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FB2021_03, released June 15, 2021

Gene: Dmel\kuz

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General Information
Symbol
Dmel\kuz
Species
D. melanogaster
Name
kuzbanian
Annotation Symbol
CG7147
Feature Type
protein_coding_gene
FlyBase ID
FBgn0259984
Gene Model Status
Current
Stock Availability
30 publicly available
Gene Summary
kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)34Da, l(2)br38, BG:DS07660.3

Key Links
Genomic Location
Cytogenetic map
34C4-34C6
Sequence location
2L:13,550,139..13,639,411 [+]
Recombination map
2-48
RefSeq locus
NT_033779 REGION:13550139..13639411
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables metalloendopeptidase activity
inferred from direct assay
(Sapir et al., 2005, Qi et al., 1999, Pan and Rubin, 1997)
inferred from mutant phenotype
(Lieber et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables metalloendopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN005236519
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (18 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Coleman et al., 2010)
involved_in border follicle cell migration
inferred from mutant phenotype
(Wang et al., 2007)
involved_in cardiocyte differentiation
inferred from mutant phenotype
(Albrecht et al., 2006)
involved_in glial cell migration
inferred from mutant phenotype
(Edenfeld et al., 2007)
involved_in heart morphogenesis
inferred from mutant phenotype
(Albrecht et al., 2006)
involved_in lymph gland development
inferred from mutant phenotype
(Albrecht et al., 2006)
involved_in membrane protein ectodomain proteolysis
inferred from direct assay
(Sapir et al., 2005)
involved_in muscle tissue development
inferred from mutant phenotype
(Albrecht et al., 2006)
involved_in neuroblast fate determination
inferred from direct assay
(Udolph et al., 2009)
involved_in Notch receptor processing
inferred from direct assay
(Pan and Rubin, 1997)
inferred from mutant phenotype
(Lieber et al., 2002)
involved_in Notch signaling pathway
inferred from mutant phenotype
(Langridge and Struhl, 2017, Dornier et al., 2012, Delwig and Rand, 2008, Edenfeld et al., 2007, Wang et al., 2007, Lieber et al., 2002, Qi et al., 1999)
inferred from genetic interaction with FLYBASE:H; FB:FBgn0001169, FLYBASE:Ser; FB:FBgn0004197, FLYBASE:N; FB:FBgn0004647
(Sotillos et al., 1997)
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
(Pan and Rubin, 1997)
involved_in oogenesis
inferred from mutant phenotype
(Jagut et al., 2013)
involved_in pericardial nephrocyte differentiation
inferred from mutant phenotype
(Albrecht et al., 2006)
involved_in positive regulation of border follicle cell migration
inferred from mutant phenotype
(Wang et al., 2006)
involved_in regulation of Roundabout signaling pathway
inferred from genetic interaction with FLYBASE:robo1; FB:FBgn0005631
(Coleman et al., 2010)
involved_in ventral cord development
inferred from mutant phenotype
(Meyer et al., 2014)
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in central nervous system development
traceable author statement
(McFarlane, 2003)
involved_in membrane protein ectodomain proteolysis
inferred from sequence or structural similarity with HGNC:195
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN005236519
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in Notch signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN005236519
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of axon extension
traceable author statement
(McFarlane, 2003)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in perivitelline space
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity with HGNC:195
(FlyBase Curators, 2008--)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN005236519
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
ADAM METALLOPROTEASES -
A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin superfamily of metalloproteases. ADAM proteins are characterized by a highly conserved domain organization that generally includes a prodomain, metalloprotease domain, disintegrin-like domain, cysteine rich domain, EGF-like domain, transmembrane domain and a cytoplasmic domain. The metalloprotease domain is attributed to a process known as ectodomain shedding in which it cleaves at cell surfaces to release the ectodomains of membrane proteins. ADAM proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506 and FBrf0211961).
Pathway (FlyBase)
Notch Signaling Pathway Core Components -
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731 and FBrf0192604). Core pathway components are required for signaling from the sending cell and response in the receiving cell.
Summary (Interactive Fly)

disintegrin and metalloprotease motifs - neurogenic gene - crucial for proper heart formation

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\kuz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
gene
(Laviolette et al., 2005)
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kuz-RA
FBtr0080509
NM_057839
5605
1238
kuz-RB
FBtr0080510
NM_165047
6651
1238
kuz-RC
FBtr0100660
NM_001014481
5979
1090
kuz-RF
FBtr0301412
NM_001103690
5018
1219
kuz-RG
FBtr0342903
NM_001103689
4976
1161
Additional Transcript Data and Comments
Reported size (kB)

5.6 (longest cDNA)

