FB2025_05 , released December 11, 2025
Gene: Dmel\ago
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General Information
Symbol
Dmel\ago
Species
D. melanogaster
Name
archipelago
Annotation Symbol
CG15010
Feature Type
protein_coding_gene
FlyBase ID
FBgn0041171
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
archipelago (ago) encodes a protein that is the founding member of the Ago/Fbxw7 family of tumor suppressor genes and the substrate adaptor component of the SCF-Ago ubiquitin ligase. The product of ago has various substrates including the bHLH transcription factors encoded by Myc, trh, and sima, and the G1 cell cycle kinase component encoded by CycE. The product of ago presents tissue specific roles in cell proliferation, survival, and hypoxia-induced gene expression. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
64A11-64A12
Sequence location
Recombination map
3-10
RefSeq locus
NT_037436 REGION:4246343..4254306
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:mi; FB:FBgn0261786
(Szuplewski et al., 2009)
enables ubiquitin-specific protease binding
inferred from physical interaction with UniProtKB:Q9VC56
(Li et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cyclin binding
traceable author statement
(Lee and Orr-Weaver, 2003)
Biological Process (13 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in branch fusion, open tracheal system
inferred from mutant phenotype
(Mortimer and Moberg, 2007)
involved_in cellular response to hypoxia
inferred from mutant phenotype
(Mortimer and Moberg, 2009)
involved_in DNA endoreduplication
inferred from mutant phenotype
(Shcherbata et al., 2004)
involved_in negative regulation of cellular response to hypoxia
inferred from mutant phenotype
(Mortimer and Moberg, 2013)
involved_in negative regulation of glial cell proliferation
inferred from genetic interaction with FLYBASE:slmb; FB:FBgn0283468
(Ho et al., 2009)
involved_in negative regulation of growth
inferred from mutant phenotype
(Moberg et al., 2004)
involved_in negative regulation of imaginal disc growth
inferred from mutant phenotype
(Gerlach et al., 2018)
involved_in regulation of mitotic nuclear division
inferred from mutant phenotype
(Moberg et al., 2001)
involved_in trachea development
inferred from mutant phenotype
(Mortimer and Moberg, 2009)
inferred from genetic interaction with FLYBASE:Vhl; FB:FBgn0041174
(Mortimer and Moberg, 2009)
involved_in ventral cord development
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in regulation of exit from mitosis
traceable author statement
(Lee and Orr-Weaver, 2003)
involved_in regulation of proteolysis
traceable author statement
(Lee and Orr-Weaver, 2003)
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
inferred from sequence or structural similarity with UniProtKB:Q969H0
(Gene Ontology Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of SCF ubiquitin ligase complex
inferred from sequence or structural similarity with UniProtKB:Q969H0
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
archipelago (ago) encodes a protein that is the founding member of the Ago/Fbxw7 family of tumor suppressor genes and the substrate adaptor component of the SCF-Ago ubiquitin ligase. The product of ago has various substrates including the bHLH transcription factors encoded by Myc, trh, and sima, and the G1 cell cycle kinase component encoded by CycE. The product of ago presents tissue specific roles in cell proliferation, survival, and hypoxia-induced gene expression. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
F BOX AND WD DOMAIN PROTEINS -
F box and WD domain (FBXW) proteins are F box proteins which contain WD40 repeats. F box proteins are the variable substrate adapters for Skp, Cullin, F-box (SCF) E3 ubiquitin ligase complexes. (Adapted from FBrf0225076).
Protein Function (UniProtKB)
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively (PubMed:11565033, PubMed:15182669). Required for endocycles, but not mitosis in follicle cell epithelium (PubMed:15175253).
(UniProt, Q9VZF4)
Summary (Interactive Fly)

F box component of an SCF-ubiquitin ligase - negatively regulates the levels and activity of Drosophila Myc by linking Myc to a protein degradation pathway - negatively regulates Cyclin E and Notch - regulates cell proliferation, survival, and hypoxia-induced gene expression

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ago for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VZF4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ago-RA
FBtr0073247
NM_168072
5223
1326
ago-RB
FBtr0073246
NM_168073
5268
1326
ago-RC
FBtr0073245
NM_079198
5332
1326
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
ago-PA
FBpp0073103
141.4
1326
4.90
Q9VZF4
NP_728964
AAF47869
ago-PB
FBpp0073102
141.4
1326
4.90
Q9VZF4
NP_728965
AAG22247
ago-PC
FBpp0073101
141.4
1326
4.90
Q9VZF4
NP_523922
AAG22246
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1326 aa isoforms: ago-PA, ago-PB, ago-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Part of a SCF E3 ubiquitin-protein ligase complex. Interacts with Myc and puf (PubMed:15182669, PubMed:24173801). Interacts with CycE (PubMed:11565033).

(UniProt, Q9VZF4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ago using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.44

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 3 -- 13
organism | ubiquitous

Comment: but not in pole cells

(Mortimer and Moberg, 2007)
embryonic stage 15
larval central nervous system
(Mortimer and Moberg, 2007)
larval stage
eye disc morphogenetic furrow
(Nicholson et al., 2011)
third instar larval stage
muscle cell of A1-7 ventral longitudinal muscle 1
(Mortimer and Moberg, 2013)
Additional Descriptive Data

The ventrolateral body wall muscle 12 (VLM12) expresses endogenous, nuclear ago protein.

