FlyBase Gene Report: Dmel\Nmdar2

General Information

Symbol

Dmel\Nmdar2

Species

D. melanogaster

Name

NMDA receptor 2

Annotation Symbol

CG33513

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053513

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dNR2, EG:80H7.7 , NR2

Key Links

Genomic Location

Cytogenetic map

2B1-2B1

Sequence location

X:1,483,625..1,507,809 [-]

Recombination map

1-0.2

RefSeq locus

NC_004354 REGION:1483625..1507809

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

contributes_to NMDA glutamate receptor activity

inferred from direct assay

(Xia et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ligand-gated ion channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

enables NMDA glutamate receptor activity

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in ionotropic glutamate receptor signaling pathway

inferred from direct assay

(Xia et al., 2005)

involved_in long-term memory

inferred from genetic interaction with FLYBASE:Nmdar1; FB:FBgn0010399

(Chen et al., 2012)

inferred from mutant phenotype

(Wu et al., 2007)

involved_in medium-term memory

inferred from mutant phenotype

(Wu et al., 2007)

involved_in sensory perception of touch

inferred from mutant phenotype

(Tsubouchi et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in ion transport

inferred from electronic annotation with InterPro:IPR001508

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from direct assay

(Xia et al., 2005)

part_of ionotropic glutamate receptor complex

inferred from physical interaction with FLYBASE:Nmdar1; FB:FBgn0010399

(Xia et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NMDA IONOTROPIC GLUTAMATE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NMDA IONOTROPIC GLUTAMATE RECEPTORS -: NMDA receptors are a sub-type of ionotropic glutamate receptor which are selectively activated by the agonist N-Methyl-D-aspartic acid (NMDA). The heterotetrameric complex binds glutamate, allowing the passage of Ca²⁺ ions through the channel. They are best characterized for their roles in excitatory synaptic transmission in the CNS. (Adapted from FBrf0218524 and FBrf0233872).

Summary (Interactive Fly)

voltage/Mg-dependent Ca channels activated by glutamate - required for olfactory learning

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nmdar2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nmdar2-RA

FBtr0091453

NM_001014716

3127

902

Nmdar2-RB

FBtr0091454

NM_001014715

3470

902

Nmdar2-RC

FBtr0070288

NM_001014714

4176

1083

Nmdar2-RD

FBtr0301842

NM_001169164

3184

902

Nmdar2-RE

FBtr0301843

NM_001169165

3194

941

Nmdar2-RF

FBtr0301844

NM_001169166

4837

1070

Nmdar2-RG

FBtr0339592

NM_001297859

6775

1082

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Nmdar2-PA

FBpp0089172

102.6

902

6.63

NP_001014716

AAN09051

Nmdar2-PB

FBpp0089173

102.6

902

6.63

NP_001014715

AAF45639

Nmdar2-PC

FBpp0070276

122.3

1083

8.08

NP_001014714

AAF45640

Nmdar2-PD

FBpp0291056

102.6

902

6.63

NP_001162635

ACZ95172

Nmdar2-PE

FBpp0291057

107.0

941

6.85

NP_001162636

ACZ95173

Nmdar2-PF

FBpp0291058

120.8

1070

8.27

NP_001162637

ACZ95174

Nmdar2-PG

FBpp0308664

122.1

1082

8.08

NP_001284788

AHN59259

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

902 aa isoforms: Nmdar2-PA, Nmdar2-PB, Nmdar2-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nmdar2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nmdar2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval central nervous system | ubiquitous

(Volkner et al., 2000)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | punctate | ubiquitous

(Xia et al., 2005)

neuron | subset of adult brain

(Chen et al., 2012)

dorsal anterior lateral neuron of the protocerebrum

(Chen et al., 2012)

ring neuron R4m

(Wu et al., 2007)

adult brain | faint | ubiquitous

(Wu et al., 2007)

calyx of adult mushroom body

(Wu et al., 2007)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Wu et al., 2007)

Additional Descriptive Data

Nmdar1 protein is expressed throughout the adult brain but more strongly in some cells. Staining is punctate which suggests synaptic localisation. Cells more strongly stained include four pairs of dorsal posterior medial DPM4 neurons (where it co-localises with Nmdar1 protein) and one pair of dorsal anterior lateral DAL2 neurons.

(Xia et al., 2005)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in integral component of membrane

inferred from direct assay

(Xia et al., 2005)

part_of ionotropic glutamate receptor complex

inferred from physical interaction with FLYBASE:Nmdar1; FB:FBgn0010399

(Xia et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Nmdar2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nmdar2

View exonic expression by tissue for Dmel\Nmdar2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0053513

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14794-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0053513

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nmdar2

Transgenic constructs containing regulatory region of Nmdar2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation

Gene disrupted in

Df(1)Exel8196

(Ryder, 2004.4.26)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Nmdar2^GD3192

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Nmdar2^GD1621

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Nmdar2^GD1621

viable, with Scer\GAL4^pnr-MD237

Nmdar2^GD1621

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal memory, with Scer\GAL4^ey-OK107