(Rooke et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
kuz-PA
FBpp0080087
136.4
1238
8.71
NP_477187
AAF53318
kuz-PB
FBpp0080088
136.4
1238
8.71
NP_723825
AAN10838
kuz-PC
FBpp0100122
121.2
1090
8.26
NP_001014481
AAX52664
kuz-PF
FBpp0290626
135.3
1219
8.17
NP_001097160
ABV53680
kuz-PG
FBpp0309702
128.6
1161
8.16
NP_001097159
ABV53679
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1238 aa isoforms: kuz-PA, kuz-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

1239 (aa)

(Rooke et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kuz using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Sotillos et al., 1997)
embryonic stage 15
epidermis
(Fambrough et al., 1996)
presumptive embryonic/larval central nervous system
(Fambrough et al., 1996)
third instar larval stage
ommatidial precursor cluster
(Sotillos et al., 1997)
morphogenetic furrow
(Sotillos et al., 1997)
imaginal disc | ubiquitous
(Sotillos et al., 1997)
larval ventral nerve cord
(Sotillos et al., 1997)
eye-antennal disc
(Sotillos et al., 1997)
oogenesis stage S9 & adult stage | female
border follicle cell
(Wang et al., 2007)
oogenesis
border follicle cell
(Wang et al., 2006)
Additional Descriptive Data

kuz expression is enriched in border follicle cells relative to other cells in the egg chamber.

(Wang et al., 2006)

kuz transcripts are expressed ubiquitously in the embryo and in imaginal discs. They are present at the highest levels in the ventral nerve cord, the morphogenetic furrow, and the developing ommatidia of the eye-antennal disc.

(Sotillos et al., 1997)

The kuz transcript is expressed in all neurons of the embryonic central nervous system, and at lower levels in the epidermis.

