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General Information
Symbol
Dmel\dpy
Species
D. melanogaster
Name
dumpy
Annotation Symbol
CG33196
Feature Type
FlyBase ID
FBgn0053196
Gene Model Status
Stock Availability
Gene Snapshot
dumpy (dpy) encodes an extracellular protein involved in epidermal-cuticle attachment, aposition of wing surfaces and trachea development. [Date last reviewed: 2019-09-26]
Also Known As

dp, SP460

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:4,477,462..4,614,300 [-]
Recombination map

2-12

RefSeq locus
NT_033779 REGION:4477462..4614300
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097
(assigned by InterPro )
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence model
inferred from electronic annotation with InterPro:IPR000967
(assigned by InterPro )
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
MUCINS -
Mucin/mucin-like proteins are heavily O-glycosylated proteins characterized by proline, threonine and serine tandem repeats. Mucins form extracellular matrix networks or act as mucosal secretion lubricants. (Adapted from FBrf0205867.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
dp: dumpy
thumb
dpo: dumpy-oblique
From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 65.
thumb
dpov: dumpy-oblique vortex
Edith Wallace, unpublished.
dp alleles have variable effects on wing length and shape and on the thoracic cuticle. Presence of wing phenotype indicated by o = oblique in the allelic designation and of thoracic phenotype by v = vortex or cm = comma. The wing effect is an oblique truncation affecting the margins of the first and second posterior cells in weak alleles and reducing wings to approximately half normal length in extreme genotypes, where the truncation is more nearly perpendicular to the long axis of wing. Margins remain intact; angle between veins L2 and L5 increased, and intercrossvein distance decreased. Phenotype resembles rudimentary. Thoracic phenotype comprises five types of hypodermal irregularities: first vortices, second vortices, commas, pre-episternal pits, and posterior invagination; all five have the form of pits, eruptions, or raised pits of the cuticle (Metcalfe, 1970, Genetics 65: 627-54). First vortices are hypodermal pits or eruptions located posterolaterally on the scutum; they disrupt the acrostichal rows, resulting in surrounding whorls of microchaete. Second vortices are located anterolaterally on the scutum and resemble first vortices morphologically. Commas are comma-shaped depressions at the anterior margin of the scutum. The pre-episternal pit is in the pre-episternal plate immediately anterior to the sternopleural chaetae, which sometimes exhibit disturbed orientation (Metcalf, 1969, DIS 44: 91). The posterior invagination occurs between the laterotergite plate and the metanotum (Metcalf, 1969); different alleles exhibit different combinations of these traits. Musculature attached to disturbed regions of the cuticle often degenerates (Metcalfe, 1970). Some alleles show reduced body size and small weak legs (dph, dpobw females, dpolv/dpov). Phenotypic expression enhanced by increased temperature during development; wing and thorax effects show dominance when heterozygotes exposed to increased temperatures at 12-16 and 8-10 hr of pupal life, respectively (Blanc and Child, 1940, Physiol. Zool. 13: 65-72). Normal larvae fed 6-azauracil produce adults with oblique phenocopies; 6-azauracil feeding suppresses dp (Rizki and Rizki, 1965, Science 150: 222-23), su(r) enhances the oblique phenotype (Stroman, 1974, Hereditas 78: 157-68). The four genotypes studied [dpo2, dpovN, dpv2, and dpv; e(dpv)] show increased orotate phosphoribosyl transferase activity during third larval instar and enhanced incorportion of labeled glucose into chitin (Blass and Hunt, 1980, Mol. Gen. Genet. 178: 437-42). Many alleles are lethal when homozygous; they are identified by l in the allelic designation. Lethal stages vary among alleles, e.g., dpolv is embryonic lethal; dplv1, and dplvI die at the egg-larval boundary; dplm homozygotes die primarily at larval ecdysis between the first and second larval instar with some death at hatching and at ecdysis of second-instar larvae; dpobm homozygotes die mostly at hatching but a few die during first and second larval instars (Metcalfe, 1971, Genet. Res. 17: 173-83). In Me/+ heterozygotes, many dp alleles show a dominant oblique effect when heterozygous for dp+ and dp; dpv is an exception (Carlson, 1959). dpv homozygotes normal; show thoracic phenotype only if third chromosomes homozygous for e(dpv).
Gene Model and Products
Number of Transcripts
16
Number of Unique Polypeptides
16

Please see the JBrowse view of Dmel\dpy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0332355
59206
19560
FBtr0305141
47440
15638
FBtr0305142
48068
15105
FBtr0305145
26263
8579
FBtr0332343
68745
22743
FBtr0332344
62656
20710
FBtr0332345
71382
22949
FBtr0332346
69016
22830
FBtr0332347
56449
18641
FBtr0332348
69435
22300
FBtr0332349
67506
21657
FBtr0332350
63747
20404
FBtr0332351
56567
18014
FBtr0332352
47000
14825
FBtr0332353
54801
18095
FBtr0332354
50529
15998
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0304632
2082.0
19560
4.77
FBpp0293671
1662.7
15638
4.68
FBpp0293672
1606.4
15105
4.65
FBpp0293675
915.9
8579
5.21
FBpp0304620
2421.1
22743
4.89
FBpp0304621
2204.3
20710
4.89
FBpp0304622
2443.4
22949
4.91
FBpp0304623
2430.9
22830
4.91
FBpp0304624
1986.2
18641
5.40
FBpp0304625
2373.9
22300
4.88
FBpp0304626
2306.1
21657
4.87
FBpp0304627
2176.1
20404
4.97
FBpp0304628
1915.8
18014
4.70
FBpp0304629
1576.3
14825
4.63
FBpp0304630
1927.0
18095
5.35
FBpp0304631
1702.8
15998
5.16
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dpy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dpy in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 309 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dpy
Transgenic constructs containing regulatory region of dpy
Deletions and Duplications ( 57 )
Disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
thorax & microchaeta
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (58)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
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No
Yes
2 of 15
No
No
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No
No
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No
No
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No
Yes
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Yes
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Yes
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Yes
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No
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Yes
1 of 15
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No
1 of 15
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No
No
1  
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No
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Yes
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Yes
1 of 15
No
Yes
1 of 15
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Yes
1 of 15
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No
1 of 15
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No
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No
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No
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No
1 of 15
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No
1 of 15
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No
1 of 15
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No
1 of 15
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No
1 of 15
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No
1 of 15
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No
1 of 15
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No
1 of 15
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1 of 15
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1 of 15
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No
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No
Yes
1 of 15
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No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (49)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
Yes
3 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
0  
1 of 15
No
No
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No
No
1 of 15
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No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (43)
3 of 13
Yes
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
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No
No
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No
Yes
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Yes
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No
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Yes
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Yes
1 of 13
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Yes
1 of 13
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No
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No
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No
No
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No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
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No
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No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (47)
2 of 12
Yes
Yes
2 of 12
Yes
Yes
2 of 12
Yes
Yes
2 of 12
Yes
Yes
2 of 12
Yes
Yes
2 of 12
Yes
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
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No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
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No
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No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (90)
3 of 15
Yes
Yes
3 of 15
Yes
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
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No
1 of 15
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No
1 of 15
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No
1 of 15
No
Yes
1 of 15
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Yes
1 of 15
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Yes
1 of 15
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No
1 of 15
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No
1 of 15
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Yes
1 of 15
No
No
1 of 15
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No
1 of 15
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No
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1 of 15
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Yes
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Yes
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Yes
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Yes
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Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (26)
4 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
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No
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Yes
1 of 15
No
No
1 of 15
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No
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No
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No
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No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (5)
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes