FB2020_05, released Oct 14, 2020

Gene: Dmel\foxo

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General Information
Symbol
Dmel\foxo
Species
D. melanogaster
Name
forkhead box, sub-group O
Annotation Symbol
CG3143
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038197
Gene Model Status
Current
Stock Availability
40 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

dFOXO, forkhead box sub-group O, Forkhead box O, forkhead transcription factor, FOXO1

Key Links
Genomic Location
Cytogenetic map
88A5-88A8
Sequence location
3R:14,056,945..14,087,978 [+]
Recombination map

3-54

RefSeq locus
NT_033777 REGION:14056945..14087978
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (50 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Teleman et al., 2008, Vihervaara and Puig, 2008, Puig et al., 2003)
inferred from mutant phenotype
(Mahoney et al., 2016, Wang et al., 2011, Francis et al., 2010)
DNA-binding transcription factor activity
inferred from mutant phenotype
(assigned by UniProt )
(Junger et al., 2003)
protein binding
inferred from physical interaction with UniProtKB:Q9VS24
(assigned by UniProt )
(Teleman et al., 2005)
RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Bai et al., 2013, Francis et al., 2010, Mattila et al., 2009, Puig et al., 2003)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (40 terms)
Terms Based on Experimental Evidence (40 terms)
CV Term
Evidence
References
cellular response to amino acid starvation
inferred from direct assay
(Kramer et al., 2008)
cellular response to oxidative stress
inferred from mutant phenotype
(Junger et al., 2003)
cellular response to starvation
inferred from expression pattern
(Wang et al., 2011)
inferred from mutant phenotype
(Teleman et al., 2008, Vihervaara and Puig, 2008, Junger et al., 2003)
circadian rhythm
inferred from mutant phenotype
(Zheng et al., 2007)
compound eye morphogenesis
inferred from mutant phenotype
(Goberdhan et al., 2005)
dendrite morphogenesis
inferred from mutant phenotype
(Iyer et al., 2013)
determination of adult lifespan
inferred from genetic interaction with FLYBASE:aop; FB:FBgn0000097
(Alic et al., 2014)
inferred from genetic interaction with FLYBASE:pnt; FB:FBgn0003118
(Alic et al., 2014)
inferred from mutant phenotype
(Giannakou et al., 2004, Hwangbo et al., 2004)
female germ-line stem cell population maintenance
inferred from mutant phenotype
(Yang et al., 2013)
glucose homeostasis
inferred from mutant phenotype
(assigned by UniProt )
(Vihervaara and Puig, 2008)
insulin receptor signaling pathway
inferred from genetic interaction with FLYBASE:Akt1; FB:FBgn0010379
(Junger et al., 2003, Puig et al., 2003)
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
(Junger et al., 2003)
inferred from genetic interaction with FLYBASE:chico; FB:FBgn0024248
(Junger et al., 2003)
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0026317
(Junger et al., 2003)
inferred from genetic interaction with FLYBASE:Pten; FB:FBgn0026379
(Junger et al., 2003)
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Junger et al., 2003)
inferred from mutant phenotype
(Zhang et al., 2011, Hwangbo et al., 2004)
locomotor rhythm
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Metaxakis et al., 2014)
lymph gland development
inferred from mutant phenotype
(Benmimoun et al., 2012)
multicellular organism aging
inferred from mutant phenotype
(assigned by UniProt )
(Hwangbo et al., 2004)
negative regulation of cell growth
inferred from mutant phenotype
(assigned by UniProt )
(Junger et al., 2003)
negative regulation of cell population proliferation
inferred from mutant phenotype
(Kramer et al., 2003, Puig et al., 2003)
inferred from mutant phenotype
(assigned by UniProt )
(Junger et al., 2003)
negative regulation of cell size
inferred from mutant phenotype
(Kramer et al., 2003)
negative regulation of fat cell proliferation
inferred from mutant phenotype
(Diangelo and Birnbaum, 2009)
negative regulation of insulin receptor signaling pathway
inferred from mutant phenotype
(assigned by UniProt )
(Puig et al., 2003)
negative regulation of lipid storage
inferred from direct assay
(Karpac et al., 2013)
negative regulation of multicellular organism growth
inferred from mutant phenotype
(Kramer et al., 2003)
negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Bai et al., 2013)
negative regulation of wound healing
inferred from mutant phenotype
(Kakanj et al., 2016)
positive regulation of autophagy
inferred from mutant phenotype
(Tas et al., 2018)
positive regulation of cell cycle arrest
inferred from mutant phenotype
(Puig et al., 2003)
positive regulation of entry into reproductive diapause
inferred from mutant phenotype
(Schiesari et al., 2016)
positive regulation of feeding behavior
inferred from mutant phenotype
(Hong et al., 2012)
inferred from genetic interaction with FLYBASE:mnb; FB:FBgn0259168
(Hong et al., 2012)
positive regulation of octopamine signaling pathway
inferred from mutant phenotype
(Metaxakis et al., 2014)
positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Mahoney et al., 2016, Bai et al., 2013, Wang et al., 2011, Francis et al., 2010)
inferred from direct assay
(Mattila et al., 2009, Teleman et al., 2008, Puig et al., 2003)
positive regulation of triglyceride catabolic process
inferred from mutant phenotype
(Wang et al., 2011)
regulation of autophagy
inferred from mutant phenotype
(Juhász et al., 2007)
regulation of growth
inferred from genetic interaction with FLYBASE:14-3-3ε; FB:FBgn0020238
(Nielsen et al., 2008)
regulation of hemocyte proliferation
inferred from mutant phenotype
(Sinenko et al., 2010)
regulation of lipid metabolic process
inferred from mutant phenotype
(assigned by UniProt )
(Vihervaara and Puig, 2008)
regulation of macroautophagy
inferred from mutant phenotype
(Juhász et al., 2007)
regulation of multicellular organism growth
inferred from mutant phenotype
(Koyama et al., 2014)
regulation of organ growth
inferred from mutant phenotype
(Koyama et al., 2014)
regulation of transcription, DNA-templated
inferred from mutant phenotype
(assigned by UniProt )
(Junger et al., 2003)
response to bacterium
inferred from mutant phenotype
(Dionne et al., 2006)
inferred from direct assay
(Wagner et al., 2009)
response to oxidative stress
inferred from mutant phenotype
(Zheng et al., 2007)
response to starvation
inferred from direct assay
(Kang et al., 2017)
inferred from mutant phenotype
(Koyama et al., 2014)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
glucose homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
insulin receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000215135
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(assigned by UniProt )
(Puig et al., 2003)
cytosol
inferred from direct assay
(Kang et al., 2017, Wang et al., 2011, Betschinger et al., 2006)
nucleus
inferred from direct assay
(Kang et al., 2017, Wang et al., 2011)
inferred from direct assay
(assigned by UniProt )
(Puig et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred by curator from GO:0001228
(Vihervaara and Puig, 2008)
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
FORK HEAD BOX TRANSCRIPTION FACTORS -
The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Protein Function (UniProtKB)
Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.
(UniProt, Q95V55)
Summary (Interactive Fly)

forkhead domain transcription factor - a target of the insulin receptor signaling pathway - modulates growth and proliferation - regulates RNA interference and protects from RNA virus infection - promotes Wingless signaling - A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\foxo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
foxo-RB
FBtr0082886
NM_206483
3939
613
foxo-RC
FBtr0082887
NM_206482
3548
613
foxo-RF
FBtr0305052
NM_142073
3708
622
foxo-RG
FBtr0337094
NM_001275628
3450
622
foxo-RH
FBtr0346723
NM_001316497
3566
619
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
foxo-PB
FBpp0089343
67.4
613
5.42
NP_996205
AAS65147
foxo-PC
FBpp0089344
67.4
613
5.42
NP_996204
AAS65148
foxo-PF
FBpp0293589
68.3
622
5.29
NP_650330
AAF55012
foxo-PG
FBpp0308010
68.3
622
5.29
NP_001262557
AGB95938
foxo-PH
FBpp0312334
68.1
619
5.58
NP_001303426
ALI30566
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

622 aa isoforms: foxo-PF, foxo-PG
613 aa isoforms: foxo-PB, foxo-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with melt.