(Mortimer and Moberg, 2013)

A strong pulse of nuclear ago protein is seen in the area of the morphogenetic furrow (MF) and are subsequently refined into a restricted pattern in the first few rows of cells posterior to the MF. ago becomes restricted to a single cell nucleus that occupies an anterior location within the nascent elav-positive cluster.

(Nicholson et al., 2011)

ago is widely expressed during most of embryogenesis and is concentrated in the nervous system at later stages.

(Mortimer and Moberg, 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ago in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ago
Transgenic constructs containing regulatory region of ago
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel9000
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with ago1)
lethal (with ago3)
lethal (with ago5-HA-2760)
lethal (with agoΔ3-7)
lethal - all die before end of first instar larval stage (with ago1)
lethal - all die before end of first instar larval stage (with ago3)
lethal - all die before end of first instar larval stage (with Df(3L)Exel9000)
partially lethal - majority die
partially lethal - majority die (with Df(3L)BSC370)
viable, with Scer\GAL4VP16.nanos.UTR
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR
male semi-sterile, with ago5-HA-2760
male semi-sterile, with agoβTub85D.mCherry
male sterile
male sterile (with Df(3L)BSC370)
Other Phenotypes
Allele
abnormal cell number | germline clone | oogenesis
abnormal mitotic cell cycle | somatic clone
abnormal neuroanatomy
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal oxidative stress response (with agoEP1135)
abnormal oxidative stress response (with agoΔ3-7)
decreased body size, with Scer\GAL4en-e16E
decreased cell number | adult stage | somatic clone
decreased cell size, with Scer\GAL4en-e16E
flightless, with Scer\GAL4Mef2.PR
increased cell number | somatic clone
increased cell size, with Scer\GAL4en.PU
increased cell size | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased occurrence of cell division | larval stage | somatic clone
increased occurrence of cell division | pupal stage | somatic clone
increased occurrence of cell division | somatic clone
increased size | adult stage, with Scer\GAL4Bx-MS1096
increased size | oogenesis, with Scer\GAL4VP16.nanos.UTR
some die during first instar larval stage (with ago1)
some die during first instar larval stage (with ago3)
some die during first instar larval stage (with Df(3L)Exel9000)
some die during second instar larval stage
some die during third instar larval stage
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4salm.EPv
visible | recessive | somatic clone
Phenotype manifest in
Allele
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax Ap4
egg chamber | increased number, with Scer\GAL4VP16.nanos.UTR
embryonic/larval dorsal tracheal branch (with ago1)
embryonic/larval dorsal tracheal branch (with ago3)
embryonic/larval ganglionic tracheal branch (with ago1)
embryonic/larval ganglionic tracheal branch (with ago3)
embryonic/larval ganglionic tracheal branch (with agoΔ3-7)
embryonic/larval tracheal dorsal trunk, with Scer\GAL4btl.PS
embryonic/larval tracheal dorsal trunk (with ago1)
embryonic/larval tracheal dorsal trunk (with ago3)
embryonic/larval tracheal lateral trunk (with ago1)
embryonic/larval tracheal lateral trunk (with ago3)
embryonic/larval tracheal section | conditional
eye | somatic clone
eye disc | pupal stage | somatic clone
