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FB2026_01
,
released March 12, 2026
eyc
a fly homolog of p47, a protein co-factor of the p97 ATPase involved in membrane fusion - mutation results in a lethal failure of nuclear envelope assembly in early zygotic divisions and results in defective photoreceptor morphogenesis - evolutionary conserved five transmembrane protein
Please see the JBrowse view of Dmel\prom for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\prom using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\prom in JBrowse2-106
2-110.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: prom CG30165 CG30166
The symbol "CG4556" has been used erroneously in FlyBase to name 2 separate annotations in different releases of the genome annotation. The release 2 annotation "CG4556" was split into 3 separate annotations (CG4556, CG30164, CG30165) in release 3 of the genome annotation, but one of these annotations mistakenly retained the "CG4556" label instead of being given a new annotation number. Annotations CG30164, CG30165 and CG30166 were subsequently merged as CG42310 (which corresponds to prom) in release 5.9 of the genome annotation. The annotation labelled "CG4556" in release 3 of the genome annotation has been renamed to CG42383 in release 5.10 of the genome annotation to avoid confusion. The CG42383 annotation lies within an intron of the CG42310 annotation in release 5.10 of the genome annotation.
Annotations CG30164, CG30165 and CG30166 merged as CG42310 (which corresponds to prom) in release 5.9 of the genome annotation.
The previous identification of CG42383 as the transcript responsible for the "eyes closed (eyc)" phenotype (FBrf0141505) was in error; the prom04012b and prom2 mutants previously referred to as "eyc" mutations map to the prom transcript.
Source for split of: CG4556
Annotation CG4556 split into CG4556, CG30164, CG30165 in release 3 of the genome annotation.
FlyBase curator comment: in FBrf0141505, the "eyes closed (eyc)" complementation group is stated to correspond to the CG42383 annotation. However, FBrf0198649 shows that the prom04012b and prom2 mutants (referred to as "eycP" and "eyc1" respectively in FBrf0198649) map to the prom transcription unit (CG42383 maps within an intron of prom). These two alleles are thus listed as alleles of prom in FlyBase. The "UAS-eyc" construct (P{UAS-eyc.S}) described in FBrf0141505 contains the CG42383 open reading frame and is thus associated with the CG42383 gene in FlyBase. The "eyc" synonym thus appears under both the prom and CG42383 genes in FlyBase.
