FB2020_06, released Dec 22, 2020

Gene: Dmel\aux

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General Information
Symbol
Dmel\aux
Species
D. melanogaster
Name
auxilin
Annotation Symbol
CG1107
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037218
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Snapshot
auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

auxillin, dAux

Key Links
Genomic Location
Cytogenetic map
82A1-82A1
Sequence location
3R:4,211,783..4,227,518 [+]
Recombination map

3-47.1

RefSeq locus
NT_033777 REGION:4211783..4227518
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables clathrin binding
inferred from biological aspect of ancestor with PANTHER:PTN000571055
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in clathrin-dependent endocytosis
inferred from mutant phenotype
(Kandachar et al., 2008)
involved_in compound eye morphogenesis
inferred from mutant phenotype
(Eun et al., 2008)
involved_in negative regulation of neuron death
inferred from mutant phenotype
(Wishart et al., 2012)
involved_in sperm individualization
inferred from mutant phenotype
(Zhou et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in clathrin coat disassembly
inferred from biological aspect of ancestor with PANTHER:PTN000571055
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in clathrin-dependent endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000571055
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in Golgi stack
inferred from direct assay
(Zhou et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000571055
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in intracellular membrane-bounded organelle
inferred from biological aspect of ancestor with PANTHER:PTN000571055
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000571055
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.
HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES -
The Heat Shock Protein 40 (Hsp40) family of co-chaperones are essential factors in the Hsp70 chaperone cycle. The Hsp40 family is diverse in size and structure, but a number of them are about 40kDa and have been identified as products of heat shock genes. Their defining feature is the DnaJ or J-domain corresponding to the N-terminal 70 amino acids of the Escherichia coli co-chaperone DnaJ. (Adapted from FBrf0173155).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\aux for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
aux-RA
FBtr0078965
NM_164317
4410
1165
aux-RB
FBtr0078966
NM_141181
4312
1165
aux-RC
FBtr0336705
NM_001275314
4276
1153
aux-RD
FBtr0336706
NM_001275315
4288
1157
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
aux-PA
FBpp0078604
127.9
1165
6.27
NP_730785
AAF52168
aux-PB
FBpp0078605
127.9
1165
6.27
NP_649438
AAF52169
aux-PC
FBpp0307686
126.7
1153
6.12
NP_001262243
AGB95626
aux-PD
FBpp0307687
127.1
1157
6.27
NP_001262244
AGB95627
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1165 aa isoforms: aux-PA, aux-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aux using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in Golgi stack
inferred from direct assay
(Zhou et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\aux in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of aux
Transgenic constructs containing regulatory region of aux
Deletions and Duplications ( 13 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with aux727)
lethal (with auxD128)
lethal (with auxD136)
lethal (with auxF37)
lethal (with auxI670K)
lethal (with auxK47)
lethal (with auxL7)
lethal (with auxW328X)
lethal (with auxW1150X)
lethal (with Df(3R)ED5021)
lethal | cold sensitive (with auxK47)
lethal | cold sensitive (with auxL7)
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage, with auxW328X/auxL78H
lethal - all die before end of embryonic stage (with auxL78H), with auxΔJ.UAS.mRFP(Unk)
lethal - all die before end of embryonic stage (with auxW328X), with auxΔJ.UAS.mRFP(Unk)
lethal - all die before end of embryonic stage (with Df(3R)ED5021)
lethal - all die before end of larval stage (with auxL78H)
lethal - all die before end of larval stage (with auxW328X)
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
viable (with auxD128)
viable (with auxD136)
viable (with auxK47)
Sterility
Allele
female sterile
female sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
male sterile
male sterile (with auxG257E)
male sterile (with auxI670K)
male sterile (with auxL78H)
Other Phenotypes
Allele
decreased cell number | adult stage, with Scer\GAL4ple.PU
decreased cell number | adult stage | progressive, with Scer\GAL4Ddc.PU
decreased cell number | adult stage | progressive, with Scer\GAL4ple.PU
locomotor behavior defective | adult stage | progressive, with Scer\GAL4Ddc.PU
locomotor behavior defective | adult stage | progressive, with Scer\GAL4ple.PU
neuroanatomy defective
neuroanatomy defective | adult stage, with Scer\GAL4ple.PU
neuroanatomy defective | adult stage | progressive, with Scer\GAL4Ddc.PU
