nc82, mAb nc82, nc-82
Gene model reviewed during 5.48
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.42
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\brp using the Feature Mapper tool.
brp protein is expressed in larva and adults as discrete puncta in the presynatic active zone of the mushroom body alpha/beta, alpha'/beta' and gamma neurons and calyx.
brp protein labels the presynaptic terminals in the medulla and lamina. Co-expression of brp and Scer\GAL4cry.PE labelled cell projections was observed in the medulla, corresponding to DN3 neurons, but not in the lamina.
brp localizes opposite to clusters of glutamate receptors in the neuromuscular junction of late-stage embryos.
In lamina cross section, expression of brp is largely restricted to the ring of R1-R6 terminals within the photoreceptor cartridge, and shows a punctate distribution. Using immunoelectron microscopy, immunosignals are localized to regions of the T-bar ribbon in photoreceptor tetrads, specifically at the edge of the ribbon's platform. It is also expressed in the neuropils of the central brain.
nc82 is used as a generic marker for neuropil structures.
GBrowse - Visual display of RNA-Seq signalsView Dmel\brp in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG34146 and CG12932 merged as CG42344 in release 5.9 of the genome annotation.
Annotations CG12933, CG30336 and CG30337 merged as CG34146 (which corresponds to brp) in release 5.1 of the genome annotation.
Annotation CG1931 split into CG30337 and CG30336 in release 3 of the genome annotation.
brp mutant neuromuscular synapses suffer from active zone membrane defects, a complete loss of presynaptic dense bodies and severely depressed evoked vesicle release. Presynaptic Ca2+-channels become diffusely distributed in brp mutants.
RNAi knockdown flies show synaptic defects, impairment of walking behaviour and unstable flight.
Encodes a protein which is expressed in the neuropil structures of the adult brain.