(Fambrough et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in perivitelline space
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kuz in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 80 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kuz
Transgenic constructs containing regulatory region of kuz
Aberrations (Deficiencies and Duplications) ( 131 )
Inferred from experimentation ( 131 )
Gene duplicated in
Dp(2;3)17
(Roote, 1997.6.3, Roote, 1996.8)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Gene disrupted in
Df(2L)b80e3
(Roote et al., 1996)
Df(2L)b80f1
(Roote, 1995.3.27)
Df(2L)b80k
(Roote, 1996.8, Roote, 1995.3.27)
Df(2L)b84a2
(Roote et al., 1996)
Df(2L)b84a7
(Roote et al., 1996)
Df(2L)b84h14
(Alexandrova et al., 1996, Roote, 1995.3.27)
Df(2L)b85f2
(Alexandrova et al., 1996)
Df(2L)b87e25
(Thibault et al., 2004, Ashraf et al., 1999, Iyengar et al., 1999, Roote, 1996.8, Roote, 1995.3.27)
Df(2L)b88b15
(Roote, 1996.8)
Df(2L)b88c25
(Roote, 2000.6.5, Roote, 2000.7.3, Alexandrova et al., 1996, Roote, 1996.8, Roote et al., 1996)
Df(2L)b88c58
(Roote, 1996.8, Alexandrov and Alexandrova, 1991)
Df(2L)b88c75
(Alexandrova et al., 1996, Roote, 1996.8, Roote, 1995.3.27)
Df(2L)b88f43
(Roote, 1996.8, Roote, 1995.3.27)
Df(2L)b88h49
(Sotillos et al., 1997, Roote, 1996.8, Roote et al., 1996)
Df(2L)b89e64b
(Roote, 2000.6.5)
Df(2L)b89e68
(Roote, 2000.6.5)
Df(2L)b89e72
(Roote, 2000.6.5)
Df(2L)b89e80a
(Roote, 2000.6.5, Roote, 2000.7.3)
Df(2L)b89e88a
(Roote, 2000.6.5)
Df(2L)b89e88b
(Roote, 2000.6.5)
Df(2L)b89e96
(Roote, 2000.6.5)
Df(2L)BSC147
(Christensen and Cook, 2006.3.8)
Df(2L)BSC691
(Christensen et al., 2008.12.28)
Df(2L)Exel7058
(Ryder, 2004.4.26)
Df(2L)k07245Lk05605R-mr1
(Roote, 2000.6.13)
Df(2L)k07245Lk05605R-mr3
(Roote, 2000.6.13)
Df(2L)k07245-rv1
(Roote, 2000.6.13)
Df(2L)PZ07130-mr1
(Roote, 2000.6.13)
In(2L)b82a1
(Roote, 1995.3.27)
In(2L)b88e16
(Roote, 2000.6.5)
Tp(1;2)TE34Cc
(Gubb et al., 1986)
Tp(2;Y)b88b15
(Alexandrova et al., 1996, Roote, 1995.3.27)
Ts(YSt;2Lt)G74+Ts(YSt;2Rt)A80
(Roote et al., 1996, Roote, 1995.3.27)
Gene not disrupted in
Df(2L)64j
(Roote, 2000.7.3, Iyengar et al., 1999)
Df(2L)A47
(Fossett et al., 1994)
Df(2L)A48
(Fossett et al., 1994)
Df(2L)A63
(Fossett et al., 1994)
Df(2L)A72
(Fossett et al., 1994)
Df(2L)A178
(Fossett et al., 1994)
Df(2L)A215
(Fossett et al., 1994)
Df(2L)A217
(Fossett et al., 1994)
Df(2L)A220
(Fossett et al., 1994)
Df(2L)A245
(Fossett et al., 1994)
Df(2L)A246
(Fossett et al., 1994)
Df(2L)A264
(Fossett et al., 1994)
Df(2L)A266
(Fossett et al., 1994)
Df(2L)A267
(Fossett et al., 1994)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994)
Df(2L)A379
(Fossett et al., 1994)
Df(2L)A400
(Fossett et al., 1994)
Df(2L)A445
(Fossett et al., 1994)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)b75
(Roote, 2000.7.3)
Df(2L)b77c
(Roote, 2000.7.3)
Df(2L)b78j
(Roote, 2000.7.3)
Df(2L)b79b4
(Roote, 2000.7.3)
Df(2L)b80c1
(Iyengar et al., 1999)
Df(2L)b80k
(Roote, 2000.7.3)
Df(2L)b81l42
(Roote, 2000.7.3)
Df(2L)b83d29a
(Roote, 2000.7.3)
Df(2L)b83l1
(Roote, 2000.7.3)
Df(2L)b84a4
(Roote, 2000.7.3, Bonfini et al., 1992)
Df(2L)b84a8
(Roote, 2000.7.3)
Df(2L)b84a9
(Iyengar et al., 1999)
Df(2L)b84h1
(Bonfini et al., 1992)
Df(2L)b84h50
(Roote, 1996.8)
Df(2L)b85b1
(Roote, 2000.7.3)
Df(2L)b85f1
(Roote, 2000.7.3)
Df(2L)b88f40
(Roote, 2000.7.3)
Df(2L)b88g83
(Roote, 2000.7.3)
Df(2L)b88g96
(Roote, 1996.8)
Df(2L)b89e68
(Roote, 2000.7.3)
Df(2L)b89e72
(Roote, 2000.7.3)
Df(2L)b91l5
(Roote, 2000.7.3)
Df(2L)k07245-mr2
(Roote, 2000.6.13)
Df(2L)k07245-mr11
(Roote, 2000.6.13)
Df(2L)k07245-mr31
(Roote, 2000.6.13)
Df(2L)k07245-mr32
(Roote, 2000.6.13)
Df(2L)Sco7
(Bonfini et al., 1992)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-7
(Gubb et al., 1985)
Df(2L)TE35B-8
(Gubb et al., 1985)
Df(2L)TE35B-9
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-11
(Gubb et al., 1985)
Df(2L)TE35B-12
(Gubb et al., 1985)
Df(2L)TE35B-15
(Gubb et al., 1985)
Df(2L)TE35BC-1
(Gubb et al., 1984)
Df(2L)TE35BC-3
(Gubb et al., 1984)
Df(2L)TE35BC-4
(Gubb et al., 1984)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Gubb et al., 1984)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-28
(Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Gubb et al., 1984)
Df(2L)TE35BC-35
(Gubb et al., 1984)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2LR)b71k1A
(Bonfini et al., 1992)
In(2LR)b81a2LDTD43R
(Bonfini et al., 1992)
In(2LR)b81a2
(Bonfini et al., 1992)
Tp(2;2)A446
(Fossett et al., 1994)
Gene partially disrupted in
Df(2L)k07245-mr9
(Roote, 2000.6.13)
Df(2L)k07245-mr28
(Roote, 2000.6.13)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2L)BSC147)
lethal | recessive