(UniProt, Q95V55)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\foxo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
organism | ubiquitous | uniform

Comment: maternally deposited

(Lee and Frasch, 2004)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
epipharynx primordium
(Fisher et al., 2012)
garland cell primordium
(Fisher et al., 2012)
hypopharynx proper primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic/larval garland cell
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic stage 12 -- 17
endodermal derivative
(Lee and Frasch, 2004)
ectodermal derivative
(Lee and Frasch, 2004)
embryonic labral segment
(Lee and Frasch, 2004)
embryonic epidermis of embryonic thoracic segment
(Lee and Frasch, 2004)
embryonic epidermis of embryonic abdominal segment
(Lee and Frasch, 2004)
Additional Descriptive Data

foxo transcript is maternally expressed; the maternal contribution completely disappears prior to cellularization. Somatic expression is undetectable until embryonic stage 11; transcript is expressed in the endoderm and ectoderm at embryonic stage 12. Lower levels of foxo transcript are observed in the ventral portions of the thoracic and head segments; strong expression is observed in labral segment. A cluster of foxo-expressing cells, possibly associated with the stomatogastric nervous system, is observed near the developing proventriculus. Expression in the epidermis of the trunk segments and in the endoderm persists into later stages

(Lee and Frasch, 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
late third instar larval stage
neuroblast
(Siegrist et al., 2010)
adult stage
adult fat body
(Zheng et al., 2007)
early third instar larval stage
prothoracic gland
(Koyama et al., 2014)
third instar larval stage
embryonic/larval fat body
(Chung et al., 2010)
ventral nerve cord | subset
(Nechipurenko and Broihier, 2012)
motor neuron | subset
(Nechipurenko and Broihier, 2012)
embryonic stage 16 -- 17
ventral nerve cord | subset
(Nechipurenko and Broihier, 2012)
motor neuron | subset
(Nechipurenko and Broihier, 2012)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
fat body
(Hyun et al., 2009)
Additional Descriptive Data

foxo protein is localized to the nucleus of cells in the prothoracic gland in newly ecdysed third instar larvae. In fed larvae, by 5 hours after the beginning of the third instar, foxo protein is evenly dispersed; by 10 hours, it is mostly localized to the cytoplasm of prothoracic gland cells.

(Koyama et al., 2014)

foxo staining can be observed in a subset of cells in the ventral nerve cord in embryos and larvae. No repo staining is seen in foxo-positive cells, showing that foxo is not present in repo-positive glia. Co-staining with antibodies against phosphorylated Mad, a marker for motor neurons (FBrf0145176), shows that most motor neurons express foxo, and most foxo-positive cells are motor neurons.

(Nechipurenko and Broihier, 2012)

foxo is found predominantly in the neuroblast cytoplasm in late third instar larvae. By 72hrs after pupal formation, foxo can be found in the neuroblast nucleus.

(Siegrist et al., 2010)

foxo protein is detected in the fat bodies in both the head and abdomen of adult flies.

