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General Information
Symbol
Dmel\αTub67C
Species
D. melanogaster
Name
α-Tubulin at 67C
Annotation Symbol
CG8308
Feature Type
FlyBase ID
FBgn0087040
Gene Model Status
Stock Availability
Gene Summary
α-Tubulin at 67C (αTub67C) encodes a protein that form heterodimers with β-tubulins to polymerise and form microtubules. Tubulin molecules containing the product of αTub67C are essential for fast growth of the microtubules during the initial cleavage divisions of embryogenesis. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
Also Known As

α-tubulin, tubulin, α-Tub, α4-tubulin, α-Tub67C

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:9,681,268..9,683,370 [+]
Recombination map
3-31
RefSeq locus
NT_037436 REGION:9681268..9683370
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000172598
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR003008, InterPro:IPR008280
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000172598
(assigned by GO_Central )
Biological Process (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
inferred from mutant phenotype
involved_in embryonic cleavage
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in mRNA transport
inferred from mutant phenotype
involved_in nuclear division
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000172598
(assigned by GO_Central )
involved_in mitotic cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000172598
(assigned by GO_Central )
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
located_in cytoplasm
inferred from high throughput direct assay
located_in nucleus
inferred from high throughput direct assay
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000172598
(assigned by GO_Central )
located_in microtubule
inferred from biological aspect of ancestor with PANTHER:PTN000172598
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the tubulin family. (P06606)
Summaries
Gene Snapshot
α-Tubulin at 67C (αTub67C) encodes a protein that form heterodimers with β-tubulins to polymerise and form microtubules. Tubulin molecules containing the product of αTub67C are essential for fast growth of the microtubules during the initial cleavage divisions of embryogenesis. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
ALPHA TUBULINS -
Tubulins are cytoskeletal proteins. α- and β-tubulin heterodimers polymerise to form microtubules, the roles of which include mechanical strength, intracellular trafficking and chromosome segregation. (Adapted from PMID:1121746).
Protein Function (UniProtKB)
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
(UniProt, P06606)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
αTub67C (α4t)
A structural gene for α-Tubulin. It is transcribed into mRNA that is maternal in origin and is synthesized in the nurse cells; the transcript accumulates in 0- to 3-hr embryos and adult ovaries (Kalfayan and Wensink, 1982; Matthews et al., 1989). The protein is clearly different from the other α-Tubulins of Drosophila melanogaster as well as from those of other animal species. A stable pool of α67C tubulin is found in ovaries, unfertilized eggs, and embryos, but synthesis of the protein probably only occurs in the ovary (Matthews et al., 1989).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\αTub67C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076393
1617
462
Additional Transcript Data and Comments
Reported size (kB)

1.5 (northern blot)

2.043 (sequence analysis)

1.8 (northern blot)

1.3 (unknown)

1.7 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076122
51.2
462
4.89
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

462 (aa); 55 (kD predicted)

Comments

The location of maternal and constitutive

α-tubulins is indistinguishable until ~8 hrs of development as determined

by staining with maternal α-tubulin-specific and general α-tubulin

antibodies.

External Data
Subunit Structure (UniProtKB)

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

(UniProt, P06606)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\αTub67C using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-12 hr AEL

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

αTub67C protein is most abundant in early embryos. Levels decline between 6 and 9 hours and it is nearly undetectable after 18hr. By 8hrs, maternal tubulin has diminished in most cells of the embryo but is retained in the ventral midline. At 15hrs, staining occurs only in a single pair of connective fibers on either side of the midline.