neuroanatomy defective | adult stage | progressive, with Scer\GAL4ple.PU
neuroanatomy defective | maternal effect
short lived, with Scer\GAL4Ddc.PU
short lived, with Scer\GAL4ple.PU
some die during embryonic stage
some die during embryonic stage, with auxW328X/auxL78H
some die during embryonic stage (with auxL78H), with auxΔJ.UAS.mRFP(Unk)
some die during embryonic stage (with auxW328X), with auxΔJ.UAS.mRFP(Unk)
some die during embryonic stage (with Df(3R)ED5021)
some die during larval stage (with auxL78H)
some die during larval stage (with auxW328X)
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible (with auxD128)
visible (with auxD136)
visible (with auxK47)
Phenotype manifest in
Allele
anterior sternopleural bristle | ectopic
anterior sternopleural bristle | ectopic (with auxI670K)
anterior sternopleural bristle | ectopic (with auxW328X)
anterior sternopleural bristle | ectopic (with auxW1150X)
cystic bulge (with auxG257E)
cystic bulge (with auxI670K)
cystic bulge (with auxL78H)
dopaminergic PPL1 neuron | adult stage | progressive, with Scer\GAL4Ddc.PU
dopaminergic PPM1 neuron | adult stage | progressive, with Scer\GAL4Ddc.PU
dopaminergic PPM1 neuron | adult stage | progressive, with Scer\GAL4ple.PU
dopaminergic PPM2 neuron | adult stage | progressive, with Scer\GAL4Ddc.PU
dopaminergic PPM2 neuron | adult stage | progressive, with Scer\GAL4ple.PU
dopaminergic PPM3 neuron | adult stage, with Scer\GAL4ple.PU
eye
eye (with auxD128)
eye (with auxG257E)
eye (with auxI670K)
eye (with auxK47)
eye (with auxL7)
eye (with auxL78H)
eye (with auxW328X)
eye (with auxW1150X)
eye | heat sensitive
eye photoreceptor cell (with aux727)
eye photoreceptor cell (with auxD128)
eye photoreceptor cell (with auxD136)
eye photoreceptor cell (with auxK47)
eye photoreceptor cell (with auxL7)
eye photoreceptor cell | ectopic (with aux727)
eye photoreceptor cell | ectopic (with auxD128)
eye photoreceptor cell | ectopic (with auxK47)
eye photoreceptor cell | ectopic (with auxL7)
eye photoreceptor cell | supernumerary (with auxG257E)
eye photoreceptor cell | supernumerary (with auxI670K)
eye photoreceptor cell | supernumerary (with auxL78H)
individualization stage spermatid (with auxG257E)
individualization stage spermatid (with auxI670K)
individualization stage spermatid (with auxL78H)
inner photoreceptor cell | supernumerary
male germline stem cell (with auxG257E)
male germline stem cell (with auxI670K)
notopleural bristle | ectopic
notopleural bristle | ectopic (with auxI670K)
notopleural bristle | ectopic (with auxW328X)
notopleural bristle | ectopic (with auxW1150X)
olfactory receptor neuron
ommatidial precursor cluster | somatic clone
ommatidium
ommatidium (with aux727)
ommatidium (with auxD128)
ommatidium (with auxK47)
ommatidium (with auxL7)
outer photoreceptor cell | supernumerary
posterior crossvein
posterior crossvein (with auxI670K)
posterior crossvein (with auxW328X)
posterior crossvein (with auxW1150X)
presumptive embryonic/larval peripheral nervous system | maternal effect
scutellar bristle | ectopic
scutellar bristle | ectopic (with auxI670K)
scutellar bristle | ectopic (with auxW328X)
scutellar bristle | ectopic (with auxW1150X)
scutellar bristle | supernumerary (with auxG257E)
scutellar bristle | supernumerary (with auxI670K)
scutellar bristle | supernumerary (with auxL78H)
sternopleural bristle | supernumerary (with auxG257E)
sternopleural bristle | supernumerary (with auxI670K)
sternopleural bristle | supernumerary (with auxL78H)
ventral nerve cord | maternal effect
vibrissae
vibrissae (with auxI670K)
vibrissae (with auxW328X)
vibrissae (with auxW1150X)
wing (with auxC2)
wing (with auxD128)
wing (with auxK47)
wing (with auxL7)
wing blade (with auxD128)
wing blade (with auxD136)
wing blade (with auxK47)
wing vein
wing vein (with auxI670K)
wing vein (with auxW328X)
wing vein (with auxW1150X)
wing vein | ectopic
wing vein | ectopic (with auxC2)
wing vein | ectopic (with auxD128)
wing vein | ectopic (with auxK47)
wing vein | ectopic (with auxL7)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GAK
15 of 15
Yes
Yes
1  
Hsap\DNAJC6
11 of 15
No
Yes
1  
Hsap\AAK1
2 of 15
No
No
Hsap\BMP2K
2 of 15
No
No
Hsap\PTEN
1 of 15
No
No
91  
Hsap\TNS1
1 of 15
No
No
Hsap\TNS2
1 of 15
No
No
Hsap\TNS3
1 of 15
No
No
Hsap\TPTE2
1 of 15
No
No
Hsap\TPTE
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gak
15 of 15
Yes
Yes
Mmus\Dnajc6
11 of 15
No
Yes
Mmus\Aak1
2 of 15
No
No
Mmus\Bmp2k
2 of 15
No
No
Mmus\Pten
1 of 15
No
No
Mmus\Tns1
1 of 15
No
No
Mmus\Tns2
1 of 15
No
No
Mmus\Tns3
1 of 15
No
No
Mmus\Tpte
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Gak
13 of 13
Yes
Yes
Rnor\Dnajc6
7 of 13
No
Yes
Rnor\Aak1
2 of 13
No
No
Rnor\Bmp2k
1 of 13
No
Yes
Rnor\Pten
1 of 13
No
No
Rnor\Tns1
1 of 13
No
No
Rnor\Tns3
1 of 13
No
No
Rnor\Tpte2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\gak
8 of 12
Yes
Yes
Xtro\dnajc6
6 of 12
No
Yes
Xtro\aak1
2 of 12
No
No
Xtro\bmp2k
2 of 12
No
No
Xtro\pten
1 of 12
No
No
Xtro\tns1
1 of 12
No
No
Xtro\tns2
1 of 12
No
No
Xtro\tpte2
1 of 12
No
No
Danio rerio (Zebrafish) (12)
