dFOXO, forkhead box sub-group O, Forkhead box O, forkhead transcription factor, FOXO1
forkhead domain transcription factor - a target of the insulin receptor signaling pathway - modulates growth and proliferation - regulates RNA interference and protects from RNA virus infection - promotes Wingless signaling - A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons
Gene model reviewed during 5.48
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.02
Interacts with melt.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\foxo using the Feature Mapper tool.
foxo transcript is maternally expressed; the maternal contribution completely disappears prior to cellularization. Somatic expression is undetectable until embryonic stage 11; transcript is expressed in the endoderm and ectoderm at embryonic stage 12. Lower levels of foxo transcript are observed in the ventral portions of the thoracic and head segments; strong expression is observed in labral segment. A cluster of foxo-expressing cells, possibly associated with the stomatogastric nervous system, is observed near the developing proventriculus. Expression in the epidermis of the trunk segments and in the endoderm persists into later stages
foxo protein is localized to the nucleus of cells in the prothoracic gland in newly ecdysed third instar larvae. In fed larvae, by 5 hours after the beginning of the third instar, foxo protein is evenly dispersed; by 10 hours, it is mostly localized to the cytoplasm of prothoracic gland cells.
foxo staining can be observed in a subset of cells in the ventral nerve cord in embryos and larvae. No repo staining is seen in foxo-positive cells, showing that foxo is not present in repo-positive glia. Co-staining with antibodies against phosphorylated Mad, a marker for motor neurons (FBrf0145176), shows that most motor neurons express foxo, and most foxo-positive cells are motor neurons.
GBrowse - Visual display of RNA-Seq signalsView Dmel\foxo in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: foxo anon-WO0118547.374
Source for merge of foxo anon-WO0118547.374 was sequence comparison ( date:051113 ).
foxo acts cell autonomously to inhibit the formation of microtubule loops.
foxo plays an important role in the ability of young Drosophila larvae to withstand the stress of nutritional starvation.
foxo controls lifespan and regulates insulin signalling in the brain and fat body.
foxo is a crucial mediator of insulin signalling, mediating the reduction in cell number in insulin-signalling mutants. Epistasis analysis provides strong genetic evidence that foxo is required to mediate the organismal growth arrest that is elicited in insulin-signaling mutants.
foxo appears to be a key transcriptional regulator that controls both downstream target genes responsible for growth as well as upstream feedback targets in the insulin signalling pathway.
Area matching Drosophila EST AA539898.