follicle cell & nucleus | somatic clone
individualization stage spermatid
interommatidial bristle | ectopic | somatic clone
investment cone
larval fat cell | somatic clone, with Scer\GAL4Act5C.PP
larval lateral F tracheal branch | cell non-autonomous, with Scer\GAL4tey-5053A
larval lateral G tracheal branch (with ago1)
larval lateral G tracheal branch (with agoΔ3-7)
larval lateral H tracheal branch (with ago1)
larval lateral H tracheal branch (with ago3)
larval lateral H tracheal branch (with agoΔ3-7)
larval lateral H tracheal branch | cell non-autonomous, with Scer\GAL4tey-5053A
larval RP2 motor neuron | ectopic
larval RP2 motor neuron | ectopic (with Df(3L)GN50)
larval tracheal system, with Scer\GAL4btl.PS
larval tracheal system (with ago1)
larval tracheal system (with ago3)
mitotic cell cycle | somatic clone
nurse cell, with Scer\GAL4VP16.nanos.UTR
nurse cell & nucleus | germ-line clone
nurse cell | germline clone
nurse cell | increased number, with Scer\GAL4VP16.nanos.UTR
secondary pigment cell | ectopic | somatic clone
seminal vesicle
tertiary pigment cell | ectopic | somatic clone
tracheal fusion cell (with ago1)
tracheal fusion cell (with ago3)
tracheal lumen (with ago1)
tracheal lumen (with ago3)
tracheal primordium (with ago1)
tracheal primordium (with ago3)
tracheole (with ago1)
tracheole (with agoΔ3-7)
tracheole | cell non-autonomous, with Scer\GAL4tey-5053A
tracheole | increased number (with ago1)
tracheole | increased number (with ago3)
tracheole | increased number (with agoΔ3-7)
tracheole | increased number | heat sensitive, with Scer\GAL4hs.PB
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4salm.EPv
wing | posterior, with Scer\GAL4en.PU
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc | larval stage | somatic clone
wing disc | somatic clone
wing vein, with Scer\GAL4en.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (78)
Hsap\FBXW7
9 of 14
Yes
Yes
Hsap\BTRC
2 of 14
No
No
1  
Hsap\CDRT1
2 of 14
No
Yes
Hsap\FBXW2
2 of 14
No
Yes
Hsap\FBXW8
2 of 14
No
Yes
Hsap\FBXW9
2 of 14
No
Yes
Hsap\FBXW10
2 of 14
No
Yes
Hsap\FBXW11
2 of 14
No
No
1  
Hsap\TRAF7
2 of 14
No
Yes
Hsap\WDR86
2 of 14
No
Yes
Hsap\APAF1
1 of 14
No
No
Hsap\ATG16L2
1 of 14
No
No
Hsap\BOP1
1 of 14
No
No
Hsap\CDC40
1 of 14
No
No
Hsap\COPA
1 of 14
No
No
Hsap\CORO1C
1 of 14
No
No
Hsap\DAW1
1 of 14
No
No
Hsap\DCAF5
1 of 14
No
No
1  
Hsap\DCAF6
1 of 14
No
No
Hsap\DCAF8
1 of 14
No
No
2  
Hsap\DCAF8L1
1 of 14
No
No
Hsap\DCAF8L2
1 of 14
No
No
Hsap\DMWD
1 of 14
No
No
Hsap\DTL
1 of 14
No
No
Hsap\ECT2L
1 of 14
No
No
Hsap\EED
1 of 14
No
No
Hsap\EFCAB8
1 of 14
No
No
Hsap\FBXO16
1 of 14
No
Yes
Hsap\FBXO24
1 of 14
No
Yes
Hsap\FBXW4
1 of 14
No
No
Hsap\GNB3
1 of 14
No
No
Hsap\GNB5
1 of 14
No
No
Hsap\KATNB1
1 of 14
No
No
Hsap\KIF21A
1 of 14
No
No
Hsap\KIF21B
1 of 14
No
No
1  
Hsap\LOC102724159
1 of 14
No
No
Hsap\LYST
1 of 14
No
No
Hsap\MLST8
1 of 14
No
No
Hsap\NBEA
1 of 14
No
No
Hsap\NBEAL1
1 of 14
No
No
Hsap\NBEAL2
1 of 14
No
No
Hsap\NLE1
1 of 14
No
No
Hsap\PAAF1
1 of 14
No
No
Hsap\PAFAH1B1
1 of 14
No
No
1  
Hsap\PAK1IP1
1 of 14
No
No
Hsap\PLAA
1 of 14
No
No
Hsap\PLRG1
1 of 14
No
No
Hsap\POC1A
1 of 14
No
No
1  
Hsap\POC1B
1 of 14
No
No
1  
Hsap\PRPF4
1 of 14
No
No
Hsap\PRPF19
1 of 14
No
No
4  
Hsap\PWP2
1 of 14
No
No
1  
Hsap\RRP9
1 of 14
No
No
1  
Hsap\SCAP
1 of 14
No
No
1  
Hsap\SNRNP40
1 of 14
No
No
Hsap\STRN4
1 of 14
No
No
Hsap\TAF5
1 of 14
No
No
Hsap\TBL3
1 of 14
No
No
Hsap\TEP1
1 of 14
No
No
Hsap\UTP15
1 of 14
No
No
Hsap\WDFY3
1 of 14
No
No
2  
Hsap\WDFY4
