AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Evidence supports alternative transcription start site within intronic TE (RAMPAGE CAGE data, FBrf0220331; EST data; RNA-Seq junction data). May be specific to sequenced strain; not included in gene model.
Low-frequency RNA-Seq exon junction(s) not annotated.
Apparent introns not annotated: probable artifact due to repetitive sequence.
Gene model reviewed during 5.55
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fuss using the Feature Mapper tool.
fuss transcript is expressed in 1 to 3 cells per hemineuromere in the embryonic central nervous system. In the third instar larva, fuss is detected in clusters of cells in the medioanterior protocerebrum, in the subesophageal ganglion and in the ventral nerve cord.
fuss transcript is detected in the embryonic and larval brain and ventral nerve cord. In the brain, the number of labelled cells increases significantly throughout embryogenesis, with the majority of these cells being located in the ocular protocerebrum. The number of labelled cells in the ventral nerve cord also increases, from one or two per segment, to three to five cells. At the later stage 16, expression is also detected in a single pair of cells adjacent to the midline. In third instar larvae, expression of fuss is detected in the dorsoanterior region of the brain, where the mushroom bodies will form, and in the subesophageal ganglion. In third instar larva, fuss transcript is expressed ubiquitously at low level in the CNS. In the brain, stronger expression is detected in groups of cells in the dorsoanterior region of the brain, where the mushroom bodies are located. In the ventral nerve cord, fuss trancript is expressed in 3 to 5 cells per segment.
fuss protein expression is mainly observed during embryonic development in the embryonic brain, the developing stomatogastric nervous system, single cells lying anterior to the CNS which will develop into inner gustatory neurons, and the ventral nerve cord. It is expressed post-mitotically and specifically in neuronal cells. fuss protein first appears at embryonic stage 13 and the number of fuss-positive cells increases continuously from early to late embryonic stages. At embryonic stage 16, expression can be observed in two to five cells per hemineuromere with ascending numbers from posterior to anterior. fuss expression partially overlaps with the interneuron marker dac, overlaps with toy expression in one neuron per abdominal hemineuromere and with ap in two ventral interneurons per hemineuromere in the embryonic ventral nerve cord. The fuss positive cells are interneurons. fuss is expressed in a subset of gustatory neurons in larval and adult stages. In larvae, fuss expression is observed in inner gustatory sense organs. It is expressed in two pairs of neurons in the dorsal pharyngeal sensilla, one neuron pair in the dorsal pharyngeal organ, and two neuron pairs in the posterior pharyngeal sensilla. These neurons are associated with bitter sensing and caffeine response. Later in adults, fuss expression continues in gustatory receptor neurons (GRNs) of the proboscis. It is also expressed in two GRNs each in the last two tarsal segments in every leg. Based upon comparison with markers for specific sensilla, fuss is expressed in bitter neurons in S- and I-type sensilla and in salt attracting neurons in L-type sensilla. Targeted DamID experiments to identify genes coexpressed with fuss in adult neurons show that toy, ato, and acj6 are expressed in fuss-positive neurons while ple and Ilp2 are not.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fuss in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: CORL CG11093
Named 'fussel' as it is the ortholog of the human 'functional suppressing element 15 (fussel-15)' gene.