EP2237, dTIEG
zinc finger transcription factor, dorsal closure, wing disc, regulator of growth, transcriptional partner of Yorkie, promotes cell cycling, essential for dietary sugar tolerance, modulates Dpp signalling and the JAK/STAT pathway
Please see the JBrowse view of Dmel\cbt for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.42
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cbt using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
cbt transcripts are observed in imaginal discs by in situ hybridization. Expression is generalized but not uniform. For example, expression in the hinge region is lower than in the rest of the disc.
cbt protein is nuclear and is first detected in the germ plasm and pole cells of syncytial embryos, and subsequently, in blastoderm stages and during gastrulation. During germband retraction and dorsal closure it is localized in the yolk cell nuclei, lateral epidermis, and the gut primordium/hindgut. It is also present in the amnioserosa at these stages, despite the mRNA not being detected in this tissue.
JBrowse - Visual display of RNA-Seq signals
View Dmel\cbt in JBrowse
2-1
2-0.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2-unspecified : A stable S2 cell line expressing an inducible cbt-Tag:V5 fusion protein was generated.
dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.
cbt is essential for dorsal closure.
Identification: in a gain-of-function screen for genes involved in the generation of planar cell polarity.
Source for merge of: EP2237 CG4427
Source for identity of: cabut EP2237
