FlyBase Gene Report: Dmel\kuz

General Information

Symbol

Dmel\kuz

Species

D. melanogaster

Name

kuzbanian

Annotation Symbol

CG7147

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259984

Gene Model Status

Current

Stock Availability

30 publicly available

Gene Snapshot

kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. [Date last reviewed: 2019-09-26]

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

l(2)34Da, l(2)br38, BG:DS07660.3

Key Links

Genomic Location

Cytogenetic map

34C4-34C6

Sequence location

2L:13,550,139..13,639,411 [+]

Recombination map

2-48

RefSeq locus

NT_033779 REGION:13550139..13639411

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (22 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from direct assay

(Sapir et al., 2005, Qi et al., 1999, Pan and Rubin, 1997)

inferred from mutant phenotype

(Lieber et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (18 terms)

Terms Based on Experimental Evidence (16 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Coleman et al., 2010)

involved_in border follicle cell migration

inferred from mutant phenotype

(Wang et al., 2007)

involved_in cardiocyte differentiation

inferred from mutant phenotype

(Albrecht et al., 2006)

involved_in glial cell migration

inferred from mutant phenotype

(Edenfeld et al., 2007)

involved_in heart morphogenesis

inferred from mutant phenotype

(Albrecht et al., 2006)

involved_in lymph gland development

inferred from mutant phenotype

(Albrecht et al., 2006)

involved_in membrane protein ectodomain proteolysis

inferred from direct assay

(Sapir et al., 2005)

involved_in muscle tissue development

inferred from mutant phenotype

(Albrecht et al., 2006)

involved_in neuroblast fate determination

inferred from direct assay

(Udolph et al., 2009)

involved_in Notch receptor processing

inferred from mutant phenotype

(Lieber et al., 2002)

inferred from direct assay

(Pan and Rubin, 1997)

involved_in Notch signaling pathway

inferred from mutant phenotype

(Langridge and Struhl, 2017, Dornier et al., 2012, Delwig and Rand, 2008, Edenfeld et al., 2007, Wang et al., 2007, Lieber et al., 2002, Qi et al., 1999)

inferred from genetic interaction with FLYBASE:H; FB:FBgn0001169, FLYBASE:Ser; FB:FBgn0004197, FLYBASE:N; FB:FBgn0004647

(Sotillos et al., 1997)

inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647

(Pan and Rubin, 1997)

involved_in oogenesis

inferred from mutant phenotype

(Jagut et al., 2013)

involved_in pericardial nephrocyte differentiation

inferred from mutant phenotype

(Albrecht et al., 2006)

involved_in positive regulation of border follicle cell migration

inferred from mutant phenotype

(Wang et al., 2006)

involved_in regulation of Roundabout signaling pathway

inferred from genetic interaction with FLYBASE:robo1; FB:FBgn0005631

(Coleman et al., 2010)

involved_in ventral cord development

inferred from mutant phenotype

(Meyer et al., 2014)

inferred from high throughput mutant phenotype

(Bivik et al., 2015)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in central nervous system development

traceable author statement

(McFarlane, 2003)

involved_in membrane protein ectodomain proteolysis

inferred from sequence or structural similarity with HGNC:195

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in Notch signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of axon extension

traceable author statement

(McFarlane, 2003)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity with HGNC:195

(FlyBase Curators, 2008--)

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ADAM METALLOPROTEASES

Pathway (FlyBase)

Notch Signaling Pathway Core Components

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ADAM METALLOPROTEASES -: A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin superfamily of metalloproteases. ADAM proteins are characterized by a highly conserved domain organization that generally includes a prodomain, metalloprotease domain, disintegrin-like domain, cysteine rich domain, EGF-like domain, transmembrane domain and a cytoplasmic domain. The metalloprotease domain is attributed to a process known as ectodomain shedding in which it cleaves at cell surfaces to release the ectodomains of membrane proteins. ADAM proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506 and FBrf0211961).

