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FB2021_04, released August 17, 2021

Gene: Dmel\anchor

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General Information
Symbol
Dmel\anchor
Species
D. melanogaster
Name
anchor
Annotation Symbol
CG7510
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036741
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
74E2-74E3
Sequence location
3L:17,621,824..17,630,971 [+]
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17621824..17630971
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in intracellular signal transduction
inferred from electronic annotation with InterPro:IPR000591
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR004776
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR004776
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\anchor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
anchor-RA
FBtr0075182
NM_140741
3823
949
anchor-RB
FBtr0333121
NM_001275066
4338
957
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
anchor-PA
FBpp0074947
105.0
949
8.38
NP_648998
AAF49321
anchor-PB
FBpp0305332
106.0
957
8.26
NP_001261995
AGB94688
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\anchor using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous

Comment: apically cleared

(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
embryonic stage 11 -- 12
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval fat body
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\anchor in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of anchor
Transgenic constructs containing regulatory region of anchor
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel9005
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal size | adult stage, with Scer\GAL4A9
abnormal size | adult stage, with Scer\GAL4Bx-MS1096
abnormal size | adult stage, with Scer\GAL4dpp.blk1
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4hs.PU
abnormal size | adult stage, with Scer\GAL4nub.PU
abnormal size | larval stage, with Scer\GAL4A9
decreased occurrence of cell division | larval stage, with Scer\GAL4A9
increased occurrence of cell division | larval stage, with Scer\GAL4A9
increased occurrence of cell division | larval stage, with Scer\GAL4en-e16E
majority die during embryonic stage, with Scer\GAL4Act.PU
majority die during embryonic stage, with Scer\GAL4Tub.PU
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4A9
visible | adult stage, with Scer\GAL4Bx-MS1096
visible | adult stage, with Scer\GAL4dpp.blk1
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage, with Scer\GAL4hs.PU
visible | adult stage, with Scer\GAL4nub.PU
Phenotype manifest in
Allele
anterior-posterior compartment boundary of the wing blade, with Scer\GAL4dpp.blk1
dorsal-ventral compartment boundary of the wing disc, with Scer\GAL4A9
embryonic/larval somatic muscle, with Scer\GAL4Mef2.PR
mesothoracic tergum, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4A9
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4nub.PU
wing disc posterior compartment, with Scer\GAL4en-e16E
wing posterior compartment, with Scer\GAL4en-e16E
wing pouch, with Scer\GAL4A9
wing pouch, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4A9
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4dpp.blk1
wing vein, with Scer\GAL4en-e16E
wing vein, with Scer\GAL4hs.PU
wing vein | increased number, with Scer\GAL4A9
wing vein | increased number, with Scer\GAL4Bx-MS1096
wing vein | increased number, with Scer\GAL4dpp.blk1
wing vein | increased number, with Scer\GAL4en-e16E
wing vein | increased number, with Scer\GAL4hs.PU
wing vein | increased number, with Scer\GAL4nub.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GPR155
14 of 15
Yes
Yes
2  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gpr155
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Gpr155
13 of 13
Yes
Yes
Rnor\Deptor
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\gpr155
9 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\gpr155b
13 of 15
Yes
Yes
Drer\gpr155a
12 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (6)
Atha\EIR1
1 of 9
Yes
Yes
Atha\PIN4
1 of 9
Yes
Yes
Atha\PIN5
1 of 9
Yes
Yes
Atha\PIN6
1 of 9
Yes
Yes
Atha\PIN7
1 of 9
Yes
Yes
Atha\PIN8
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901ZE )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012422
Drosophila simulans
Dsim\GD14719
Drosophila sechellia
Dsec\GM25711
Drosophila erecta
Dere\GG13626
Drosophila yakuba
Dyak\GE19922
Drosophila ananassae
Dana\GF10541
Drosophila pseudoobscura pseudoobscura
Dpse\GA23548
Drosophila persimilis
Dper\GL24908
Drosophila willistoni
Dwil\GK12021
Drosophila virilis
Dvir\GJ12278
Drosophila mojavensis
Dmoj\GI12388
Drosophila grimshawi
Dgri\GH16123
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500YM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007014
Musca domestica
House fly
Mdoa\17007463
Musca domestica
House fly
Mdoa\17005402
Glossina morsitans
Tsetse fly
Gmor\GMOY003171
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12876
Mayetiola destructor
Hessian fly
Mdes\Mdes008700
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005795
Anopheles darlingi
American malaria mosquito
Adar\ADAC008753
Anopheles darlingi
American malaria mosquito
Adar\ADAC008769
Anopheles gambiae
Malaria mosquito
Agam\AGAP006992
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016045
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02V7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011733
Danaus plexippus
Monarch butterfly
Dple\DPOGS204839-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL013899
Apis florea
Little honeybee
Aflo\2414975236
Apis mellifera
Western honey bee
Amel\LOC724877
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18507
Bombus terrestris
Buff-tailed bumblebee
Bter\15212548
Linepithema humile
Argentine ant
Lhum\LH20960
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0003e9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010800
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10870
Tribolium castaneum
Red flour beetle
Tcas\TC015971
Pediculus humanus
Human body louse
Phum\PHUM574310
Rhodnius prolixus
Kissing bug
Rpro\RPRC001954
Cimex lectularius
Bed bug
Clec\CLEC008012
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002958
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08460
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02QI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006448
Ixodes scapularis
Black-legged tick
Isca\ISCW021618
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66360.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01200
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312099
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306598
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G046L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gpr155
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001604gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024374
Ciona intestinalis
Vase tunicate
Cint\LOC100179069
Gallus gallus
Domestic chicken
Ggal\GPR155
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GPR155; G protein-coupled receptor 155
    14 of 15
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        anchor
        suppressible
        dpp
        (Wang et al., 2018)
        anchor
        suppressible
        gbb
        (Wang et al., 2018)
        anchor
        enhanceable
        gbb
        (Wang et al., 2018)
        anchor
        suppressible
        Mad
        (Wang et al., 2018)
        anchor
        suppressible
        Med
        (Wang et al., 2018)
        anchor
        suppressible
        put
        (Wang et al., 2018)
        anchor
        suppressible
        sax
        (Wang et al., 2018)
        anchor
        suppressible
        tkv
        (Wang et al., 2018)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        dpp
        suppressible
        anchor
        (Wang et al., 2018)
        gbb
        suppressible
        anchor
        (Wang et al., 2018)
        gbb
        enhanceable
        anchor
        (Wang et al., 2018)
        Mad
        suppressible
        anchor
        (Wang et al., 2018)
        Med
        suppressible
        anchor
        (Wang et al., 2018)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-45
        Cytogenetic map
        74E2-74E3
        Sequence location
        3L:17,621,824..17,630,971 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        74E2-74E3
        Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-45

        (FlyBase, 2016)

        3-41.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (19)
        cDNA Clones (33)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: anchor CG7510

          (Wang et al., 2018)
          Source for database merge of

          Source for merge of: CG7510 anon-74EFa

          (FlyBase, 1996-)
          Additional comments

          scaRNA:mgU4-65 is encoded in an intron of CG7510.

          (Graveley et al., 2011)
          Other Comments

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Identification: 3.9kb transcript identified during molecular analysis of the Eip74EF genomic region.

          (Burtis et al., 1990)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 40 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB
          EMBL-EBI Single Cell Expression Atlas
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL
          modMine - A data warehouse for the modENCODE project
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Synonyms and Secondary IDs (3)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (35)