FB2025_04 , released October 2, 2025
Gene: Dmel\eIF4EHP
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General Information
Symbol
Dmel\eIF4EHP
Species
D. melanogaster
Name
eukaryotic translation initiation factor 4E homologous protein
Annotation Symbol
CG33100
Feature Type
protein_coding_gene
FlyBase ID
FBgn0053100
Gene Model Status
Current
Stock Availability
23 publicly available
Gene Summary
eukaryotic translation initiation factor 4E homologous protein (eIF4EHP) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA and functions as a negative regulator of translation. The product of eIF4EHP contributes to embryonic patterning by negatively regulating translation of the products of cad and hb, and is also implicated in regulating ecdysone biosynthesis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

4EHP, d4EHP, 4E-HP, eIF4E-8

Key Links
Genomic Location
Cytogenetic map
95D11-95E1
Sequence location
Recombination map
3-83
RefSeq locus
NT_033777 REGION:24063077..24108960
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables mRNA regulatory element binding translation repressor activity
inferred from mutant phenotype
(Ruscica et al., 2019)
enables protein binding
inferred from physical interaction with FLYBASE:bcd; FB:FBgn0000166
(Cho et al., 2005)
inferred from physical interaction with UniProtKB:Q7KQM6
(Ruscica et al., 2019)
inferred from physical interaction with FLYBASE:brat; FB:FBgn0010300
(Cho et al., 2006)
enables RNA 7-methylguanosine cap binding
inferred from direct assay
(Cho et al., 2005, Hernandez et al., 2005)
enables translation repressor activity
inferred from genetic interaction with FLYBASE:bcd; FB:FBgn0000166
(Cho et al., 2005)
NOT enables eukaryotic initiation factor 4G binding
inferred from direct assay
(Hernandez et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables RNA 7-methylguanosine cap binding
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
enables RNA binding
inferred from electronic annotation with InterPro:IPR001040
(InterPro Project Members, 2004-)
enables translation initiation factor activity
inferred from electronic annotation with InterPro:IPR001040
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in negative regulation of translation
inferred from genetic interaction with FLYBASE:bcd; FB:FBgn0000166
(Cho et al., 2005)
involved_in positive regulation of ecdysteroid biosynthetic process
inferred from mutant phenotype
(Valzania et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in translational initiation
inferred from electronic annotation with InterPro:IPR001040
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of eukaryotic translation initiation factor 4F complex
inferred from direct assay
(Ruscica et al., 2019)
part_of translation repressor complex
inferred from direct assay
(Zhai et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of eukaryotic translation initiation factor 4F complex
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
eukaryotic translation initiation factor 4E homologous protein (eIF4EHP) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA and functions as a negative regulator of translation. The product of eIF4EHP contributes to embryonic patterning by negatively regulating translation of the products of cad and hb, and is also implicated in regulating ecdysone biosynthesis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CYTOPLASMIC TRANSLATION INITIATION FACTORS -
Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).
Summary (Interactive Fly)

Eukaryotic initiation factor 4E - a cap binding protein that inhibits hunchback, caudal and bicoid mRNA translation - essential for the larval-pupal transition and required in the prothoracic gland for ecdysone biosynthesis

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\eIF4EHP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry E1JIV5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Shares 3' UTR sequences with downstream gene.

Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region.

Gene model reviewed during 6.04

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eIF4EHP-RA
FBtr0084587
NM_176552
1855
223
eIF4EHP-RB
FBtr0300475
NM_001170239
2401
248
eIF4EHP-RC
FBtr0303159
NM_001202345
4539
186
eIF4EHP-RD
FBtr0303160
NM_001202346
1324
242
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
eIF4EHP-PA
FBpp0083972
25.8
223
7.88
Q8T3K5
NP_788729
AAF56233
eIF4EHP-PB
FBpp0289702
28.7
248
8.72
E1JIV5
NP_001163710
ACZ95004
eIF4EHP-PC
FBpp0292258
21.6
186
7.03
C1C3I0
NP_001189274
ADV37364
eIF4EHP-PD
FBpp0292259
28.3
242
9.09
A0A0B4JDB9
NP_001189275
ADV37365
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4EHP using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.67

