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FB2026_02
,
released June 18, 2026
lips, afadin, lip
glgf/dhr motif scaffolding protein - interacts with genes in both the Notch and the Ras pathways - in a complex with Pins, Canoe contributes to proper Mud localization and spindle orientation, as well as to the correct asymmetric distribution of cell-fate determinants in metaphase NBs
Please see the JBrowse view of Dmel\cno for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
No evidence for 13aa QQQRYLGQSLPAE from SWP:Q24279 in the 18th exon of this gene.
Gene model reviewed during 6.03
8.2, 7.5, 7.0 (northern blot)
1893 (aa); 200 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cno using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
cno transcripts are most abundant in embryos, decrease in larvae, and increase again in pupae and adults. The relative abundance of the three transcript species varies with developmental stage. In early stage 5 embryos, a low uniform level of cno transcripts is seen. At the cellular blastoderm stage, expression is seen along the dorsal midline and in three ectodermal stripes in the central region of the embryo. During stages 7-10, expression is confined to the dorsal furrows and the posterior midgut rudiment. Ectodermal expression becomes evident in stage 10. In stage 13, focal stainings are detected near the attachment site of the midgut with the foregut and hindgut. In eye discs, cno is expressed ubiquitously with a higher concentration of transcripts in the lateral edge region.
cno protein is localized to the adherens junctions of neuroepithelial cell in the larval inner and outer optic anlagen.
JBrowse - Visual display of RNA-Seq signals
View Dmel\cno in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
cno is required for normal proneural wave progression.
cno regulates linkage between adherens junctions and the actin cytoskeleton during morphogenesis.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
New annotation (CG31537) in release 3 of the genome annotation.
Mutants are isolated in an EMS mutagenesis screen to identify zygotic mutations affecting germ cell migration at discrete points during embryogenesis: mutants exhibit pattern defects (dorsal open).
The mechanism by which cno product controls cone cell formation in the developing compound eye is studied.
cno mutants display failure of dorsal closure.
Source for merge of: lip cno
Source for merge of: cno CG31537
Source for merge of: cno anon-WO0172774.47
snRNA:U4atac:82E is encoded in an intron of cno.
Annotations CG2534 and CG31537 merged as CG42312 in release 5.9 of the genome annotation.
"S(CycEJP)68S10" is unlikely to correspond to "cno"; mutations in the two loci complement each other.
Source for merge of cno anon-WO0172774.47 was sequence comparison ( date:051113 ).
Eleven further alleles (all EMS) discarded by Tubingen.
Source for identity of: cno CG2534
