Please see the JBrowse view of Dmel\ago for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Part of a SCF E3 ubiquitin-protein ligase complex. Interacts with Myc and puf (PubMed:15182669, PubMed:24173801). Interacts with CycE (PubMed:11565033).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ago using the Feature Mapper tool.
The ventrolateral body wall muscle 12 (VLM12) expresses endogenous, nuclear ago protein.
A strong pulse of nuclear ago protein is seen in the area of the morphogenetic furrow (MF) and are subsequently refined into a restricted pattern in the first few rows of cells posterior to the MF. ago becomes restricted to a single cell nucleus that occupies an anterior location within the nascent elav-positive cluster.
ago is widely expressed during most of embryogenesis and is concentrated in the nervous system at later stages.
GBrowse - Visual display of RNA-Seq signals
View Dmel\ago in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: ago CG15010
Source for merge of: ago anon-WO0118547.345
Source for merge of ago anon-WO0118547.345 was sequence comparison ( date:051113 ).
dsRNA has been made from templates generated with primers directed against this gene.
Mutants in ago show increased tissue growth.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Area matching Drosophila EST AA392932 (inverted).
Clones of mutant cells in the eye disc result in cell fate changes and overrepresentation of mutant cells in the eye.