FB2021_03, released June 15, 2021

Gene: Dmel\HtrA2

Open Close
General Information
Symbol
Dmel\HtrA2
Species
D. melanogaster
Name
HTRA2-related serine protease
Annotation Symbol
CG8464
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038233
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th. (UniProt, Q9VFJ3)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

dOmi, omi, DmHtrA2

Key Links
Genomic Location
Cytogenetic map
88C3-88C3
Sequence location
3R:14,509,049..14,511,712 [-]
Recombination map
3-55
RefSeq locus
NT_033777 REGION:14509049..14511712
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables peptidase activity
inferred from direct assay
(Tain et al., 2009, Khan et al., 2008)
enables protein binding
inferred from physical interaction with FLYBASE:rho-7; FB:FBgn0033672
(Whitworth et al., 2008)
inferred from physical interaction with UniProtKB:Q24306
(assigned by UniProt )
(Khan et al., 2008, Igaki et al., 2007)
enables serine hydrolase activity
inferred from direct assay
(Kumar et al., 2021)
enables serine-type endopeptidase activity
inferred from direct assay
(Challa et al., 2007)
inferred from mutant phenotype
(assigned by UniProt )
(Khan et al., 2008, Igaki et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in ectopic germ cell programmed cell death
inferred from mutant phenotype
(Yacobi-Sharon et al., 2013)
involved_in mitochondrion organization
inferred from mutant phenotype
(Tain et al., 2009)
involved_in positive regulation of apoptotic process
inferred from mutant phenotype
(Challa et al., 2007)
involved_in positive regulation of cysteine-type endopeptidase activity
inferred from direct assay
(Challa et al., 2007)
involved_in regulation of apoptotic process
inferred from mutant phenotype
(assigned by UniProt )
(Khan et al., 2008, Challa et al., 2007, Igaki et al., 2007)
involved_in spermatogenesis
inferred from mutant phenotype
(Yun et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrial intermembrane space
inferred from direct assay
(assigned by UniProt )
(Khan et al., 2008, Igaki et al., 2007)
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrion
inferred from direct assay
(Khan et al., 2008, Whitworth et al., 2008)
located_in Nebenkern
inferred from direct assay
(Yun et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase S1C family. (Q9VFJ3)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RHG PROTEINS -
RHG proteins possess a 12 amino acid RHG motif. This motif, also known as the IAP-binding motif (IBM), interacts with the BIR domain of Inhibitor of apoptosis proteins (IAPs) and relieving IAP-mediated caspase inhibition. Over-expression of individual RHG proteins is sufficient to induce apoptosis. (Adapted from FBrf0225510).
S1C SERINE PEPTIDASES -
S1C serine peptidases belong to MEROPS family S1, subfamily C. It is a relatively small family in Drosophila melanogaster. (Adapted from FBrf0239469.)
Protein Function (UniProtKB)
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th.
(UniProt, Q9VFJ3)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\HtrA2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
HtrA2-RA
FBtr0082987
NM_142109
1415
422
HtrA2-RB
FBtr0330045
NM_001275636
2512
422
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
HtrA2-PA
FBpp0082446
46.0
422
10.00
NP_650366
AAF55062
HtrA2-PB
FBpp0303078
46.0
422
10.00
NP_001262565
AGB95946
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

422 aa isoforms: HtrA2-PA, HtrA2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with th/DIAP1 (via BIR 2 domain) (PubMed:18259196). Interacts with Pink1 and rho-7 (PubMed:19048081).

(UniProt, Q9VFJ3)
Post Translational Modification

Ubiquitinated by th, thereby antagonizing induced cell death.

Autoproteolytically cleaved into active forms in the mitochondria.

