FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Sox21a
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General Information
Symbol
Dmel\Sox21a
Species
D. melanogaster
Name
Sox21a
Annotation Symbol
CG7345
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036411
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
Sox21a (Sox21a) encodes a Sox family transcription factor involved in the differentiation of stem cells in the midgut. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
70D2-70D2
Sequence location
Recombination map
3-42
RefSeq locus
NT_037436 REGION:14103481..14108118
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in midgut development
inferred from mutant phenotype
(Chen et al., 2016)
involved_in negative regulation of cell differentiation
inferred from mutant phenotype
(Zhai et al., 2015)
involved_in stem cell proliferation
inferred from mutant phenotype
(Meng and Biteau, 2015)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in brain development
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Meng and Biteau, 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Sox21a (Sox21a) encodes a Sox family transcription factor involved in the differentiation of stem cells in the midgut. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -
The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).
Summary (Interactive Fly)

essential for enterocyte differentiation from enteroblast in the midgut - involved in feedback amplification loop that leads to rapid production from intestinal stem cells of differentiation-defective enteroblasts and subsequent tumorigenesis - Sox100B directly regulates Sox21a to promote differentiation - Sox21a and GATAe form a functional relay to orchestrate EB differentiation - genetic interaction between peroxisomes and the JAK and STAT signaling restores the expression defect of Sox21a in peroxisome defective cells

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Sox21a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PFG6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884..

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sox21a-RA
FBtr0075748
NM_140437
2335
388
Sox21a-RB
FBtr0330178
NM_001274898
2335
407
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sox21a-PA
FBpp0075490
40.8
388
10.58
Q9VUD1
NP_648694
AAF49756
Sox21a-PB
FBpp0303211
42.6
407
10.57
M9PFG6
NP_001261827
AGB94520
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sox21a using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.40

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood
enteroblast of posterior adult midgut epithelium
(Chen et al., 2016)
day 5 of adulthood -- day 7 of adulthood
intestinal stem cell of posterior adult midgut epithelium
(Chen et al., 2016)
day 7 of adulthood
enterocyte of posterior adult midgut epithelium
(Chen et al., 2016)
Additional Descriptive Data

Sox21a appears to be preferentially expressed in differentiating enteroblasts in the midgut epithelium. It is not detected in newly eclosed adults. Weak expression is observed in enteroblasts and intestinal stem cells of the midgut epithelium at 5 days and it increases with age. Expression is higher in enteroblasts than in intestinal stem cells.

