raps, Rapsynoid, Rad
involved in asymmetric cell divisions and establishment of cell polarity - Prefoldin acts synergistically with Pins to regulate asymmetric division of both neuroblasts and intermediate neural progenitors
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Gene model reviewed during 5.46
3.3 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
658 (aa); 72 (kD predicted)
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Comment: maternally deposited
raps is observed as a crescent in the apical cortex in neuroblasts after delamination. It is also observed in cortical crescents in the dividing cells of procephalic mitotic domain 9.
GBrowse - Visual display of RNA-Seq signals
View Dmel\pins in GBrowse 23-94
3-94
3-91.1
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: pins raps
Source for merge of: Rad pins
Source for merge of: raps CG5692
'raps' renamed to 'pins' based on clear preference for the latter over the former in the published literature, and at the request of author O'Kane who first characterized and named the gene in FBrf0128604.
raps is involved in the control of asymmetric divisions of neuroblasts.
In raps mutants, the asymmetric divisions of neuroblasts are altered; insc protein is no longer asymmetrically localized in the dividing neuroblast and the neuroblast division produces two daughter cells of similar sizes. However, the morphologically symmetrical divisions of raps mutant neuroblasts still lead to daughter cells with different fates, as shown by differences in gene expression.
Identification: identified as a protein that binds to insc in a yeast two-hybrid screen.
Isolated using a yeast two-hybrid system.