Gene model reviewed during 5.55
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Interacts with aub (PubMed:19959991). Interacts (when methylated on arginine residues) with tud (PubMed:19959991). Forms a complex with smg, twin, aub, nos mRNA and piRNAs that target the nos 3'-untranslated region, in early embryos (PubMed:20953170). Interacts (via the N-terminal region when symmetrically methylated on arginine residues) with papi (via C-terminus); this interaction is RNA-independent and may be required for AGO3 localization to the nuage (PubMed:21447556). Interacts with TER94 and tral (PubMed:21447556).
Symmetrically dimethylated on Arg-4, Arg-68 and Arg-70, most likely by csul.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AGO3 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\AGO3 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
AGO3 acts to amplify piRNA pools and to enforce on them an antisense bias, increasing the number of piRNAs that can act to silence transposons.
New annotation (CG40300) in release 3 of the genome annotation.