lethal - all die before end of P-stage | recessive
lethal - all die during embryonic stage
partially lethal - majority die
partially lethal - majority die | recessive
viable
Other Phenotypes
Allele
abnormal behavior | somatic clone
abnormal cell migration, with Scer\GAL4c306, Scer\GAL4slbo.2.6
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4repo
abnormal neuroanatomy | dominant | embryonic stage 16
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage 16
abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4ap-md544
abnormal neuroanatomy | embryonic stage 16 | recessive
abnormal neuroanatomy | embryonic stage | recessive
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | somatic clone, with Scer\GAL4sca-109-68
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo.PU
decreased cell number, with Scer\GAL4c306, Scer\GAL4slbo.2.6
increased cell number | embryonic stage
increased cell number | embryonic stage | recessive
some die during embryonic stage
some die during pharate adult stage | recessive
visible
visible | dominant
visible | recessive
visible | recessive | somatic clone
Phenotype manifest in
Allele
aCC neuron | ectopic | somatic clone, with Scer\GAL4sca-109-68
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax | ectopic
apterous-expressing neuron of the lateral cluster of the thorax | embryonic stage | increased number
apterous-expressing neuron of the lateral cluster of the thorax Ap4 | increased number
border follicle cell, with Scer\GAL4c306, Scer\GAL4slbo.2.6
border follicle cell, with Scer\GAL4slbo.2.6
border follicle cell | heat sensitive, with Scer\GAL4slbo.2.6
commissure | embryonic stage 16
commissure | embryonic stage 16, with Scer\GAL4ap-md544
dMP2 neuron | ectopic | somatic clone, with Scer\GAL4sca-109-68
dorsal mesothorax
egg chamber | somatic clone
EL neuron | embryonic stage | increased number
embryonic dorsal vessel, with Scer\GAL4twi.PG
embryonic ganglion mother cell
embryonic heart cardioblast
embryonic heart cardioblast | increased number
embryonic heart cardioblast | increased number, with Scer\GAL4twi.PG
embryonic pericardial cell
embryonic pericardial cell, with Scer\GAL4twi.PG
embryonic somatic muscle, with Scer\GAL4sim.PS
embryonic somatic muscle, with Scer\GAL4twi.PG
eye
eye, with Scer\GAL432B
eye disc | somatic clone
eye photoreceptor cell
follicle cell | somatic clone
haltere
imaginal disc
larval longitudinal connective
larval longitudinal connective, with Scer\GAL4elav-C155
larval longitudinal connective, with Scer\GAL4sim.PS
larval longitudinal connective | embryonic stage 16
larval longitudinal connective | embryonic stage 16, with Scer\GAL4ap-md544
larval ventral nerve cord | third instar larval stage, with Scer\GAL4repo.PU
larval ventral nerve cord commissure
leg
lymph gland primordium
macrochaeta
macrochaeta | somatic clone
microchaeta
microchaeta | ectopic
microchaeta | somatic clone
nervous system
neuroblast MP2 | somatic clone, with Scer\GAL4sca-109-68
neuroblast NB1-1 | somatic clone, with Scer\GAL4sca-109-68
neuroblast NB4-2 | somatic clone, with Scer\GAL4sca-109-68
neuron & eye | somatic clone
neuron | P-stage
ommatidium | somatic clone
oocyte associated follicular epithelium | somatic clone
pCC neuron | somatic clone, with Scer\GAL4sca-109-68
peripheral glial cell, with Scer\GAL4repo
presumptive embryonic/larval central nervous system, with Scer\GAL4sim.PS
presumptive embryonic/larval central nervous system | germline clone
RP2 motor neuron | ectopic | somatic clone
RP2 motor neuron | ectopic | somatic clone, with Scer\GAL4sca-109-68
RP2sib neuron | somatic clone
RP2sib neuron | somatic clone, with Scer\GAL4sca-109-68
scutum & macrochaeta
scutum & macrochaeta, with Scer\GAL432B
scutum & macrochaeta | somatic clone
scutum & microchaeta
sense organ
subperineurial glial cell | somatic clone, with Scer\GAL4sca-109-68
symmetrical commissure
tarsal segment
vMP2 neuron | somatic clone, with Scer\GAL4sca-109-68
wing
wing, with Scer\GAL432B
wing margin | somatic clone
wing sensillum | somatic clone
wing vein, with Scer\GAL432B
wing vein | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADAM10
14 of 15
Yes
Yes
Hsap\ADAM2
2 of 15
No
No
Hsap\ADAM7
2 of 15
No
No
Hsap\ADAM17
2 of 15
No
No
Hsap\ADAM18
2 of 15
No
No
1  
Hsap\ADAM21
2 of 15
No
No
1  
Hsap\ADAM23
2 of 15
No
No
Hsap\ADAM28
2 of 15
No
No
Hsap\ADAM30
2 of 15
No
No
Hsap\ADAM32
2 of 15
No
No
Hsap\ADAMDEC1
2 of 15
No
No
Hsap\ADAM9
1 of 15
No
No
Hsap\ADAM11
1 of 15
No
No
Hsap\ADAM12
1 of 15
No
No
Hsap\ADAM15
1 of 15
No
No
Hsap\ADAM19
1 of 15
No
No
Hsap\ADAM20
1 of 15
No
No
Hsap\ADAM22
1 of 15
No
No
Hsap\ADAM29
1 of 15
No
No
Hsap\ADAM33
1 of 15
No
No
Hsap\ATN1
1 of 15
No
No
6  
Hsap\LOC101928551