(Zheng et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(assigned by UniProt )
(Puig et al., 2003)
cytosol
inferred from direct assay
(Kang et al., 2017, Wang et al., 2011, Betschinger et al., 2006)
nucleus
inferred from direct assay
(Kang et al., 2017, Wang et al., 2011)
inferred from direct assay
(assigned by UniProt )
(Puig et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\foxo in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 41 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of foxo
Transgenic constructs containing regulatory region of foxo
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4- :
lethal | heat sensitive, with Scer\GAL4hs.PB
lethal - all die before end of larval stage, with Scer\GAL4Act.PU
viable
viable, with Scer\GAL4UAS.cHa, Scer\GAL4tin.cBa
Sterility
Allele
fertile
fertile, with Scer\GAL4VP16.mat.αTub67C
Other Phenotypes
Allele
body size defective, with Scer\GAL4Ilp2.PR
body size defective, with Scer\GAL4ppl.PP
chemical resistant | RU486 conditional, with Scer\GAL4Switch1.106
chemosensitive behavior defective
circadian rhythm defective (with foxo21)
circadian rhythm defective (with foxo25)
decreased cell number, with Scer\GAL4bab1-Gal4, Scer\GAL80ts.αTub84B
decreased cell number, with Scer\GAL4dpp.blk1
decreased cell number, with Scer\GAL4ey.PH
decreased cell number, with Scer\GAL4hs.PB
decreased cell number | adult stage, with Scer\GAL4Fer2.2359
decreased cell number | adult stage, with Scer\GAL4GMR58E02
decreased cell number | adult stage (with foxo21)
decreased cell number | adult stage (with foxo25)
decreased cell number | adult stage | progressive | recessive
decreased cell size, with Scer\GAL4hs.PB
decreased cell size | somatic clone, with Scer\GAL4Act.PU
decreased fecundity | female, with Scer\GAL4Switch1.106
decreased occurrence of cell division | adult stage, with Scer\GAL4NP0001
decreased occurrence of cell division | larval stage, with Scer\GAL4nab
delayed aging, with Scer\GAL4Mef2.PR, Scer\GAL80ts.αTub84B
delayed aging, with Scer\GAL4Mhc.PW
delayed aging, with Scer\GAL4UAS.cHa, Scer\GAL4tin.cBa
developmental rate defective
developmental rate defective (with foxo25)
developmental rate defective (with foxoΔ94)
developmental rate defective | nutrition conditional, with Scer\GAL4phm.PO
developmental rate defective | nutrition conditional (with foxo21)
developmental rate defective | nutrition conditional (with foxo25)
feeding behavior defective, with Scer\GAL4Mhc.PW
feeding behavior defective | adult stage, with Scer\GAL4sNPF-R.2.5
feeding behavior defective | larval stage, with Scer\GAL4Act5C.PI
immune response defective, with Scer\GAL4NP0001
immune response defective (with foxo21)
immune response defective (with foxo25)
immune response defective (with foxoBG01018)
increased cell death, with Scer\GAL4ey.PU
increased cell death, with Scer\GAL4GMR.PU
increased cell death, with Scer\GAL4ptc-559.1
large body | pharate adult stage | nutrition conditional, with Scer\GAL4phm.PO
locomotor behavior defective | adult stage | progressive (with foxo21)
locomotor behavior defective | adult stage | progressive (with foxo25)
locomotor behavior defective | larval stage, with Scer\GAL4Act5C.PI
locomotor behavior defective | recessive
locomotor behavior defective | third instar larval stage, with Scer\GAL4109(2)80
long lived, with Scer\GAL4Ilp2.215-55, foxoUAS.cFa
long lived, with Scer\GAL4Ilp2.215-55, foxoΔ94
long lived, with Scer\GAL4Mhc.PW
long lived | female | RU486 conditional, with Scer\GAL4Switch1.106
long lived | male limited
long lived | nutrition conditional
long lived | RU486 conditional, with Scer\GAL4bun-Switch1.32
long lived | RU486 conditional, with Scer\GAL4Switch1.106
long lived | RU486 conditional, with Scer\GAL4Switch1.106, foxoUAS.cFa
long lived | RU486 conditional, with Scer\GAL4Switch1.106, foxoΔ94
majority die during third instar larval stage, with Df(3R)Exel8159, Scer\GAL4phm.PO, foxoUAS.cKc
majority die during third instar larval stage, with Df(3R)Exel8159, Scer\GAL4phm.PO, foxoΔ94
neuroanatomy defective, with Scer\GAL4221
neuroanatomy defective, with Scer\GAL4ppk.1.9
neuroanatomy defective | pharate adult stage, with Scer\GAL4CCAP.PP
neuroanatomy defective | third instar larval stage, with Scer\GAL4ppk.PU
oxidative stress response defective (with foxo21)
oxidative stress response defective (with foxo25)
premature aging (with foxo21)
premature aging (with foxo25)
short lived
short lived, with Scer\GAL4NP5130
short lived, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
short lived (with foxo21)
short lived (with foxo25)
short lived | nutrition conditional (with foxo21)
short lived | nutrition conditional (with foxo25)
short lived | recessive
small body
small body, with Scer\GAL4hs.PB
small body (with foxo21)
small body (with foxo25)
small body (with foxoΔ94)
small body | adult stage, with Scer\GAL4Ilp2.PR
small body | male limited | pharate adult stage | nutrition conditional, with Scer\GAL4phm.PO
small body | third instar larval stage, with Scer\GAL4RapGAP1-OK6
small body | third instar larval stage | nutrition conditional, with Scer\GAL4phm.PO
some die during larval stage, with Scer\GAL4Act.PU
starvation stress response defective
starvation stress response defective | adult stage, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
stress response defective
stress response defective (with foxo21)
stress response defective (with foxo25)
temperature response defective
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4C-765
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
wild-type | RU486 conditional, with Scer\GAL4Switch1.106
Phenotype manifest in
Allele
A1-7 dorsal acute muscle 1, with Scer\GAL4kirre.PU
abdominal adult fat mass, with Scer\GAL4Mhc.PW
abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9
adult, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
adult anterior midgut epithelium, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
adult brain, with Scer\GAL4Mhc.PW
adult gut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
adult heart, with Scer\GAL4UAS.cHa, Scer\GAL4tin.cBa
anterior crossvein, with Scer\GAL4ptc-559.1
autophagosome | adult stage
bouton, with Scer\GAL4RapGAP1-OK6
dopaminergic PAM neuron | adult stage, with Scer\GAL4Fer2.2359
dopaminergic PAM neuron | adult stage, with Scer\GAL4GMR58E02
dopaminergic PAM neuron | adult stage | progressive
dorsal appendage | drug conditional, with Tn10\tetRrtTA.Act5C
dorso-lateral dopaminergic neuron (with foxo21)
dorso-lateral dopaminergic neuron (with foxo25)
egg chorion | drug conditional, with Tn10\tetRrtTA.Act5C
embryonic/larval fat body | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval neuromuscular junction
embryonic/larval neuromuscular junction, with Scer\GAL4elav.PLu
embryonic/larval neuromuscular junction, with Scer\GAL4RapGAP1-OK6
embryonic/larval neuromuscular junction, with Scer\GAL4Toll-6-D42
embryonic/larval somatic muscle, with Scer\GAL4kirre.PU
embryonic myoblast, with Scer\GAL4kirre.PU
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.PB
eye | nutrition conditional, with Scer\GAL4GMR.PU
eye disc, with Scer\GAL4GMR.PU
female germline stem cell | conditional (with foxo21)
female germline stem cell | conditional (with foxo25)
germarium cap cell, with Scer\GAL4bab1-Gal4, Scer\GAL80ts.αTub84B
indirect flight muscle | adult stage | progressive (with foxo21)
indirect flight muscle | adult stage | progressive (with foxo25)
interommatidial bristle, with Scer\GAL4GMR.PF
intestinal stem cell, with Scer\GAL4esg.PU
intestinal stem cell, with Scer\GAL4NP0001
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaD, with Scer\GAL4221
larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4ppk.PU
larval neuroblast, with Scer\GAL4nab
microtubule
microtubule, with Scer\GAL4elav.PLu
microtubule, with Scer\GAL4RapGAP1-OK6
microtubule, with Scer\GAL4Toll-6-D42
muscle cell, with Scer\GAL4Mef2.PR, Scer\GAL80ts.αTub84B
muscle cell, with Scer\GAL4Mhc.PW
muscle cell (with foxo21)
muscle cell (with foxo25)
mushroom body neuroblast
neurite | pharate adult stage, with Scer\GAL4CCAP.PP
ommatidium
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PU
ommatidium, with Scer\GAL4hs.PB
retina, with Scer\GAL4Mhc.PW
segment border muscle, with Scer\GAL4kirre.PU
synaptic vesicle
synaptic vesicle, with Scer\GAL4RapGAP1-OK6
testis (with foxo21)
testis (with foxo25)
type I bouton
type I bouton, with Scer\GAL4RapGAP1-OK6
type I bouton | supernumerary
wing
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4C-765
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4hs.PB
wing, with Scer\GAL4ptc-559.1
wing (with foxo25)
wing (with foxoΔ94)
wing cell, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FOXO3
9 of 15
Yes
Yes
2  
Hsap\FOXO1
8 of 15
No
Yes
0  
Hsap\FOXO4
8 of 15
No
Yes
Hsap\FOXO6
6 of 15
No
Yes
Hsap\FOXO3B
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Foxo1
8 of 15
Yes
Yes
2  
Mmus\Foxo3
8 of 15
Yes
Yes
Mmus\Foxo4
7 of 15
No
Yes
Mmus\Foxo6
5 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Foxo3
8 of 13
Yes
Yes
Rnor\Foxo1
6 of 13
No
Yes
Rnor\Foxo4
6 of 13
No
Yes
Rnor\Foxo6
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\foxo3
8 of 12
Yes
Yes
Xtro\foxo4
8 of 12
Yes
Yes
Xtro\foxo1
6 of 12
No
Yes
Xtro\foxo6
3 of 12
No
Yes
Xtro\LOC100490156
1 of 12
No
Yes
Xtro\snx24
1 of 12
No
Yes
Danio rerio (Zebrafish) (7)
Drer\foxo1a
8 of 15
Yes
Yes
Drer\foxo1b
8 of 15
Yes
Yes
Drer\foxo3a
8 of 15
Yes
Yes
Drer\foxo4
8 of 15
Yes
Yes
Drer\foxo3b
7 of 15
No
Yes
Drer\foxo6b
7 of 15
No
Yes
Drer\foxo6a
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\daf-16
7 of 15
Yes
Yes
Cele\let-381
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091909DI )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012524
Drosophila simulans
Dsim\GD18943
Drosophila sechellia
Dsec\GM24148
Drosophila erecta
Dere\GG16833
Drosophila yakuba
Dyak\GE24216
Drosophila ananassae
Dana\GF16233
Drosophila pseudoobscura pseudoobscura
Dpse\GA16248
Drosophila persimilis
Dper\GL24235
Drosophila willistoni
Dwil\GK22687
Drosophila virilis
Dvir\GJ14344
Drosophila mojavensis
Dmoj\GI21984
Drosophila grimshawi
Dgri\GH22274
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AEU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007719
Musca domestica
House fly
Mdoa\17007013
Glossina morsitans
Tsetse fly
Gmor\GMOY010251
Glossina morsitans
Tsetse fly
Gmor\GMOY004829
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07889
Mayetiola destructor
Hessian fly
Mdes\Mdes008506
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012847
Anopheles darlingi
American malaria mosquito
Adar\ADAC004360
Anopheles gambiae
Malaria mosquito
Agam\AGAP001577
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016795
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016794
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BSP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008092
Bombyx mori
Silkmoth
Bmor\BGIBMGA008094
Danaus plexippus
Monarch butterfly
Dple\DPOGS208862-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208863-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002929
Heliconius melpomene
Postman butterfly
Hmel\HMEL002928
Apis florea
Little honeybee
Aflo\3181469220
Apis mellifera
Western honey bee
Amel\GB48301
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11449
Bombus terrestris
Buff-tailed bumblebee
Bter\15206097
Linepithema humile
Argentine ant
Lhum\LH26205
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001cc4
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001cc6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021644
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008919
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08516
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08515
Tribolium castaneum
Red flour beetle
Tcas\TC032156
Tribolium castaneum
Red flour beetle
Tcas\TC032157
Pediculus humanus
Human body louse
Phum\PHUM222020
Pediculus humanus
Human body louse
Phum\PHUM222030
Rhodnius prolixus
Kissing bug
Rpro\RPRC001967
Cimex lectularius
Bed bug
Clec\CLEC010887
Cimex lectularius
Bed bug
Clec\CLEC010886
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008827
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14322
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BQG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010853
Ixodes scapularis
Black-legged tick
Isca\ISCW015581
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59744.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62181.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g03070
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_109005
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06K3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027018gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-FoxO_1
Ciona intestinalis
Vase tunicate
Cint\foxo
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026153
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015297
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000017034
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005658
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bin
1 of 10
croc
1 of 10
fd19B
1 of 10
fd59A
1 of 10
fd96Ca
1 of 10
fd96Cb
1 of 10
fd102C
1 of 10
fkh
1 of 10
FoxK
1 of 10
FoxL1
1 of 10
FoxP
1 of 10
jumu
1 of 10
slp1
1 of 10
slp2
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
FOXO1; forkhead box O1
model of  alveolar rhabdomyosarcoma
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 9 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
FOXO3; forkhead box O3
9 of 15
602681
       