Pathway (FlyBase)

Notch Signaling Pathway Core Components -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731 and FBrf0192604). Core pathway components are required for signaling from the sending cell and response in the receiving cell.

Summary (Interactive Fly)

disintegrin and metalloprotease motifs - neurogenic gene - crucial for proper heart formation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\kuz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

gene

(Laviolette et al., 2005)

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

kuz-RA

FBtr0080509

NM_057839

5605

1238

kuz-RB

FBtr0080510

NM_165047

6651

1238

kuz-RC

FBtr0100660

NM_001014481

5979

1090

kuz-RF

FBtr0301412

NM_001103690

5018

1219

kuz-RG

FBtr0342903

NM_001103689

4976

1161

Additional Transcript Data and Comments

Reported size (kB)

5.6 (longest cDNA)

(Rooke et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

kuz-PA

FBpp0080087

136.4

1238

8.71

NP_477187

AAF53318

kuz-PB

FBpp0080088

136.4

1238

8.71

NP_723825

AAN10838

kuz-PC

FBpp0100122

121.2

1090

8.26

NP_001014481

AAX52664

kuz-PF

FBpp0290626

135.3

1219

8.17

NP_001097160

ABV53680

kuz-PG

FBpp0309702

128.6

1161

8.16

NP_001097159

ABV53679

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1238 aa isoforms: kuz-PA, kuz-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

1239 (aa)

(Rooke et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

M12.211

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kuz using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kuz_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Sotillos et al., 1997)

third instar larval stage

ommatidial precursor cluster

(Sotillos et al., 1997)

morphogenetic furrow

(Sotillos et al., 1997)

imaginal disc | ubiquitous

(Sotillos et al., 1997)

ventral nerve cord

(Sotillos et al., 1997)

eye-antennal disc

(Sotillos et al., 1997)

embryonic stage 15

epidermis

(Fambrough et al., 1996)

presumptive embryonic/larval central nervous system

(Fambrough et al., 1996)

oogenesis stage S9 & adult stage | female

border follicle cell

(Wang et al., 2007)

oogenesis

border follicle cell

(Wang et al., 2006)

Additional Descriptive Data

kuz expression is enriched in border follicle cells relative to other cells in the egg chamber.

(Wang et al., 2006)

kuz transcripts are expressed ubiquitously in the embryo and in imaginal discs. They are present at the highest levels in the ventral nerve cord, the morphogenetic furrow, and the developing ommatidia of the eye-antennal disc.

(Sotillos et al., 1997)

The kuz transcript is expressed in all neurons of the embryonic central nervous system, and at lower levels in the epidermis.

(Fambrough et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: P{Switch2}kuz^GSG4064-1

Stage

Tissue/Position (including subcellular localization)

Reference

Reporter: PBac{602.P.SVS-1}kuz^CPTI000031

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

Reporter: PBac{681.P.FSVS-1}kuz^CPTI001303

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

fan-shaped body

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kuz in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kuz

View exonic expression by tissue for Dmel\kuz

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259984

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7147

Flygut - An atlas of the Drosophila adult midgut

FBgn0259984

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 80 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 25 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kuz

Transgenic constructs containing regulatory region of kuz

Deletions and Duplications ( 131 )

Duplicated in

Dp(2;3)17

(Roote, 1997.6.3, Roote, 1996.8)

Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74

(Roote et al., 1996)

Disrupted in

Df(2L)b80e3

(Roote et al., 1996)

Df(2L)b80f1

(Roote, 1995.3.27)

Df(2L)b80k

(Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b84a2

(Roote et al., 1996)

Df(2L)b84a7

(Roote et al., 1996)

Df(2L)b84h14

(Alexandrova et al., 1996, Roote, 1995.3.27)

Df(2L)b85f2

(Alexandrova et al., 1996)

Df(2L)b87e25

(Thibault et al., 2004, Ashraf et al., 1999, Iyengar et al., 1999, Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b88b15

(Roote, 1996.8)

Df(2L)b88c25

(Roote, 2000.6.5, Roote, 2000.7.3, Alexandrova et al., 1996, Roote, 1996.8, Roote et al., 1996)