1 of 14
No
No
Hsap\WDR3
1 of 14
No
No
Hsap\WDR4
1 of 14
No
No
1  
Hsap\WDR5B
1 of 14
No
No
1  
Hsap\WDR5
1 of 14
No
No
11  
Hsap\WDR12
1 of 14
No
No
Hsap\WDR17
1 of 14
No
No
Hsap\WDR20
1 of 14
No
No
Hsap\WDR38
1 of 14
No
No
Hsap\WDR44
1 of 14
No
No
Hsap\WDR48
1 of 14
No
No
Hsap\WDR49
1 of 14
No
No
Hsap\WDR64
1 of 14
No
No
Hsap\WDR81
1 of 14
No
No
Hsap\WDR83
1 of 14
No
No
Hsap\WDTC1
1 of 14
No
No
1  
Hsap\WSB1
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (47)
Rnor\Fbxw7
8 of 14
Yes
Yes
Rnor\Btrc
2 of 14
No
No
Rnor\Fbxw2
2 of 14
No
Yes
Rnor\Fbxw9
2 of 14
No
Yes
Rnor\Fbxw11
2 of 14
No
No
Rnor\Traf7
2 of 14
No
Yes
Rnor\Apaf1
1 of 14
No
No
Rnor\Coro1c
1 of 14
No
No
Rnor\Daw1
1 of 14
No
No
Rnor\Dmwd
1 of 14
No
No
Rnor\Dtl
1 of 14
No
No
Rnor\Fbxo16
1 of 14
No
Yes
Rnor\Fbxo24
1 of 14
No
Yes
Rnor\Fbxw4
1 of 14
No
No
Rnor\Fbxw8
1 of 14
No
Yes
Rnor\Fbxw10
1 of 14
No
Yes
Rnor\Gnb5
1 of 14
No
No
Rnor\Kif21a
1 of 14
No
No
Rnor\Kif21b
1 of 14
No
No
Rnor\Nle1
1 of 14
No
No
Rnor\Pafah1b1
1 of 14
No
No
Rnor\Pak1ip1
1 of 14
No
No
Rnor\Plaa
1 of 14
No
No
Rnor\Plrg1
1 of 14
No
No
Rnor\Poc1a
1 of 14
No
No
Rnor\Poc1b
1 of 14
No
No
Rnor\Prpf4
1 of 14
No
No
Rnor\Prpf19
1 of 14
No
No
Rnor\Rrp9
1 of 14
No
No
Rnor\Snrnp40
1 of 14
No
No
Rnor\Tep1
1 of 14
No
Yes
Rnor\Utp15
1 of 14
No
No
Rnor\Wdr1
1 of 14
No
No
Rnor\Wdr5b
1 of 14
No
No
Rnor\Wdr5
1 of 14
No
No
Rnor\Wdr12
1 of 14
No
No
Rnor\Wdr20
1 of 14
No
No
Rnor\Wdr38
1 of 14
No
No
Rnor\Wdr44
1 of 14
No
No
Rnor\Wdr48
1 of 14
No
No
Rnor\Wdr49
1 of 14
No
No
Rnor\Wdr64
1 of 14
No
No
Rnor\Wdr83
1 of 14
No
No
Rnor\Wdr86
1 of 14
No
No
Rnor\Wdr95
1 of 14
No
No
Rnor\Wdsub1
1 of 14
No
No
Rnor\Wsb2
1 of 14
No
No
Mus musculus (laboratory mouse) (42)
Mmus\Fbxw7
8 of 14
Yes
Yes
Mmus\Btrc
2 of 14
No
No
Mmus\Fbxw2
2 of 14
No
Yes
Mmus\Fbxw8
2 of 14
No
Yes
Mmus\Fbxw9
2 of 14
No
Yes
Mmus\Traf7
2 of 14
No
Yes
Mmus\Wdr86
2 of 14
No
Yes
Mmus\Wdr95
2 of 14
No
No
Mmus\Apaf1
1 of 14
No
No
Mmus\Coro1c
1 of 14
No
No
Mmus\Daw1
1 of 14
No
No
Mmus\Dmwd
1 of 14
No
No
Mmus\Dtl
1 of 14
No
No
Mmus\Ect2l
1 of 14
No
No
Mmus\Fbxo24
1 of 14
No
Yes
Mmus\Fbxw4
1 of 14
No
No
Mmus\Fbxw10
1 of 14
No
Yes
Mmus\Fbxw11
1 of 14
No
No
Mmus\Gnb5
1 of 14
No
No
Mmus\Kif21a
1 of 14
No
No
1  
Mmus\Kif21b
1 of 14
No
No
Mmus\Mlst8
1 of 14
No
No
Mmus\Nle1
1 of 14
No
No
Mmus\Pafah1b1
1 of 14
No
No
Mmus\Pak1ip1
1 of 14
No
No
Mmus\Plaa
1 of 14
No
No
Mmus\Plrg1
1 of 14
No
No
Mmus\Poc1a
1 of 14
No
No
Mmus\Prpf4
1 of 14
No
No
Mmus\Prpf19
1 of 14
No
No
Mmus\Rrp9
1 of 14
No
No
Mmus\Snrnp40
1 of 14
No
No
Mmus\Utp15
1 of 14
No
No
Mmus\Wdr5b
1 of 14
No
No
Mmus\Wdr5
1 of 14
No
No
Mmus\Wdr20
1 of 14
No
No
Mmus\Wdr38
1 of 14
No
No
Mmus\Wdr44
1 of 14
No
No
Mmus\Wdr48
1 of 14
No
No
Mmus\Wdr49
1 of 14
No
No
Mmus\Wdr64
1 of 14
No
No
Mmus\Wdr83
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (51)
Xtro\fbxw7
5 of 13
Yes
Yes
Xtro\bop1
1 of 13
No
No
Xtro\brwd3
1 of 13
No
No
Xtro\btrc
1 of 13
No
No
Xtro\cdrt1
1 of 13
No
Yes
Xtro\ciao1
1 of 13
No
No
Xtro\copa
1 of 13
No
No
Xtro\daw1
1 of 13
No
No
Xtro\dcaf5
1 of 13
No
No
Xtro\dcaf8
1 of 13
No
No
Xtro\dtl
1 of 13
No
No
Xtro\eed
1 of 13
No
No
Xtro\efcab8
1 of 13
No
No
Xtro\fbxw8
1 of 13
No
No
Xtro\gnb5
1 of 13
No
No
Xtro\jazf1
1 of 13
No
No
Xtro\katnb1
1 of 13
No
No
Xtro\lamtor2
1 of 13
No
No
Xtro\LOC100485515
1 of 13
No
Yes
Xtro\LOC100491248
1 of 13
No
Yes
Xtro\LOC100498290
1 of 13
No
No
Xtro\LOC101734139
1 of 13
No
Yes
Xtro\LOC101734744
1 of 13
No
No
Xtro\LOC105947157
1 of 13
No
Yes
Xtro\LOC116408632
1 of 13