      FOXO1; forkhead box O1
      8 of 15
      136533
       
      FOXO4; forkhead box O4
      8 of 15
      300033
          FOXO6; forkhead box O6
          6 of 15
          611457
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Show neighbor-neighbor interactions:
              Select Layout:
              Legend:
              Protein
              RNA
              Selected Interactor(s)
              Interactions Browser
              View in Interactions Browser
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              foxo - 14-3-3ε
              anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry, western blot
              (Vinayagam et al., 2016, Glatter et al., 2011, Nielsen et al., 2008)
              foxo - 14-3-3ζ
              anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot, peptide massfingerprinting
              (Vinayagam et al., 2016, Glatter et al., 2011, Nielsen et al., 2008)
              foxo - AGO2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Act5C
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Aldh
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Antp
              two hybrid array
              (Shokri et al., 2019)
              foxo - Blimp-1
              two hybrid array
              (Shokri et al., 2019)
              foxo - BtbVII
              two hybrid array
              (Shokri et al., 2019)
              foxo - BuGZ
              two hybrid array
              (Shokri et al., 2019)
              foxo - CCT1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CCT6
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG11180
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG11723
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG11906
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG13096
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG14711
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG15019
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG1513
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG15336
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG15784
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG1620
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG17801
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG17803
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG1785
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG2691
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG30122
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG31460
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG31550
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG31955
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG32121
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG32772
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG3335
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG33695
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG3817
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG4364
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG4730
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG6418
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG6693
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG6769
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG7564
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CG8089
              two hybrid array
              (Shokri et al., 2019)
              foxo - CG9667
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Caf1-55
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Cdc5
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Chc
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Claspin
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - CrebB
              two hybrid array
              (Shokri et al., 2019)
              foxo - CtBP
              two hybrid array
              (Shokri et al., 2019)
              foxo - Ctf4
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Dlip3
              two hybrid array
              (Shokri et al., 2019)
              foxo - Dr
              two hybrid array
              (Shokri et al., 2019)
              foxo - E2f1
              two hybrid array
              (Shokri et al., 2019)
              foxo - Fer2
              two hybrid array
              (Shokri et al., 2019)
              foxo - Fib
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - H2.0
              two hybrid array
              (Shokri et al., 2019)
              foxo - Hey
              two hybrid array
              (Shokri et al., 2019)
              foxo - HmgD
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Hrb98DE
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Hsap\ATXN3
              anti tag coimmunoprecipitation, anti tag western blot
              (Kwon et al., 2018)
              foxo - Hsc70-3
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Iswi
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Kr-h1
              anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
              (Kang et al., 2017)
              foxo - Lime
              two hybrid array
              (Shokri et al., 2019)
              foxo - Lrrk
              protein kinase assay, autoradiography
              (Kanao et al., 2010)
              foxo - MRP
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Mi-2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Mink
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - NAT1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Nop60B
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Nup358
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Pak3
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Poxm
              two hybrid array
              (Shokri et al., 2019)
              foxo - Poxn
              two hybrid array
              (Shokri et al., 2019)
              foxo - Prp19
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Prp8
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Ptx1
              two hybrid array
              (Shokri et al., 2019)
              foxo - RAF2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Ranbp9
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Ref1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Rheb
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RhoGEF2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Rm62
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpI1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpI135
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL10
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL13A
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL14
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL15
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL17
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL18
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL18A
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL19
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL23
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL23A
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL26
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL35A
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL7A
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpL9
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpLP1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpLP2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS11
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS14a
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS15
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS17
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS19b
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS23
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS26
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS5a
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS6
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS7
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - RpS9
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Rpt2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Rpt4
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Sam-S
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Sarm
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Sf3b2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Spps
              two hybrid array
              (Shokri et al., 2019)
              foxo - Sry-β
              two hybrid array
              (Shokri et al., 2019)
              foxo - Su(z)12
              two hybrid array
              (Shokri et al., 2019)
              foxo - Syp
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - TBPH
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - TfIIFβ
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - Trl
              two hybrid array
              (Shokri et al., 2019)
              foxo - Ubx
              bimolecular fluorescence complementation, fluorescence microscopy
              (Bischof et al., 2018)
              foxo - Vsx2
              two hybrid array
              (Shokri et al., 2019)
              foxo - Zn72D
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - abd-A
              bimolecular fluorescence complementation, fluorescence microscopy
              (Bischof et al., 2018)
              foxo - alt
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - ana2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - arm
              anti tag coimmunoprecipitation, anti tag western blot, western blot, anti bait coimmunoprecipitation
              (Zhang et al., 2016)
              foxo - bif
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - bowl
              two hybrid array
              (Shokri et al., 2019)
              foxo - brm
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - bsf
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - bun
              two hybrid array
              (Shokri et al., 2019)
              foxo - cbt
              two hybrid array
              (Shokri et al., 2019)
              foxo - cindr
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - cora
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - croc
              two hybrid array
              (Shokri et al., 2019)
              foxo - cyc
              two hybrid array
              (Shokri et al., 2019)
              foxo - da
              two hybrid array
              (Shokri et al., 2019)
              foxo - dmrt11E
              two hybrid array
              (Shokri et al., 2019)
              foxo - dsx
              two hybrid array
              (Shokri et al., 2019)
              foxo - eIF3a
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF3b
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF3c
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF3e
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF3f1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF3h
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF3i
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF3k
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - eIF4G1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - erm
              two hybrid array
              (Shokri et al., 2019)
              foxo - exex
              two hybrid array
              (Shokri et al., 2019)
              foxo - ey
              coimmunoprecipitation, anti tag western blot
              (Okamoto and Nishimura, 2015)
              foxo - fd96Cb
              two hybrid array
              (Shokri et al., 2019)
              foxo - glo
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - hng2
              two hybrid array
              (Shokri et al., 2019)
              foxo - ind
              two hybrid array
              (Shokri et al., 2019)