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (38)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adam10
14 of 15
Yes
Yes
Mmus\Adam1a
2 of 15
No
No
Mmus\Adam1b
2 of 15
No
No
Mmus\Adam2
2 of 15
No
No
Mmus\Adam3
2 of 15
No
No
Mmus\Adam4
2 of 15
No
No
Mmus\Adam5
2 of 15
No
No
Mmus\Adam6a
2 of 15
No
No
Mmus\Adam6b
2 of 15
No
No
Mmus\Adam7
2 of 15
No
No
Mmus\Adam17
2 of 15
No
No
Mmus\Adam18
2 of 15
No
No
Mmus\Adam21
2 of 15
No
No
Mmus\Adam23
2 of 15
No
No
Mmus\Adam24
2 of 15
No
No
Mmus\Adam26a
2 of 15
No
No
Mmus\Adam26b
2 of 15
No
No
Mmus\Adam28
2 of 15
No
No
Mmus\Adam29
2 of 15
No
No
Mmus\Adam30
2 of 15
No
No
Mmus\Adam32
2 of 15
No
No
Mmus\Adam34
2 of 15
No
No
Mmus\Adamdec1
2 of 15
No
No
Mmus\Gm4787
2 of 15
No
No
Mmus\Gm5346
2 of 15
No
No
Mmus\Adam8
1 of 15
No
No
Mmus\Adam9
1 of 15
No
No
Mmus\Adam11
1 of 15
No
No
Mmus\Adam12
1 of 15
No
No
Mmus\Adam15
1 of 15
No
No
Mmus\Adam19
1 of 15
No
No
Mmus\Adam20
1 of 15
No
No
Mmus\Adam22
1 of 15
No
No
Mmus\Adam25
1 of 15
No
No
Mmus\Adam33
1 of 15
No
No
Mmus\Adam39
1 of 15
No
No
Mmus\Gm5347
1 of 15
No
Yes
Mmus\Gm33242
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (35)
Rnor\Adam10
8 of 13
Yes
Yes
Rnor\Adam2
2 of 13
No
No
Rnor\Adam3a
2 of 13
No
No
Rnor\Adam4
2 of 13
No
No
Rnor\Adam5
2 of 13
No
No
Rnor\Adam6a
2 of 13
No
No
Rnor\Adam7
2 of 13
No
No
Rnor\Adam18
2 of 13
No
No
Rnor\Adam23
2 of 13
No
No
Rnor\Adam24
2 of 13
No
No
Rnor\Adam28
2 of 13
No
No
Rnor\Adam30
2 of 13
No
No
Rnor\Adam32
2 of 13
No
No
Rnor\Adam34l
2 of 13
No
No
Rnor\Adamdec1
2 of 13
No
No
Rnor\LOC108348202
2 of 13
No
Yes
Rnor\Adam1a
1 of 13
No
No
Rnor\Adam4l1
1 of 13
No
Yes
Rnor\Adam8
1 of 13
No
No
Rnor\Adam9
1 of 13
No
No
Rnor\Adam11
1 of 13
No
No
Rnor\Adam12
1 of 13
No
No
Rnor\Adam15
1 of 13
No
No
Rnor\Adam17
1 of 13
No
No
Rnor\Adam19
1 of 13
No
No
Rnor\Adam22
1 of 13
No
No
Rnor\Adam26a
1 of 13
No
No
Rnor\Adam33
1 of 13
No
No
Rnor\Adam34
1 of 13
No
Yes
Rnor\LOC685187
1 of 13
No
Yes
Rnor\LOC100360238
1 of 13
No
No
Rnor\LOC100910087
1 of 13
No
No
Rnor\LOC100910977
1 of 13
No
No
Rnor\LOC102550654
1 of 13
No
Yes
Rnor\LOC103690152
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (18)
Xtro\adam10
9 of 12
Yes
Yes
Xtro\adam17
2 of 12
No
No
Xtro\adam23
2 of 12
No
No
Xtro\adam7
1 of 12
No
No
Xtro\adam9
1 of 12
No
No
Xtro\adam11
1 of 12
No
No
Xtro\adam12
1 of 12
No
No
Xtro\adam19
1 of 12
No
No
Xtro\adam22
1 of 12
No
No
Xtro\adam28
1 of 12
No
No
Xtro\adam33
1 of 12
No
No
Xtro\LOC100145070
1 of 12
No
Yes
Xtro\LOC100486640
1 of 12
No
No
Xtro\LOC100491788
1 of 12
No
Yes
Xtro\LOC100493925
1 of 12
No
No
Xtro\LOC100498252
1 of 12
No
No
Xtro\LOC101735040
1 of 12
No
No
Xtro\LOC105946911
1 of 12
No
No
Danio rerio (Zebrafish) (20)
Drer\adam10a
10 of 15
Yes
Yes
Drer\adam10b
8 of 15
No
Yes
Drer\si:ch1073-396h14.1
5 of 15
No
Yes
Drer\adam17a
2 of 15
No
No
Drer\adam17b
2 of 15
No
No
Drer\adam23a
2 of 15
No
No
Drer\zgc:174164
2 of 15
No
No
Drer\adam8a
1 of 15
No
No
Drer\adam8b
1 of 15
No
No
Drer\adam9
1 of 15
No
No
Drer\adam11
1 of 15
No
No
Drer\adam12
1 of 15
No
No
Drer\adam12
1 of 15
No
No
Drer\adam15
1 of 15
No
No
Drer\adam19a
1 of 15
No
No
Drer\adam19b
1 of 15
No
No
Drer\adam22
1 of 15
No
No
Drer\adam28
1 of 15
No
No
Drer\LOC101882358
1 of 15
No
No
Drer\LOC101884782
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\sup-17
14 of 15
Yes
Yes
Cele\adm-4
2 of 15
No
No
Cele\adm-2
1 of 15
No
No
Cele\F27D9.7
1 of 15
No
No
Cele\tag-275
1 of 15
No
No
Cele\unc-71
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901KV )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001697
Drosophila simulans
Dsim\GD15481
Drosophila sechellia
Dsec\GM10663
Drosophila erecta
Dere\GG23868
Drosophila yakuba
Dyak\GE18670
Drosophila ananassae
Dana\GF22940
Drosophila pseudoobscura pseudoobscura
Dpse\GA20137
Drosophila persimilis
Dper\GL26072
Drosophila willistoni
Dwil\GK24503
Drosophila virilis
Dvir\GJ17864
Drosophila mojavensis
Dmoj\GI17667
Drosophila grimshawi
Dgri\GH12996
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501SG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016149
Glossina morsitans
Tsetse fly
Gmor\GMOY006223
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09607
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00479
Mayetiola destructor
Hessian fly
Mdes\Mdes008512
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002663
Anopheles darlingi
American malaria mosquito
Adar\ADAC009942
Anopheles gambiae
Malaria mosquito
Agam\AGAP008790
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016694
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01KK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002480
Danaus plexippus
Monarch butterfly
Dple\DPOGS208907-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014673