(UniProt, Q9VFJ3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HtrA2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrial intermembrane space
inferred from direct assay
(assigned by UniProt )
(Khan et al., 2008, Igaki et al., 2007)
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrion
inferred from direct assay
(Khan et al., 2008, Whitworth et al., 2008)
located_in Nebenkern
inferred from direct assay
(Yun et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\HtrA2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of HtrA2
Transgenic constructs containing regulatory region of HtrA2
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene partially disrupted in
Df(3R)HtrA2Δ1
(Tain et al., 2009)
Gene disrupted in
Df(3R)HtrA2Df1
(Yacobi-Sharon et al., 2013)
Df(3R)HtrA2Df2
(Yacobi-Sharon et al., 2013)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority die
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4da.G32
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4Tub.PU
viable (with Df(3R)ED5644)
Sterility
Allele
female fertile
fertile, with Scer\GAL4da.G32
male fertile
male sterile
male sterile (with Df(3R)ED5644)
male sterile (with HtrA2NSO)
male sterile (with HtrA2V110E)
Other Phenotypes
Allele
abnormal locomotor behavior
chemical resistant | adult stage, with Scer\GAL4da.G32
chemical sensitive
decreased cell death (with Df(3R)HtrA2Df1)
decreased cell death (with Df(3R)HtrA2Df2)
decreased cell death | dominant
flightless
radiation resistant | third instar larval stage, with Scer\GAL4da.G32
short lived
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
visible
visible, with Scer\GAL4GMR.PF
visible | heat sensitive
visible | heat sensitive, with Scer\GAL4GMR.PF
visible | pupal stage, with Scer\GAL4da.G32
Phenotype manifest in
Allele
eye
eye, with Scer\GAL4GMR.PF
eye | heat sensitive
eye | heat sensitive, with Scer\GAL4GMR.PF
eye | pupal stage, with Scer\GAL4da.G32
indirect flight muscle, with Scer\GAL4Mef2.PR
investment cone (with Df(3R)ED5644)
male germline cell
male germline cell (with Df(3R)HtrA2Df1)
male germline cell (with Df(3R)HtrA2Df2)
mitochondrion & indirect flight muscle
spermatid cyst (with Df(3R)ED5644)
spermatogonial cyst
spermatozoon
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HTRA2
13 of 15
Yes
Yes
1  
Hsap\HTRA1
11 of 15
No
Yes
Hsap\HTRA3
10 of 15
No
Yes
Hsap\HTRA4
6 of 15
No
Yes
Hsap\PSMD9
1 of 15
No
No
1  
Hsap\TYR
1 of 15
No
Yes
Hsap\TYSND1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Htra2
13 of 15
Yes
Yes
Mmus\Htra1
10 of 15
No
Yes
Mmus\Htra3
8 of 15
No
Yes
Mmus\Htra4
8 of 15
No
Yes
Mmus\Psmd9
1 of 15
No
No
Mmus\Tysnd1
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
Rnor\Htra2
12 of 13
Yes
Yes
Rnor\Htra1
8 of 13
No
Yes
Rnor\Htra3
7 of 13
No
Yes
Rnor\Htra4
5 of 13
No
Yes
Rnor\Psmd9
1 of 13
No
No
Rnor\Tysnd1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\htra1
8 of 12
Yes
Yes
Xtro\htra4
8 of 12
Yes
Yes
Xtro\htra2
2 of 12
No
Yes
Xtro\htra3
2 of 12
No
Yes
Xtro\psmd9
1 of 12
No
No
Xtro\tysnd1
1 of 12
No
No
Danio rerio (Zebrafish) (53)
Drer\htra1b
10 of 15
Yes
Yes
Drer\htra1a
9 of 15
No
Yes
Drer\si:busm1-sl7.7
9 of 15
No
Yes
Drer\si:dkey-10b15.8
9 of 15
No
Yes
Drer\si:dkey-84o3.7
9 of 15
No
Yes
Drer\htra4
8 of 15
No
Yes
Drer\si:dkey-19p15.4
8 of 15
No
Yes
Drer\si:dkey-33c12.12
8 of 15
No
Yes
Drer\htra3a
7 of 15
No
Yes
Drer\htra3b
7 of 15
No
Yes
Drer\LOC100331049
7 of 15
No
Yes
Drer\si:dkey-112g5.13
7 of 15
No
Yes
Drer\zgc:174193
7 of 15
No
Yes
Drer\LOC793110
6 of 15
No
Yes
Drer\LOC797799
6 of 15
No
Yes
Drer\si:dkey-33c12.10
6 of 15
No
Yes
Drer\si:dkey-84o3.2
6 of 15
No
Yes
Drer\si:dkey-112g5.16
6 of 15
No
Yes
Drer\si:dkey-33c12.13
5 of 15
No
Yes
Drer\LOC799006
4 of 15
No
Yes
Drer\LOC560917
3 of 15
No
Yes
Drer\LOC793521
3 of 15
No
Yes
Drer\LOC100331451
3 of 15
No
Yes
Drer\LOC103909414
3 of 15
No
Yes
Drer\LOC110437759
3 of 15
No
Yes
Drer\LOC562245
2 of 15
No
Yes
Drer\LOC799834
2 of 15
No
Yes
Drer\LOC100149563
2 of 15
No
Yes
Drer\LOC100330882
2 of 15
No
Yes
Drer\LOC100333082
2 of 15
No
Yes
Drer\LOC100535800
2 of 15
No
Yes
Drer\LOC101883763
2 of 15
No
Yes
Drer\LOC103911769
2 of 15
No
Yes
Drer\LOC108179121
2 of 15
No
Yes
Drer\LOC110437735
2 of 15
No
Yes
Drer\LOC110437830
2 of 15
No
Yes
Drer\LOC110437862
2 of 15
No
Yes
Drer\LOC110438860
2 of 15
No
Yes
Drer\LOC110438863
2 of 15
No
Yes
Drer\LOC110438864
2 of 15
No
Yes
Drer\LOC110438948
2 of 15
No
Yes
Drer\LOC110438950
2 of 15
No
Yes
Drer\LOC110438955
2 of 15
No
Yes
Drer\LOC110438956
2 of 15
No
Yes
Drer\LOC110438965
2 of 15
No
Yes
Drer\si:dkey-33c12.11
2 of 15
No
Yes
Drer\LOC559585
1 of 15
No
Yes
Drer\LOC100149285
1 of 15
No
Yes
Drer\LOC110437853
1 of 15
No
Yes
Drer\LOC110437868
1 of 15
No
Yes
Drer\LOC110438960
1 of 15
No
Yes
Drer\LOC110438961
1 of 15
No
Yes
Drer\psmd9
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\psmd-9
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (6)
Atha\DEG14
7 of 9
Yes
Yes
Atha\DEG1
2 of 9
No
Yes
Atha\DEG8
2 of 9
No
Yes
Atha\DEG5
1 of 9
No
Yes
Atha\DEG6
1 of 9
No
Yes
Atha\DEG16
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\NMA111
6 of 15
Yes
Yes
Scer\NAS2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC23G3.12c
4 of 12
Yes
Yes
Spom\SPBC1685.05
2 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908Z4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011207
Drosophila simulans
Dsim\GD20417
Drosophila sechellia
Dsec\GM25850
Drosophila erecta
Dere\GG21285
Drosophila yakuba
Dyak\GE26447
Drosophila ananassae
Dana\GF17480
Drosophila pseudoobscura pseudoobscura
Dpse\GA21097
Drosophila persimilis
Dper\GL24014
Drosophila willistoni
Dwil\GK12147
Drosophila virilis
Dvir\GJ24448
Drosophila mojavensis
Dmoj\GI24802
Drosophila grimshawi
Dgri\GH13631
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508S2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020097
Glossina morsitans
Tsetse fly
Gmor\GMOY006773
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06301
Mayetiola destructor
Hessian fly
Mdes\Mdes008009
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006373
Anopheles darlingi
American malaria mosquito
Adar\ADAC007338
Anopheles gambiae
Malaria mosquito
Agam\AGAP000240
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019291
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005160
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W047S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002317
Bombyx mori
Silkmoth
Bmor\BGIBMGA002318
Danaus plexippus
Monarch butterfly
Dple\DPOGS208208-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208209-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002358
Apis florea
Little honeybee
Aflo\2747350788
Apis florea
Little honeybee
Aflo\3153106676
Apis mellifera
Western honey bee
Amel\GB52923
Apis mellifera
Western honey bee
Amel\HtrA2
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18011
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22581
Bombus terrestris
Buff-tailed bumblebee
Bter\15210725
Bombus terrestris
Buff-tailed bumblebee
Bter\15210720
Linepithema humile
Argentine ant
Lhum\LH18248
Linepithema humile
Argentine ant
Lhum\LH18202
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000a66
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000a5e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000369
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003441
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10852
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07422
Tribolium castaneum
Red flour beetle
Tcas\TC012681
Tribolium castaneum
Red flour beetle
Tcas\TC003009
Tribolium castaneum
Red flour beetle
Tcas\TC003010
Pediculus humanus
Human body louse
Phum\PHUM228500
Pediculus humanus
Human body louse
Phum\PHUM529710
Rhodnius prolixus
Kissing bug
Rpro\RPRC014366
Rhodnius prolixus
Kissing bug
Rpro\RPRC014391
Rhodnius prolixus
Kissing bug
Rpro\RPRC009595
Rhodnius prolixus
Kissing bug
Rpro\RPRC014390
Cimex lectularius
Bed bug
Clec\CLEC000674
Cimex lectularius
Bed bug
Clec\CLEC002152
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007786
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02435
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02436
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DQL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000386
Strigamia maritima
European centipede
Smar\SMAR003311
Ixodes scapularis
Black-legged tick
Isca\ISCW020167
Ixodes scapularis
Black-legged tick
Isca\ISCW007523
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57881.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64276.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01740
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_51732
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307522
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0LXR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nagk_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Omi/HtrA2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nagk
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000025030
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009973
Gallus gallus
Domestic chicken
Ggal\HTRA1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027539
Gallus gallus
Domestic chicken
Ggal\HTRA3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG3589
1 of 10
CG9588
1 of 10
cmpy
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
HtrA2ΔPDZ.GMR
model of  Parkinson's disease
CEA
(Khan et al., 2008)
HtrA2Δ1
model of  Parkinson's disease
CEA
(Tain et al., 2009)
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 5 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
HTRA2; HtrA serine peptidase 2
13 of 15
606441
 