              foxo - kis
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - kn
              two hybrid array
              (Shokri et al., 2019)
              foxo - kst
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - l(1)G0020
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - larp
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - lds
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - maf-S
              two hybrid array
              (Shokri et al., 2019)
              foxo - mle
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - msn
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - nonA
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - pan
              anti tag coimmunoprecipitation, anti tag western blot
              (Zhang et al., 2016)
              foxo - pav
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - pho
              two hybrid array
              (Shokri et al., 2019)
              foxo - pic
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - pit
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - pll
              pull down, anti tag western blot, anti tag coimmunoprecipitation
              (Wu et al., 2015)
              foxo - pzg
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - qkr58E-2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - qkr58E-3
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - rn
              two hybrid array
              (Shokri et al., 2019)
              foxo - ro
              two hybrid array
              (Shokri et al., 2019)
              foxo - rump
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - run
              two hybrid array
              (Shokri et al., 2019)
              foxo - schlank
              two hybrid array
              (Shokri et al., 2019)
              foxo - sip2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - sle
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - sna
              two hybrid array
              (Shokri et al., 2019)
              foxo - sqd
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - sug
              two hybrid array
              (Shokri et al., 2019)
              foxo - tyf
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - usp
              pull down, anti tag western blot, anti bait coimmunoprecipitation, western blot
              (Koyama et al., 2014)
              foxo - vig
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - vig2
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - yps
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - α-Spec
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - αCOP
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              foxo - β'COP
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              foxo
              suppressible
              14-3-3ε
              (Nielsen et al., 2008)
              foxo
              enhanceable
              14-3-3ε
              (Nielsen et al., 2008)
              foxo
              suppressible
              Akt1
              (Kanao et al., 2010, Vereshchagina et al., 2008, Goberdhan et al., 2005, Kramer et al., 2003, Puig et al., 2003)
              foxo
              enhanceable
              Akt1
              (Slade and Staveley, 2015)
              foxo|wdb
              suppressible
              Akt1
              (Vereshchagina et al., 2008)
              CG1139|foxo
              suppressible
              Akt1
              (Goberdhan et al., 2005)
              Pi3K92E|foxo
              suppressible
              Akt1
              (Goberdhan et al., 2005)
              foxo|path
              suppressible
              Akt1
              (Goberdhan et al., 2005)
              foxo|pnt
              suppressible
              aop
              (Alic et al., 2014)
              foxo
              suppressible
              bsk
              (Wang et al., 2005)
              foxo
              enhanceable
              CG1139
              (Goberdhan et al., 2005)
              foxo
              enhanceable
              Cln3
              (Tuxworth et al., 2011)
              foxo|Lrrk
              enhanceable
              Diap1
              (Kanao et al., 2010)
              foxo
              suppressible
              dj-1β
              (Hwang et al., 2013)
              Lrrk|foxo
              suppressible
              Dronc
              (Kanao et al., 2010)
              foxo
              suppressible
              Fer2
              (Tas et al., 2018)
              foxo
              enhanceable
              Fer2
              (Tas et al., 2018)
              foxo
              suppressible
              for
              (Kanao et al., 2012)
              foxo
              suppressible
              futsch
              (Nechipurenko and Broihier, 2012)
              foxo
              suppressible
              Gycα99B
              (Kanao et al., 2012)
              foxo
              suppressible
              Gycβ100B
              (Kanao et al., 2012)
              foxo
              enhanceable
              hep
              (Wang et al., 2005)
              Lrrk|foxo
              suppressible
              hid
              (Kanao et al., 2010)
              for|foxo
              enhanceable
              Lrrk
              (Kanao et al., 2012)
              foxo
              enhanceable
              Lrrk
              (Kanao et al., 2010)
              foxo
              suppressible
              mts
              (Vereshchagina et al., 2008)
              foxo|wdb
              suppressible
              mts
              (Vereshchagina et al., 2008)
              foxo
              enhanceable
              Nos
              (Kanao et al., 2012)
              foxo
              enhanceable
              path
              (Goberdhan et al., 2005)
              foxo
              enhanceable
              Pi3K92E
              (Goberdhan et al., 2005, Junger et al., 2003, Kramer et al., 2003)
              foxo
              suppressible
              Pi3K92E
              (Kramer et al., 2003)
              foxo
              suppressible
              Pten
              (Nowak et al., 2013)
              foxo
              suppressible
              Ras64B
              (Kramer et al., 2003)
              foxo
              enhanceable
              Rheb
              (Goberdhan et al., 2005)
              foxo
              enhanceable
              rictor
              (Hietakangas and Cohen, 2007, Lee and Chung, 2007)
              foxo
              suppressible
              rictor
              (Lee and Chung, 2007)
              foxo
              enhanceable
              S6k
              (Goberdhan et al., 2005)
              foxo
              suppressible
              srl
              (Mukherjee and Duttaroy, 2013)
              foxo
              suppressible
              Thor
              (Tettweiler, 2005, Tettweiler et al., 2005)
              foxo
              enhanceable
              Tor|path
              (Goberdhan et al., 2005)
              foxo
              enhanceable
              trbl
              (Das et al., 2014)
              foxo
              enhanceable
              usp
              (Koyama et al., 2014)
              foxo
              enhanceable
              wdb
              (Vereshchagina et al., 2008)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              14-3-3ε
              suppressible
              foxo
              (Nielsen et al., 2008)
              Akt1
              enhanceable
              foxo
              (Slade and Staveley, 2015)
              Akt1
              suppressible
              foxo
              (Slade and Staveley, 2015, Junger et al., 2003)
              Atg1
              suppressible
              foxo
              (Wagner et al., 2009)
              BG02257
              suppressible
              foxo
              (Rollmann et al., 2006)
              BG02514
              enhanceable
              foxo
              (Rollmann et al., 2006)
              chico
              suppressible
              foxo
              (Junger et al., 2003)
              chico
              enhanceable
              foxo
              (Junger et al., 2003)
              Cln3
              suppressible
              foxo
              (Tuxworth et al., 2011)
              Dark
              suppressible
              foxo
              (Obata et al., 2014)
              Daxx
              suppressible
              foxo
              (Hwang et al., 2013)
              egh
              suppressible
              foxo
              (Dahlgaard et al., 2012)
              Fer2
              suppressible
              foxo
              (Tas et al., 2018)
              Fer2
              enhanceable
              foxo
              (Tas et al., 2018)
              for
              suppressible
              foxo
              (Kanao et al., 2012)
              grim
              enhanceable
              foxo
              (Chuang et al., 2014)
              hep
              suppressible
              foxo
              (Wang et al., 2005)
              Ide
              suppressible
              foxo
              (Galagovsky et al., 2014)
              InR
              suppressible
              foxo
              (Su et al., 2018, Metaxakis et al., 2014, Slack et al., 2011, Junger et al., 2003)
              LamC
              enhanceable
              foxo
              (Chandran et al., 2019)
              LamC
              suppressible
              foxo
              (Chandran et al., 2019)
              mnb
              suppressible
              foxo
              (Hong et al., 2012)
              ND-75
              suppressible
              foxo
              (Sinenko et al., 2011)
              park
              suppressible
              foxo
              (Tain et al., 2009)
              Pi3K92E
              suppressible
              foxo
              (Slack et al., 2011, Colombani et al., 2005, Junger et al., 2003)
              Pi3K92E|btl::Egfr
              suppressible
              foxo
              (Read et al., 2009)
              pie
              suppressible
              foxo
              (Xing et al., 2015)
              Pink1
              suppressible
              foxo
              (Koh et al., 2012)
              Pink1
              suppressible
              Sirt1|foxo
              (Koh et al., 2012)
              pnt
              enhanceable
              foxo
              (Alic et al., 2014)
              Pten
              suppressible
              foxo
              (Junger et al., 2003)
              puc
              suppressible
              foxo
              (Wang et al., 2005)
              Rel
              suppressible
              foxo
              (Molaei et al., 2019)
              rpr
              suppressible
              foxo
              (Slack et al., 2011)
              Sirt1
              suppressible
              foxo
              (Griswold et al., 2008)
              Trap1
              suppressible
              foxo
              (Kim et al., 2016)
              Tsc1
              enhanceable
              foxo
              (Junger et al., 2003)
              usp
              enhanceable
              foxo
              (Koyama et al., 2014)
              External Data
              Subunit Structure (UniProtKB)
              Interacts with melt.
              (UniProt, Q95V55 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Insulin-like Receptor Signaling Pathway Core Components -
              The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
              Metabolic Pathways
              External Data
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3R
              Recombination map