Apis florea
Little honeybee
Aflo\2147488593
Apis mellifera
Western honey bee
Amel\GB49985
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14924
Bombus terrestris
Buff-tailed bumblebee
Bter\15203979
Linepithema humile
Argentine ant
Lhum\LH21800
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008291
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11144
Tribolium castaneum
Red flour beetle
Tcas\TC001512
Pediculus humanus
Human body louse
Phum\PHUM259590
Rhodnius prolixus
Kissing bug
Rpro\RPRC007479
Cimex lectularius
Bed bug
Clec\CLEC025001-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI062391
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16871
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02I4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007864
Strigamia maritima
European centipede
Smar\SMAR002131
Ixodes scapularis
Black-legged tick
Isca\ISCW014660
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77108.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g05320
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310789
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01J4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unk_18
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adam10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adam10L_1
Ciona intestinalis
Vase tunicate
Cint\LOC100184040
Gallus gallus
Domestic chicken
Ggal\ADAM10
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Kul
5 of 10
Tace
3 of 10
mmd
2 of 10
CG34298
1 of 10
Meltrin
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    kuzDN.UAS
    ameliorates  brain cancer
    modeled by Vps35E42
    (Li et al., 2018)
    kuzUAS.cFa
    exacerbates  Alzheimer's disease
    modeled by Appld
    (Bourdet et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ADAM10; ADAM metallopeptidase domain 10
    14 of 15
    602192
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    kuz - Dl
    protease assay, western blot, inferred by author
    (Qi et al., 1999)
    kuz - N
    protease assay, western blot, inferred by author
    (Pan and Rubin, 1997)
    kuz - Tsp3A
    anti tag coimmunoprecipitation, anti tag western blot
    (Dornier et al., 2012)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    kuz
    suppressible
    dap
    (Bivik et al., 2016)
    kuz
    suppressible
    E(spl)m8-HLH
    (Sotillos et al., 1997)
    kuz
    suppressible
    H
    (Sotillos et al., 1997)
    kuz
    suppressible
    N
    (Wang et al., 2007, Lieber et al., 2002, Sotillos et al., 1997)
    kuz
    enhanceable
    N
    (Pan and Rubin, 1997)
    kuz
    enhanceable
    pros
    (Ulvklo et al., 2012)
    kuz
    enhanceable
    robo1
    (Coleman et al., 2010)
    kuz
    enhanceable
    robo1|sli
    (Coleman et al., 2010)
    kuz
    enhanceable
    sli
    (Coleman et al., 2010)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Appl
    enhanceable
    kuz
    (Bourdet et al., 2015)
    comm
    suppressible
    kuz
    (Coleman et al., 2010)
    H
    suppressible
    kuz
    (Sotillos et al., 1997)
    Hs3st-B
    enhanceable
    kuz
    (Kamimura et al., 2004)
    N
    suppressible
    kuz
    (Lieber et al., 2002, Sotillos et al., 1997)
    N
    enhanceable
    kuz
    (Sotillos et al., 1997)
    Nsf2
    suppressible
    kuz
    (Laviolette et al., 2005)
    robo1
    enhanceable
    kuz
    (Coleman et al., 2010)
    robo1|sli
    enhanceable
    kuz
    (Coleman et al., 2010)
    Ser
    enhanceable
    kuz
    (Sotillos et al., 1997)
    sli
    enhanceable
    kuz
    (Coleman et al., 2010)
    SNF4Aγ
    suppressible
    kuz
    (Wentzell et al., 2012)
    uif
    enhanceable
    kuz
    (Xie et al., 2012)
    Vps35
    suppressible
    kuz
    (Li et al., 2018)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Notch Signaling Pathway Core Components -
    The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731 and FBrf0192604). Core pathway components are required for signaling from the sending cell and response in the receiving cell.
    Metabolic Pathways
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-48
    Cytogenetic map
    34C4-34C6
    Sequence location
    2L:13,550,139..13,639,411 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    34C4-34C6
    Limits computationally determined from genome sequence between P{PZ}kuz03782&P{lacW}kuzk14817 and P{lacW}CG7364k07245
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    34C4-34C5
    (determined by in situ hybridisation)
    (Ashburner et al., 1999, Spradling et al., 1999, Rooke et al., 1996)
    34C4-34C5
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    2-48

