PAR-4, dlkb1, STK11
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lkb1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Lkb1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
BrdU incorporation analysis and phosphohistone H3 immunostaining reveal that lkb1 expression does not affect G1/S or G2/M cell cycle progression.
lkb1 regulates organ size of the central nervous system by inducing developmental apoptosis during embryogenesis.
The tumor-suppressing activity of lkb1 is unrelated to the negative regulation of cell growth control.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, centrosome abnormalities and spindle abnormalities are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
lkb1 is required for early A-P polarity of the oocyte and for the repolarization of the oocyte cytoskeleton that defines the embryonic A-P axis.