Df(2L)b88c58

(Roote, 1996.8, Alexandrov and Alexandrova, 1991)

Df(2L)b88c75

(Alexandrova et al., 1996, Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b88f43

(Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b88h49

(Sotillos et al., 1997, Roote, 1996.8, Roote et al., 1996)

(Roote, 2000.6.5)

(Roote, 2000.6.5)

(Roote, 2000.6.5)

(Roote, 2000.6.5, Roote, 2000.7.3)

(Roote, 2000.6.5)

(Roote, 2000.6.5)

(Roote, 2000.6.5)

(Christensen and Cook, 2006.3.8)

Df(2L)BSC691

(Christensen et al., 2008.12.28)

Df(2L)Exel7058

(Ryder, 2004.4.26)

Df(2L)k07245^Lk05605^R-mr1

(Roote, 2000.6.13)

Df(2L)k07245^Lk05605^R-mr3

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 1995.3.27)

(Roote, 2000.6.5)

(Gubb et al., 1986)

Tp(2;Y)b88b15

(Alexandrova et al., 1996, Roote, 1995.3.27)

Ts(YSt;2Lt)G74+Ts(YSt;2Rt)A80

(Roote et al., 1996, Roote, 1995.3.27)

Not disrupted in

Df(2L)64j

(Roote, 2000.7.3, Iyengar et al., 1999)

Df(2L)A47

(Fossett et al., 1994)

Df(2L)A48

(Fossett et al., 1994)

Df(2L)A63

(Fossett et al., 1994)

Df(2L)A72

(Fossett et al., 1994)

Df(2L)A178

(Fossett et al., 1994)

Df(2L)A215

(Fossett et al., 1994)

Df(2L)A217

(Fossett et al., 1994)

Df(2L)A220

(Fossett et al., 1994)

Df(2L)A245

(Fossett et al., 1994)

Df(2L)A246

(Fossett et al., 1994)

Df(2L)A264

(Fossett et al., 1994)

Df(2L)A266

(Fossett et al., 1994)

Df(2L)A267

(Fossett et al., 1994)

Df(2L)A337

(Fossett et al., 1994)

Df(2L)A376

(Fossett et al., 1994)

Df(2L)A379

(Fossett et al., 1994)

Df(2L)A400

(Fossett et al., 1994)

Df(2L)A445

(Fossett et al., 1994)

Df(2L)Adh-nBR100

(Fossett et al., 1994)

Df(2L)Adh-nBR101

(Fossett et al., 1994)

Df(2L)Adh-nBR102

(Fossett et al., 1994)

Df(2L)Adh-nBR103

(Fossett et al., 1994)

Df(2L)Adh-nBR105

(Fossett et al., 1994)

Df(2L)Adh-nBR106

(Fossett et al., 1994)

Df(2L)Adh-nBR107

(Fossett et al., 1994)

Df(2L)Adh-nBR117

(Fossett et al., 1994)

Df(2L)Adh-nBR118

(Fossett et al., 1994)

Df(2L)Adh-nBR119

(Fossett et al., 1994)

Df(2L)Adh-nBR120

(Fossett et al., 1994)

Df(2L)Adh-nBR121

(Fossett et al., 1994)

Df(2L)Adh-nBR122

(Fossett et al., 1994)

Df(2L)Adh-nBR125

(Fossett et al., 1994)

Df(2L)Adh-nBR126

(Fossett et al., 1994)

Df(2L)Adh-nBR127

(Fossett et al., 1994)

Df(2L)Adh-nBR128

(Fossett et al., 1994)

Df(2L)Adh-nBR129

(Fossett et al., 1994)

Df(2L)Adh-nBR130

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR131

(Fossett et al., 1994)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Iyengar et al., 1999)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3, Bonfini et al., 1992)

Df(2L)b84a8

(Roote, 2000.7.3)

Df(2L)b84a9

(Iyengar et al., 1999)

Df(2L)b84h1

(Bonfini et al., 1992)