    (FlyBase, 2016)

    2-44.4

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (30)
    Genomic Clones (46)
    cDNA Clones (88)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: kuz CG7147

    (Guan, 1999.11)
    Source for database merge of

    Source for merge of: kuz l(2)c00136

    (Gene Disruption Project members and Exelixis, 2005)

    Source for merge of: kuz GS11410

    (FlyBase, 1996-)
    Additional comments
    Other Comments

    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

    (Stroschein-Stevenson et al., 2006)

    kuz can mediate S2 cleavage of N.

    (Lieber et al., 2002)

    The kuz metalloprotease is required for Dl ligand cleavage at the cell surface.

    (Qi et al., 1999)

    Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

    (Roch et al., 1998)

    A dominant negative form of kuz indicates that kuz is probably not involved in the release of the intracellular domain of Notch-1 protein during signalling.

    (Schroeter et al., 1998)

    kuz provides a proteolytic activity synthesised by axons and required by them to extend growth cones through the extracellular matrix.

    (Pan and Rubin, 1997)

    kuz is a component of the N signalling pathway and is involved in the activation of the N protein.

    (Sotillos et al., 1997)

    Lack of maternal kuz function does not contribute to the axon extension phenotype of kuz mutant embryos.

    (Fambrough et al., 1996)

    Identified in an adult mosaic screen; required for lateral inhibition in proneural clusters.

    (Rooke et al., 1996)

    Mosaic analysis indicates that kuz is required for cells to receive signals inhibiting the neural fate. Analyses further reveal that the development of a neuron requires a kuz-mediated positive signal from neighbouring cells.

    (Rooke et al., 1996)
    Origin and Etymology
    Discoverer
    Etymology

    The gene name "kuzbanian" recalls the physical appearance of the Koozbanians (an alien life-form version of the television characters the Muppets), who sported wildly uncontrollable hair sticking up on the tops of their heads, reminiscent of the striking supernumerary bristle phenotype in mosaics for a null kuz mutation.