No
Yes
Xtro\lrwd1
1 of 13
No
No
Xtro\mlst8
1 of 13
No
No
Xtro\nwd1
1 of 13
No
No
Xtro\pafah1b1
1 of 13
No
No
Xtro\plaa
1 of 13
No
No
Xtro\plrg1
1 of 13
No
No
Xtro\poc1a
1 of 13
No
No
Xtro\poc1b
1 of 13
No
No
Xtro\rcvrn.1
1 of 13
No
No
Xtro\rrp9
1 of 13
No
No
Xtro\scap
1 of 13
No
No
Xtro\snrnp40
1 of 13
No
No
Xtro\spag16
1 of 13
No
Yes
Xtro\taf5
1 of 13
No
No
Xtro\thul16
1 of 13
No
Yes
Xtro\th
1 of 13
No
No
Xtro\wdfy3
1 of 13
No
No
Xtro\wdr1
1 of 13
No
No
Xtro\wdr4
1 of 13
No
No
Xtro\wdr5
1 of 13
No
No
Xtro\wdr20
1 of 13
No
No
Xtro\wdr47
1 of 13
No
No
Xtro\wdr48
1 of 13
No
No
Xtro\wdr49
1 of 13
No
No
Xtro\wdr83
1 of 13
No
No
Xtro\wdr86
1 of 13
No
No
Danio rerio (Zebrafish) (44)
Drer\fbxw7
8 of 14
Yes
Yes
Drer\fbxw2
2 of 14
No
Yes
Drer\fbxw8
2 of 14
No
Yes
Drer\fbxw9
2 of 14
No
Yes
Drer\fbxw10
2 of 14
No
Yes
Drer\fbxw11a
2 of 14
No
No
Drer\fbxw11b
2 of 14
No
No
Drer\traf7
2 of 14
No
Yes
Drer\brwd1
1 of 14
No
No
Drer\daw1
1 of 14
No
No
Drer\dtl
1 of 14
No
No
Drer\ect2l
1 of 14
No
No
Drer\fbxw4
1 of 14
No
No
Drer\grwd1
1 of 14
No
No
Drer\katnb1
1 of 14
No
No
Drer\kif21a
1 of 14
No
No
Drer\LOC100534785
1 of 14
No
No
Drer\LOC103911894
1 of 14
No
No
Drer\mlst8
1 of 14
No
No
Drer\nle1
1 of 14
No
No
Drer\pafah1b1a
1 of 14
No
No
Drer\pafah1b1b
1 of 14
No
No
Drer\pak1ip1
1 of 14
No
No
Drer\plaa
1 of 14
No
No
Drer\poc1a
1 of 14
No
No
Drer\poc1b
1 of 14
No
No
Drer\prpf4
1 of 14
No
No
Drer\prpf19
1 of 14
No
No
Drer\pwp2h
1 of 14
No
No
Drer\rrp9
1 of 14
No
No
Drer\si:cabz01066312.1
1 of 14
No
No
Drer\si:ch211-154o6.3
1 of 14
No
Yes
Drer\tbl3
1 of 14
No
No
Drer\wdr3
1 of 14
No
No
Drer\wdr5
1 of 14
No
No
Drer\wdr20a
1 of 14
No
No
Drer\wdr20b
1 of 14
No
No
Drer\wdr44
1 of 14
No
No
Drer\wdr48a
1 of 14
No
No
Drer\wdr48b
1 of 14
No
No
Drer\wdr83
1 of 14
No
No
Drer\wdr95
1 of 14
No
No
Drer\wsb1
1 of 14
No
Yes
Drer\zmp:0000000529
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (28)
Cele\sel-10
7 of 14
Yes
Yes
Cele\lin-23
2 of 14
No
No
Cele\mec-15
2 of 14
No
Yes
Cele\adpr-1
1 of 14
No
No
Cele\atg-16.2
1 of 14
No
No
Cele\cdt-2
1 of 14
No
No
Cele\copa-1
1 of 14
No
No
Cele\F13H8.2
1 of 14
No
No
Cele\gpb-1
1 of 14
No
No
Cele\klp-12
1 of 14
No
No
Cele\lis-1
1 of 14
No
No
Cele\mes-6
1 of 14
No
No
Cele\prp-4
1 of 14
No
No
Cele\prp-17
1 of 14
No
No
Cele\rack-1
1 of 14
No
No
Cele\sym-4
1 of 14
No
No
Cele\T02H6.1
1 of 14
No
No
Cele\ufd-3
1 of 14
No
No
Cele\wdfy-3
1 of 14
No
No
Cele\wdr-5.1
1 of 14
No
No
Cele\wdr-5.2
1 of 14
No
No
Cele\wdr-5.3
1 of 14
No
No
Cele\wdr-20
1 of 14
No
No
Cele\wdr-37
1 of 14
No
No
Cele\wdr-48
1 of 14
No
No
Cele\Y39G10AR.9
1 of 14
No
Yes
Cele\Y41C4A.32
1 of 14
No
No
Cele\Y48B6A.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (46)
Agam\AgaP_AGAP005359
10 of 12
Yes
Yes
Agam\AgaP_AGAP001944
2 of 12
No
No
Agam\WDY_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP000142
1 of 12
No
No
Agam\AgaP_AGAP000981
1 of 12
No
No
Agam\AgaP_AGAP001146
1 of 12
No
No
Agam\AgaP_AGAP001149
1 of 12
No
No
Agam\AgaP_AGAP001361
1 of 12
No
No
Agam\AgaP_AGAP002019
1 of 12
No
No
Agam\AgaP_AGAP002088
1 of 12
No
No
Agam\AgaP_AGAP002173
1 of 12
No
No
Agam\AgaP_AGAP003346
1 of 12
No
No
Agam\AgaP_AGAP003389
1 of 12
No
No
Agam\AgaP_AGAP003524
1 of 12
No
No
Agam\AgaP_AGAP003891
1 of 12
No
No
Agam\AgaP_AGAP004756
1 of 12
No
No
Agam\AgaP_AGAP004798
1 of 12
No
No
Agam\AgaP_AGAP004827
1 of 12
No
No
Agam\AgaP_AGAP005320
1 of 12
No
No
Agam\AgaP_AGAP005631
1 of 12
No
No
Agam\AgaP_AGAP005911
1 of 12
No
No
Agam\AgaP_AGAP005912
1 of 12
No
No
Agam\AgaP_AGAP005913