(Roote, 1996.8)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 1996.8)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Bonfini et al., 1992)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35B-3

(Gubb et al., 1985)

Df(2L)TE35B-4

(Gubb et al., 1985)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35B-7

(Gubb et al., 1985)

Df(2L)TE35B-8

(Gubb et al., 1985)

Df(2L)TE35B-9

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-11

(Gubb et al., 1985)

Df(2L)TE35B-12

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35BC-1

(Gubb et al., 1984)

Df(2L)TE35BC-3

(Gubb et al., 1984)

Df(2L)TE35BC-4

(Gubb et al., 1984)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-7

(Gubb et al., 1984)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Gubb et al., 1984)

Df(2L)TE35BC-28

(Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

In(2L)TE35B-13

(Gubb et al., 1985)

In(2LR)b71k1A

(Bonfini et al., 1992)

In(2LR)b81a2^LDTD43^R

(Bonfini et al., 1992)

In(2LR)b81a2

(Bonfini et al., 1992)

Tp(2;2)A446

(Fossett et al., 1994)

Partially disrupted in

Df(2L)k07245-mr9

(Roote, 2000.6.13)

Df(2L)k07245-mr28

(Roote, 2000.6.13)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal (with Df(2L)BSC147)

kuz^{MI03306-TG4.1}

lethal | recessive

lethal - all die before end of embryonic stage

lethal - all die before end of P-stage | recessive

kuz^1405Rev11

partially lethal - majority die

kuz⁰³⁷⁸²

partially lethal - majority die | recessive

kuz⁰³⁷⁸²

viable

Other Phenotypes

Allele

behavior defective | somatic clone

kuz¹

cell migration defective, with Scer\GAL4^c306, Scer\GAL4^slbo.2.6

kuz^KK103555

decreased cell number, with Scer\GAL4^c306, Scer\GAL4^slbo.2.6

kuz^KK103555

increased cell number | embryonic stage

kuz^e29-4

increased cell number | embryonic stage | recessive

kuz^e29-4

neuroanatomy defective

neuroanatomy defective, with Scer\GAL4^repo

kuz^DN.UAS

neuroanatomy defective | dominant | embryonic stage 16

kuz^H143

neuroanatomy defective | embryonic stage

neuroanatomy defective | embryonic stage 16

neuroanatomy defective | embryonic stage 16, with Scer\GAL4^ap-md544

kuz^DN.UAS

neuroanatomy defective | embryonic stage 16 | recessive

kuz^H143

neuroanatomy defective | embryonic stage | recessive

kuz^e29-4

neuroanatomy defective | somatic clone

kuz^k01405

neuroanatomy defective | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

neuroanatomy defective | third instar larval stage, with Scer\GAL4^repo.PU

kuz^UAS.G

some die during embryonic stage

some die during pharate adult stage | recessive

kuz^1405Rev11

visible

kuz^e29-4

visible | dominant

visible | recessive

visible | recessive | somatic clone

Phenotype manifest in

Allele

aCC neuron | ectopic | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

apterous-expressing neuron of the lateral cluster of the thorax

apterous-expressing neuron of the lateral cluster of the thorax | ectopic

apterous-expressing neuron of the lateral cluster of the thorax | embryonic stage | supernumerary

kuz^e29-4

apterous-expressing neuron of the lateral cluster of the thorax Ap4 | supernumerary