              3-54

              Cytogenetic map
              88A5-88A8
              Sequence location
              3R:14,056,945..14,087,978 [+]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              88A5-88A8
              Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              88A-88A
              (determined by in situ hybridisation)
              (Weber et al., 2005)
              88A-88B
              (Staveley et al., 2001)
              Experimentally Determined Recombination Data
              Location

              3-54

              (FlyBase, 2016)

              3-52.5

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (40)
              Genomic Clones (30)
              cDNA Clones (54)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Nechipurenko and Broihier, 2012, Shin et al., 2011, Kanao et al., 2010, Slaidina et al., 2009, Puig et al., 2003)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: foxo CG3143

              (Staveley, 2001.8.23, Staveley et al., 2001)
              Source for database merge of

              Source for merge of: foxo anon-WO0118547.374

              (FlyBase, 1996-)
              Additional comments

              Source for merge of foxo anon-WO0118547.374 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Other Comments

              foxo acts cell autonomously to inhibit the formation of microtubule loops.

              (Nechipurenko and Broihier, 2012)

              foxo plays an important role in the ability of young Drosophila larvae to withstand the stress of nutritional starvation.

              (Kramer et al., 2008)

              foxo controls lifespan and regulates insulin signalling in the brain and fat body.

              (Hwangbo et al., 2004)

              Thor is a relevant foxo target gene. Cellular stress may activate foxo and inhibit growth through the action of target genes such as Thor.

              (Junger et al., 2003)

              foxo is a crucial mediator of insulin signalling, mediating the reduction in cell number in insulin-signalling mutants. Epistasis analysis provides strong genetic evidence that foxo is required to mediate the organismal growth arrest that is elicited in insulin-signaling mutants.

              (Junger et al., 2003)

              Mutants are viable and of normal size, but more sensitive to oxidative stress than wild type. Removal of foxo accelerates the cell cycle at the expense of cell size in a chico background.

              (Junger et al., 2003)

              foxo appears to be a key transcriptional regulator that controls both downstream target genes responsible for growth as well as upstream feedback targets in the insulin signalling pathway.

              (Puig et al., 2003)

              Area matching Drosophila EST AA539898.