1 of 12
No
No
Agam\AgaP_AGAP006113
1 of 12
No
No
Agam\AgaP_AGAP006357
1 of 12
No
No
Agam\AgaP_AGAP007166
1 of 12
No
No
Agam\AgaP_AGAP007626
1 of 12
No
No
Agam\AgaP_AGAP007731
1 of 12
No
No
Agam\AgaP_AGAP007816
1 of 12
No
Yes
Agam\AgaP_AGAP008129
1 of 12
No
No
Agam\AgaP_AGAP008550
1 of 12
No
No
Agam\AgaP_AGAP008620
1 of 12
No
No
Agam\AgaP_AGAP008925
1 of 12
No
No
Agam\AgaP_AGAP009506
1 of 12
No
No
Agam\AgaP_AGAP009574
1 of 12
No
No
Agam\AgaP_AGAP009615
1 of 12
No
No
Agam\AgaP_AGAP010251
1 of 12
No
No
Agam\AgaP_AGAP010305
1 of 12
No
No
Agam\AgaP_AGAP011336
1 of 12
No
No
Agam\AgaP_AGAP011678
1 of 12
No
No
Agam\AgaP_AGAP011849
1 of 12
No
No
Agam\AgaP_AGAP012479
1 of 12
No
No
Agam\AgaP_AGAP012731
1 of 12
No
No
Agam\AgaP_AGAP012877
1 of 12
No
No
Agam\AgaP_AGAP013233
1 of 12
No
No
Agam\BOP1_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (80)
Atha\AT5G40880
2 of 13
Yes
Yes
Atha\AT5G49200
2 of 13
Yes
Yes
Atha\AT5G51980
2 of 13
Yes
Yes
Atha\FBX2
2 of 13
Yes
Yes
Atha\ZFWD1
2 of 13
Yes
Yes
Atha\AGB1
1 of 13
No
No
Atha\ASG2
1 of 13
No
No
Atha\AT1G11160
1 of 13
No
No
Atha\AT1G24130
1 of 13
No
No
Atha\AT1G24530
1 of 13
No
No
Atha\AT1G47610
1 of 13
No
No
Atha\AT1G48870
1 of 13
No
No
Atha\AT1G49450
1 of 13
No
Yes
Atha\AT1G52360
1 of 13
No
No
Atha\AT1G62020
1 of 13
No
No
Atha\AT1G64610
1 of 13
No
No
Atha\AT1G65030
1 of 13
No
No
Atha\AT1G79990
1 of 13
No
No
Atha\AT2G20330
1 of 13
No
No
Atha\AT2G21390
1 of 13
No
No
Atha\AT2G26490
1 of 13
No
Yes
Atha\AT2G37160
1 of 13
No
No
Atha\AT2G37670
1 of 13
No
No
Atha\AT2G40360
1 of 13
No
No
Atha\AT2G43770
1 of 13
No
No
Atha\AT3G15470
1 of 13
No
No
Atha\AT3G15980
1 of 13
No
No
Atha\AT3G16650
1 of 13
No
No
Atha\AT3G18860
1 of 13
No
No
Atha\AT3G18950
1 of 13
No
No
Atha\AT3G21540
1 of 13
No
No
Atha\AT3G27640
1 of 13
No
No
Atha\AT3G45620
1 of 13
No
No
Atha\AT3G50390
1 of 13
No
No
Atha\AT3G51930
1 of 13
No
Yes
Atha\AT3G53390
1 of 13
No
No
Atha\AT4G02660
1 of 13
No
No
Atha\AT4G03020
1 of 13
No
No
Atha\AT4G34380
1 of 13
No
Yes
Atha\AT4G35140
1 of 13
No
No
Atha\AT4G38480
1 of 13
No
No
Atha\AT5G02430
1 of 13
No
No
Atha\AT5G08390
1 of 13
No
No
Atha\AT5G24320
1 of 13
No
No
Atha\AT5G42010
1 of 13
No
No
Atha\AT5G50120
1 of 13
No
Yes
Atha\AT5G52820
1 of 13
No
No
Atha\AT5G53500
1 of 13
No
No
Atha\AT5G54200
1 of 13
No
No
Atha\ATH1
1 of 13
No
No
Atha\BEL1
1 of 13
No
No
Atha\BEL10
1 of 13
No
No
Atha\BLH1
1 of 13
No
No
Atha\BLH2
1 of 13
No
No
Atha\BLH3
1 of 13
No
No
Atha\BLH4
1 of 13
No
No
Atha\BLH5
1 of 13
No
No
Atha\BLH6
1 of 13
No
No
Atha\BLH7
1 of 13
No
No
Atha\BLH8
1 of 13
No
No
Atha\CYP71
1 of 13
No
No
Atha\DWA3
1 of 13
No
No
Atha\EMB2271
1 of 13
No
No
Atha\FIE
1 of 13
No
No
Atha\LRS1
1 of 13
No
No
Atha\LST8-1
1 of 13
No
No
Atha\MSI1
1 of 13
No
No
Atha\PRL1
1 of 13
No
No
Atha\RACK1B_AT
1 of 13
No
No
Atha\RPL
1 of 13
No
No
Atha\SCD1
1 of 13
No
No
Atha\SMU1
1 of 13
No
No
Atha\SPI
1 of 13
No
No
Atha\TAF5
1 of 13
No
No
Atha\TOZ
1 of 13
No
No
Atha\TRM82
1 of 13
No
No
Atha\VIP3
1 of 13
No
No
Atha\WDR5a
1 of 13
No
No
Atha\WDR5b
1 of 13
No
No
Atha\YAO
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (29)
Scer\CDC4
5 of 13
Yes
Yes
Scer\MET30
5 of 13
Yes
Yes
Scer\RRT13
4 of 13
No
Yes
Scer\CAF4
2 of 13
No
Yes
Scer\MDV1
2 of 13
No
Yes
Scer\BPH1
1 of 13
No
No
Scer\CDC40
1 of 13
No
No
Scer\COP1
1 of 13
No
No
Scer\DGR2
1 of 13
No
No
Scer\DIP2
1 of 13
No
No
Scer\DOA1
1 of 13
No
No
Scer\DUF1
1 of 13
No
No
Scer\ERB1
1 of 13
No
No
Scer\HIR1
1 of 13
No
No
Scer\LAF1
1 of 13
No
No
Scer\LST8
1 of 13
No
No
Scer\MAK11
