FlyBase Gene Report: Dmel\Ubi-p5E

General Information

Symbol

Dmel\Ubi-p5E

Species

D. melanogaster

Name

Ubiquitin-5E

Annotation Symbol

CG32744

Feature Type

protein_coding_gene

FlyBase ID

FBgn0086558

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Ub, ubiquitin, Ubi

Key Links

Genomic Location

Cytogenetic map

5E4-5E4

Sequence location

X:6,276,876..6,279,647 [-]

Recombination map

1-16

RefSeq locus

NC_004354 REGION:6276876..6279647

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables protein tag activity

inferred from biological aspect of ancestor with PANTHER:PTN000071508

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000003962

(Gene Ontology Curators, 2002-)

enables structural constituent of ribosome

inferred from biological aspect of ancestor with PANTHER:PTN000071508

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in modification-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000071508

(GO Reference Genome Project, 2011-)

involved_in protein ubiquitination

inferred from sequence or structural similarity with SGD:S000003962

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000071508

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in polytene chromosome band

inferred from direct assay

(Izquierdo, 1994)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosolic ribosome

inferred from biological aspect of ancestor with PANTHER:PTN000071508

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000071508

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UBIQUITIN

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

UBIQUITIN -: Ubiquitin is a small (76 amino acid), highly conserved protein found in all eukaryotes. Through its covalent attachment to other proteins, ubiquitin can modify protein activity in numerous ways. The most well known is the targeting of proteins for proteasomal degradation. Ubiquitin is often expressed as a fusion protein, either as polyubiquitin or fused with the ribosomal proteins L40 and S27a. Ubiquitin monomers are generated by post-translational cleavage. (Adapted from PMID:12729753 and PMID:27012465)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ubi-p5E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W418)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ubi-p5E-RA

FBtr0070933

NM_167065

1916

534

Ubi-p5E-RB

FBtr0345892

NM_001298008

2390

534

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ubi-p5E-PA

FBpp0070894

60.0

534

7.91

FBpp0311816

60.0

534

7.91

Q9W418

NP_001284937

AHN59408

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

534 aa isoforms: Ubi-p5E-PA, Ubi-p5E-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubi-p5E using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ubi-p5E_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.05

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Zhan et al., 2012)

adult stage | male

testis

(Zhan et al., 2012)

adult stage | female

organism

(Zhan et al., 2012)

Additional Descriptive Data

Ubi-p5E is expressed in all developmental stages tested and in both sexes.

(Zhan et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in polytene chromosome band

inferred from direct assay

(Izquierdo, 1994)

Expression Deduced from Reporters

Reporter: P{Ubi-GAL4.U}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- adult stage

organism | ubiquitous

(Bloomington Drosophila Stock Center, 2017)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ubi-p5E in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ubi-p5E

View exonic expression by tissue for Dmel\Ubi-p5E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

326237/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086558

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086558

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086558

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32744

Flygut - An atlas of the Drosophila adult midgut

FBgn0086558

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ubi-p5E

Transgenic constructs containing regulatory region of Ubi-p5E

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 22 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Ubi-p5E^null

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (20)

Hsap\UBC

6 of 14

Yes

5 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Hsap\OASL

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (31)

Rnor\Ubc

6 of 14

Yes

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Fau

1 of 14

Rnor\Isg15

1 of 14

Yes

Rnor\LOC687780

1 of 14

Rnor\Nedd8

1 of 14

Rnor\Oas1a

1 of 14

Yes

Rnor\Oas1b

1 of 14

Yes

Rnor\Oas1d

1 of 14

Yes

Rnor\Oas1e

1 of 14

Yes

Rnor\Oas1i

1 of 14

Yes

Rnor\Oasl2

1 of 14

Yes

Rnor\Oasl

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (31)

Mmus\Ubb

6 of 14

Yes

Mmus\Ubc

6 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Nedd8

1 of 14

Mmus\Oas1a

1 of 14

Yes

Mmus\Oas1c

1 of 14

Yes

Mmus\Oas1d

1 of 14

Yes

Mmus\Oas1e

1 of 14

Yes

Mmus\Oas1f

1 of 14

Yes

Mmus\Oas1g

1 of 14

Yes

Mmus\Oas1h

1 of 14

Yes

Mmus\Oasl1

1 of 14

Yes

Mmus\Oasl2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\ubb

3 of 13

Yes

Xtro\ubc

3 of 13

Yes

Xtro\erich1

2 of 13

Xtro\ccno

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (14)

Drer\ubc

8 of 14

Yes

Drer\si:ch211-202a12.4

6 of 14

Yes

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (18)

