FB2020_06, released Dec 22, 2020

Gene: Dmel\Asap

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General Information
Symbol
Dmel\Asap
Species
D. melanogaster
Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain
Annotation Symbol
CG30372
Feature Type
protein_coding_gene
FlyBase ID
FBgn0050372
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
ArfGAP with SH3 domain, ankyrin repeat and PH domain (Asap) encodes a GTPase activating proteins for Arf family GTPases. Arf proteins regulate actin dynamics, cell shape, and cell positioning within epithelia such as the eye. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Asap1

Key Links
Genomic Location
Cytogenetic map
44B2-44B2
Sequence location
2R:8,114,286..8,123,001 [-]
Recombination map

2-58

RefSeq locus
NT_033778 REGION:8114286..8123001
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9Y154
(assigned by UniProt )
(Johnson et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTPase activator activity
inferred from electronic annotation with InterPro:IPR001164
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence model
(Bernards, 2003)
enables phosphatidylinositol phosphate binding
inferred from sequence or structural similarity with MGI:MGI:1342335
(FlyBase Curators, 2008--)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in compound eye morphogenesis
inferred from mutant phenotype
(assigned by UniProt )
(Johnson et al., 2011)
involved_in mitotic cleavage furrow ingression
inferred from mutant phenotype
(assigned by UniProt )
(Rodrigues et al., 2016)
involved_in positive regulation of cellular protein localization
inferred from mutant phenotype
(assigned by UniProt )
(Rodrigues et al., 2016)
involved_in regulation of Golgi organization
inferred from mutant phenotype
(assigned by UniProt )
(Rodrigues et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of GTPase activity
inferred from electronic annotation with InterPro:IPR037844
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in regulation of GTPase activity
inferred from sequence model
(Bernards, 2003)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
(Johnson et al., 2011)
located_in apical part of cell
inferred from direct assay
(assigned by UniProt )
(Shao et al., 2010)
colocalizes_with cytoplasm
inferred from direct assay
(assigned by UniProt )
(Rodrigues et al., 2016)
located_in cytoplasm
inferred from direct assay
(Johnson et al., 2011)
colocalizes_with nucleus
inferred from direct assay
(assigned by UniProt )
(Rodrigues et al., 2016)
colocalizes_with plasma membrane
inferred from direct assay
(assigned by UniProt )
(Rodrigues et al., 2016)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS -
ArfGAPs are GTPase activating proteins for ARF family GTPases. ARFGAPs contain a characteristic 130 amino acid module, the ArfGAP domain, originally defined as the minimal fragment possessing ArfGAP activity. (Adapted from FBrf0158741, PMID:15731001 and PMID:18809720).
Protein Function (UniProtKB)
Probable GTPase-activating protein (GAP) for Arf family proteins (Probable). Involved in Golgi apparatus organization by targeting Arf1 to the Golgi, which may be important for membrane trafficking during epithelial morphogenesis (PubMed:27535433). Regulates the positioning of interommatidial precursor cells during compound eye morphogenesis together with Arf6 and Cindr (PubMed:21976699). Required for cleavage furrow ingression in early embryonic cells (PubMed:27535433).
(UniProt, A1Z7A6)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Asap for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Asap-RB
FBtr0100140
NM_001014504
4210
1155
Asap-RC
FBtr0300954
NM_001169614
4980
1127
Asap-RD
FBtr0339300
NM_001299254
5028
1143
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Asap-PB
FBpp0099488
127.3
1155
7.03
NP_001014504
AAF59133
Asap-PC
FBpp0290176
124.3
1127
6.87
NP_001163085
ACZ94364
Asap-PD
FBpp0308409
126.2
1143
6.94
NP_001286183
AHN55981
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Cindr.