              (Davies, 2001.3.15)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 80 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (36)
              Reported As
              Symbol Synonym
              3143
              (Ravi et al., 2009)
              Afx
              (Puig, 2001.10.2)
              CG3143
              (Buescher et al., 2013, Aoki et al., 2012, Glatter et al., 2011, Mosallanejad et al., 2010, Ni et al., 2010.12.1, Sun et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.1.15, Khokhar et al., 2008)
              DFOXO
              (Afschar et al., 2016)
              DfoxO
              (Thanh et al., 2020)
              Dfoxo
              (Wang et al., 2005, Staveley, 2001.8.23, Staveley et al., 2001)
              DmQ95V5
              (Mazet et al., 2003)
              FKHR
              (Tipping and Perrimon, 2014, Zhang, 2001.9.5)
              FOXO
              (Ishibashi et al., 2020, Jacobs et al., 2020, Sudhakar et al., 2020, Wen et al., 2020, Xia et al., 2020, Galenza and Foley, 2019, Gupta et al., 2019, Lang et al., 2019, Baranski et al., 2018, Cara et al., 2018, Gruntenko and Rauschenbach, 2018, Lee et al., 2018, Min and Tatar, 2018, Piper and Partridge, 2018, Schultzhaus et al., 2018, Keesey et al., 2017, Lee et al., 2017, Moeller et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Percival-Smith, 2017, Sheng et al., 2017, Yun et al., 2017, Alfa and Kim, 2016, Brill et al., 2016, Jun et al., 2016, Kim et al., 2016, Niwa and Niwa, 2016, Yaniv and Schuldiner, 2016, Grotewiel and Bettinger, 2015, Kopp et al., 2015, Lashmanova et al., 2015, Tiebe et al., 2015, Liu et al., 2014, Mirth et al., 2014, Mulakkal et al., 2014, Owusu-Ansah and Perrimon, 2014, Piccirillo et al., 2014, Wong et al., 2014, Andersen et al., 2013, Banerjee et al., 2013, Erion and Sehgal, 2013, Erkosar et al., 2013, Ferrandon, 2013, Hyun, 2013, Nässel et al., 2013, Nirala et al., 2013, Shingleton and Frankino, 2013, Sim and Denlinger, 2013, Yamanaka et al., 2013, Dahlgaard et al., 2012, Eleftherianos and Castillo, 2012, Hamilos et al., 2012, Hong et al., 2012, Koh et al., 2012, Kounatidis and Ligoxygakis, 2012, Lv et al., 2012, Mirth and Shingleton, 2012, Noebels et al., 2012, Papatheodorou et al., 2012, Xu et al., 2012, Eliazer and Buszczak, 2011, Harrison and Haddad, 2011, Oldham, 2011, Schiesari et al., 2011, Slack et al., 2011, Wang et al., 2011, Zhang et al., 2011, Becker et al., 2010, Birse et al., 2010, Bland et al., 2010, Francis et al., 2010, Amcheslavsky et al., 2009, Hyun et al., 2009, Lee et al., 2009, Mojsilovic-Petrovic et al., 2009, Nuzhdin et al., 2009, Tain et al., 2009, Harvey et al., 2008, Lee et al., 2008, Owusu-Ansah et al., 2008, Skorupa et al., 2008, Teleman et al., 2008, Dionne, 2007, Dionne and Schneider, 2007, Fuss et al., 2007, Hietakangas and Cohen, 2007, Lavery et al., 2007, Lee and Chung, 2007, Libert, 2007, Scott et al., 2007, Tong et al., 2007, Zheng et al., 2007, Zinke et al., 2007, Dionne and Schneider, 2006, Fuss et al., 2006, Hennig et al., 2006, Lavery and Stern, 2006, Takacs-Vellai, 2006, Wu and Brown, 2006, Jordan et al., 2005, Nijhout, 2003, Puig et al., 2003)
              FOXO1
              (Chuang et al., 2014, Gonzalez, 2013)
              FoxO
              (Gupta and Stocker, 2020, Li et al., 2020, Matsumura et al., 2020, Ahlers et al., 2019, Brown et al., 2019, Wu et al., 2019, Koyama and Mirth, 2018, Nowak et al., 2018, Searle and Pillus, 2018, Kapahi et al., 2017, Chen et al., 2015, Das and Dobens, 2015, Diop and Bodmer, 2015, Okamoto and Nishimura, 2015, Koyama et al., 2014, Wang et al., 2014, Koyama et al., 2013, Mukherjee and Duttaroy, 2013, Nowak et al., 2013, Nechipurenko and Broihier, 2012, Crozatier and Vincent, 2011, Muñoz-Soriano and Paricio, 2011, Sinenko et al., 2011, Lee et al., 2010, Owusu-Ansah and Banerjee, 2009, Read et al., 2009, Wang et al., 2009, Nielsen et al., 2008, Lee and Frasch, 2004)
              Foxo
              (Lin and Hsu, 2020, Luo et al., 2020, Chandran et al., 2019, Meltzer et al., 2019, Inoue et al., 2018, Kwon et al., 2018, Lehmann, 2018, Musselman and Kühnlein, 2018, Staats et al., 2018, Liu and Jin, 2017, Zhao and Karpac, 2017, Aggarwal et al., 2016, Kaynar et al., 2016, Schiesari et al., 2016, Choo et al., 2015, Fan et al., 2015, Jasper, 2015, Ma et al., 2015, Homem et al., 2014, Lam et al., 2014, Schleich et al., 2014, Wang et al., 2014, Ayyaz and Jasper, 2013, Olson et al., 2013, Homem and Knoblich, 2012, Kuo et al., 2012, Biteau et al., 2011, Boyd et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Biteau et al., 2010, Sinenko et al., 2010, Zhang et al., 2010, Hull-Thompson et al., 2009, Karpac et al., 2009, Qian and Bodmer, 2009, Howlett et al., 2008, Juhász et al., 2007, Wessells et al., 2007, Jorgensen and Tyers, 2004, Lee and Frasch, 2004, Zid et al., 2004)
              Foxo1
              (Yadav et al., 2016)
              Q95V55
              (Mazet et al., 2003)
              anon-WO0118547.374
              cg3143
              (Mazet et al., 2003)
              dFOXO
              (Bayliak et al., 2019, Lushchak et al., 2019, Westfall et al., 2019, Álvarez-Rendón et al., 2018, Zhang et al., 2018, Antikainen et al., 2017, Blice-Baum et al., 2017, Chng et al., 2017, Kang et al., 2017, Mathew et al., 2017, Mattila and Hietakangas, 2017, Tokusumi et al., 2017, Whon et al., 2017, Zhu et al., 2017, Altintas et al., 2016, Donovan and Marr, 2016, Mahoney et al., 2016, Webb et al., 2016, Wu and Storey, 2016, Balakrishnan et al., 2015, Chen et al., 2015, Kim et al., 2015, Nässel et al., 2015, Spellberg and Marr, 2015, Tokusumi et al., 2015, Alic et al., 2014, Bülow et al., 2014, Metaxakis et al., 2014, Ostojic et al., 2014, Varma et al., 2014, Buescher et al., 2013, Hada et al., 2013, Hur et al., 2013, Hwang et al., 2013, Kannan and Fridell, 2013, Kwak et al., 2013, Neckameyer and Argue, 2013, Parisi et al., 2013, Rera et al., 2013, Shim et al., 2013, Sim and Denlinger, 2013, Ahn et al., 2012, Banerjee et al., 2012, Eleftherianos and Castillo, 2012, Hong et al., 2012, Iliadi et al., 2012, Jin et al., 2012, Kuo et al., 2012, Lee et al., 2012, Rera et al., 2012, Tokusumi et al., 2012, Alic et al., 2011, Gáliková et al., 2011, Nishimura et al., 2011, Partridge et al., 2011, Rajan and Perrimon, 2011, Sharma et al., 2011, Slack et al., 2011, Wang et al., 2011, Wigby et al., 2011, Bülow et al., 2010, Chung et al., 2010, Hwang et al., 2010, Tiefenböck et al., 2010, Hong et al., 2009, Ikeya et al., 2009, Lee et al., 2009, Mojsilovic-Petrovic et al., 2009, Zid et al., 2009, Giannakou et al., 2008, Hansen and Pletcher, 2008, Hsu et al., 2008, Lee et al., 2008, Stieper et al., 2008, Vihervaara and Puig, 2008, Villa-Cuesta et al., 2008, Yu et al., 2008, Casas-Tinto et al., 2007, Giannakou et al., 2007, Hoshizaki and Gibbs, 2007, Lasko and Sonenberg, 2007, Marr et al., 2007, Min et al., 2007, Tountas and Fortini, 2007, Xue et al., 2007, Betschinger et al., 2006, Herranz et al., 2006, Liu and Lehmann, 2006, Liu and Lehmann, 2006, Luong et al., 2006, Takacs-Vellai, 2006, Brandt et al., 2005, Colombani et al., 2005, Colombani et al., 2005, Flatt et al., 2005, Giannakou et al., 2005, Giannakou et al., 2005, Kenyon C., 2005, King-Jones and Thummel, 2005, Orme and Leevers, 2005, Partridge et al., 2005, Puig and Tjian, 2005, Shingleton, 2005, Shingleton et al., 2005, Tatar, 2005, Tettweiler, 2005, Tettweiler et al., 2005, van der Heide and Smidt, 2005, Wittwer et al., 2005, Giannakou et al., 2004, Hwangbo et al., 2004, Junger et al., 2004, Tatar et al., 2004, Wessells et al., 2004, Junger et al., 2003, Kramer et al., 2003, Lochhead et al., 2003, Puig et al., 2003)
