dp, SP460
Please see the JBrowse view of Dmel\dpy for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 5.51
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dpy using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\dpy in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dp is essential for the integrity of the inner layer of the apical extracellular matrix and its link to the the apical surface of the epidermis in the embryo.
New annotation (CR33195) in release 3 of the genome annotation.
The dp gene encodes the longest transcript and protein in the Release 3 Genome Annotation.
The dp gene is extraordinarily large and encodes a 70kb cDNA which codes for a 2.5 MDa extracellular matrix protein.
9 alleles of dp have been isolated in a genetic screen for autosomal mutations that produce blisters in somatic wing clones.
Phenotypic variation of the genetic components underlying oviposition behaviour is analysed using the complete diallel mating design.
Recombination between alleles belonging to the same or different phenotypic classes allows construction of genetic map with clusters of discontinuously distributed alleles; o and olv alleles found in several clusters, other phenotypic classes confined to a single cluster.
dp alleles have variable effects on wing length and shape and on the thoracic cuticle. Presence of wing phenotype indicated by o = oblique in the allelic designation and of thoracic phenotype by v = vortex or cm = comma. The wing effect is an oblique truncation affecting the margins of the first and second posterior cells in weak alleles and reducing wings to approximately half normal length in extreme genotypes, where the truncation is more nearly perpendicular to the long axis of wing. Margins remain intact; angle between veins L2 and L5 increased and intercrossvein distance decreased. Phenotype resembles rudimentary. Thoracic phenotype comprises five types of hypodermal irregularities: first vortices, second vortices, commas, pre-episternal pits and posterior invagination; all five have the form of pits, eruptions, or raised pits of the cuticle (Metcalfe, 1970). First vortices are hypodermal pits or eruptions located posterolaterally on the scutum; they disrupt the acrostichal rows, resulting in surrounding whorls of microchaete. Second vortices are located anterolaterally on the scutum and resemble first vortices morphologically. Commas are comma-shaped depressions at the anterior margin of the scutum. The pre-episternal pit is in the pre-episternal plate immediately anterior to the sternopleural chaetae, which sometimes exhibit disturbed orientation (Metcalf, 1969). The posterior invagination occurs between the laterotergite plate and the metanotum (Metcalf, 1969); different alleles exhibit different combinations of these traits. Musculature attached to disturbed regions of the cuticle often degenerates (Metcalfe, 1970). Some alleles show reduced body size and small weak legs (dpovh, dpobw females, dpolv/dpov1). Phenotypic expression enhanced by increased temperature during development; wing and thorax effects show dominance when heterozygotes exposed to increased temperatures at 12-16 and 8-10 hr of pupal life, respectively (Blanc and Child, 1940). Normal larvae fed 6-azauracil produce adults with oblique phenocopies; 6-azauracil feeding suppresses dp (Rizki and Rizki, 1965), su(r) enhances the oblique phenotype (Stroman, 1974). The four genotypes studied <up>dpo2, dpovN, dpv2 and dpv; e(dpv)</up> show increased orotate phosphoribosyl transferase activity during third larval instar and enhanced incorporation of labeled glucose into chitin (Blass and Hunt, 1980). Many alleles are lethal when homozygous; they are identified by l in the allelic designation. Lethal stages vary among alleles, e.g., dpolv is embryonic lethal; dplv1 and dplvI die at the egg-larval boundary; dplm homozygotes die primarily at larval ecdysis between the first and second larval instar with some death at hatching and at ecdysis of second-instar larvae; dpobm homozygotes die mostly at hatching but a few die during first and second larval instars (Metcalfe, 1971). In Me/+ heterozygotes, many dp alleles show a dominant oblique effect when heterozygous for dp+ and dp; dpv is an exception (Carlson, 1959). dpv homozygotes normal; show thoracic phenotype only if third chromosomes homozygous for e(dpv).
Source for merge of: dp CG15637
Source for merge of: dp BcDNA:SD02173
Source for merge of dp BcDNA:SD02173 was a shared cDNA ( date:030728 ).
One, two, or three of the phenotypic attributes of dp (o, l, or v) may be expressed in an allele, and alleles are classified according to which attributes they exhibit; the information is generally included in the superscript designation; the order olv is roughly in accord with map order. As a rule, the heteroallelic combination of any two alleles exhibits only phenotypic features common to the two alleles <up>e.g., dpo/dpv is normal, and dpov1/dplv1 exhibits thoracic but not wing abnormalities (Carlson, 1959)</up>. Partial complementations between some pairs of olv and l or lv alleles are exceptions to this rule (Carlson, 1959; Grace, 1980).
Source for identity of: dpy dp
Renamed from 'dp' to 'dpy' to minimise confusion with the 'Dp' (' DP transcription factor') gene symbol, from which it differed only by case.