation of circadian rhythm

inferred from mutant phenotype

(Beckwith et al., 2017)

involved_in somatic sex determination

inferred from mutant phenotype

(Fan et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mRNA splicing, via spliceosome

inferred by curator from GO:0071011,GO:0071013

(Herold et al., 2009)

involved_in regulation of mRNA splicing, via spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000567596

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleus

inferred from direct assay

(Fan et al., 2014)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of exon-exon junction complex

traceable author statement

(Gatfield et al., 2003)

part_of spliceosomal complex

inferred from biological aspect of ancestor with PANTHER:PTN000567596

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NON-CANONICAL SERINE AND ARGININE RICH SPLICING FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NON-CANONICAL SERINE AND ARGININE RICH SPLICING FACTORS -: Non-canonical serine and arginine rich splicing factors are involved in the regulation of splicing. They contain an RS domain but lack the RNA-binding motifs that typify their canonical counterparts. They are recruited to pre-RNA by interacting with proteins bound to exonic sequences rather than directly binding RNA. (Adapted from FBrf0243536.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Srrm1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VU43)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Srrm1-RA

FBtr0075883

NM_140370

3862

954

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Srrm1-PA

FBpp0075617

107.6

954

12.13

Q9VU43

NP_648627

AAF49848

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Srrm1 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.23

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism | ubiquitous

(Fan et al., 2014)

embryonic stage 5 -- 6

organism | restricted

(Fan et al., 2014)

embryonic stage 9 -- 10

organism | segmentally repeated

(Fan et al., 2014)

embryonic stage 11 -- 12

larval ventral nerve cord

(Fan et al., 2014)

embryonic brain

(Fan et al., 2014)

embryonic stage 13 -- 14

embryonic/larval midgut

(Fan et al., 2014)

embryonic stage 13 -- 17

larval central nervous system

(Fan et al., 2014)

third instar larval stage

eye disc morphogenetic furrow

(Fan et al., 2014)

eye disc

(Fan et al., 2014)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Fan et al., 2014)

Comment: expression assayed in cultured cells

(Gatfield and Izaurralde, 2002)

Additional Descriptive Data

Srrm1 transcripts are ubiquitous and at high levels in 0-1 hr embryos and then accumulate around the embryonic periphery at 2-3 hr. At 4-5 pattern they are observed in a segmental pattern. At 7-8 hr, they accumulate in the ventral nerve cord and brain. Later they are primarily restricted to the developing CNS with some expression in the midgut. By 16 hr, Srrm1 is detected exclusively in the condensed CNS.

(Fan et al., 2014)

Srrm1 transcripts are expressed in S2 cells.

(Gatfield and Izaurralde, 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism | ubiquitous

(Fan et al., 2014)

embryonic stage 4

organism | gradient

(Fan et al., 2014)

primordial germ cell

(Fan et al., 2014)

embryonic stage 13 -- 14

embryonic/larval midgut

(Fan et al., 2014)

embryonic hemocyte primordium

(Fan et al., 2014)

embryonic/larval anus

(Fan et al., 2014)

third instar larval stage

ommatidial precursor cluster

(Fan et al., 2014)

eye disc | restricted

(Fan et al., 2014)

imaginal disc | ubiquitous

(Fan et al., 2014)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

Comment: expression assayed in cultured cells

(Gatfield and Izaurralde, 2002)

Additional Descriptive Data

Srrm1 protein staining is ubiquitous in early embryos and is observed in a puctate pattern in nuclei. Staining remains punctate and nuclear until cellularization. At ~11 hr of development, low levels of protein are seen widely distributed around the embryo with higher concentrations in the midgut, anus, and regions of hemocyte development in the head area. Fairly uniform distribution of Srrm1 protein is observed in imaginal discs, except in the eye disc, where higher levels are observed in differentiating photoreceptor precursors.

(Fan et al., 2014)

Srrm1 protein isdetected in S2 cells.