1 of 13
No
No
Scer\PAC1
1 of 13
No
No
Scer\PRP46
1 of 13
No
No
Scer\PWP2
1 of 13
No
No
Scer\RPN14
1 of 13
No
No
Scer\RRP9
1 of 13
No
No
Scer\RSA4
1 of 13
No
No
Scer\TAF5
1 of 13
No
No
Scer\TRM82
1 of 13
No
No
Scer\TUP1
1 of 13
No
No
Scer\UFO1
1 of 13
No
No
Scer\UTP13
1 of 13
No
No
Scer\UTP15
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (23)
Spom\pof1
4 of 12
Yes
Yes
Spom\pop1
4 of 12
Yes
Yes
Spom\pop2
4 of 12
Yes
Yes
Spom\pof10
2 of 12
No
Yes
Spom\SPCC126.01c
2 of 12
No
Yes
Spom\bun62
1 of 12
No
No
Spom\bun107
1 of 12
No
No
Spom\caf4
1 of 12
No
Yes
Spom\cdt2
1 of 12
No
No
Spom\cpc2
1 of 12
No
No
Spom\cyp9
1 of 12
No
No
Spom\lub1
1 of 12
No
No
Spom\pof11
1 of 12
No
No
Spom\prp17
1 of 12
No
No
Spom\skb15
1 of 12
No
No
Spom\SPAC2E1P5.05
1 of 12
No
No
Spom\SPAC3H5.08c
1 of 12
No
No
Spom\SPBC3D6.12
1 of 12
No
No
Spom\SPBC18H10.05
1 of 12
No
No
Spom\SPCC18.05c
1 of 12
No
No
Spom\sum1
1 of 12
No
No
Spom\taf73
1 of 12
No
No
Spom\tup12
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:ago. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (39)
slmb
3 of 13
WDY
2 of 13
adp
1 of 13
αCOP
1 of 13
bchs
1 of 13
β'COP
1 of 13
CG1671
1 of 13
CG3436
1 of 13
CG4935
1 of 13
CG5033
1 of 13
CG6015
1 of 13
CG8001
1 of 13
CG8064
1 of 13
CG9123
1 of 13
CG10064
1 of 13
CG10931
1 of 13
CG12608
1 of 13
CG30116
1 of 13
CG33969
1 of 13
CG34133
1 of 13
CG43367
1 of 13
esc
1 of 13
escl
1 of 13
Gβ13F
1 of 13
kat80
1 of 13
l(2)09851
1 of 13
l(2)dtl
1 of 13
Lis-1
1 of 13
Plap
1 of 13
Ski8
1 of 13
Smu1
1 of 13
Taf5
1 of 13
Tango4
1 of 13
U3-55K
1 of 13
Uaf1
1 of 13
Wdr20
1 of 13
Wdr81
1 of 13
wds
1 of 13
wuho
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
FBXW7; F-box and WD repeat domain containing 7
9 of 14
606278
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
ago
enhanceable
awd
(Mortimer and Moberg, 2007)
ago
suppressible
bnl
(Mortimer and Moberg, 2013)
ago
suppressible
btl
(Mortimer and Moberg, 2007)
slmb|ago
suppressible
gcm
(Ho et al., 2009)
ago|Myc
enhanceable
puf
(Li et al., 2013)
Myc|ago
suppressible
puf
(Li et al., 2013)
ago
suppressible
scny
(Thevenon et al., 2020)
ago
suppressible
sima
(Mortimer and Moberg, 2013)
ago
suppressible
trh
(Mortimer and Moberg, 2007)
ago
suppressible
Vhl
(Mortimer and Moberg, 2013)
ago
enhanceable
Vhl
(Mortimer and Moberg, 2013)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
btl::Egfr
enhanceable
ago
(Zhu et al., 2005)
btl|stumps
suppressible
ago
(Zhu et al., 2005)
caup
enhanceable
ago
(Barrios et al., 2015)
CycE
suppressible
ago
(Brumby et al., 2004, Moberg et al., 2001)
Myc
suppressible
ago
(Li et al., 2013, Moberg et al., 2004)
Myc
enhanceable
ago
(Li et al., 2013, Secombe et al., 2007)
numb
suppressible
ago
(Ouyang et al., 2011)
Otud6
suppressible
ago
(Villa et al., 2024)
p53
suppressible
ago
(Ouyang et al., 2011)
puf
enhanceable
ago
(Li et al., 2013)
Pvr
enhanceable
ago
(Zhu et al., 2005)
Ras85D
enhanceable
ago
(Friedman et al., 2011)
Vhl
enhanceable
ago
(Mortimer and Moberg, 2013, Mortimer and Moberg, 2009)
Vhl
suppressible
ago
(Mortimer and Moberg, 2013)
External Data
Subunit Structure (UniProtKB)
Part of a SCF E3 ubiquitin-protein ligase complex. Interacts with Myc and puf (PubMed:15182669, PubMed:24173801). Interacts with CycE (PubMed:11565033).
(UniProt, Q9VZF4 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-10
Cytogenetic map
64A11-64A12
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
64A11-64A12
Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