Drer\gak
10 of 15
Yes
Yes
Drer\dnajc6
7 of 15
No
Yes
Drer\aak1a
2 of 15
No
No
Drer\aak1b
2 of 15
No
No
Drer\bmp2k
2 of 15
No
No
Drer\ptenb
1 of 15
No
No
Drer\si:ch211-191a24.3
1 of 15
No
No
Drer\tns1a
1 of 15
No
No
Drer\tns1b
1 of 15
No
No
Drer\tns2a
1 of 15
No
No
Drer\tns2b
1 of 15
No
No
Drer\tpte
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\gakh-1
9 of 15
Yes
Yes
Cele\dnj-25
4 of 15
No
Yes
Cele\daf-18
1 of 15
No
No
Cele\sel-5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (7)
Atha\AT1G21660
1 of 9
Yes
Yes
Atha\AT1G30280
1 of 9
Yes
Yes
Atha\AT4G12770
1 of 9
Yes
Yes
Atha\AT4G12780
1 of 9
Yes
Yes
Atha\AT4G36520
1 of 9
Yes
Yes
Atha\AUL1
1 of 9
Yes
Yes
Atha\JAC1
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\SWA2
4 of 15
Yes
Yes
Scer\AKL1
1 of 15
No
No
Scer\ARK1
1 of 15
No
No
Scer\PRK1
1 of 15
No
No
Scer\TDA1
1 of 15
No
No
Scer\TEP1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\ucp7
2 of 12
Yes
Yes
Spom\ppk29
1 of 12
No
No
Spom\ppk30
1 of 12
No
No
Spom\ppk38
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901B9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007586
Drosophila simulans
Dsim\GD19706
Drosophila sechellia
Dsec\GM10735
Drosophila erecta
Dere\GG12187
Drosophila yakuba
Dyak\auxillin
Drosophila ananassae
Dana\GF17690
Drosophila pseudoobscura pseudoobscura
Dpse\GA10740
Drosophila persimilis
Dper\GL12305
Drosophila willistoni
Dwil\GK12070
Drosophila virilis
Dvir\GJ14155
Drosophila mojavensis
Dmoj\GI22854
Drosophila grimshawi
Dgri\GH18708
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504RX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020160
Musca domestica
House fly
Mdoa\17016378
Musca domestica
House fly
Mdoa\17022297
Musca domestica
House fly
Mdoa\17004721
Glossina morsitans
Tsetse fly
Gmor\GMOY003412
Glossina morsitans
Tsetse fly
Gmor\GMOY002139
Glossina morsitans
Tsetse fly
Gmor\GMOY002060
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08069
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12610
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07205
Mayetiola destructor
Hessian fly
Mdes\Mdes009486
Mayetiola destructor
Hessian fly
Mdes\Mdes015627
Mayetiola destructor
Hessian fly
Mdes\Mdes016957
Mayetiola destructor
Hessian fly
Mdes\Mdes019116
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005425
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009305
Anopheles darlingi
American malaria mosquito
Adar\ADAC004796
Anopheles darlingi
American malaria mosquito
Adar\ADAC004271
Anopheles gambiae
Malaria mosquito
Agam\AGAP002469
Anopheles gambiae
Malaria mosquito
Agam\AGAP003715
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004075
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008013
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00PY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012412
Bombyx mori
Silkmoth
Bmor\BGIBMGA004687
Danaus plexippus
Monarch butterfly
Dple\DPOGS207550-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009730
Apis florea
Little honeybee
Aflo\2158673778
Apis florea
Little honeybee
Aflo\2542875412
Apis mellifera
Western honey bee
Amel\LOC413462
Apis mellifera
Western honey bee
Amel\GB41837
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22352
Bombus terrestris
Buff-tailed bumblebee
Bter\15208052
Linepithema humile
Argentine ant
Lhum\LH11157
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002787
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000708
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07573
Tribolium castaneum
Red flour beetle
Tcas\TC012067
Pediculus humanus
Human body louse
Phum\PHUM047670
Rhodnius prolixus
Kissing bug
Rpro\RPRC000971
Rhodnius prolixus
Kissing bug
Rpro\RPRC014321
Cimex lectularius
Bed bug
Clec\CLEC006043
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI089162
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005127
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00783
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00OK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014675
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76988.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g02810
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_213883
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06HJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GakL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GakL_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022443
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007520
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019094
Gallus gallus
Domestic chicken
Ggal\DNAJC6
Gallus gallus
Domestic chicken
Ggal\GAK
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Nak
2 of 10
Pten
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
auxGD7187
model of  Parkinson's disease
CEA
(Song et al., 2017)
auxKK100927
model of  Parkinson's disease
CEA
(Song et al., 2017)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
GAK; cyclin G associated kinase
15 of 15
602052
       
