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General Information
Symbol
Dmel\Ir41a
Species
D. melanogaster
Name
Ionotropic receptor 41a
Annotation Symbol
CG33492
Feature Type
FlyBase ID
FBgn0040849
Gene Model Status
Stock Availability
Gene Summary
Contribute a Gene Snapshot for this gene.
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:4,917,519..5,021,955 [+]
Recombination map
2-55
RefSeq locus
NT_033778 REGION:4917519..5021955
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence model
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:Ir92a; FB:FBgn0038789
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence model
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Group (FlyBase)
    ANTENNAL IONOTROPIC RECEPTORS -
    Ionotropic Receptors (IR) expressed in antennal sensory neurons in Drosophila are largely thought to act as odor-responsive ion channels. IRs are a subfamily of ionotropic glutamate receptors that do not bind glutamate. Some only form functional receptors in the presence of coreceptor IRs. The profile of expression of IRs, together with broadly expressed co-receptors underlies the precise odor-responsiveness of subpopulations of antennal neurons. (Adapted from FBrf0222310).
    Gene Model and Products
    Number of Transcripts
    1
    Number of Unique Polypeptides
    1

    Please see the JBrowse view of Dmel\Ir41a for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Gene model reviewed during 5.47

    Low-frequency RNA-Seq exon junction(s) not annotated.

    Gene model reviewed during 5.48

    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    FBtr0336974
    2345
    648
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    FBpp0307916
    73.9
    648
    5.76
    Polypeptides with Identical Sequences

    There is only one protein coding transcript and one polypeptide associated with this gene

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir41a using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\Ir41a in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    EMBL-EBI Single Cell Expression Atlas
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Flygut - An atlas of the Drosophila adult midgut
    Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 3 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 2 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Ir41a
    Transgenic constructs containing regulatory region of Ir41a
    Aberrations (Deficiencies and Duplications) ( 1 )
    Inferred from experimentation ( 1 )
    Gene partially disrupted in
    Inferred from location ( 0 )
      Alleles Representing Disease-Implicated Variants
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Other Phenotypes
      Allele
      Phenotype manifest in
      Allele
      Orthologs
      Human Orthologs (via DIOPT v8.0)
      Homo sapiens (Human) (17)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      2 of 15
      Yes
      No
      1 of 15
      No
      No
      1  
      1 of 15
      No
      No
      2  
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1  
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      Model Organism Orthologs (via DIOPT v8.0)
      Mus musculus (laboratory mouse) (17)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      1 of 15
      Yes
      No
      2  
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      Rattus norvegicus (Norway rat) (16)
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      1 of 13
      Yes
      No
      Xenopus tropicalis (Western clawed frog) (11)
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      1 of 12
      Yes
      No
      Danio rerio (Zebrafish) (29)
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      Yes
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      1 of 15
      Yes
      No
      Caenorhabditis elegans (Nematode, roundworm) (1)
      1 of 15
      Yes
      No
      Arabidopsis thaliana (thale-cress) (0)
      No records found.
      Saccharomyces cerevisiae (Brewer's yeast) (0)
      No records found.
      Schizosaccharomyces pombe (Fission yeast) (0)
      No records found.
      Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919060K )
      Organism
      Common Name
      Gene
      AAA Syntenic Ortholog
      Multiple Dmel Genes in this Orthologous Group
      Drosophila suzukii
      Spotted wing Drosophila
      Drosophila simulans
      Drosophila sechellia
      Drosophila erecta
      Drosophila yakuba
      Drosophila ananassae
      Drosophila pseudoobscura pseudoobscura
      Drosophila persimilis
      Drosophila willistoni
      Drosophila virilis
      Drosophila mojavensis
      Drosophila grimshawi
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915056M )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Musca domestica
      House fly
      Musca domestica
      House fly
      Musca domestica
      House fly
      Musca domestica
      House fly
      Glossina morsitans
      Tsetse fly
      Lucilia cuprina
      Australian sheep blowfly
      Lucilia cuprina
      Australian sheep blowfly
      Lucilia cuprina
      Australian sheep blowfly
      Mayetiola destructor
      Hessian fly
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Aedes aegypti
      Yellow fever mosquito
      Anopheles darlingi
      American malaria mosquito
      Anopheles darlingi
      American malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D9H )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Bombyx mori
      Silkmoth
      Danaus plexippus
      Monarch butterfly
      Heliconius melpomene
      Postman butterfly
      Dendroctonus ponderosae
      Mountain pine beetle
      Tribolium castaneum
      Red flour beetle
      Pediculus humanus
      Human body louse
      Rhodnius prolixus
      Kissing bug
      Rhodnius prolixus
      Kissing bug
      Rhodnius prolixus
      Kissing bug
      Rhodnius prolixus
      Kissing bug
      Rhodnius prolixus
      Kissing bug
      Rhodnius prolixus
      Kissing bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0D7B )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Daphnia pulex
      Water flea
      Daphnia pulex
      Water flea
      Daphnia pulex
      Water flea
      Daphnia pulex
      Water flea
      Daphnia pulex
      Water flea
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
      No non-Arthropod Metazoa orthologies identified
      Paralogs
      Paralogs (via DIOPT v8.0)
      Drosophila melanogaster (Fruit fly) (65)
      3 of 10
      3 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      2 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      1 of 10
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-55
        Cytogenetic map
        Sequence location
        2R:4,917,519..5,021,955 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        41C5-41D1
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (3)
        Genomic Clones (59)
        cDNA Clones (84)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Ir41a CG33492

          Source for database merge of
          Additional comments
          Other Comments

          Annotation CG17587 restored as CG33492 in release 3.2 of the genome annotation.

          Annotation CG17587 was eliminated in release 3 of the genome annotation, October 2002.

          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 21 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          EMBL-EBI Single Cell Expression Atlas
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL
          modMine - A data warehouse for the modENCODE project
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Synonyms and Secondary IDs (7)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (47)