HTRA1; HtrA serine peptidase 1
11 of 15
602194
HTRA3; HtrA serine peptidase 3
10 of 15
608785
      HTRA4; HtrA serine peptidase 4
      6 of 15
      610700
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          HtrA2
          suppressible
          Diap1
          (Khan et al., 2008)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          park
          enhanceable
          HtrA2
          (Tain et al., 2009)
          Pink1
          enhanceable
          HtrA2
          (Whitworth et al., 2008, Yun et al., 2008)
          Pink1
          suppressible
          HtrA2
          (Tain et al., 2009, Whitworth et al., 2008)
          Pink1|park
          suppressible
          HtrA2
          (Whitworth et al., 2008)
          rho-7
          enhanceable
          HtrA2
          (Whitworth et al., 2008)
          rho-7
          suppressible
          HtrA2
          (Whitworth et al., 2008)
          YME1L
          suppressible
          HtrA2
          (Qi et al., 2016)
          External Data
          Subunit Structure (UniProtKB)
          Interacts with th/DIAP1 (via BIR 2 domain) (PubMed:18259196). Interacts with Pink1 and rho-7 (PubMed:19048081).
          (UniProt, Q9VFJ3 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3R
          Recombination map
          3-55
          Cytogenetic map
          88C3-88C3
          Sequence location
          3R:14,509,049..14,511,712 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          88C3-88C3
          Limits computationally determined from genome sequence between P{PZ}cv-c06951 and P{PZ}put10460
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-55

