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FB2026_01
,
released March 12, 2026
CapG, dcap-g, l(2)49Ff, l(2)vr9, vr9
Armadillo-like helical HEAT domain protein - non-SMC subunit of the condensin complex - responsible for ensuring that replicated chromosomes are condensed prior to metaphase
Please see the JBrowse view of Dmel\Cap-G for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cap-G using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Cap-G expression is highest at 0-2hr AEL, with levels declining as embryogenesis progresses. Expression is also high in adult males, but undetectable in adult females or in larvae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Cap-G in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Immunoprecipitation and complex formation studies provide evidence that Cap-G does not associate with condensin II-specific subunits, while it can be readily detected in complexes with condensin I-specific proteins in vitro and in vivo.
Cap-G has a role in disassembly of the synaptonemal complex and proper retention of the chromosomes in a metaphase I-arrested state during female meiosis.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in defects in chromosome condensation and chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Chromosome condensation appears largely unaffected in mutant embryos, while massive defects in sister chromatid segregation occur during mitosis.
Cap-G is required during mitosis for chromosome condensation during prophase and prometaphase.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
Mutants are embryonic lethal and show defects in chromosome segregation in mitosis. There are no obvious defects in condensation at prophase and metaphase, but chromosome structure is affected, as evidenced by the failure of chromosome arms to separate fully at anaphase. Chromatid separation at the centromere is unaffected, and localization and delocalization of the mei-S332 centromeric cohesion protein is also normal.
Source for merge of: CG17054 CG13327
Source for merge of: Cap-G l(2)49Ff
Annotation CG17054 split into CG34438 (which corresponds to Cap-G) and CG34439 in release 5.2 of the genome annotation.
Annotations CG13328 and CG17054 merged as CG17054 in release 3.2 of the genome annotation.
Source for identity of: Cap-G CG17054