Cele\ubq-1

7 of 14

Yes

Cele\C16C8.4

2 of 14

Yes

Cele\C16C8.11

2 of 14

Yes

Cele\F14D2.11

2 of 14

Yes

Cele\F52C6.2

2 of 14

Cele\F52C6.3

2 of 14

Cele\F52C6.4

2 of 14

Yes

Cele\ned-8

2 of 14

Cele\ubq-2

2 of 14

Cele\C16C8.5

1 of 14

Yes

Cele\C16C8.13

1 of 14

Yes

Cele\C16C8.14

1 of 14

Yes

Cele\C16C8.25

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP001971

7 of 12

Yes

Agam\AgaP_AGAP002599

6 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (48)

Atha\UBQ10

9 of 13

Yes

Atha\UBQ14

8 of 13

Atha\UBQ3

6 of 13

Yes

6 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Yes

Atha\AT1G53980

2 of 13

Yes

Atha\AT2G32350

2 of 13

Yes

Atha\AT2G36170

2 of 13

Atha\AT4G03360

2 of 13

Atha\AT4G03370

2 of 13

Yes

Atha\AT4G05230

2 of 13

Atha\AT4G05240

2 of 13

Yes

Atha\AT4G05250

2 of 13

Yes

Atha\AT4G05260

2 of 13

Yes

Atha\AT4G05270

2 of 13

Yes

Atha\AT4G05310

2 of 13

Yes

Atha\AT5G09340

2 of 13

Yes

Atha\AT7SL-1

2 of 13

Yes

Atha\EVE1

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Atha\AT1G53945

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\UBI4

8 of 13

Yes

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (9)

Spom\ubi4

8 of 12

Yes

4 of 12

4 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ubi-p5E. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (11)

11 of 13

5 of 13

5 of 13

4 of 13

4 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

6 of 14

5 of 14

RPS27A; ribosomal protein S27a

3 of 14

191343

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ubi-p5E - CG5958

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Ubi-p5E - CYLD

deubiquitinase assay, molecular weight estimation by staining, anti tag western blot

(Asaoka et al., 2016, Tsichritzis et al., 2007)

Ubi-p5E - Cap-H2

anti bait coimmunoprecipitation, anti tag western blot

(Buster et al., 2013)

Ubi-p5E - Dronc

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Kamber Kaya et al., 2017)

Ubi-p5E - Fbxl7

anti tag coimmunoprecipitation, anti tag western blot

(Bosch et al., 2014)

Ubi-p5E - Gpat4

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Ubi-p5E - Graf

pull down, western blot

(Kim et al., 2017)

Ubi-p5E - LUBEL

pull down, western blot, enzymatic study

(Asaoka et al., 2016)

Ubi-p5E - Lsd-1

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Ubi-p5E - Lsd-2

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Ubi-p5E - Marf

anti bait coimmunoprecipitation, western blot

(Poole et al., 2010)

Ubi-p5E - Pi3K21B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Ubi-p5E - Rbf

anti tag coimmunoprecipitation, anti tag western blot

(Raj et al., 2012)

Ubi-p5E - SAK

anti tag coimmunoprecipitation, western blot

(Klebba et al., 2015)

Ubi-p5E - Ufl1

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Ubi-p5E - bam

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, anti bait coimmunoprecipitation

(Ji et al., 2017)

Ubi-p5E - dachs

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Bosch et al., 2014)

Ubi-p5E - grim

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Yeh and Bratton, 2013)

Ubi-p5E - lwr

pull down, western blot

(Shih et al., 2002)

Ubi-p5E - morgue

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting, pull down

(Zhou et al., 2013)

Ubi-p5E - rdx

anti tag coimmunoprecipitation, anti tag western blot

(Zhou et al., 2015)

Ubi-p5E - rngo

anti bait coimmunoprecipitation, anti tag western blot, pull down

(Morawe et al., 2011)

Ubi-p5E - smo

anti tag coimmunoprecipitation, covalent binding, anti tag western blot

(Yang et al., 2013)

Ubi-p5E - sturkopf

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

amls

suppressible

Ubi-p5E

(Reim et al., 2014)

Axn

suppressible

Ubi-p5E

(Reim et al., 2014)

Nsf2

suppressible

Ubi-p5E

(Laviolette et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

77488

DroID - A comprehensive database of gene and protein interactions.

FBgn0086558

MIST (protein-protein) - An integrated Molecular Interaction Database

326237

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Regulation of pyruvate metabolism

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-16

Cytogenetic map

5E4-5E4

Sequence location

X:6,276,876..6,279,647 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5E4-5E4

Limits computationally determined from genome sequence between P{EP}EP1457^EP1457&P{EP}CG5928^EP1083 and P{EP}EP1311&P{EP}EP1384

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Hybridization of a polyubiquitin probe to 5E is seen in Canton-S but not in the Vallecas stock.