3-10

(FlyBase, 2016)

3-9.2

(Comeron et al., 2012)

3-

(Moberg and Hariharan, 2000)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (11)
Genomic Clones (18)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (87)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      ago acts an antagonist of the physiological response to hypoxia. ago protein physically associates with sima protein and restricts sima protein levels in vivo. Reducing ago activity in larval muscle cells elicits enhanced branching of nearby tracheal cells in normoxia.

      (Mortimer and Moberg, 2013)

      dsRNA has been made from templates generated with primers directed against this gene.

      (Pilot et al., 2006)

      Mutants in ago show increased tissue growth.

      (Moberg et al., 2004)

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)

      Area matching Drosophila EST AA392932 (inverted).

      (Davies, 2001.3.15)

      ago is involved in developmental regulation of CycE degradation.

      (Moberg et al., 2001)

      Clones of mutant cells in the eye disc result in cell fate changes and overrepresentation of mutant cells in the eye.

      (Moberg and Hariharan, 2000)
      Relationship to Other Genes
      Source for database merge of

      Source for merge of: ago CG15010

      (Moberg et al., 2001)

      Source for merge of: ago anon-WO0118547.345

      (FlyBase, 1996-)
      Additional comments

      Source for merge of ago anon-WO0118547.345 was sequence comparison ( date:051113 ).

      (FlyBase, 1996-)
      Nomenclature History
      Source for database identify of
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (11)
      Reported As
      Symbol Synonym
      Ago
      (Barbosa et al., 2021, Chen et al., 2019, Mirzoyan et al., 2019, Lee et al., 2017, Yadav et al., 2016, Barrios and Campuzano, 2015, Li et al., 2015, Wong et al., 2013, Lee et al., 2012, Roberts et al., 2012, Klusza and Deng, 2011, Cunha-Ferreira et al., 2009, Skaar et al., 2009, Shibutani et al., 2008, Galletti et al., 2007, Martin et al., 2007)
      CG15010
      (Meadows, 2018.10.31, Schertel et al., 2013, Roberts et al., 2012, Ni et al., 2011.7.19, Berger et al., 2008, Ni et al., 2008, Gandhi et al., 2007, Pilot et al., 2006, Stanyon et al., 2004, Das et al., 2002, Halfon et al., 2002, Koepp et al., 2001)
      DmFbw7
      (Koepp et al., 2001)
      FBXW3
      (Roberts et al., 2012)
      FBXW7
      (Ivatt et al., 2014)
      SCFAgo
      (Mortimer and Moberg, 2005)
      ago
      (Vedelek et al., 2024, Villa et al., 2024, Jiang et al., 2022, Stephenson et al., 2022, Bilder et al., 2021, Zhang et al., 2021, Kuang et al., 2020, Thevenon et al., 2020, Bangi et al., 2019, Bivik Stadler et al., 2019, Deshpande et al., 2019, Meltzer et al., 2019, Zahoor et al., 2019, Bala Tannan et al., 2018, Eusebio et al., 2018, Salazar and Yamamoto, 2018, Li et al., 2017, Suisse et al., 2017, Barrios et al., 2015, Bivik et al., 2015, Ribeiro et al., 2014, Bandura et al., 2013, Li et al., 2013, Mortimer and Moberg, 2013, Schertel et al., 2013, Webber et al., 2013, Adamson and Lajeunesse, 2012, Japanese National Institute of Genetics, 2012.5.21, Roberts et al., 2012, Du et al., 2011, Friedman et al., 2011, Nicholson et al., 2011, Toku et al., 2011, Ho et al., 2009, Mortimer and Moberg, 2009, Nicholson et al., 2009, Rhiner et al., 2009, Szuplewski et al., 2009, Ho et al., 2008, Zhou et al., 2008, Magalhaes et al., 2007, Mortimer and Moberg, 2007, Mortimer and Moberg, 2007, Secombe et al., 2007, Tyler et al., 2007, Ho et al., 2006, Firth and Baker, 2005)
      anon-WO0118547.345
      cdc4
      (Brumby et al., 2004)
      Name Synonyms
      Archipelago
      (Barrios et al., 2015, Pawar et al., 2011, Herranz et al., 2010, Ho et al., 2009, Galletti et al., 2007, Mortimer and Moberg, 2007, Secombe et al., 2007)
      archipelago
      (Salazar and Yamamoto, 2018, Hsu and Drummond-Barbosa, 2017, Bandura et al., 2013, Li et al., 2013, Ouyang et al., 2011, Mandal et al., 2010, Mortimer and Moberg, 2009, Nicholson et al., 2009, Rhiner et al., 2009, Szuplewski et al., 2009, Berger et al., 2008, Mortimer and Moberg, 2007, Tountas and Fortini, 2007, Ho et al., 2006, Moberg and Hariharan, 2000)
      Secondary FlyBase IDs
      • FBgn0035516
      • FBgn0062079
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 60 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      References (145)