border follicle cell, with Scer\GAL4^c306, Scer\GAL4^slbo.2.6

kuz^KK103555

border follicle cell, with Scer\GAL4^slbo.2.6

kuz^DN.UAS

border follicle cell | heat sensitive, with Scer\GAL4^slbo.2.6

kuz^DN.UAS

commissure

kuz^unspecified

dMP2 neuron | ectopic | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

dorsal mesothorax

kuz^k01405

egg chamber | somatic clone

kuz^soynut-46.10

EL neuron | embryonic stage | supernumerary

kuz^e29-4

embryonic dorsal vessel, with Scer\GAL4^twi.PG

kuz^DN.UAS

embryonic ganglion mother cell

kuz^e29-4

embryonic heart cardioblast

kuz^e29-4

embryonic heart cardioblast | supernumerary

embryonic heart cardioblast | supernumerary, with Scer\GAL4^twi.PG

kuz^DN.UAS

embryonic pericardial cell

kuz^R1-4

embryonic pericardial cell, with Scer\GAL4^twi.PG

kuz^DN.UAS

embryonic somatic muscle, with Scer\GAL4^sim.PS

kuz^DN.UAS

embryonic somatic muscle, with Scer\GAL4^twi.PG

kuz^DN.UAS

eye

eye, with Scer\GAL4^32B

kuz^DN.UAS

eye disc | somatic clone

kuz^40-19

eye photoreceptor cell

kuz^DN.ro.hs

follicle cell | somatic clone

kuz^soynut-46.10

haltere

kuz^k01405

imaginal disc

leg

kuz^k01405

longitudinal connective

kuz^unspecified

longitudinal connective, with Scer\GAL4^elav-C155

kuz^DN.UAS

longitudinal connective, with Scer\GAL4^sim.PS

kuz^DN.UAS

longitudinal connective | embryonic stage 16

longitudinal connective | embryonic stage 16, with Scer\GAL4^ap-md544

kuz^DN.UAS

lymph gland primordium

kuz^R1-4

macrochaeta

macrochaeta | somatic clone

microchaeta

kuz^k01405

microchaeta | ectopic

kuz^DN.hs

microchaeta | somatic clone

midline crossing tract | embryonic stage 16

midline crossing tract | embryonic stage 16, with Scer\GAL4^ap-md544

kuz^DN.UAS

nervous system

kuz^e29-4

neuroblast MP2 | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

neuroblast NB1-1 | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

neuroblast NB4-2 | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

neuron & eye | somatic clone

kuz^ES24

neuron | P-stage

kuz^k01405

ommatidium | somatic clone

kuz¹

oocyte associated follicular epithelium | somatic clone

kuz^soynut-46.10

pCC neuron | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

peripheral glial cell, with Scer\GAL4^repo

kuz^DN.UAS

presumptive embryonic/larval central nervous system, with Scer\GAL4^sim.PS

kuz^DN.UAS

presumptive embryonic/larval central nervous system | germline clone

kuz^e29-4

RP2 motor neuron | ectopic | somatic clone

kuz^k01405

RP2 motor neuron | ectopic | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

RP2sib neuron | somatic clone

kuz^k01405

RP2sib neuron | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

scutum & macrochaeta

scutum & macrochaeta, with Scer\GAL4^32B

kuz^DN.UAS

scutum & macrochaeta | somatic clone

kuz¹

scutum & microchaeta

kuz^DN.hs

sense organ

kuz^k01405

subperineurial glial cell | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

tarsal segment

kuz^k01405

ventral nerve cord | third instar larval stage, with Scer\GAL4^repo.PU

kuz^UAS.G

ventral nerve cord commissure

kuz^unspecified

vMP2 neuron | somatic clone, with Scer\GAL4^sca-109-68

kuz^DN.UAS

wing

wing, with Scer\GAL4^32B

kuz^DN.UAS

wing margin | somatic clone

kuz^H143

wing sensillum | somatic clone

kuz^k01405

wing vein, with Scer\GAL4^32B

kuz^DN.UAS

wing vein | somatic clone

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ADAM10

14 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (38)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Adam10

14 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Gm33242

1 of 15

Yes

Rattus norvegicus (Norway rat) (35)

Rnor\Adam10

8 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\Adam1a

1 of 13

Rnor\Adam4l1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\LOC685187

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\LOC103690152

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (18)

Xtro\adam10

9 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\LOC100486640

1 of 12

Xtro\LOC100491788

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (20)

Drer\adam10a

10 of 15

Yes

Drer\adam10b

8 of 15

Yes

Drer\si:ch1073-396h14.1

5 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\sup-17

14 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901KV )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20137