To compare synthesis and accumulation of α-tubulin proteins, 35S</up>methionine radiolabeled tissues were subjected to Western analysis using monoclonal anti-α-tubulin antibody. A stable pool of αTub67C protein was detected in ovaries, unfertilized eggs, and embryos, but synthesis was detected only in ovaries.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
located_in cytoplasm
inferred from high throughput direct assay
located_in nucleus
inferred from high throughput direct assay
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\αTub67C in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of αTub67C
Transgenic constructs containing regulatory region of αTub67C
Aberrations (Deficiencies and Duplications) ( 10 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
centrosome & cleavage nucleus
centrosome & cleavage nucleus (with Df(3L)21mrx1)
microtubule & oocyte
microtubule & oocyte (with Df(3L)55)
oocyte & chromatin
spindle & cleavage nucleus
spindle & cleavage nucleus (with Df(3L)21mrx1)
spindle & oocyte (with αTub67C1)
spindle & oocyte (with αTub67C2)
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (25)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
Yes
5 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
1  
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
Yes
5 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
6 of 13
Yes
Yes
5 of 13
No
Yes
4 of 13
No
No
4 of 13
No
No
4 of 13
No
Yes
3 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (25)
5 of 12
Yes
Yes
4 of 12
No
Yes
4 of 12
No
Yes
3 of 12
No
No
3 of 12
No
No
3 of 12
No
No
3 of 12
No
No
3 of 12
No
No
3 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (25)
6 of 15
Yes
Yes
5 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (17)
7 of 15
Yes
Yes
6 of 15
No
Yes
6 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
No
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
4 of 9
Yes
No
4 of 9
Yes
No
4 of 9
Yes
No
4 of 9
Yes
No
1 of 9
No
No
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
7 of 15
Yes
No
6 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
4 of 12
Yes
No
4 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907ZA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504MW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
7 of 10
7 of 10
6 of 10
5 of 10
3 of 10
3 of 10
3 of 10
3 of 10
2 of 10
2 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
    (UniProt, P06606 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-31
    Cytogenetic map
    Sequence location
    3L:9,681,268..9,683,370 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    67C4-67C4
    Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    67C-67C
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location

    3-32.26 +/- 1.26

    3-

    Notes

    Left arm.

    Stocks and Reagents
    Stocks (15)
    Genomic Clones (25)
    cDNA Clones (41)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: αTub67C CG8308

      Source for database merge of
      Additional comments
      Other Comments

      RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

      sub mutants do not interact with alleles of γTub37C, αTub67C, msps, tacc or wisp.

      Mutations in αTub67C specifically impair achiasmate segregation.

      In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

      The αTub67C gene product is involved in the formation of the sperm aster, cleavage spindle apparatus formation or function and the differentiation of the embryonic nervous system.

      Nurse cell-specific genes are functional in the pseudonurse cells of otu mutants, but the transport of pum, otu, ovo and bcd RNAs to the cytoplasm is affected.

      Mutant females produce androgenetic offspring, the mutant protein results in an aberrant oocyte- and early-embryo-specific α-tubulin. The production of androgenetic exceptions is greatly enhanced when the parental females are heterozygous for αTub67C and homozygous for ncdD.

      A PCR based assay has been used to determine whether the encoded mRNAs exhibit changes in poly(A) status upon translational activation.

      αTub67C is required for nuclear division in the oocyte and early embryo. Both meiosis and cleavage stage mitoses are severely affected by mutations that result in a substantial decrease in the αTub67C/αTub84B+αTub84D ratio, though an increase has little effect on meiosis while still disrupting mitotic spindle formation.

      This maternally provided tubulin is found in all classes of microtubule from syncitial blastoderm to completion of germ band retraction, subsequently it is only retained in the CNS. Its localisation is not affected by mutations in other tubulins.

      In D.melanogaster, two multigene families, each made up of four members, code for α- and β-tubulins. Tubulins are a highly conserved family of proteins that are the main structural components of microtubules in mitotic and meiotic spindles, cilia, flagella, neural processes and the cytoskeleton; nontubulin proteins (MAPS or microtubule-associated proteins) are involved along with tubulins in the formation of specialized microtubules (FBrf0045282; FBrf0046966). αTub67C is transcribed in the nurse cells, the transcript is maternally inherited; the transcript accumulates in 0- to 3-hr embryos and adult ovaries (FBrf0037623; FBrf0049502). A stable pool of αTub67C tubulin is found in ovaries, unfertilized eggs and embryos, but synthesis of the protein probably only occurs in the ovary (FBrf0049502).

      Loss-of-function mutations are female sterile. These alleles show a dominant reduction in female fertility (FBrf0058107).

      Origin and Etymology
      Discoverer
      Etymology

      Mutation is named "Tomaj" after a Hungarian clan that vanished by the beginning of the 14th century but their names survived in the names of settlements.

      Named for a Hungarian family that vanished by the beginning of the 14th century.

      Identification
      External Crossreferences and Linkouts ( 37 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (61)
      Reported As
      Symbol Synonym
      Fs(3)Sz14
      Fs(3)Sz22
      Fs(3)Tom
      α4-tubulin
      α4t
      αTub4
      Name Synonyms
      Female sterile (3) Kavar
      Tubulin at 67C
      alpha Tubulin 67C
      alpha tubulin
      tubulin67C
      α-Tubulin at 67C
      αTubulin 67C
      Secondary FlyBase IDs
      • FBgn0001055
      • FBgn0004236
      • FBgn0001067
      • FBgn0003883
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (293)