(Chen et al., 2016)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Meng and Biteau, 2015)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sox21a in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sox21a
Transgenic constructs containing regulatory region of Sox21a
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3L)btl-ΔOh24
(Kondo and Hayashi, 2013)
Df(3L)Exel6120
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Bx-MS1096
lethal | cold sensitive, with Scer\GAL4Bx-MS1096
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal cell number | adult stage, with Scer\GAL4Su(H).GBE
decreased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased cell number | adult stage, with Scer\GAL4Su(H).GBE
increased cell number | adult stage | progressive
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased occurrence of cell division | adult stage
increased occurrence of cell division | adult stage, with Scer\GAL4Delta-05151-G
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
increased occurrence of cell division | adult stage, with Scer\GAL4Su(H).GBE
neoplasia | adult stage | progressive
neoplasia | adult stage | somatic clone
short lived | female
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult anterior midgut epithelium
adult anterior midgut epithelium, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
adult gut, with Scer\GAL4Su(H).GBE
adult midgut
adult midgut, with Scer\GAL4Delta-05151-G
adult midgut, with Scer\GAL4NP5130
adult midgut, with Scer\GAL4Su(H).GBE, Scer\GAL80ts.αTub84B
adult midgut, with Scer\GAL4Tub.PU
adult midgut | progressive
adult midgut | somatic clone
adult midgut | somatic clone, with Scer\GAL4Tub.PU
adult midgut enterocyte | decreased number, with Scer\GAL4Su(H).GBE
adult midgut epithelium, with Scer\GAL4Su(H).GBE
enteroblast
enteroblast | adult stage | increased number, with Scer\GAL4Su(H).GBE
enteroblast | increased number, with Scer\GAL4Su(H).GBE, Scer\GAL80ts.αTub84B
enteroblast | progressive
enteroblast | somatic clone
enterocyte, with Scer\GAL4Su(H).GBE
enterocyte | increased number, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
enterocyte | somatic clone
enteroendocrine cell | somatic clone
intestinal stem cell
intestinal stem cell, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
intestinal stem cell | progressive
intestinal stem cell | somatic clone
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (40)
Hsap\SOX2
9 of 14
Yes
Yes
1  
Hsap\SOX14
8 of 14
No
Yes
Hsap\SOX21
7 of 14
No
Yes
0  
Hsap\SOX1
5 of 14
No
No
Hsap\SOX3
5 of 14
No
Yes
Hsap\SOX4
5 of 14
No
No
Hsap\SOX7
5 of 14
No
No
Hsap\SOX11
5 of 14
No
No
Hsap\SOX12
5 of 14
No
No
1  
Hsap\SOX15
5 of 14
No
Yes
1  
Hsap\SOX17
5 of 14
No
Yes
1  
Hsap\SOX18
5 of 14
No
No
Hsap\SOX8
4 of 14
No
No
Hsap\SOX9
4 of 14
No
No
Hsap\SOX10
4 of 14
No
No
Hsap\SOX13
4 of 14
No
No
Hsap\SRY
4 of 14
No
Yes
Hsap\SOX5
3 of 14
No
No
Hsap\SOX6
3 of 14
No
No
Hsap\SOX30
3 of 14
No
Yes
Hsap\BBX
1 of 14
No
No
1  
Hsap\CFAP65
1 of 14
No
Yes
Hsap\CIC
1 of 14
No
No
1  
Hsap\HBP1
1 of 14
No
No
Hsap\HMG20A
1 of 14
No
No
1  
Hsap\HMG20B
1 of 14
No
No
1  
Hsap\HMGB1
1 of 14
No
No
1  
Hsap\HMGB1P1
1 of 14