Drosophila persimilis

Dper\GL26072

Drosophila willistoni

Dwil\GK24503

Drosophila virilis

Dvir\GJ17864

Drosophila mojavensis

Dmoj\GI17667

Drosophila grimshawi

Dgri\GH12996

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501SG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17016149

Glossina morsitans

Tsetse fly

Gmor\GMOY006223

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09607

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00479

Mayetiola destructor

Hessian fly

Mdes\Mdes008512

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002663

Anopheles darlingi

American malaria mosquito

Adar\ADAC009942

Anopheles gambiae

Malaria mosquito

Agam\AGAP008790

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ016694

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01KK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002480

Danaus plexippus

Monarch butterfly

Dple\DPOGS208907-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014673

Apis florea

Little honeybee

Aflo\2147488593

Apis mellifera

Western honey bee

Amel\GB49985

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14924

Bombus terrestris

Buff-tailed bumblebee

Bter\15203979

Linepithema humile

Argentine ant

Lhum\LH21800

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008291

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11144

Tribolium castaneum

Red flour beetle

Tcas\TC001512

Pediculus humanus

Human body louse

Phum\PHUM259590

Rhodnius prolixus

Kissing bug

Rpro\RPRC007479

Cimex lectularius

Bed bug

Clec\CLEC025001-PB

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI062391

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16871

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02I4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007864

Strigamia maritima

European centipede

Smar\SMAR002131

Ixodes scapularis

Black-legged tick

Isca\ISCW014660

Stegodyphus mimosarum

African social velvet spider

Smim\KFM77108.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g05320

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_310789

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01J4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unk_18

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adam10

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adam10L_1

Ciona intestinalis

Vase tunicate

Cint\LOC100184040

Gallus gallus

Domestic chicken

Ggal\ADAM10

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

Kul

5 of 10

Tace

3 of 10

mmd

2 of 10

CG34298

1 of 10

Meltrin

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

ADAM10; ADAM metallopeptidase domain 10

model of Alzheimer's disease 18

IEA

(FlyBase, 2019-)

model of reticulate acropigmentation of Kitamura

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

kuz^DN.UAS

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

kuz^UAS.cFa

exacerbates Alzheimer's disease

modeled by Appl^d

(Bourdet et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADAM10; ADAM metallopeptidase domain 10

14 of 15

602192

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

kuz - Dl

protease assay, western blot, inferred by author

(Qi et al., 1999)

kuz - N

protease assay, western blot, inferred by author

(Pan and Rubin, 1997)

kuz - Tsp3A

anti tag coimmunoprecipitation, anti tag western blot

(Dornier et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kuz

suppressible

dap

(Bivik et al., 2016)

kuz

suppressible

E(spl)m8-HLH

(Sotillos et al., 1997)

kuz

suppressible

(Sotillos et al., 1997)

kuz

suppressible

(Wang et al., 2007, Lieber et al., 2002, Sotillos et al., 1997)

kuz

enhanceable

(Pan and Rubin, 1997)

kuz

enhanceable

pros

(Ulvklo et al., 2012)

kuz

enhanceable

robo1

(Coleman et al., 2010)

kuz

enhanceable

robo1|sli

(Coleman et al., 2010)

kuz

enhanceable

sli

(Coleman et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Appl

enhanceable

kuz

(Bourdet et al., 2015)

comm

suppressible

kuz

(Coleman et al., 2010)

suppressible

kuz

(Sotillos et al., 1997)

Hs3st-B

enhanceable

kuz

(Kamimura et al., 2004)

enhanceable

kuz

(Sotillos et al., 1997)

suppressible

kuz

(Lieber et al., 2002, Sotillos et al., 1997)

Nsf2

suppressible

kuz

(Laviolette et al., 2005)

robo1

enhanceable

kuz

(Coleman et al., 2010)

robo1|sli

enhanceable

kuz

(Coleman et al., 2010)

Ser

enhanceable

kuz

(Sotillos et al., 1997)

sli

enhanceable

kuz

(Coleman et al., 2010)

SNF4Aγ

suppressible

kuz

(Wentzell et al., 2012)

enhanceable

(Xie et al., 2012)

suppressible

(Li et al., 2018)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60806

DroID - A comprehensive database of gene and protein interactions.

