FlyBase Gene Report: Dmel\Erk7

General Information

Symbol

Dmel\Erk7

Species

D. melanogaster

Name

Extracellularly regulated kinase 7

Annotation Symbol

CG32703

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052703

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

mitogen-activated protein kinase (2.7.11.24)

Gene Summary

Extracellularly regulated kinase 7 (Erk7) encodes an unconventional ERK family member with a role in the organization of the early secretory pathway. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

ERK

Key Links

Genomic Location

Cytogenetic map

8D3-8D4

Sequence location

X:9,261,376..9,267,698 [-]

Recombination map

1-27

RefSeq locus

NC_004354 REGION:9261376..9267698

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR003527

(InterPro Project Members, 2004-)

enables MAP kinase activity

inferred from electronic annotation with InterPro:IPR003527

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in axoneme assembly

inferred from mutant phenotype

(Dobbelaere et al., 2023)

involved_in cellular response to amino acid starvation

inferred from mutant phenotype

(Zacharogianni et al., 2011)

involved_in cellular response to starvation

inferred from mutant phenotype

(Hasygar and Hietakangas, 2014)

involved_in ciliary transition zone assembly

inferred from mutant phenotype

(Dobbelaere et al., 2023)

involved_in Golgi organization

inferred from mutant phenotype

(Zacharogianni et al., 2011)

involved_in lipid droplet organization

inferred from mutant phenotype

(Zacharogianni et al., 2011)

involved_in negative regulation of cell size

inferred from mutant phenotype

(Zacharogianni et al., 2011)

involved_in negative regulation of protein secretion

inferred from mutant phenotype

(Zacharogianni et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

is_active_in ciliary basal body

inferred from direct assay

(Dobbelaere et al., 2023)

located_in cytoplasm

inferred from direct assay

(Zacharogianni et al., 2011)

located_in endoplasmic reticulum membrane

inferred from direct assay

(Zacharogianni et al., 2011)

located_in nuclear envelope

inferred from direct assay

(Zacharogianni et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ATYPICAL MITOGEN ACTIVATED PROTEIN KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q9W354)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

MAP kinase activity

(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.24)

(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.24)

protein serine/threonine kinase activity

Summaries

Gene Snapshot

Extracellularly regulated kinase 7 (Erk7) encodes an unconventional ERK family member with a role in the organization of the early secretory pathway. [Date last reviewed: 2018-11-15]

Gene Group (FlyBase)

ATYPICAL MITOGEN ACTIVATED PROTEIN KINASES -: Atypical Mitogen-activated protein kinases are proline-directed serine/threonine kinases that share significant sequence homology with the kinase domain of conventional MAPKs. They are not part of the conventional MAPK cascade and differ in key residues of the activation loop. (Adapted from PMID:21372320).

Protein Function (UniProtKB)

Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner (PubMed:21847093, PubMed:25393288). In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly (PubMed:21847093). Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53 (PubMed:25393288).

(UniProt, Q9W354)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Erk7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W354)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Erk7-RA

FBtr0071329

NM_167188

3721

916

Erk7-RB

FBtr0302965

NM_001201639

3640

916

Erk7-RC

FBtr0302966

NM_001201640

2296

451

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Erk7-PA

FBpp0071264

105.7

916

9.13

FBpp0292090

105.7

916

9.13

FBpp0292091

52.4

451

10.31

M9MSN4

NP_001188569

ADV37651

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

916 aa isoforms: Erk7-PA, Erk7-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W354

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Erk7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Erk7_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.90

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in ciliary basal body

inferred from direct assay

(Dobbelaere et al., 2023)

located_in cytoplasm

inferred from direct assay

(Zacharogianni et al., 2011)

located_in endoplasmic reticulum membrane

inferred from direct assay

(Zacharogianni et al., 2011)

located_in nuclear envelope

inferred from direct assay

(Zacharogianni et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Erk7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Erk7

View exonic expression by tissue for Dmel\Erk7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052703

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31877/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052703

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052703

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052703

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32703

Flygut - An atlas of the Drosophila adult midgut

FBgn0052703

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Erk7

Transgenic constructs containing regulatory region of Erk7

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 17 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Erk7¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Erk7^GD5183