              dFoxO
              (Bednářová et al., 2018, Buhler et al., 2018, Iyer et al., 2016, Obata and Miura, 2015, Wu et al., 2015, Waterson et al., 2014, Callan et al., 2012, Kanao et al., 2012, Bauer et al., 2010, Delanoue et al., 2010, De Luca et al., 2010, Kanao et al., 2010, Song et al., 2010, Villa-Cuesta et al., 2010, Fridell et al., 2009, Read et al., 2009, Slaidina et al., 2009, Mattila et al., 2008, Bauer et al., 2007, Mattila and Puig, 2007)
              dFoxo
              (Weigelt et al., 2020, Augustin et al., 2018, Kashio et al., 2017, Kenmoku et al., 2017, Morrow and Tanguay, 2015, Wu et al., 2015, Gallant, 2013, Okamoto et al., 2013, Kuo et al., 2012, Tuxworth et al., 2011, Sun et al., 2010, Tiefenböck et al., 2010, Diangelo et al., 2009, Slaidina et al., 2009, Wessells et al., 2009, Sage et al., 2008, Bülow et al., 2007, Sage et al., 2007, Balaban et al., 2005)
              dfoxO
              (Binh et al., 2019, Hu et al., 2015, Wang et al., 2015)
              dfoxo
              (Ma et al., 2020, Dobson et al., 2017, Tain et al., 2017, Constantinou et al., 2016, Gruntenko et al., 2016, Woods et al., 2016, Zhang et al., 2016, Al Saud et al., 2015, Park et al., 2015, Slack et al., 2015, Alic et al., 2014, Metaxakis et al., 2014, Omata et al., 2014, Wang et al., 2014, Gimenez et al., 2013, Yang et al., 2013, Bai et al., 2012, Kuo et al., 2012, Papatheodorou et al., 2012, Sun et al., 2012, Alic et al., 2011, Partridge et al., 2011, Slack et al., 2010, Tiefenböck et al., 2010, Wagner et al., 2009, Broughton et al., 2008, Buch et al., 2008, Min et al., 2008, Nielsen et al., 2008, Luo et al., 2007)
              fd88A
              (Lee and Frasch, 2004)
              foxO
              (Campbell et al., 2018, McLaughlin et al., 2016, Sears and Broihier, 2016, Nechipurenko and Broihier, 2012)
              foxo
              (Gupta and Stocker, 2020, Kierdorf et al., 2020, Liu, 2020.4.30, Vandehoef et al., 2020, Asri et al., 2019, Banerjee et al., 2019, Birnbaum et al., 2019, Blice-Baum et al., 2019, Chandran et al., 2019, Dreyer and Shingleton, 2019, Drummond-Barbosa, 2019, Durmaz et al., 2019, Evangelakou et al., 2019, Gumeni et al., 2019, Hall et al., 2019, Huang et al., 2019, Leech et al., 2019, Lenaerts et al., 2019, Molaei et al., 2019, Pahl et al., 2019, Robles-Murguia et al., 2019, Saavedra and Perrimon, 2019, Shokri et al., 2019, Su et al., 2019, Toshniwal et al., 2019, Westfall et al., 2019, Yoshinari et al., 2019, Zheng, 2019.3.1, Bischof et al., 2018, Gáliková and Klepsatel, 2018, Ghiglione et al., 2018, Lin et al., 2018, Sharma et al., 2018, Singh and Chowdhuri, 2018, Takahashi et al., 2018, Tsai et al., 2018, Hoedjes et al., 2017, Kang et al., 2017, Karaiskos et al., 2017, Lin et al., 2017, Pamudurti et al., 2017, Transgenic RNAi Project members, 2017-, Tsakiri et al., 2017, Clandinin and Owens, 2016-, Dobson et al., 2016, Fink et al., 2016, Gruntenko et al., 2016, Kakanj et al., 2016, Kuleesha et al., 2016, Palu and Thummel, 2016, Schwartz et al., 2016, Sieber et al., 2016, Slade and Staveley, 2016, Vinayagam et al., 2016, Baëza et al., 2015, Calap-Quintana et al., 2015, Gene Disruption Project members, 2015-, Mensah et al., 2015, Schertel et al., 2015, Slade and Staveley, 2015, Sopko et al., 2015, Tower, 2015, Xing et al., 2015, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Das et al., 2014, Ghosh et al., 2014, Guo et al., 2014, Horiguchi et al., 2014, Ikmi et al., 2014, Bai et al., 2013, Iyer et al., 2013, Karpac et al., 2013, Partridge, 2013.2.12, Soh et al., 2013, Sopko and Perrimon, 2013, Tixier et al., 2013, Tixier et al., 2013, Yang et al., 2013, Aoki et al., 2012, Iliadi et al., 2012, Kuo et al., 2012, Papatheodorou et al., 2012, Rynes et al., 2012, Spokony and White, 2012.5.22, Wang et al., 2012, Carreira et al., 2011, Cognigni et al., 2011, Glatter et al., 2011, Grimberg et al., 2011, Karpac et al., 2011, Sinenko et al., 2011, Sousa-Nunes et al., 2011, Tang et al., 2011, Tatar, 2011, Tuxworth et al., 2011, Xiang et al., 2011, Yamamoto and Tatar, 2011, Ables and Drummond-Barbosa, 2010, Becker et al., 2010, Carvalho et al., 2010, Demontis and Perrimon, 2010, Heublein et al., 2010, Kockel et al., 2010, Kühnlein, 2010, LaFever et al., 2010, Magwire et al., 2010, Siegrist et al., 2010, Alvarez-Ponce et al., 2009, Carreira et al., 2009, Demontis and Perrimon, 2009, Diangelo and Birnbaum, 2009, Kent et al., 2009, Mattila et al., 2009, Mojsilovic-Petrovic et al., 2009, Read et al., 2009, Song et al., 2009, Tsubouchi et al., 2009, Zid et al., 2009, Griswold et al., 2008, Khokhar et al., 2008, Kramer et al., 2008, Mensch et al., 2008, Wang et al., 2008, Zhao et al., 2008, Adryan et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Slade et al., 2007, Zheng et al., 2007, Dionne et al., 2006, Edgar, 2006, Koh et al., 2006, Lazzaro and Galac, 2006, Puig, 2006.4.24, Rollmann et al., 2006, Goberdhan et al., 2005, Teleman et al., 2005)
              foxo|dFOXO
              (Alvarez-Ponce et al., 2012)
              Name Synonyms
              Forkhead Box O
              (Luo et al., 2007)
              Forkhead bOX-containing protein, subfamily O
              (Slack et al., 2011)
              Forkhead box
              (Lee et al., 2010)
              Forkhead box O
              (Diop and Bodmer, 2015, Sinenko et al., 2011, Lee et al., 2010)
              Forkhead box type O
              (Villa-Cuesta et al., 2010)
              Foxo
              (Cui et al., 2020)
              dFOXO
              (Gems and Partridge, 2013)
              forkhead box sub-group O
              (Xia et al., 2020, Kühnlein, 2010, Zhao et al., 2008)
              forkhead box, sub-group O
              (Magwire et al., 2010, Mensch et al., 2008, Kramer et al., 2003)
              forkhead box, subgroup O
              (Carreira et al., 2009)
              forkhead box-containing protein, O subfamily
              (Wu and Brown, 2006)
              forkhead boxO transcription factor
              (Gruntenko et al., 2016)
              forkhead transcription factor
              (Zhang et al., 2018, Boyd et al., 2011)
              Secondary FlyBase IDs
              • FBgn0062059
              Datasets (1)
              Study focus (1)
              Experimental Role
              Project
              Project Type
              Title
              • bait_protein
              PPI_InR-Tor_interaction_map
              Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
              References (606)