No
No
Hsap\HMGB2
1 of 14
No
No
Hsap\HMGB3
1 of 14
No
No
1  
Hsap\HMGB4
1 of 14
No
No
Hsap\HMGXB3
1 of 14
No
Yes
Hsap\HMGXB4
1 of 14
No
No
Hsap\LEF1
1 of 14
No
No
2  
Hsap\MEIOSIN
1 of 14
No
Yes
Hsap\SSRP1
1 of 14
No
No
1  
Hsap\TCF7
1 of 14
No
No
Hsap\TCF7L1
1 of 14
No
No
1  
Hsap\TOX3
1 of 14
No
No
Hsap\TOX4
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (17)
Rnor\Sox2
9 of 14
Yes
Yes
Rnor\Sox14
8 of 14
No
Yes
Rnor\Sox7
5 of 14
No
No
Rnor\Sox11
5 of 14
No
No
Rnor\Sox12
5 of 14
No
No
Rnor\Sox17
5 of 14
No
No
Rnor\Sox18
5 of 14
No
No
Rnor\Sox8
4 of 14
No
No
Rnor\Sox9
4 of 14
No
No
Rnor\Sox10
4 of 14
No
No
Rnor\Sox13
4 of 14
No
No
Rnor\Sox5
3 of 14
No
No
Rnor\Sox6
3 of 14
No
No
Rnor\Sry
3 of 14
No
Yes
Rnor\Cfap65
1 of 14
No
Yes
Rnor\Cic
1 of 14
No
No
Rnor\Hmgxb3
1 of 14
No
Yes
Mus musculus (laboratory mouse) (28)
Mmus\Sox2
9 of 14
Yes
Yes
4  
Mmus\Sox14
8 of 14
No
Yes
Mmus\Sox21
7 of 14
No
Yes
Mmus\Sox1
5 of 14
No
No
Mmus\Sox3
5 of 14
No
Yes
Mmus\Sox4
5 of 14
No
No
Mmus\Sox7
5 of 14
No
No
Mmus\Sox11
5 of 14
No
No
Mmus\Sox12
5 of 14
No
No
Mmus\Sox15
5 of 14
No
Yes
Mmus\Sox17
5 of 14
No
No
Mmus\Sox18
5 of 14
No
No
Mmus\Sry
5 of 14
No
Yes
Mmus\Sox8
4 of 14
No
No
Mmus\Sox9
4 of 14
No
No
Mmus\Sox10
4 of 14
No
No
Mmus\Sox13
4 of 14
No
No
Mmus\Sox5
3 of 14
No
No
Mmus\Sox6
3 of 14
No
No
Mmus\Sox30
3 of 14
No
Yes
Mmus\Sox16
2 of 14
No
Yes
Mmus\Sox19
2 of 14
No
Yes
Mmus\Cfap65
1 of 14
No
Yes
Mmus\Cic
1 of 14
No
No
Mmus\Hmg20b
1 of 14
No
No
Mmus\Hmgb4
1 of 14
No
No
Mmus\Hmgxb3
1 of 14
No
Yes
Mmus\Meiosin
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (41)
Xtro\sox14
6 of 13
Yes
Yes
Xtro\sox2
5 of 13
No
Yes
Xtro\sox1
4 of 13
No
Yes
Xtro\sox3
3 of 13
No
No
Xtro\sox4
3 of 13
No
No
Xtro\sox7
3 of 13
No
No
Xtro\sox11
3 of 13
No
No
Xtro\sox17a
3 of 13
No
No
Xtro\sox17b.1
3 of 13
No
No
Xtro\sox17b.2
3 of 13
No
No
Xtro\sox18
3 of 13
No
No
Xtro\sox21
3 of 13
No
Yes
Xtro\sox8
2 of 13
No
No
Xtro\sox9
2 of 13
No
No
Xtro\sox10
2 of 13
No
No
Xtro\sox13
2 of 13
No
No
Xtro\bbx
1 of 13
No
No
Xtro\cdk1
1 of 13
No
No
Xtro\cic
1 of 13
No
No
Xtro\hbp1
1 of 13
No
No
Xtro\hmg20a
1 of 13
No
No
Xtro\hmg20b
1 of 13
No
No
Xtro\hmgb1
1 of 13
No
No
Xtro\hmgb2
1 of 13
No
No
Xtro\hmgb3
1 of 13
No
No
Xtro\hmgxb4
1 of 13
No
No
Xtro\LOC101732411
1 of 13
No
Yes
Xtro\LOC101734060
1 of 13
No
Yes
Xtro\LOC116407953
1 of 13
No
No
Xtro\mob3c
1 of 13
No
No
Xtro\pcmt1
1 of 13
No
No
Xtro\pms1
1 of 13
No
No
Xtro\sox5
1 of 13
No
No
Xtro\sox6
1 of 13
No
No
Xtro\sox15
1 of 13
No
Yes
Xtro\tcf7l1
1 of 13
No
No
Xtro\tcf7
1 of 13
No
No
Xtro\tox2
1 of 13
No
No
Xtro\tox3
1 of 13
No
No
Xtro\tox4
1 of 13
No
No
Xtro\vegfc
1 of 13
No
Yes
Danio rerio (Zebrafish) (33)
Drer\sox2
9 of 14
Yes
Yes
Drer\sox14
8 of 14
No
Yes
Drer\sox1b
6 of 14
No
Yes
Drer\sox3
6 of 14
No
Yes
Drer\sox19a
6 of 14
No
Yes
Drer\sox19b
6 of 14
No
Yes
Drer\sox21a
6 of 14
No
Yes
Drer\sox21b
6 of 14
No
No
Drer\sox1a
5 of 14
No
No
Drer\sox4a
5 of 14
No
No
Drer\sox11a
5 of 14
No
No
Drer\sox11b
5 of 14
No
No
Drer\sox12
5 of 14
No
No
Drer\sox18
5 of 14
No
No
Drer\LOC103910042
4 of 14
No
Yes
Drer\sox4b
4 of 14
No
No
Drer\sox7
4 of 14
No
No
Drer\sox8b
4 of 14
No
No
Drer\sox9a
4 of 14
No
No