(UniProt, A1Z7A6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Asap using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
(Johnson et al., 2011)
located_in apical part of cell
inferred from direct assay
(assigned by UniProt )
(Shao et al., 2010)
colocalizes_with cytoplasm
inferred from direct assay
(assigned by UniProt )
(Rodrigues et al., 2016)
located_in cytoplasm
inferred from direct assay
(Johnson et al., 2011)
colocalizes_with nucleus
inferred from direct assay
(assigned by UniProt )
(Rodrigues et al., 2016)
colocalizes_with plasma membrane
inferred from direct assay
(assigned by UniProt )
(Rodrigues et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Asap in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Asap
Transgenic constructs containing regulatory region of Asap
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
flight defective, with Scer\GAL4Mef2.PR
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ASAP2
12 of 15
Yes
Yes
Hsap\ASAP1
11 of 15
No
Yes
Hsap\ASAP3
7 of 15
No
Yes
Hsap\ACAP1
2 of 15
No
No
Hsap\ACAP2
2 of 15
No
No
Hsap\ACAP3
2 of 15
No
No
Hsap\AGAP1
2 of 15
No
No
Hsap\AGAP2
2 of 15
No
No
Hsap\AGAP3
2 of 15
No
No
Hsap\AGAP4
2 of 15
No
No
Hsap\AGAP5
2 of 15
No
No
Hsap\AGAP6
2 of 15
No
No
Hsap\ADAP1
1 of 15
No
No
Hsap\ADAP2
1 of 15
No
Yes
Hsap\AGAP9
1 of 15
No
No
Hsap\AGAP10P
1 of 15
No
No
Hsap\AGAP11
1 of 15
No
No
Hsap\AGFG1
1 of 15
No
No
Hsap\AGFG2
1 of 15
No
No
Hsap\APPL1
1 of 15
No
Yes
Hsap\APPL2
1 of 15
No
Yes
Hsap\ARAP1
1 of 15
No
No
Hsap\ARAP2
1 of 15
No
No
Hsap\ARAP3
1 of 15
No
No
Hsap\ARFGAP1
1 of 15
No
No
2  
Hsap\ARFGAP2
1 of 15
No
No
Hsap\ARFGAP3
1 of 15
No
No
Hsap\GIT1
1 of 15
No
No
Hsap\GIT2
1 of 15
No
No
Hsap\LOC107984026
1 of 15
No
Yes
Hsap\SMAP1
1 of 15
No
No
Hsap\SMAP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (29)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Asap2
12 of 15
Yes
Yes
Mmus\Asap1
11 of 15
No
Yes
Mmus\Asap3
6 of 15
No
Yes
Mmus\Acap1
2 of 15
No
No
Mmus\Acap2
2 of 15
No
No
Mmus\Acap3
2 of 15
No
No
Mmus\Agap2
2 of 15
No
No
Mmus\Agap3
2 of 15
No
No
Mmus\9030624G23Rik
1 of 15
No
Yes
Mmus\Adap1
1 of 15
No
Yes
Mmus\Adap2
1 of 15
No
Yes
Mmus\Agap1
1 of 15
No
No
Mmus\Agfg1
1 of 15
No
No
Mmus\Agfg2
1 of 15
No
No
Mmus\Appl1
1 of 15
No
Yes
Mmus\Appl2
1 of 15
No
Yes
Mmus\Arap1
1 of 15
No
No
Mmus\Arap2
1 of 15
No
No
Mmus\Arap3
1 of 15
No
No
Mmus\Arfgap1
1 of 15
No
No
Mmus\Arfgap2
1 of 15
No
No
Mmus\Arfgap3
1 of 15
No
No
Mmus\Git1
1 of 15
No
No
Mmus\Git2
1 of 15
No
No
Mmus\Gm3944
1 of 15
No
Yes
Mmus\Gm19924
1 of 15
No
Yes
Mmus\Gmps
1 of 15
No
No
Mmus\Smap1
1 of 15
No
No
Mmus\Smap2
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Asap1
8 of 13
Yes
Yes
Rnor\Asap2
3 of 13
No
Yes
Rnor\Asap3
3 of 13
No
Yes
Rnor\Acap1
2 of 13
No
No
Rnor\Acap2
2 of 13
No
No
Rnor\Acap3
2 of 13
No
No
Rnor\Agap1
2 of 13
No
No
Rnor\Agap2
2 of 13
No
No
Rnor\Agap3
2 of 13
No
No
Rnor\Adap2
1 of 13
No
Yes
Rnor\Agfg1
1 of 13
No
No
Rnor\Agfg2
1 of 13
No
No
Rnor\Appl1
1 of 13
No
Yes
Rnor\Appl2
1 of 13
No
Yes
Rnor\Arfgap1
1 of 13
No
No
Rnor\Arfgap2
1 of 13
No
No
Rnor\Git2
1 of 13
No
No
Rnor\Smap1
1 of 13
No
No
Rnor\Smap2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (22)
Xtro\asap2
6 of 12
Yes
Yes
Xtro\asap1
5 of 12
No
Yes
Xtro\acap1
2 of 12
No
No
Xtro\acap2
2 of 12
No
No
Xtro\acap3
2 of 12
No
No
Xtro\agap1
2 of 12
No
No
Xtro\agap2
2 of 12
No
No
Xtro\arap3
2 of 12
No
No
Xtro\adap1l
1 of 12
No
Yes
Xtro\adap1
1 of 12
No
Yes
Xtro\agap3
1 of 12
No
No
Xtro\agfg1
1 of 12
No
No
Xtro\appl1
1 of 12
No
Yes
Xtro\appl2
1 of 12
No
Yes
Xtro\arfgap1
1 of 12
No
No
Xtro\arfgap2
1 of 12
No
No
Xtro\asap3
1 of 12
No
Yes
Xtro\git1
1 of 12
No
No
Xtro\git2
1 of 12
No
No
Xtro\LOC100489773
1 of 12
No
Yes
Xtro\smap1
1 of 12
No
No
Xtro\smap2
1 of 12
No
No
Danio rerio (Zebrafish) (31)
Drer\asap1b
11 of 15
Yes
Yes
Drer\asap2a
10 of 15
No
Yes
Drer\asap2b
10 of 15
No
Yes
Drer\unm_sa1614
8 of 15
No
Yes
Drer\asap1a
6 of 15
No
Yes
Drer\acap3a
2 of 15
No
No
Drer\acap3b
2 of 15
No
No
Drer\agap1
2 of 15
No
No
Drer\agap2
2 of 15
No
No
Drer\agap3
2 of 15
No
No
Drer\asap3
2 of 15
No
Yes
Drer\si:ch211-168b3.1
2 of 15
No
No
Drer\zgc:162872
2 of 15
No
No
Drer\acap1
1 of 15
No
No
Drer\acap2
1 of 15
No
No
Drer\adap2
1 of 15
No
Yes
Drer\agfg1a
1 of 15
No
No
Drer\appl1
1 of 15
No
Yes
Drer\appl2
1 of 15
No
Yes
Drer\arap1a
1 of 15
No
No
Drer\arap3
1 of 15
No
No
Drer\arfgap2
1 of 15
No
No
Drer\arfgap3
1 of 15
No
No
Drer\git1
1 of 15
No
No
Drer\git2a
1 of 15
No
No
Drer\LOC100005008
1 of 15
No
No
Drer\LOC110438288
1 of 15
No
No
Drer\smap1
1 of 15
No
No
Drer\smap2
1 of 15
No
No
Drer\zgc:92360
1 of 15
No
Yes
Drer\zmp:0000000660
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\cnt-1
2 of 15
Yes
No
Cele\cnt-2
2 of 15
Yes
No
Cele\F07F6.4
1 of 15
No
No
Cele\F07F6.7
1 of 15
No
Yes