Nmdar2^{dsRNA.UAS.cWa}

abnormal memory, with Scer\GAL4^Feb170

abnormal memory | adult stage, with Hsap\RELA^AD.R58E02, Scer\GAL4^DBD.R37E10

Nmdar2^HMS02012

abnormal neuroanatomy | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

abnormal sleep | adult stage

Nmdar2^attP

abnormal touch response, with Scer\GAL4^109(2)80

Nmdar2^GD3192

abnormal touch response, with Scer\GAL4^1003.3

Nmdar2^GD3192

abnormal touch response | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

some die during pupal stage, with Scer\GAL4^pnr-MD237

Nmdar2^GD3192

Phenotype manifest in

Allele

larval dorsal multidendritic neuron ddaA | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

sensory dendrite | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar2^GD3192

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GRIN2D

14 of 15

Yes

Hsap\GRIN2C

12 of 15

Yes

Hsap\GRIN2A

11 of 15

Yes

Hsap\GRIN2B

11 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Hsap\HSP90B1

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Grin2d

13 of 15

Yes

Mmus\Grin2c

12 of 15

Yes

Mmus\Grin2a

11 of 15

Yes

Mmus\Grin2b

11 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Rattus norvegicus (Norway rat) (16)

Rnor\Grin2d

12 of 13

Yes

Rnor\Grin2a

11 of 13

Yes

Rnor\Grin2b

11 of 13

Yes

Rnor\Grin2c

11 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\Grin3b

2 of 13

Yes

Rnor\Gria1

1 of 13

Rnor\Gria2

1 of 13

Rnor\Grik1

1 of 13

Xenopus tropicalis (Western clawed frog) (13)

Xtro\grin2c

8 of 12

Yes

Xtro\grin2d

8 of 12

Yes

Xtro\grin2b

6 of 12

Yes

Xtro\grin2a

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\grik5-like.1

1 of 12

Danio rerio (Zebrafish) (33)

Drer\grin2bb

12 of 15

Yes

Drer\grin2ca

12 of 15

Yes

Drer\grin2cb

12 of 15

Yes

Drer\grin2ab

10 of 15

Yes

Drer\grin2da

9 of 15

Yes

Drer\grin2aa

8 of 15

Yes

Drer\LOC100149482

8 of 15

Yes

Drer\LOC110438919

4 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\grin3ba

2 of 15

Yes

Drer\LOC100331381

2 of 15

Drer\LOC100334689

2 of 15

Drer\LOC100334883

2 of 15

Yes

Drer\gria4a

1 of 15

Drer\grik5

1 of 15

Drer\grin3bb

1 of 15

Yes

Drer\LOC100537813

1 of 15

Drer\si:ch211-251b21.1

1 of 15

Drer\si:dkey-183j2.10

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\nmr-2

15 of 15

Yes

Cele\C08B6.5

1 of 15

Cele\F59E12.8

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T25E4.2

1 of 15

Yes

Cele\W02A2.5

1 of 15

Cele\ZK867.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (20)

Atha\GLR3.5

4 of 9

Yes

Atha\GLR5

4 of 9

Yes

3 of 9

3 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901C8 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13251

Drosophila persimilis

Dper\GL14372

Drosophila willistoni

Dwil\GK18818

Drosophila willistoni

Dwil\GK14575

Drosophila virilis

Dvir\GJ15548

Drosophila mojavensis

Dmoj\GI16039

Drosophila grimshawi

Dgri\GH17573

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500YY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021701

Glossina morsitans

Tsetse fly

Gmor\GMOY012037

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04895

Mayetiola destructor

Hessian fly

Mdes\Mdes003193

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013695

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008090

Anopheles darlingi

American malaria mosquito

Adar\ADAC006268

Anopheles gambiae

Malaria mosquito

Agam\NMDAR2

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013901

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00LM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA011691

Danaus plexippus

Monarch butterfly

Dple\DPOGS213629-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006650

Heliconius melpomene

Postman butterfly

Hmel\HMEL009738

Apis florea

Little honeybee

Aflo\4008729636

Apis mellifera

Western honey bee

Amel\GB48097

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19588

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19587

Bombus terrestris

Buff-tailed bumblebee

Bter\15209904

Linepithema humile

Argentine ant

Lhum\LH15719

Linepithema humile

Argentine ant

Lhum\LH15718

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002e5c

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012232

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10229

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00593

Tribolium castaneum

Red flour beetle

Tcas\TC032553

Pediculus humanus

Human body louse

Phum\PHUM390520

Pediculus humanus

Human body louse

Phum\PHUM390530

Rhodnius prolixus

Kissing bug

Rpro\RPRC001831

Rhodnius prolixus

Kissing bug

Rpro\RPRC006099

Rhodnius prolixus

Kissing bug

Rpro\RPRC006100

Cimex lectularius

Bed bug

Clec\CLEC007577

Cimex lectularius

Bed bug

Clec\CLEC007578

Cimex lectularius

Bed bug

Clec\CLEC005289

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008628

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18965

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18980

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00KF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011236

Strigamia maritima

European centipede

Smar\SMAR009463

Strigamia maritima

European centipede

Smar\SMAR001281

Strigamia maritima

European centipede

Smar\SMAR011168

Ixodes scapularis

Black-legged tick

Isca\ISCW005598

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73572.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80285.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80287.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65673.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73571.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g09360