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

male sterile

Erk7¹

Other Phenotypes

Allele

abnormal developmental rate

Erk7¹

abnormal developmental rate, with Scer\GAL4^Cg.PA

abnormal developmental rate, with Scer\GAL4^Ilp2.PR

Erk7^{UAS.Tag:V5,Tag:polyHis}

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Erk7^GD9774

decreased body size | larval stage, with Scer\GAL4^Cg.PA

Erk7^{UAS.Tag:V5,Tag:polyHis}

decreased body size | P-stage, with Scer\GAL4^Cg.PA

Erk7^{UAS.Tag:V5,Tag:polyHis}

decreased body size | P-stage, with Scer\GAL4^Ilp2.PR

Erk7^{UAS.Tag:V5,Tag:polyHis}

decreased body size | pupal stage, with Scer\GAL4^Ilp2.PR

Erk7^{UAS.Tag:V5,Tag:polyHis}

decreased size | somatic clone, with Scer\GAL4^Act.PU

Erk7^{UAS.Tag:V5,Tag:polyHis}

increased body weight | larval stage

Erk7¹

increased body weight | larval stage, with Scer\GAL4^Cg.PA

increased mortality during development

Erk7¹

increased size

Erk7¹

Phenotype manifest in

Allele

fat body

Erk7¹

fat body, with Scer\GAL4^Cg.PA

Erk7^HMC04378

fat cell | somatic clone, with Scer\GAL4^Cg.PA

Erk7^{UAS.Tag:V5,Tag:polyHis}

lipid droplet | decreased number | somatic clone, with Scer\GAL4^Cg.PA

Erk7^{UAS.Tag:V5,Tag:polyHis}

lipid droplet | increased number

Erk7¹

lipid droplet | increased number, with Scer\GAL4^Cg.PA

Erk7^HMC04378

nucleolus

Erk7¹

nucleolus | somatic clone, with Scer\GAL4^Act.PU

Erk7^{UAS.Tag:V5,Tag:polyHis}

nucleus

Erk7¹

nucleus, with Scer\GAL4^Cg.PA

Erk7^HMC04378

nucleus | somatic clone, with Scer\GAL4^Act.PU

Erk7^{UAS.Tag:V5,Tag:polyHis}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (32)

Hsap\MAPK15

11 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

Rnor\Mapk15

12 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (25)

Mmus\Mapk15

12 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (27)

Xtro\mapk15

8 of 13

Yes

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (33)

Drer\mapk15

10 of 14

Yes

5 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-151g10.3

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (25)

Cele\mapk-15

10 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP009207

4 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (41)

Atha\ATMPK8

4 of 13

Yes

Atha\ATMPK13

4 of 13

Yes

Atha\MPK1

4 of 13

Yes

Atha\MPK2

4 of 13

Yes

Atha\MPK3

4 of 13

Yes

Atha\MPK4

4 of 13

Yes

Atha\MPK5

4 of 13

Yes

Atha\MPK6

4 of 13

Yes

Atha\MPK7

4 of 13

Yes

Atha\MPK9

4 of 13

Yes

Atha\MPK10

4 of 13

Yes

Atha\MPK11

4 of 13

Yes

Atha\MPK12

4 of 13

Yes

Atha\MPK14

4 of 13

Yes

Atha\MPK15

4 of 13

Yes

Atha\MPK16

4 of 13

Yes

Atha\MPK17

4 of 13

Yes

Atha\MPK19

4 of 13

Yes

Atha\MPK20

4 of 13

Yes

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\SLT2

4 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\pmk1

3 of 12

Yes

Spom\spk1

3 of 12

Yes

Spom\sty1

2 of 12

Spom\cdc7

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Erk7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (19)

6 of 13

p38a

5 of 13

p38b

5 of 13

bsk

4 of 13

p38c

4 of 13

nmo

3 of 13

CG8565

2 of 13

CG42366

2 of 13

Akt

1 of 13

Cdk2

1 of 13

CG5790

1 of 13

Hipk

1 of 13

hpo

1 of 13

lok

1 of 13

PKD

1 of 13

Slik

1 of 13

Srpk79D

1 of 13

SRPK

1 of 13

Tao

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MAPK15; mitogen-activated protein kinase 15