Drer\sox10
4 of 14
No
No
Drer\sox17
4 of 14
No
No
Drer\sox32
4 of 14
No
Yes
Drer\sox8a
3 of 14
No
No
Drer\sox9b
3 of 14
No
No
Drer\sox13
3 of 14
No
No
Drer\sox5
2 of 14
No
No
Drer\sox6
2 of 14
No
No
Drer\bbx
1 of 14
No
No
Drer\cfap65
1 of 14
No
Yes
Drer\cica
1 of 14
No
No
Drer\hmgb2a
1 of 14
No
No
Drer\hmgxb3
1 of 14
No
Yes
Drer\tcf7l1b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\sox-3
9 of 14
Yes
Yes
Cele\sem-2
5 of 14
No
Yes
Cele\sox-2
5 of 14
No
Yes
Cele\sox-4
5 of 14
No
Yes
Cele\egl-13
2 of 14
No
No
Cele\gei-3
1 of 14
No
No
Cele\hmg-1.1
1 of 14
No
No
Cele\hmg-1.2
1 of 14
No
No
Cele\hmg-3
1 of 14
No
No
Cele\hmg-4
1 of 14
No
No
Cele\pop-1
1 of 14
No
No
Cele\swsn-3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (18)
Agam\AgaP_AGAP010922
5 of 12
Yes
No
Agam\AgaP_AGAP005183
4 of 12
No
No
Agam\AgaP_AGAP009957
4 of 12
No
No
Agam\AgaP_AGAP010919
4 of 12
No
No
Agam\AgaP_AGAP010923
4 of 12
No
No
Agam\AgaP_AGAP000066
3 of 12
No
No
Agam\AgaP_AGAP000922
3 of 12
No
No
Agam\AgaP_AGAP012033
3 of 12
No
No
Agam\AgaP_AGAP000005
1 of 12
No
No
Agam\AgaP_AGAP000281
1 of 12
No
No
Agam\AgaP_AGAP001099
1 of 12
No
No
Agam\AgaP_AGAP004789
1 of 12
No
No
Agam\AgaP_AGAP004791
1 of 12
No
No
Agam\AgaP_AGAP012334
1 of 12
No
No
Agam\AgaP_AGAP012335
1 of 12
No
No
Agam\AgaP_AGAP012389
1 of 12
No
No
Agam\AgaP_AGAP012411
1 of 12
No
No
Agam\AgaP_AGAP013411
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\3xHMG-box1
2 of 13
Yes
No
Atha\3xHMG-box2
2 of 13
Yes
No
Atha\AT2G34450
1 of 13
No
No
Atha\HMG
1 of 13
No
No
Atha\HMGB1
1 of 13
No
No
Atha\HMGB2
1 of 13
No
No
Atha\HMGB3
1 of 13
No
No
Atha\HMGB4
1 of 13
No
No
Atha\HMGB5
1 of 13
No
No
Atha\HMGB6
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\ROX1
3 of 13
Yes
No
Scer\ABF2
1 of 13
No
No
Scer\IXR1
1 of 13
No
No
Scer\NHP6A
1 of 13
No
No
Scer\NHP6B
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\matmc_1
3 of 12
Yes
No
Spom\matmc_2
3 of 12
Yes
No
Spom\ste11
3 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sox21a. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
SoxN
8 of 13
Sox21b
7 of 13
Sox14
6 of 13
Sox15
6 of 13
D
5 of 13
Sox100B
5 of 13
Sox102F
4 of 13
cic
2 of 13
pan
2 of 13
bbx
1 of 13
Dsp1
1 of 13
Hmg-2
1 of 13
HmgD
1 of 13
HmgZ
1 of 13
Ssrp
1 of 13
tHMG1
1 of 13
tHMG2
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 5 )
Potential Models Based on Orthology ( 5 )
Modifiers Based on Experimental Evidence ( 3 )
Allele
Disease
Interaction
References
Sox21a6
model of  intestinal cancer
is ameliorated by upd2NIG.5988R
(Zhai et al., 2015)
is ameliorated by upd2HMS00901
(Zhai et al., 2015)
is ameliorated by Mmp2RNAi.UAS
(Zhai et al., 2015)
is ameliorated by TimpUAS.cPa
(Zhai et al., 2015)
is ameliorated by bskDN.UAS
(Zhai et al., 2015)
is ameliorated by hep1
(Zhai et al., 2015)
is exacerbated by pucE69
(Zhai et al., 2015)
Sox21aJC1
model of  intestinal cancer
is ameliorated by Sox21aUAS.cCa
(Chen et al., 2016)
is ameliorated by spiGD1779
(Chen et al., 2016)
Sox21aUAS.cCa
ameliorates  intestinal cancer
modeled by Sox21aJC1
(Chen et al., 2016)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SOX2; SRY-box transcription factor 2
9 of 14
184429
 