          (FlyBase, 2016)

          3-54.1

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (7)
          Genomic Clones (16)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (1)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Khan et al., 2008, Igaki et al., 2007)
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: HtrA2 CG8464

                (Igaki et al., 2003.6.16)
                Source for database merge of
                Additional comments
                Other Comments

                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                (Kiger et al., 2003)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 43 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DRscDB
                EMBL-EBI Single Cell Expression Atlas
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL
                modMine - A data warehouse for the modENCODE project
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Synonyms and Secondary IDs (15)
                Reported As
                Symbol Synonym
                CG8464
                (Jiang, 2019.3.1, Banerjee and Chinthapalli, 2014, Ni et al., 2010.12.1, Perkins et al., 2009, Tain et al., 2009, Khan et al., 2008, Shah et al., 2008, Yun et al., 2008, Challa et al., 2007, Tomancak et al., 2007, Giot et al., 2003)
                DmHtrA2
                (Igaki et al., 2007, Igaki et al., 2003.6.16)
                Dmel_CG8464
                (Rawlings and Barrett, 1996-)
                HtrA2
                (Kumar et al., 2021, Chen et al., 2020, Aryal and Lee, 2019, Yadav and Srikrishna, 2019, Kutscher and Shaham, 2017, M'Angale and Staveley, 2017, Transgenic RNAi Project members, 2017-, Sarov et al., 2016, Spinazzi and De Strooper, 2016, Vanhauwaert and Verstreken, 2015, Steller et al., 2014.7.9, Yacobi-Sharon and Arama, 2014.4.14, Yacobi-Sharon et al., 2013, Holland et al., 2011, Muñoz-Soriano and Paricio, 2011, Tain et al., 2009, Xu et al., 2009, Khan et al., 2008, Whitworth et al., 2008, Yun et al., 2008, Park et al., 2006)
                HtrA2/Omi
                (Biskup and Moore, 2006)
                Omi
                (Kutscher and Shaham, 2017, Spinazzi and De Strooper, 2016, Muñoz-Soriano and Paricio, 2011, Whitworth et al., 2008, Yun et al., 2008)
                Omi/HtrA2
                (Guo, 2012)
                dOmi
                (Chung et al., 2020, Qi et al., 2016, Abdelwahid et al., 2011, Xu et al., 2009, Khan et al., 2008, Challa et al., 2007)
                domi
                (Challa et al., 2007, Park et al., 2006)
                htrA2
                (Chan and McQuibban, 2013, Yacobi-Sharon et al., 2013, Whitworth et al., 2008)
                htrA2/omi
                (Yacobi-Sharon et al., 2013)
                omi
                (Napoletano et al., 2017, Chan and McQuibban, 2013, Yacobi-Sharon et al., 2013, Whitworth et al., 2008, Yun et al., 2008, Park et al., 2006)
                Name Synonyms
                HTRA2-related serine protease
                (Steller et al., 2014.7.9)
                HtrA2
                Serine protease HTRA2
                (Banerjee and Chinthapalli, 2014)
                high temperature requirement A2
                (Chan and McQuibban, 2013)
                Secondary FlyBase IDs
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (68)