FBgn0259984

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34772

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Notch Signaling Pathway Core Components -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731 and FBrf0192604). Core pathway components are required for signaling from the sending cell and response in the receiving cell.

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-48

Cytogenetic map

34C4-34C6

Sequence location

2L:13,550,139..13,639,411 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34C4-34C6

Limits computationally determined from genome sequence between P{PZ}kuz⁰³⁷⁸²&P{lacW}kuz^k14817 and P{lacW}CG7364^k07245

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

34C4-34C5

(determined by in situ hybridisation)

(Ashburner et al., 1999, Spradling et al., 1999, Rooke et al., 1996)

34C4-34C5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-48

(FlyBase, 2016)

2-44.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (30)

5804

6578

5816

24048

w¹¹¹⁸; Mi{ET1}kuz^MB03175

40316

w^*; P{Switch2}kuz^GSG4064-1

63339

w¹¹¹⁸; PBac{IT.GAL4}kuz^0468-G4

43583

y¹ w^*; Mi{MIC}kuz^MI06235

108432

108838

108440

v330255

v107036

More stocks available...

Genomic Clones (46)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (88)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0259984

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259984

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34772

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: kuz CG7147

(Guan, 1999.11)

Source for database merge of

Source for merge of: kuz l(2)c00136

(Gene Disruption Project members and Exelixis, 2005)

Source for merge of: kuz GS11410

(FlyBase, 1996-)

Additional comments

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

kuz can mediate S2 cleavage of N.

(Lieber et al., 2002)

The kuz metalloprotease is required for Dl ligand cleavage at the cell surface.

(Qi et al., 1999)

Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

(Roch et al., 1998)

A dominant negative form of kuz indicates that kuz is probably not involved in the release of the intracellular domain of Notch-1 protein during signalling.

(Schroeter et al., 1998)

kuz provides a proteolytic activity synthesised by axons and required by them to extend growth cones through the extracellular matrix.

(Pan and Rubin, 1997)

kuz is a component of the N signalling pathway and is involved in the activation of the N protein.

(Sotillos et al., 1997)

Lack of maternal kuz function does not contribute to the axon extension phenotype of kuz mutant embryos.

(Fambrough et al., 1996)

Identified in an adult mosaic screen; required for lateral inhibition in proneural clusters.

(Rooke et al., 1996)

Mosaic analysis indicates that kuz is required for cells to receive signals inhibiting the neural fate. Analyses further reveal that the development of a neuron requires a kuz-mediated positive signal from neighbouring cells.

(Rooke et al., 1996)

Origin and Etymology

Discoverer

Etymology

The gene name "kuzbanian" recalls the physical appearance of the Koozbanians (an alien life-form version of the television characters the Muppets), who sported wildly uncontrollable hair sticking up on the tops of their heads, reminiscent of the striking supernumerary bristle phenotype in mosaics for a null kuz mutation.

(Rooke, 1997.11.3)

Identification

External Crossreferences and Linkouts ( 82 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34772

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0259984

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kuz_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7147

Flygut - An atlas of the Drosophila adult midgut

FBgn0259984

FlyMine - An integrated database for Drosophila genomics

FBgn0259984

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34772

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001512

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7147

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

M12.211

modMine - A data warehouse for the modENCODE project

FBgn0259984

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q59DZ3

Linkouts

BioGRID - A database of protein and genetic interactions.

60806

DroID - A comprehensive database of gene and protein interactions.