    (Rooke, 1997.11.3)
    Identification
    External Crossreferences and Linkouts ( 84 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (22)
    Reported As
    Symbol Synonym
    11410
    (Laviolette et al., 2005)
    34Da
    (Bonfini et al., 1992)
    ADAM10
    (Krejcí et al., 2009)
    BG:DS07660.3
    (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
    CG7147
    (Meadows, 2017.1.11, Keleman et al., 2009.8.5, Perkins et al., 2009, González et al., 2008, Moorman et al., 2006, Metaxakis et al., 2005, Norga et al., 2003)
    CT22079
    (Hynes and Zhao, 2000)
    GS11410
    KUZ
    (Cassar and Kretzschmar, 2016, Preat and Goguel, 2016)
    Kuz
    (Wu et al., 2018, Li et al., 2014, Shimizu et al., 2014, Dornier et al., 2012, Xu and Gridley, 2012, Delwig and Rand, 2008, González et al., 2008, Prasad and Montell, 2007, Delwig et al., 2006, Loewer et al., 2004)
    br38
    (Gubb et al., 1985)
    kuz
    (Harrison et al., 2021, McLaughlin et al., 2021, Feuillette et al., 2020, Liu et al., 2020, Muliyil et al., 2020, Statzer and Ewald, 2020, Fic et al., 2019, Petri et al., 2019, Ray et al., 2019, Ray et al., 2019, Reinhardt et al., 2019, Joseph et al., 2018, Lee et al., 2018, Li et al., 2018, Rieche et al., 2018, Salazar and Yamamoto, 2018, Schwarz et al., 2018, Yang and Deng, 2018, Bhat, 2017, Langridge and Struhl, 2017, Lucchetta and Ohlstein, 2017, Ables et al., 2016, Bivik et al., 2016, Clandinin and Owens, 2016-, Dubois et al., 2016, Gene Disruption Project members, 2016-, Ramaker et al., 2016, Bivik et al., 2015, Blake et al., 2015, Bourdet et al., 2015, Duff et al., 2015, Palmer and Deng, 2015, Ashwal-Fluss et al., 2014, Toshima et al., 2014, Beckett et al., 2013, Jagut et al., 2013, Schneider et al., 2013, Sopko and Perrimon, 2013, Webber et al., 2013, Poeck et al., 2012, Rodriguez et al., 2012, Singh and Mlodzik, 2012, Ulvklo et al., 2012, Wentzell et al., 2012, Xie et al., 2012, Coleman et al., 2010, Egger et al., 2010, Saj et al., 2010, Terriente-Félix et al., 2010, Carmine-Simmen et al., 2009, Krejcí et al., 2009, Lake et al., 2009, Sellin et al., 2009, Udolph et al., 2009, Acar et al., 2008, Becam and Milán, 2008, Christensen et al., 2008.12.28, González et al., 2008, Buszczak et al., 2007, Edenfeld et al., 2007, Kankel et al., 2007, Menut et al., 2007, Wang et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Zhang et al., 2007, Albrecht et al., 2006, Koelzer and Klein, 2006, Langdon et al., 2006, Meyer and Aberle, 2006, Stroschein-Stevenson et al., 2006, Zhang et al., 2006, Burnette et al., 2005, Sapir et al., 2005, Kamimura et al., 2004, Kamimura et al., 2004)
    l(2)03782
    l(2)34Da
    (Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, Roote et al., 1996)
    l(2)br38
    (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1986, Gubb et al., 1984)
    l(2)c00136
    l(2)k01403
    (Chen et al., 1998)
    l34Da
    (Fossett et al., 1994)
    soy nut
    (Jagut et al., 2013)
    Name Synonyms
    Kuzbanian
    (Ng et al., 2019, Alfred and Vaccari, 2018, O'Keefe and Denton, 2018, Tan and Azzam, 2017, Cassar and Kretzschmar, 2016, Schweisguth, 2015, Li et al., 2014, Zacharioudaki and Bray, 2014, Singh and Mlodzik, 2012, Xie et al., 2012, Xu and Gridley, 2012, Esteve et al., 2011, Iijima-Ando and Iijima, 2010, Talora et al., 2008, Prasad and Montell, 2007, Delwig et al., 2006, Loewer et al., 2004)
    kuzbanian
    (Liu et al., 2020, Salazar and Yamamoto, 2018, Bourdet et al., 2015, Jagut et al., 2013, Cole et al., 2012.7.6, Poeck et al., 2012, Wentzell et al., 2012, Meyer et al., 2011, Perdigoto et al., 2011, Coleman et al., 2010, Terriente-Félix et al., 2010, Lake et al., 2009, Shalaby et al., 2009, Udolph et al., 2009, Nicholson et al., 2008, Kankel et al., 2007, Wang et al., 2007, Zeitouni et al., 2007, Albrecht et al., 2006, Langdon et al., 2006, Wang et al., 2006, Yepiskoposyan et al., 2006, Burnette et al., 2005)
    kuzbaninan
    (Carmine-Simmen et al., 2009)
    lethal (2) c00136
    Secondary FlyBase IDs
    • FBgn0086292
    • FBgn0015954
    • FBgn0001958
    • FBgn0010555
    • FBgn0069197
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (275)