SOX14; SRY-box transcription factor 14
8 of 14
604747
      SOX21; SRY-box transcription factor 21
      7 of 14
      604974
           
          SOX1; SRY-box transcription factor 1
          5 of 14
          602148
              SOX3; SRY-box transcription factor 3
              5 of 14
              313430
              SOX4; SRY-box transcription factor 4
              5 of 14
              184430
              SOX7; SRY-box transcription factor 7
              5 of 14
              612202
                  SOX11; SRY-box transcription factor 11
                  5 of 14
                  600898
                  SOX12; SRY-box transcription factor 12
                  5 of 14
                  601947
                       
                      SOX15; SRY-box transcription factor 15
                      5 of 14
                      601297
                           
                          SOX17; SRY-box transcription factor 17
                          5 of 14
                          610928
                           
                          SOX18; SRY-box transcription factor 18
                          5 of 14
                          601618
                          SOX8; SRY-box transcription factor 8
                          4 of 14
                          605923
                              SOX9; SRY-box transcription factor 9
                              4 of 14
                              608160
                              SOX10; SRY-box transcription factor 10
                              4 of 14
                              602229
                              SOX13; SRY-box transcription factor 13
                              4 of 14
                              604748
                                  SRY; sex determining region Y
                                  4 of 14
                                  480000
                                  SOX5; SRY-box transcription factor 5
                                  3 of 14
                                  604975
                                    SOX6; SRY-box transcription factor 6
                                    3 of 14
                                    607257
                                      SOX30; SRY-box transcription factor 30
                                      3 of 14
                                      606698
                                          Functional Complementation Data
                                          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                          Interactions
                                          Summary of Physical Interactions
                                          Summary of Genetic Interactions
                                          Interaction Browsers
                                          View in FlyBase Interactions Browser   View in MIST tool (external link)
                                          Please look at the allele data for full details of the genetic interactions
                                          Starting gene(s)
                                          Interaction type
                                          Interacting gene(s)
                                          Reference
                                          Sox21a
                                          suppressible
                                          bsk
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          Egfr
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          hep
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          kay
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          Mmp1
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          Mmp2
                                          (Zhai et al., 2015)
                                          Sox21a
                                          enhanceable
                                          puc
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          spi
                                          (Chen et al., 2016, Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          Timp
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          upd2
                                          (Zhai et al., 2015)
                                          Sox21a
                                          suppressible
                                          upd3
                                          (Zhai et al., 2015)
                                          Starting gene(s)
                                          Interaction type
                                          Interacting gene(s)
                                          Reference
                                          Sox100B
                                          suppressible
                                          Sox21a
                                          (Jin et al., 2020)
                                          Stat92E
                                          suppressible
                                          Sox21a
                                          (Zhai et al., 2015)
                                          upd2
                                          suppressible
                                          Sox21a
                                          (Zhai et al., 2015)
                                          External Data
                                          Linkouts
                                          DroID - A comprehensive database of gene and protein interactions.
                                          MIST (genetic) - An integrated Molecular Interaction Database
                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                          Pathways
                                          Signaling Pathways (FlyBase)
                                          Metabolic Pathways
                                          FlyBase
                                          External Links
                                          External Data
                                          Linkouts
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          Class of Gene
                                          Genomic Location and Detailed Mapping Data
                                          Chromosome (arm)
                                          3L
                                          Recombination map
                                          3-42
                                          Cytogenetic map
                                          70D2-70D2
                                          Sequence location
                                          FlyBase Computed Cytological Location
                                          Cytogenetic map
                                          Evidence for location
                                          70D2-70D2
                                          Limits computationally determined from genome sequence between P{PZ}l(3)70Da02402&P{PZ}btl00208 and P{PZ}Mpcp00564
                                          Experimentally Determined Cytological Location
                                          Cytogenetic map
                                          Notes
                                          References
                                          Experimentally Determined Recombination Data
                                          Location

