Please see the JBrowse view of Dmel\kuk for information on other features
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Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kuk using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
GBrowse - Visual display of RNA-Seq signals
View Dmel\kuk in GBrowse 23-59
3-59
3-59.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: kuk CG5175
Farnesylation is required for proper nuclear localisation of the kuk product.
In embryos injected with dsRNA made from templates generated with primers directed against this gene, nuclear morphology and subsequent epithelial organisation is defective. The nuclei elongate normally at the start of cellularisation but fail to maintain this shape and become rounded. This morphology change, together with a disruption of the centrosome-nuclear envelope interaction, cause the nuclei lose their regular apical anchoring and fall from the cortex. These nuclear defects perturb the regular columnar organisation of epithelial cells.
In contrast to wild-type, in kuk deficient embryos, the nuclei remain short until the end of cellularization.
kugelkern is German for `round kernel'.
The name "charleston" refers to the phenotype seen during cellularisation in which nuclei perform an abnormal apicobasal 'dancing' movement.