Cele\F07F6.8
1 of 15
No
Yes
Cele\F23H11.4
1 of 15
No
No
Cele\git-1
1 of 15
No
No
Cele\K02B12.7
1 of 15
No
No
Cele\W09D10.1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AGD2
3 of 9
Yes
No
Atha\AGD4
3 of 9
Yes
No
Atha\AGD1
2 of 9
No
No
Atha\SFC
2 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\AGE1
3 of 15
Yes
No
Scer\AGE2
1 of 15
No
No
Scer\GCS1
1 of 15
No
No
Scer\GLO3
1 of 15
No
No
Scer\GTS1
1 of 15
No
No
Scer\SPS18
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\cnt5
3 of 12
Yes
No
Spom\cnt6
2 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919019G )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006710
Drosophila simulans
Dsim\GD27138
Drosophila sechellia
Dsec\GM20723
Drosophila erecta
Dere\GG10676
Drosophila yakuba
Dyak\GE23312
Drosophila ananassae
Dana\GF11212
Drosophila pseudoobscura pseudoobscura
Dpse\GA15795
Drosophila persimilis
Dper\GL17382
Drosophila willistoni
Dwil\GK23159
Drosophila virilis
Dvir\GJ20227
Drosophila mojavensis
Dmoj\GI20274
Drosophila grimshawi
Dgri\GH19987
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500V6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014570
Glossina morsitans
Tsetse fly
Gmor\GMOY000531
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02817
Mayetiola destructor
Hessian fly
Mdes\Mdes000393
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003487
Anopheles darlingi
American malaria mosquito
Adar\ADAC006704
Anopheles gambiae
Malaria mosquito
Agam\AGAP007726
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010575
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01LL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002673
Bombyx mori
Silkmoth
Bmor\BGIBMGA002672
Danaus plexippus
Monarch butterfly
Dple\DPOGS201484-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015940
Apis florea
Little honeybee
Aflo\3930076468
Apis florea
Little honeybee
Aflo\2281906436
Apis mellifera
Western honey bee
Amel\GB48336
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21218
Bombus terrestris
Buff-tailed bumblebee
Bter\15213788
Linepithema humile
Argentine ant
Lhum\LH22470
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002de3
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002463
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02386
Tribolium castaneum
Red flour beetle
Tcas\TC001714
Pediculus humanus
Human body louse
Phum\PHUM503150
Rhodnius prolixus
Kissing bug
Rpro\RPRC006909
Cimex lectularius
Bed bug
Clec\CLEC004661
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05687
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01JP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009565
Ixodes scapularis
Black-legged tick
Isca\ISCW021010
Ixodes scapularis
Black-legged tick
Isca\ISCW021009
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73792.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67109.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67108.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g00390
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_202418
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G022H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ddef1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_006112gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006711
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000029131
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001710
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026442
Gallus gallus
Domestic chicken
Ggal\ASAP1
Gallus gallus
Domestic chicken
Ggal\ASAP2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CenB1A
3 of 10
ArfGAP1
2 of 10
ArfGAP3
2 of 10
CenG1A
2 of 10
CG8243
2 of 10
drongo
2 of 10
Git
2 of 10
RhoGAP15B
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    12 of 15
    603817
        ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
        11 of 15
        605953
            ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
            7 of 15
            616594
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Asap - cindr
                pull down, anti tag western blot
                (Johnson et al., 2011)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                baz
                enhanceable
                Asap
                (Shao et al., 2010)
                cindr
                enhanceable
                Asap
                (Johnson et al., 2011)
                Dcr-2|Arf51F
                enhanceable
                Asap
                (Johnson et al., 2011)
                External Data
                Subunit Structure (UniProtKB)
                Interacts with Cindr.
                (UniProt, A1Z7A6 )
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2R
                Recombination map