11 of 14

618616

MAPK1; mitogen-activated protein kinase 1

4 of 14

176948

NOONAN SYNDROME 13; NS13

Noonan syndrome 13

MAPK3; mitogen-activated protein kinase 3

4 of 14

MITOGEN-ACTIVATED PROTEIN KINASE 3; MAPK3

MAPK7; mitogen-activated protein kinase 7

4 of 14

602521

MAPK11; mitogen-activated protein kinase 11

3 of 14

602898

MAPK12; mitogen-activated protein kinase 12

3 of 14

602399

MAPK13; mitogen-activated protein kinase 13

3 of 14

602899

MAPK14; mitogen-activated protein kinase 14

3 of 14

600289

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Erk7

suppressible

nclb

(Hasygar et al., 2021)

Erk7

suppressible

sug

(Hasygar et al., 2021)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

p53

suppressible

Erk7

(Hasygar and Hietakangas, 2014)

RIOK2

suppressible

Erk7

(Hasygar and Hietakangas, 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58327

DroID - A comprehensive database of gene and protein interactions.

FBgn0052703

MIST (protein-protein) - An integrated Molecular Interaction Database

31877

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9W354

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-27

Cytogenetic map

8D3-8D4

Sequence location

X:9,261,376..9,267,698 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

8D3-8D4

Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912^EP912

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-27

(FlyBase, 2016)

1-28.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

56939

y¹ v¹; P{TRiP.HMC04378}attP2

43776

y¹ w^* Mi{MIC}Erk7^MI05843

36110

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00222}attP2

2309R-1

2309R-4

17441R-2

17441R-3

HMS00222

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00222}attP2

VDRC

v109661

P{KK102574}VIE-260B

v13444

w¹¹¹⁸; P{GD5183}v13444

v342895

P{hsFLP}1, y1 w1118; P{HD_CFD02491}attP40/CyO-GFP

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT16639

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052703

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052703

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells is seen.

(Bettencourt-Dias et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG17441 CG2309

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG17441 and CG2309 merged as CG32703 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Erk7 CG32703

(Zacharogianni et al., 2011)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG17441

CG2309

(Bettencourt-Dias et al., 2004, Stanyon et al., 2004)

CG32703

(Dobbelaere et al., 2023, Bergwitz et al., 2013, Fu and Whitfield, 2012, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

ERK

(Herrera and Bach, 2021, Lam Wong and Verheyen, 2021, Li and Hidalgo, 2021, Mark et al., 2021, Valon et al., 2021, Hayashi and Ogura, 2020, Jeon et al., 2020)

ERK7

(Hasygar et al., 2021, Hasygar and Hietakangas, 2014, Zacharogianni et al., 2011, Bjorklund et al., 2006, Morrison et al., 2000)

Erk

(Sciambra and Chtarbanova, 2021, Pan et al., 2020)

Erk7

(Klimkowski Arango and Morgante, 2025, Li et al., 2023, Jiao et al., 2021, Parra-Peralbo et al., 2021, Wang et al., 2020)

Mapk15

(Dobbelaere et al., 2023)

erk

(Nishida et al., 2021)

Name Synonyms

Extracellularly regulated kinase 7

(Zacharogianni et al., 2011)

Secondary FlyBase IDs

FBgn0030118
FBgn0030119

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31877

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W354

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W354

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W354

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052703

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31877/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052703

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052703

FlyMine - An integrated database for Drosophila genomics

FBgn0052703

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32703

MARRVEL_MODEL - MARRVEL (model organism gene)

31877

Linkouts

BioGRID - A database of protein and genetic interactions.

58327

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052703

DroID - A comprehensive database of gene and protein interactions.

FBgn0052703

DRSC - Results frm RNAi screens

FBgn0052703

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Erk7_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052703

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052703

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32703

Flygut - An atlas of the Drosophila adult midgut

FBgn0052703

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009470

MIST (protein-protein) - An integrated Molecular Interaction Database

31877

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9W354

References (55)

The following external sites may use different assemblies or annotations than FlyBase.

3.90

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