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_105539

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_246687

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_105549

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_41686

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09KH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ciona intestinalis

Vase tunicate

Cint\LOC101242030

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000011809

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000007278

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027415

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (43)

Gene Symbol

Score

Source

Alignment

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D

model of early infantile epileptic encephalopathy 46

IEA

(FlyBase, 2019-)

GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B

model of autosomal dominant non-syndromic intellectual disability 6

IEA

(FlyBase, 2019-)

model of early infantile epileptic encephalopathy 27

IEA

(FlyBase, 2019-)

GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A

model of Landau-Kleffner syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D

14 of 15

602717

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 46; DEE46

early infantile epileptic encephalopathy 46

GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C

12 of 15

138254

GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A

11 of 15

138253

EPILEPSY, FOCAL, WITH SPEECH DISORDER AND WITH OR WITHOUT MENTAL RETARDATION; FESD

Landau-Kleffner syndrome

GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B

11 of 15

138252

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0053513

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31107

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.2

Cytogenetic map

2B1-2B1

Sequence location

X:1,483,625..1,507,809 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

2B1-2B1

Limits computationally determined from genome sequence between P{EP}futsch^EP1419 and P{EP}br^EP1515

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

2B-2B

(determined by in situ hybridisation)

(Louis et al., 1997)

2B1-2B10

(determined by in situ hybridisation)

(Madueno et al., 1995)

Experimentally Determined Recombination Data

Location

1-0.2

(FlyBase, 2016)

1-0.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

84548

TI{TI}Nmdar2^attP w^*/FM7a

26019

y¹ v¹; P{TRiP.JF02044}attP2

84670

TI{2A-GAL4}Nmdar2^2A-C.GAL4 w^*

84421

TI{2A-lexA::GAD}Nmdar2^2A-C.lexA w^*

29884

Mi{ET1}Nmdar2^MB09441 inc^MB09441 w¹¹¹⁸

51274

y¹ Mi{MIC}Nmdar2^MI09281 inc^MI09281 w^*

58569

y¹ Mi{MIC}Nmdar2^MI12536 inc^MI12536 w^*

40846

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02012}attP2

40928

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02176}attP40

VDRC

v12189

w¹¹¹⁸; P{GD3192}v12189

v3196

w¹¹¹⁸; P{GD1621}v3196/TM3

v12187

w¹¹¹⁸; P{GD3192}v12187/CyO

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0053513

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0053513

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31107

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wu et al., 2007)

monoclonal

(Xia et al., 2005)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Nmdar2 EG:80H7.7

(Volkner et al., 2000)

Source for database merge of

Source for merge of: Nmdar2 CG14794

(FlyBase Genome Annotators, 2005)

Additional comments

Annotations CG14793 and CG14794 merged as CG33513 (which corresponds to Nmdar2) in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 78 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31107

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0053513

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nmdar2_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0053513

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31107

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032553

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG33513

modMine - A data warehouse for the modENCODE project

FBgn0053513

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0053513

DRSC - Results frm RNAi screens

FBgn0053513

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0053513

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14794-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0053513

FlyMine - An integrated database for Drosophila genomics

FBgn0053513

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31107

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

79G8T

(Louis et al., 1997)

CG14793

(Tsubouchi et al., 2012, Benos, 2000.12.13)

CG14794

CG33513

(Kondo et al., 2020, Hu et al., 2015, Croset et al., 2010, Ni et al., 2010.12.1, Benton et al., 2009, Lee et al., 2009, Perkins et al., 2009.1.15)

CT34603

(Littleton and Ganetzky, 2000)

DmelNmdar2

(Croset et al., 2010)

DrNR2

(Fu et al., 2001)

EG:80H7.7

(Chiang et al., 2002, Benos et al., 2001, Madueno et al., 1995)

ESTS:79G8T

NMDA-R2

(Tio et al., 2016)

NMDAR

(Koenig et al., 2015)

NMDAR2

(Guo et al., 2020, Qu et al., 2018, Malik et al., 2008)

NR2

(Banreti and Meier, 2020, Pai et al., 2013, Xia and Chiang, 2009, Zachepilo et al., 2008)

anon-sts34

dNR2

(Tabuchi et al., 2018, Liu et al., 2016, Androschuk et al., 2015, Chen et al., 2012, Larkin et al., 2010, Tamura et al., 2010, Wu et al., 2007, Xia et al., 2007, Glanzman, 2005, Xia et al., 2005)

dnmdar-II

(Volkner et al., 2000)

dsNR2

(Paranjpe et al., 2012)

nmdar2

(Baker, 2020)

nr2

(Naganos et al., 2016)

Name Synonyms

NMDA receptor

(Rothenfluh and Heberlein, 2002)

NMDA receptor 2

(Tsubouchi et al., 2012, Fu et al., 2001, Volkner et al., 2000)

dNR2

(Xia et al., 2005)

Secondary FlyBase IDs

FBgn0014432
FBgn0044503

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (95)

The following external sites may use different assemblies or annotations than FlyBase.

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