FBgn0259984

DRSC - Results frm RNAi screens

FBgn0259984

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259984

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34772

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

11410

(Laviolette et al., 2005)

34Da

(Bonfini et al., 1992)

ADAM10

(Krejcí et al., 2009)

BG:DS07660.3

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG7147

(Meadows, 2017.1.11, Keleman et al., 2009.8.5, Perkins et al., 2009, González et al., 2008, Moorman et al., 2006, Metaxakis et al., 2005, Norga et al., 2003)

CT22079

(Hynes and Zhao, 2000)

GS11410

KUZ

(Cassar and Kretzschmar, 2016, Preat and Goguel, 2016)

Kuz

(Wu et al., 2018, Li et al., 2014, Shimizu et al., 2014, Dornier et al., 2012, Xu and Gridley, 2012, Delwig and Rand, 2008, González et al., 2008, Prasad and Montell, 2007, Delwig et al., 2006, Loewer et al., 2004)

br38

(Gubb et al., 1985)

kuz

(Feuillette et al., 2020, Liu et al., 2020, Muliyil et al., 2020, Fic et al., 2019, Petri et al., 2019, Ray et al., 2019, Ray et al., 2019, Reinhardt et al., 2019, Joseph et al., 2018, Lee et al., 2018, Li et al., 2018, Rieche et al., 2018, Salazar and Yamamoto, 2018, Schwarz et al., 2018, Yang and Deng, 2018, Bhat, 2017, Langridge and Struhl, 2017, Lucchetta and Ohlstein, 2017, Ables et al., 2016, Bivik et al., 2016, Clandinin and Owens, 2016-, Dubois et al., 2016, Gene Disruption Project members, 2016-, Ramaker et al., 2016, Bivik et al., 2015, Blake et al., 2015, Bourdet et al., 2015, Duff et al., 2015, Palmer and Deng, 2015, Ashwal-Fluss et al., 2014, Toshima et al., 2014, Beckett et al., 2013, Jagut et al., 2013, Schneider et al., 2013, Sopko and Perrimon, 2013, Webber et al., 2013, Poeck et al., 2012, Rodriguez et al., 2012, Singh and Mlodzik, 2012, Ulvklo et al., 2012, Wentzell et al., 2012, Xie et al., 2012, Coleman et al., 2010, Egger et al., 2010, Saj et al., 2010, Terriente-Félix et al., 2010, Carmine-Simmen et al., 2009, Krejcí et al., 2009, Lake et al., 2009, Sellin et al., 2009, Udolph et al., 2009, Acar et al., 2008, Becam and Milán, 2008, Christensen et al., 2008.12.28, González et al., 2008, Buszczak et al., 2007, Edenfeld et al., 2007, Kankel et al., 2007, Menut et al., 2007, Wang et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Zhang et al., 2007, Albrecht et al., 2006, Koelzer and Klein, 2006, Langdon et al., 2006, Meyer and Aberle, 2006, Stroschein-Stevenson et al., 2006, Zhang et al., 2006, Burnette et al., 2005, Sapir et al., 2005, Kamimura et al., 2004, Kamimura et al., 2004)

l(2)03782

l(2)34Da

(Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, Roote et al., 1996)

l(2)br38

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1986, Gubb et al., 1984)

l(2)c00136

l(2)k01403

(Chen et al., 1998)

l34Da

(Fossett et al., 1994)

soy nut

(Jagut et al., 2013)

Name Synonyms

Kuzbanian

(Ng et al., 2019, Alfred and Vaccari, 2018, O'Keefe and Denton, 2018, Tan and Azzam, 2017, Cassar and Kretzschmar, 2016, Schweisguth, 2015, Li et al., 2014, Zacharioudaki and Bray, 2014, Singh and Mlodzik, 2012, Xie et al., 2012, Xu and Gridley, 2012, Esteve et al., 2011, Iijima-Ando and Iijima, 2010, Talora et al., 2008, Prasad and Montell, 2007, Delwig et al., 2006, Loewer et al., 2004)

kuzbaninan

(Carmine-Simmen et al., 2009)

lethal (2) c00136

Secondary FlyBase IDs

FBgn0086292
FBgn0015954
FBgn0001958
FBgn0010555
FBgn0069197

Datasets (0)

Study focus (0)

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References (270)

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