FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\anchor
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General Information
Symbol
Dmel\anchor
Species
D. melanogaster
Name
anchor
Annotation Symbol
CG7510
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036741
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
74E2-74E3
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17621824..17630971
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Wang et al., 2018)
involved_in negative regulation of BMP signaling pathway
inferred from mutant phenotype
(Wang et al., 2018)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Wang et al., 2018)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in intracellular signal transduction
inferred from electronic annotation with InterPro:IPR000591
(InterPro Project Members, 2004-)
involved_in negative regulation of BMP signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001107199
(GO Reference Genome Project, 2011-)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR004776
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR004776
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\anchor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PFK5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
anchor-RA
FBtr0075182
NM_140741
3823
949
anchor-RB
FBtr0333121
NM_001275066
4338
957
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
anchor-PA
FBpp0074947
105.0
949
8.38
Q9VVJ0
NP_648998
AAF49321
anchor-PB
FBpp0305332
106.0
957
8.26
M9PFK5
NP_001261995
AGB94688
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\anchor using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.21

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous

Comment: apically cleared

(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
embryonic stage 11 -- 12
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval fat body
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\anchor in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of anchor
Transgenic constructs containing regulatory region of anchor
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel9005
(Ryder, 2004.4.26)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal size | adult stage, with Scer\GAL4A9
abnormal size | adult stage, with Scer\GAL4Bx-MS1096
abnormal size | adult stage, with Scer\GAL4dpp.blk1
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4hs.PU
abnormal size | adult stage, with Scer\GAL4nub.PU
abnormal size | larval stage, with Scer\GAL4A9
decreased occurrence of cell division | larval stage, with Scer\GAL4A9
increased occurrence of cell division | larval stage, with Scer\GAL4A9
increased occurrence of cell division | larval stage, with Scer\GAL4en-e16E
majority die during embryonic stage, with Scer\GAL4Act.PU
majority die during embryonic stage, with Scer\GAL4Tub.PU
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4A9
visible | adult stage, with Scer\GAL4Bx-MS1096
visible | adult stage, with Scer\GAL4dpp.blk1
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage, with Scer\GAL4hs.PU
visible | adult stage, with Scer\GAL4nub.PU
Phenotype manifest in
Allele
anterior-posterior compartment boundary of the wing blade, with Scer\GAL4dpp.blk1
dorsal-ventral compartment boundary of the wing disc, with Scer\GAL4A9
larval somatic muscle cell, with Scer\GAL4Mef2.PR
mesonotum, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4A9
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4nub.PU
wing disc posterior compartment, with Scer\GAL4en-e16E
wing posterior compartment, with Scer\GAL4en-e16E
wing pouch, with Scer\GAL4A9
wing pouch, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4A9
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4dpp.blk1
wing vein, with Scer\GAL4en-e16E
wing vein, with Scer\GAL4hs.PU
wing vein | increased number, with Scer\GAL4A9
wing vein | increased number, with Scer\GAL4Bx-MS1096
wing vein | increased number, with Scer\GAL4dpp.blk1
wing vein | increased number, with Scer\GAL4en-e16E
wing vein | increased number, with Scer\GAL4hs.PU
wing vein | increased number, with Scer\GAL4nub.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\GPR155
14 of 14
Yes
Yes
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Gpr155
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Gpr155
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\gpr155
7 of 13
Yes
Yes
Xtro\sirt6
1 of 13
No
No
Xtro\tmem167b
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\gpr155a
14 of 14
Yes
Yes
Drer\gpr155b
13 of 14
No
Yes
Drer\deptor
1 of 14
No
Yes
Drer\prex1
1 of 14
No
No
Drer\prex2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006992
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\PIN8
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:anchor. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GPR155; G protein-coupled receptor 155
    14 of 14
    620855
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        anchor
        suppressible
        dpp
        (Wang et al., 2018)
        anchor
        suppressible
        gbb
        (Wang et al., 2018)
        anchor
        enhanceable
        gbb
        (Wang et al., 2018)
        anchor
        suppressible
        Mad
        (Wang et al., 2018)
        anchor
        suppressible
        Med
        (Wang et al., 2018)
        anchor
        suppressible
        put
        (Wang et al., 2018)
        anchor
        suppressible
        sax
        (Wang et al., 2018)
        anchor
        suppressible
        tkv
        (Wang et al., 2018)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        dpp
        suppressible
        anchor
        (Wang et al., 2018)
        gbb
        enhanceable
        anchor
        (Wang et al., 2018)
        gbb
        suppressible
        anchor
        (Wang et al., 2018)
        Mad
        suppressible
        anchor
        (Wang et al., 2018)
        Med
        suppressible
        anchor
        (Wang et al., 2018)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-45
        Cytogenetic map
        74E2-74E3
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        74E2-74E3
        Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-45

        (FlyBase, 2016)

        3-41.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (19)
        cDNA Clones (32)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              Identification: 3.9kb transcript identified during molecular analysis of the Eip74EF genomic region.

              (Burtis et al., 1990)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: CG7510 anon-74EFa

              (FlyBase, 1996-)
              Additional comments

              scaRNA:mgU4-65 is encoded in an intron of CG7510.

              (Graveley et al., 2011)
              Nomenclature History
              Source for database identify of

              Source for identity of: anchor CG7510

              (Wang et al., 2018)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (3)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 42 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              References (41)