                                          3-42

                                          (FlyBase, 2016)

                                          3-35.6

                                          (Comeron et al., 2012)
                                          Left of (cM)
                                          Right of (cM)
                                          Notes
                                          Stocks and Reagents
                                          Stocks (18)
                                          Genomic Clones (27)
                                          cDNA Clones (16)
                                           

                                          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                          cDNA clones, fully sequenced
                                          BDGP DGC clones
                                          Other clones
                                          Drosophila Genomics Resource Center cDNA clones

                                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                          cDNA Clones, End Sequenced (ESTs)
                                          BDGP DGC clones
                                            Other clones
                                            RNAi and Array Information
                                            Linkouts
                                            DRSC - Results frm RNAi screens
                                            Antibody Information
                                            Laboratory Generated Antibodies
                                             

                                            polyclonal

                                            (Chen et al., 2016, Meng and Biteau, 2015)
                                            Commercially Available Antibodies
                                             
                                            Cell Line Information
                                            Publicly Available Cell Lines
                                             
                                              Other Stable Cell Lines
                                               
                                                Other Comments

                                                S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                                                (Stroschein-Stevenson et al., 2006)
                                                Relationship to Other Genes
                                                Source for database merge of

                                                Source for merge of: Sox21a SoxB2.3

                                                (Cremazy et al., 2001)
                                                Additional comments
                                                Nomenclature History
                                                Source for database identify of

                                                Source for identity of: Sox21a CG7345

                                                (McKimmie et al., 2001, Overton, 2001.9.6)
                                                Nomenclature comments
                                                Etymology
                                                Synonyms and Secondary IDs (8)
                                                Datasets (0)
                                                Study focus (0)
                                                Experimental Role
                                                Project
                                                Project Type
                                                Title
                                                Study result (0)
                                                Result
                                                Result Type
                                                Title
                                                External Crossreferences and Linkouts ( 34 )
                                                Sequence Crossreferences
                                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                Other crossreferences
                                                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                FlyMine - An integrated database for Drosophila genomics
                                                InterPro - A database of protein families, domains and functional sites
                                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                                MARRVEL_MODEL - MARRVEL (model organism gene)
                                                Linkouts
                                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                DroID - A comprehensive database of gene and protein interactions.
                                                DRSC - Results frm RNAi screens
                                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                Flygut - An atlas of the Drosophila adult midgut
                                                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                                MIST (genetic) - An integrated Molecular Interaction Database
                                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                References (86)