(Gatfield and Izaurralde, 2002)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleus

inferred from direct assay

(Fan et al., 2014)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Expression Deduced from Reporters

Reporter: P{Srrm1-GAL4.3650}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | faint | restricted

(Beckwith et al., 2017)

s-LNv Pdf neuron | intense

(Beckwith et al., 2017)

accessory medulla | intense

(Beckwith et al., 2017)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Srrm1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Srrm1

View exonic expression by tissue for Dmel\Srrm1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39483/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036340

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036340

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036340

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11274

Flygut - An atlas of the Drosophila adult midgut

FBgn0036340

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Srrm1

Transgenic constructs containing regulatory region of Srrm1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6261

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^da.PU

lethal, with Scer\GAL4^nub-AC-62

Srrm1^HMC03920

lethal, with Scer\GAL4^VP16.otu

Srrm1^HMC03920

lethal | female limited, with Scer\GAL4^dome-PG14

Srrm1^HMC03920

lethal | recessive

lethal - all die before end of pupal stage | male limited | heat sensitive, with Scer\GAL4^GMR.PU

Srrm1^GE25979

partially lethal - majority die | female limited | heat sensitive, with Scer\GAL4^GMR.PU

Srrm1^GE25979

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Srrm1^GD1618

viable, with Scer\GAL4^elav.PLu

Srrm1^G18603

viable, with Scer\GAL4^Mef2.PR

Srrm1^GD1618

viable, with Scer\GAL4^pnr-MD237

Srrm1^GD1618

viable, with Scer\GAL4^tin.CΔ4

Srrm1^GD1618

Sterility

Allele

female fertile, with Scer\GAL4^esg.PU

Srrm1^GE25979

fertile (with Srrm1^G18603)

Srrm1^GE25979

fertile (with Srrm1^GE25979)

Srrm1^G18603

male fertile, with Scer\GAL4^esg.PU

Srrm1^GE25979

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Srrm1^GD1618

abnormal developmental rate | larval stage

Srrm1^G18603

abnormal locomotor rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

abnormal locomotor rhythm | adult stage, with Scer\GAL4^P2.4.Pdf, Srrm1^GL00538

Srrm1^KK108396

abnormal locomotor rhythm | adult stage, with Scer\GAL4^P2.4.Pdf, Srrm1^KK108396

Srrm1^GL00538

abnormal locomotor rhythm | adult stage, with Scer\GAL4^Pdf.Switch1a

Srrm1^KK108396

abnormal locomotor rhythm | adult stage, with Scer\GAL4^tim.PE

Srrm1^KK108396

abnormal locomotor rhythm | adult stage, with Scer\GAL4^tim.PE, Srrm1^GL00538

Srrm1^KK108396

abnormal locomotor rhythm | adult stage, with Scer\GAL4^tim.PE, Srrm1^KK108396

Srrm1^GL00538

decreased body size | larval stage

Srrm1^G18603

some die during embryonic stage, with Scer\GAL4^da.PU

Srrm1^GE25979

some die during larval stage, with Scer\GAL4^da.PU

Srrm1^GE25979

some die during pupal stage, with Scer\GAL4^da.PU

Srrm1^GE25979

some die during pupal stage | male limited | heat sensitive, with Scer\GAL4^GMR.PU

Srrm1^GE25979

visible, with Scer\GAL4^Bx-MS1096

Srrm1^NIG.11274R

visible, with Scer\GAL4^GMR.PU

visible, with Scer\GAL4^pnr-MD237

Srrm1^GD1618

visible | larval stage

Srrm1^G18603

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PU

eye | female limited | heat sensitive, with Scer\GAL4^GMR.PU

Srrm1^GE25979

male analia, with Scer\GAL4^esg.PU

Srrm1^GE25979

male genitalia, with Scer\GAL4^esg.PU

Srrm1^GE25979

mesonotum, with Scer\GAL4^pnr-MD237

Srrm1^GD1618

ommatidium, with Scer\GAL4^GMR.PU

Srrm1^GE25979

testis, with Scer\GAL4^esg.PU

Srrm1^GE25979

trichogen cell, with Scer\GAL4^pnr-MD237

Srrm1^GD1618

wing, with Scer\GAL4^Bx-MS1096

Srrm1^NIG.11274R

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\SRRM1

7 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Srrm1

9 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Srrm1

9 of 14

Yes

Mmus\Gm11639

1 of 14

Xenopus tropicalis (Western clawed frog) (1)

