Lipocalin family member, a homologue of vertebrate Apolipoprotein D and Retinol Binding Protein 4, required for JNK-mediated stress and starvation tolerance, negatively regulates Insulin signaling, disrupting glucose homeostasis, repressing growth, and extending lifespan
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NLaz using the Feature Mapper tool.
NLaz transcript is expressed in a subset of neurons and neuroblasts in the embryonic CNS from embryonic stages 12-16. At stages 14-15, NLaz transcript is observed in 12-15 cells/hemisegment; this expression is finely temporally regulated. Most NLaz-expressing cells are located ventral to the neuropil. NLaz-expressing neuroblasts are located at the ventral midline, and may be midline precursors. There is no expression in the PNS. Non-neuronally, NLaz transcript is expressed in a group of dorsal anterior visceral mesodermal cells at embryonic stages 10-11. These cells migrate to the amnioserosa at stages 12-13. NLaz is also expressed in groups of non-epithelial sessile cells on the surface of the gut epithelium at embryonic stage 16-17.
GBrowse - Visual display of RNA-Seq signalsView Dmel\NLaz in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: NLaz CG16933
Source for merge of: NLaz BcDNA:RE67583