      DNAJC6; DnaJ heat shock protein family (Hsp40) member C6
      11 of 15
      608375
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      aux
      suppressible
      Chc
      (Banks et al., 2011, Eun et al., 2008)
      aux
      suppressible
      Chc|lqf
      (Banks et al., 2011)
      aux
      enhanceable
      Clc
      (Hagedorn et al., 2006)
      aux
      suppressible
      lqf
      (Banks et al., 2011)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Blos1
      enhanceable
      aux
      (Cheli et al., 2010, Cheli et al., 2010)
      g
      enhanceable
      aux
      (Cheli et al., 2010, Cheli et al., 2010)
      Hsc70-4
      enhanceable
      aux
      (Hagedorn et al., 2006)
      lqf
      enhanceable
      aux
      (Eun et al., 2007)
      N
      enhanceable
      aux
      (Hagedorn et al., 2006)
      or
      enhanceable
      aux
      (Cheli et al., 2010, Cheli et al., 2010)
      Rab32
      enhanceable
      aux
      (Cheli et al., 2010)
      rb
      enhanceable
      aux
      (Cheli et al., 2010)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-47.1

      Cytogenetic map
      82A1-82A1
      Sequence location
      3R:4,211,783..4,227,518 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      82A1-82A1
      Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      82A-82B
      (Lloyd et al., 2000)
      Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
      (Lloyd et al., 2000)
      Experimentally Determined Recombination Data
      Location

      3-47.1

      (FlyBase, 2016)

      3-44.1

      (Comeron et al., 2012)
      Left of (cM)
      (Eun et al., 2007)
      Right of (cM)
      (Eun et al., 2007)
      Notes
      Stocks and Reagents
      Stocks (19)
      Genomic Clones (20)
      cDNA Clones (62)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: auxillin CG1107

        (Verstreken and Bellen, 2000.9.4)
        Source for database merge of

        Source for merge of: auxillin anon-WO0118547.393

        (FlyBase, 1996-)
        Additional comments

        Source for merge of auxillin anon-WO0118547.393 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Other Comments

        aux is required in N signaling cells for Dl ligand internalization and signaling during eye morphogenesis.

        (Eun et al., 2008)

        aux regulates the internalisation of Dl to control activity of the N signalling pathway.

        (Hagedorn et al., 2006)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        Area matching Drosophila EST AA540712 (inverted). This EST forms a 809bp contig with ESTs AA440879 and AA440431, and has sequence similarity to Human Cyclin G associated kinase gene.

        (Davies, 2001.3.15)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 60 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (12)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (81)