                2-58

                Cytogenetic map
                44B2-44B2
                Sequence location
                2R:8,114,286..8,123,001 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                44B2-44B2
                Limits computationally determined from genome sequence between P{lacW}Vps28k16503 and P{EP}kermitEP493
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                2-58

                (FlyBase, 2016)

                2-57.4

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (9)
                Genomic Clones (17)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (76)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Johnson et al., 2011)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Asap1 CG30372

                  (Johnson et al., 2011)

                  Source for identity of: Asap Asap1

                  (FlyBase, 2009-)
                  Source for database merge of

                  Source for merge of: CG14758 CG2226

                  (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
                  Additional comments

                  Renaming from 'Asap1' to 'Asap' as this is the sole ortholog of mammalian ASAP genes (according to OrthoDB, FBrf0216708 and FBrf0210449) and FBrf0216708 and FBrf0210449 refer to it as ASAP/dAsap.

                  (FlyBase, 2009-)

                  Annotations CG14758 and CG2226 merged as CG30372 in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  Source for merge of CG14758 CG2226 was a shared cDNA ( date:010720 ).

                  (FlyBase, 1996-)
                  Other Comments

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 51 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (10)
                  Reported As
                  Symbol Synonym
                  ASAP
                  (Schlacht et al., 2013)
                  ASAP1
                  (Zhang et al., 2018)
                  Asap
                  (Jiang et al., 2019, Zeledon et al., 2019, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-)
                  Asap1
                  (Bennett et al., 2015)
                  CG14758
                  CG2226
                  (Bernards, 2003, Robertson, 2001.1.8)
                  CG30372
                  (Zeledon et al., 2019, Murray et al., 2012, Johnson et al., 2011, Shao et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2008, Bakal et al., 2007)
                  dAsap
                  (Johnson et al., 2011)
                  Name Synonyms
                  ArfGAP with SH3 domain, ankyrin repeat and PH domain
                  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
                  Secondary FlyBase IDs
                  • FBgn0033262
                  • FBgn0033263
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (50)