l(2)34Da, l(2)br38, BG:DS07660.3
disintegrin and metalloprotease motifs - neurogenic gene - crucial for proper heart formation Genes A-D-- Genes L-R -- Genes S-Z Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D. The Interactive Fly resides on the Society for Developmental Biology's Web server.
Please see the JBrowse view of Dmel\kuz for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
5.6 (longest cDNA)
1239 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kuz using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
kuz expression is enriched in border follicle cells relative to other cells in the egg chamber.
kuz transcripts are expressed ubiquitously in the embryo and in imaginal discs. They are present at the highest levels in the ventral nerve cord, the morphogenetic furrow, and the developing ommatidia of the eye-antennal disc.
The kuz transcript is expressed in all neurons of the embryonic central nervous system, and at lower levels in the epidermis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\kuz in JBrowse2-48
2-44.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
kuz provides a proteolytic activity synthesised by axons and required by them to extend growth cones through the extracellular matrix.
Identified in an adult mosaic screen; required for lateral inhibition in proneural clusters.
Source for merge of: kuz l(2)c00136
Source for merge of: kuz GS11410
Source for identity of: kuz CG7147
The gene name "kuzbanian" recalls the physical appearance of the Koozbanians (an alien life-form version of the television characters the Muppets), who sported wildly uncontrollable hair sticking up on the tops of their heads, reminiscent of the striking supernumerary bristle phenotype in mosaics for a null kuz mutation.