(Izquierdo, 1994)

Experimentally Determined Recombination Data

Location

1-16

(FlyBase, 2016)

1-16.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38967

y¹ v¹; P{TRiP.HMS01881}attP40/CyO

Kyoto

200112

y¹ w^67c23 P{GSV1}Ubi-p5E^GS1097/Binsinscy

VDRC

v330616

P{VSH330616}attP40

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (209)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH17761

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086558

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Ubi-p5E and CG11700 were derived from a single event of segmental tandem duplication. Both encode putative Ubiquitins. Ubi-p5E is conserved, ubiquitously expressed, and likely retains the function of the ancestral gene, whereas CG11700 has accumulated many nonsynonymous substitutions, has a male-specific pattern, and has likely undergone neofunctionalization.

(Zhan et al., 2012)

Annotation CG32744 renamed CR32744 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Annotation CG18282 renamed CG32744 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Antibody staining of polytene chromosomes shows that ubiquitin is mainly associated with the compact and stabilized structure that forms the bands rather than with the more decondensed and destabilized protein-DNA structure that forms interbands and puffs.

(Izquierdo, 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: Ubi-p5E CG32744

(FlyBase, 1996-)

Additional comments

The Ubi-p5E and Ubi-p63E genes share at least 50% identity.

(Langille and Clark, 2007)

Nomenclature History

Source for database identify of

Source for identity of: CR32744 CG32744

(FlyBase Genome Annotators, 2007)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG18282

(Wang et al., 2004, Luschnig, 2003.12.17, Peter et al., 2002)

CG32744

(Zuo et al., 2025, Meadows, 2018.10.31, Ristic et al., 2016, Lu et al., 2013, Christis and Munro, 2012, Zhan et al., 2012, Ni et al., 2010.12.1, Ida et al., 2009, Ditzel et al., 2008, Hughes et al., 2008, FlyBase Genome Annotators, 2007, Langille and Clark, 2007, Marygold, 2007.1.12, Laviolette et al., 2005)

CR32744

(FlyBase Genome Annotators, 2007)

DmUb

(Shih et al., 2002)

DmUbi-p5E

(Hoe et al., 2011)

(Poole et al., 2010)

(Ji et al., 2017, Kim et al., 2017, Zhou et al., 2015, Bosch et al., 2014, Yang et al., 2013, Yeh and Bratton, 2013, Zhou et al., 2013, Raj et al., 2012, Sandu et al., 2010, Tsichritzis et al., 2007, Moberg et al., 2005, Kanuka et al., 2003)

Ubi

(Klebba et al., 2015, Wu et al., 2014, Buster et al., 2013)

Ubi-p5E

(Kagemann et al., 2025, Brener et al., 2023, Zhang et al., 2023, Blount et al., 2019, Zhang and Zhang, 2019, Asaoka et al., 2016, Ashton-Beaucage et al., 2016, Lu et al., 2013, Friedman et al., 2011, Ida et al., 2009, Fisher et al., 2008, Marygold, 2007.1.12, FlyBase, 1996-, Izquierdo, 1994)

Ubiq

(Wesley and Mok, 2003)

ubip5E

(Reim et al., 2014)

Name Synonyms

CG32744

Ubiquitin

(Kolkhof et al., 2017, Herz et al., 2006, Wesley and Mok, 2003, Zoghbi and Botas, 2002, Noll et al., 2000, Pham and Sauer, 2000)

Ubiquitin-5E

(Urban et al., 2017)

ubiquitin

(Morawe et al., 2011, Simonsen et al., 2007, Moberg et al., 2005, Park et al., 2005, Finley et al., 2003, Schmitz et al., 2003, Auluck et al., 2002, Murphey and Godenschwege, 2002)

Secondary FlyBase IDs

FBgn0014439
FBgn0052744
FBgn0029855

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

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External Crossreferences and Linkouts ( 141 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

326237

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W418

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W418

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

326237/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086558

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086558

FlyMine - An integrated database for Drosophila genomics

FBgn0086558

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32744

MARRVEL_MODEL - MARRVEL (model organism gene)

326237

Linkouts

BioGRID - A database of protein and genetic interactions.

77488

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0086558

DroID - A comprehensive database of gene and protein interactions.

FBgn0086558

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ubi-p5E_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086558

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0086558

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32744

Flygut - An atlas of the Drosophila adult midgut

FBgn0086558

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0086558

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

326237

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Regulation of pyruvate metabolism

References (82)

The following external sites may use different assemblies or annotations than FlyBase.

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