Xtro\srrm1

6 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\srrm1

8 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\rsr-1

8 of 14

Yes

Cele\unc-89

1 of 14

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP005366

9 of 12

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT2G29210

8 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC825.05c

6 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Srrm1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SRRM1; serine and arginine repetitive matrix 1

7 of 14

605975

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Fan et al., 2014)

suppressible

(Fan et al., 2014)

enhanceable

(Fan et al., 2014)

suppressible

(Fan et al., 2014)

suppressible

(Fan et al., 2014)

suppressible

(Beckwith et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Fan et al., 2014)

suppressible

(Fan et al., 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64828

DroID - A comprehensive database of gene and protein interactions.

FBgn0036340

MIST (genetic) - An integrated Molecular Interaction Database

39483

MIST (protein-protein) - An integrated Molecular Interaction Database

39483

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-39

Cytogenetic map

69F6-69F6

Sequence location

3L:13,036,821..13,040,976 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69F6-69F6

Limits computationally determined from genome sequence between P{lacW}RpS12^s2783 and P{PZ}l(3)04220⁰⁴²²⁰&P{lacW}l(3)j10B6^j10B6

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-39

(FlyBase, 2016)

3-34.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

63985

y¹ v¹; P{TRiP.HMJ30298}attP40

26938

y¹ w^*; P{EP}Srrm1^G18603

99687

w¹¹¹⁸; Srrm1^C52/TM6B, Tb¹

99686

w¹¹¹⁸; Srrm1^B103/TM6B, Tb¹

55205

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03920}attP40

605422

y¹ w^*; TI{CRIMIC.TG4.0}Srrm1^{CR71206-TG4.0}/TM3, Sb¹ Ser¹

NIG-Fly

11274R-1

P{NIG.11274R}1

11274R-3

P{NIG.11274R}3

HMJ30298

y¹ v¹; P{TRiP.HMJ30298}attP40/CyO

VDRC

v100751

P{KK108396}VIE-260B

v6439

w¹¹¹⁸; P{GD1618}v6439

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (79)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE71183

Other clones

FI04407

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036340

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036340

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Qiu et al., 2019)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Srrm1 SRm160

(Ustaoglu et al., 2019)

Nomenclature comments

Etymology

Renamed from 'SRm160' to 'Srrm1' because (i) the original symbol was based on that of the human ortholog according to its size in kDa, but the size in flies is different; and (ii) the human ortholog has been renamed to SRRM1.

(Ustaoglu et al., 2019)

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG11274

(Hosono et al., 2015, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Herold et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Gatfield et al., 2003, Giot et al., 2003, Gatfield and Izaurralde, 2002, Mount and Salz, 2000)

SRM160

(Boucher et al., 2001)

Srrm1

(Choudhury et al., 2024, Yheskel et al., 2023, Ustaoglu et al., 2019, Gene Disruption Project members, 2018-)

Name Synonyms

SRm160

Serine-arginine repetitive matrix 1

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39483

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VU43

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VU43

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39483/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036340

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036340

FlyMine - An integrated database for Drosophila genomics

FBgn0036340

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11274

MARRVEL_MODEL - MARRVEL (model organism gene)

39483

Linkouts

BioGRID - A database of protein and genetic interactions.

64828

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036340

DroID - A comprehensive database of gene and protein interactions.

FBgn0036340

DRSC - Results frm RNAi screens

FBgn0036340

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036340

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036340

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11274

Flygut - An atlas of the Drosophila adult midgut

FBgn0036340

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0036340

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013178

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

39483

MIST (protein-protein) - An integrated Molecular Interaction Database

39483

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (61)

The following external sites may use different assemblies or annotations than FlyBase.

-0.23

Report Sections