calcium channel - nociceptor - mutant is pain response defective - nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pain using the Feature Mapper tool.
pain is expressed throughout the cardiac tube. Expression is stronger in the posterior heart than in the aorta.
From stage 13-16 prior to dendritic growth, the pain transcript is localized to the cytoplasm of multidendritic neuron precursors. At stage 17 and beyond the transcript is localized to dendritic branches and the extent of the dendritic localization is greater as development proceeds. pain transcript is also observed in a small number of CNS cells, sensory neurons of the antennal maxillary complex and weak expression was observed in the chordotonal neurons. Expression outside the nervous system was detected in the dorsal vessel (heart) and gonad.
GBrowse - Visual display of RNA-Seq signalsView Dmel\pain in GBrowse 2
pain is autonomously required in the larval heart to mediate the response to mechanical stress.
pain is essential for nociception, and is required for the activation of sensory neurons by noxious heat.
Identification: genetic screen for mutants defective in a noxious heat response.