FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\Sgf11
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General Information
Symbol
Dmel\Sgf11
Species
D. melanogaster
Name
SAGA associated factor 11kDa
Annotation Symbol
CG13379
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036804
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
SAGA associated factor 11kDa (Sgf11) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Sgf11 is a component of the deubiquitinase module, interacts with the non-stop deubiquitinase, and is essential for non-stop enzymatic activity in vitro. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dSgf11

Key Links
Genomic Location
Cytogenetic map
75D6-75D6
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:18681037..18681836
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:not; FB:FBgn0013717
(Weake et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from mutant phenotype
(Zhao et al., 2008)
involved_in positive regulation of DNA-templated transcription
inferred from mutant phenotype
(Zhao et al., 2008)
involved_in regulation of DNA-templated transcription
inferred from mutant phenotype
(Weake et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
part_of DUBm complex
inferred from direct assay
(Mohan et al., 2014)
located_in nucleus
inferred from direct assay
(Weake et al., 2011)
part_of SAGA complex
inferred from direct assay
(Weake et al., 2011, Weake et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the SGF11 family. (Q9VVR6)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
SAGA associated factor 11kDa (Sgf11) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Sgf11 is a component of the deubiquitinase module, interacts with the non-stop deubiquitinase, and is essential for non-stop enzymatic activity in vitro. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
SAGA COMPLEX -
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).
Protein Function (UniProtKB)
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA-dependent manner. Binds to mRNA and is essential for total mRNA export from the nucleus. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.
(UniProt, Q9VVR6)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sgf11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VVR6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sgf11-RB
FBtr0113179
NM_001104168
800
196
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sgf11-PB
FBpp0112092
21.3
196
8.23
Q9VVR6
NP_001097638
AAF49243
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of some SAGA transcription coactivator-HAT complexes, at least composed of Ada2b, not/nonstop, Pcaf/Gcn5, Sgf11 and Spt3. Within the SAGA complex, Sgf11, e(y)2, and not/nonstop form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with not/nonstop. Interacts with the AMEX complex component xmas-2. Interacts with Cbp80; important for promoter recruitment of Sgf11 that is not associated with the DUB module.

(UniProt, Q9VVR6)
Domain

The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of not/nonstop forms the 'catalytic lobe' of the SAGA deubiquitination module.

(UniProt, Q9VVR6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sgf11 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.31

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of DUBm complex
inferred from direct assay
(Mohan et al., 2014)
located_in nucleus
inferred from direct assay
(Weake et al., 2011)
part_of SAGA complex
inferred from direct assay
(Weake et al., 2011, Weake et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sgf11 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sgf11
Transgenic constructs containing regulatory region of Sgf11
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\ATXN7L3
8 of 14
Yes
Yes
1  
Hsap\ATXN7L3B
2 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Atxn7l3
7 of 14
Yes
Yes
Rnor\Atxn7l3b
2 of 14
No
Yes
Rnor\Atxn7l1
1 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Atxn7l3
8 of 14
Yes
Yes
Mmus\Atxn7l3b
2 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\atxn7l3
5 of 13
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\atxn7l3b
9 of 14
Yes
Yes
Drer\atxn7l3a
7 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\SGF11_ANOGA
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT5G58575
8 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SGF11
3 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\sgf11
3 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sgf11. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ATXN7L3; ataxin 7 like 3
    8 of 14
    619010
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Sgf11 - Ada1-2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Weake et al., 2009)
      Sgf11 - Ada2b
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
      (Weake et al., 2011, Weake et al., 2009, Weake et al., 2008)
      Sgf11 - Atxn7
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
      (Mohan et al., 2014)
      Sgf11 - Brf
      anti bait coimmunoprecipitation, western blot
      (Popova et al., 2018)
      Sgf11 - CTCF
      pull down, molecular weight estimation by staining
      (Bonchuk et al., 2016)
      Sgf11 - Cbp80
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, ion exchange chromatography, molecular sieving, peptide massfingerprinting
      (Gurskiy et al., 2012)
      Sgf11 - Gcn5
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
      (Gurskiy et al., 2012, Weake et al., 2008)
      Sgf11 - Pbp45
      anti bait coimmunoprecipitation, western blot
      (Popova et al., 2018)
      Sgf11 - Saf6
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Weake et al., 2009)
      Sgf11 - Sf3b5
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Stegeman et al., 2016)
      Sgf11 - Sgf29
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Weake et al., 2009)
      Sgf11 - Spt20
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Stegeman et al., 2016)
      Sgf11 - Spt3
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Stegeman et al., 2016)
      Sgf11 - e(y)2
      anti tag coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining, anti bait coimmunoprecipitation, western blot, two hybrid, three hybrid
      (Erez et al., 2021, Popova et al., 2018, Hu et al., 2017.6.13, Bonchuk et al., 2016, Mohan et al., 2014, Gurskiy et al., 2012)
      Sgf11 - not
      anti bait coimmunoprecipitation, western blot, three hybrid, anti tag coimmunoprecipitation, anti tag western blot, molecular sieving, Identification by mass spectrometry
      (Erez et al., 2021, Popova et al., 2018, Mohan et al., 2014, Gurskiy et al., 2012, Weake et al., 2008)
      Sgf11 - phol
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      Sgf11 - wda
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Weake et al., 2009)
      Sgf11 - xmas
      anti bait coimmunoprecipitation, western blot
      (Gurskiy et al., 2012)
      RNA-protein
      Physical Interaction
      Assay
      References
      Sgf11 - Hsp70
      anti bait coimmunoprecipitation, primer specific pcr
      (Gurskiy et al., 2012)
      Sgf11 - Ras64B
      anti bait coimmunoprecipitation, primer specific pcr
      (Gurskiy et al., 2012)
      Sgf11 - βTub56D
      anti bait coimmunoprecipitation, primer specific pcr
      (Gurskiy et al., 2012)
      Summary of Genetic Interactions
      Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      Component of some SAGA transcription coactivator-HAT complexes, at least composed of Ada2b, not/nonstop, Pcaf/Gcn5, Sgf11 and Spt3. Within the SAGA complex, Sgf11, e(y)2, and not/nonstop form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with not/nonstop. Interacts with the AMEX complex component xmas-2. Interacts with Cbp80; important for promoter recruitment of Sgf11 that is not associated with the DUB module.
      (UniProt, Q9VVR6 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-45
      Cytogenetic map
      75D6-75D6
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      75D6-75D6
      Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-45

      (FlyBase, 2016)

      3-41.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (5)
      Genomic Clones (19)
      cDNA Clones (6)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Li et al., 2017, Gurskiy et al., 2012)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (6)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 28 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (49)