Dmerlin, BG01543, D-Mer
ERM family, protein 4.1 superfamily - functions to restrain cell proliferation - a junctional component also associated with endocytosis - the spatial organization of Hippo signaling at the plasma membrane is mediated by the tumor suppressor Merlin/NF2.
Gene model reviewed during 5.51
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mer using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mer in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Mer BG01543
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Mer is specifically required only in the posterior follicle cells to initiate axis formation in the oocyte. It is not required to specify posterior follicle cell identity in response to the grk signal from the oocyte, but is required for the unknown polarising signal back to the oocyte. Mer is also required non-autonomously to maintain cell polarity and limit proliferation in the posterior follicle cells (that have received the grk signal), but is not required in embryos and larvae.
Mer and Moe are frequently coexpressed in developing tissues, but their subcellular localisations are distinct. Moe shows continuous plasma membrane association and Mer is localised in punctate structures that are associated with both the plasma membrane and the cytoplasm. Mer is associated with endocytic compartments in cultured cells.