- Tools
- Downloads
- Links
- Community
- Species
- About
- Help
FB2025_02
,
released April 17, 2025
β-arrestin, kurtz-arrestin
non-visual β-arrestin that functions in GPCR desensitization - regulates the Hedgehog pathway, the Notch pathway, MAPK signaling and Toll signaling - modifies exploratory activity and olfactory sensitivity
Please see the JBrowse view of Dmel\krz for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.53
2.0 (northern blot)
470 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\krz using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
krz message is detected in all developmental stages, including aged adults. Early embryonic expression is ubiquitous; in later stages expression is detected in the CNS, maxillary cirri, and the antennal sense organs. In third instar larvae, expression is detected in fat bodies, the ventral part of the thoracic-abdominal ganglia, the deuterocerebrum, the eye-antennal imaginal disc, and the wing disc. In larval wing discs expression is detected in the notum region and in a thin stripe that winds throughout the wing primordium.
krz protein is ubiquitously expressed in all imaginal discs in third instar larvae. It is detected at higher levels closer to the apical side of the epithelium.
JBrowse - Visual display of RNA-Seq signals
View Dmel\krz in JBrowse3-103
3-99.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
The exploratory phase of open field activity requires krz function in the nervous system.
Mutants have three distinct phenotypes. They precociously disaggregate their larval fat bodies, form melanotic tumours and have a broad lethal phase.
Source for merge of: krz l(3)S095214
Source for merge of: kurtz-arrestin CG1487
"ird6" may correspond to the "krz" or "mod" gene or both; the ird61 mutation fails to complement the lethality of "krz" alleles (krzS047819) and deficiences which affect "mod" (Df(3R)A4-4L2 and Df(3R)A4-4L3).
The gene is named "kurtz" after the character in Joseph Conrad's "The Heart of Darkness" in which Conrad symbolically uses the contrast of light and dark. The character Kurtz is defined by his darkness and is a metaphor for the krz arrestin mutants, which form melanotic tumours.
