E3 ubiquitin ligase - negatively regulates the Notch signaling pathway and the genes and - contributes to neuromuscular synaptogenesis, transverse tubule formation in muscles, and muscle function - formation and actin-dependent patterning of the heart
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nedd4 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Nedd4 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Nedd4 CG7555
Source for merge of: Nedd4 CG32184
Annotations CG7555 and CG32184 merged as CG42279 in release 5.8 of the genome annotation.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
New annotation (CG32184) in release 3 of the genome annotation.
Identification: in a yeast two hybrid assay for proteins that interacts with the intracellular domain of comm.