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
prothoracic gland
(Valzania et al., 2016)
corpus allatum
(Valzania et al., 2016)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of eukaryotic translation initiation factor 4F complex
inferred from direct assay
(Ruscica et al., 2019)
part_of translation repressor complex
inferred from direct assay
(Zhai et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\eIF4EHP in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 33 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eIF4EHP
Transgenic constructs containing regulatory region of eIF4EHP
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal (with Df(3R)Exel6197)
lethal | recessive
lethal - all die before end of P-stage, with Scer\GAL4Tub.PU
lethal - all die during larval stage, with Scer\GAL4da.G32
lethal - all die during larval stage, with Scer\GAL4phtm.PO
lethal - all die during larval stage | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | maternal effect
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal behavior | recessive
abnormal developmental rate | recessive | second instar larval stage
abnormal developmental rate | second instar larval stage, with Scer\GAL4da.G32
abnormal developmental rate | third instar larval stage, with Scer\GAL4phtm.PO
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
decreased body size | larval stage, with Scer\GAL4da.G32
decreased body size | larval stage | recessive
decreased cell size | larval stage, with Scer\GAL4phtm.PO
increased body size | larval stage, with Scer\GAL4phtm.PO
some die during embryonic stage | maternal effect
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
visible | larval stage, with Scer\GAL4da.G32
visible | larval stage | recessive
Phenotype manifest in
Allele
embryonic head segment | maternal effect
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
mesonotum, with Scer\GAL4pnr-MD237
prothoracic gland | larval stage, with Scer\GAL4phtm.PO
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\EIF4E2
12 of 14
Yes
Yes
1  
Hsap\EIF4E1B
4 of 14
No
No
Hsap\EIF4E3
4 of 14
No
Yes
Hsap\EIF4E
4 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Eif4e2
11 of 14
Yes
Yes
Rnor\Eif4e3
4 of 14
No
Yes
Rnor\Eif4e
3 of 14
No
No
Rnor\Eif4e1b
1 of 14
No
Yes
Mus musculus (laboratory mouse) (4)
Mmus\Eif4e2
11 of 14
Yes
Yes
Mmus\Eif4e1b
4 of 14
No
No
Mmus\Eif4e3
4 of 14
No
Yes
Mmus\Eif4e
4 of 14
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\eif4e2
7 of 13
Yes
Yes
Xtro\MGC89871
6 of 13
No
Yes
Xtro\eif4e1b
2 of 13
No
No
Xtro\eif4e3
2 of 13
No
Yes
Xtro\eif4e
2 of 13
No
No
Xtro\ganc
1 of 13
No
No
Xtro\kirrel2
1 of 13
No
No
Xtro\mark2
1 of 13
No
No
Danio rerio (Zebrafish) (7)
Drer\eif4e2
12 of 14
Yes
Yes
Drer\eif4e2rs1
12 of 14
Yes
Yes
Drer\eif4e1b
4 of 14
No
No
Drer\eif4e3
4 of 14
No
Yes
Drer\eif4ea
4 of 14
No
No
Drer\eif4eb
4 of 14
No
No
Drer\eif4e1c
3 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ife-4
12 of 14
Yes
Yes
Cele\ife-2
3 of 14
No
No
Cele\ife-5
3 of 14
No
No
Cele\ife-1
2 of 14
No
No
Cele\ife-3
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP002948
11 of 12
Yes
Yes
Agam\AgaP_AGAP007172
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\NCBP
9 of 13
Yes
Yes
Atha\AT1G29550
3 of 13
No
No
Atha\eIF4E3
3 of 13
No
No
Atha\EIF4E
3 of 13
No
No
Atha\LSP1
3 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CDC33
2 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\tif45
2 of 12
Yes
No
Spom\tif452
2 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:eIF4EHP. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
eIF4E6
6 of 13
eIF4E7
6 of 13
eIF4E1
5 of 13
eIF4E3
5 of 13
eIF4E4
5 of 13
eIF4E5
5 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    eIF4EHPGL01035
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    eIF4EHPHMS02703
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EIF4E2; eukaryotic translation initiation factor 4E family member 2
    12 of 14
    605895
         
        EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
        4 of 14
            EIF4E3; eukaryotic translation initiation factor 4E family member 3
            4 of 14
            609896
                EIF4E; eukaryotic translation initiation factor 4E
                4 of 14
                133440
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Summary of Genetic Interactions
                  Interaction Browsers
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  FlyBase
                  External Links
                  External Data
                  Linkouts
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Class of Gene
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3R
                  Recombination map
                  3-83
                  Cytogenetic map
                  95D11-95E1
                  Sequence location
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  95D11-95E1
                  ; Limits computationally determined from genome sequence between P{PZ}Atg600096 and P{PZ}Syx1A06737&P{PZ}Syx1A10660
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Experimentally Determined Recombination Data
                  Location

                  3-83

                  (FlyBase, 2016)

                  3-82.6

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (23)
                  Genomic Clones (25)
                  cDNA Clones (102)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  monoclonal

                  (Liang et al., 2023)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      brat and 4EHP interact physically and both play a role in hb regulation.

                      (Cho et al., 2006)
                      Relationship to Other Genes
                      Source for database merge of
                      Additional comments

                      Annotation CG10716 split into CG33100 and CG31136 (Syx1A) in release 3 of the genome annotation. In addition release 3 annotation CG31136 (Syx1A) contains sequences corresponding to release 2 annotation CG18615.

                      (FlyBase Genome Annotators, 2002-2003)
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: 4EHP CG33100

                      (Lasko, 2005.9.7)

                      Source for identity of: eIF4EHP 4EHP

                      (Marygold et al., 2017)
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (13)
                      Reported As
                      Symbol Synonym
                      4E-HP
                      (Hernández et al., 2013, Hernandez et al., 2012, Tettweiler et al., 2012, Vazquez-Pianzola and Suter, 2012)
                      4EHP
                      (Liang et al., 2023, Riemondy et al., 2023, Connacher and Goldstrohm, 2021, Ruscica et al., 2019, Muñoz-Soriano et al., 2018, Clandinin and Owens, 2016-, Ng et al., 2016, Valzania et al., 2016, Zuberek et al., 2016, Kim et al., 2015, Olesnicky et al., 2014, de Celis et al., 2013.9.11, Rodriguez et al., 2012, Carreira et al., 2011, Reis et al., 2010, Temme et al., 2010, Ayroles et al., 2009, Edwards et al., 2009, Buszczak et al., 2007, Marygold et al., 2007, Tadros et al., 2007, Zhang et al., 2007, Cho et al., 2005)
                      CG10716
                      (Robertson, 2001.5.6)
                      CG33100
                      (Marygold et al., 2017, Hosono et al., 2015, Hernández et al., 2013, Tettweiler et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Hazelett et al., 2009, Hernandez and Vazquez-Pianzola, 2005, Hernandez et al., 2005, Myrick et al., 2005.5.16)
                      CT30033
                      (Xie and Ding, 2000)
                      d4EHP
                      (Olesnicky et al., 2012, Singh et al., 2011, Yarunin et al., 2011, Okumura et al., 2007, Cho et al., 2006, Cho et al., 2005, Cho et al., 2005, Hernandez and Vazquez-Pianzola, 2005)
                      d4eHP
                      (Flora et al., 2018)
                      eIF4E
                      (Lasko, 2020)
                      eIF4E-8
                      (Hernandez et al., 2006, Hernandez and Vazquez-Pianzola, 2005, Hernandez et al., 2005)
                      eIF4EHP
                      (Dyson et al., 2025, Feuillette et al., 2020, Lee et al., 2018, Marygold et al., 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-)
                      Name Synonyms
                      4EHP
                      (Cho et al., 2005, Lasko, 2005.9.7)
                      Eukaryotic translation initiation factor 4E homologous protein
                      (Ko et al., 2023)
                      eIF4E-Homologous Protein
                      eukaryotic translation initiation factor 4E homologous protein
                      Secondary FlyBase IDs
                      • FBgn0039148
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 62 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
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