lwf, beltless, lot's wife, blt, lots wife
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene merge based on EST/cDNA data (RE74651)
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drd using the Feature Mapper tool.
Comment: authors state "late (darkly pigmented)" pupa
GBrowse - Visual display of RNA-Seq signalsView Dmel\drd in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG32589 and CG5652 merged as CG33968 in release 4.3 of the genome annotation.
Not allelic to any of six adult-lethal (adl) genes mapping between v and f.
Mutant flies show a reduction in the transfer of ingested food from the crop to the midgut and an increased rate of crop contraction compared to controls.
Mutant drd flies store significantly more food in their crops and defecate less than wild-type flies.
Identification: In an EMS screen for mutations that confer salt sensitivity in Drosophila.
Embryos in which beltless function has been reduced using RNA interference display a range of cuticular defects, ranging from partially differentiated cuticle to misdirected and partially formed denticle belts, and lack of denticle belts in abdominal segments A2-A4. The embryos fail to hatch.
The ovaries of adult females in which beltless function has been reduced using RNA interference are smaller than normal 72 hours after treatment with dsRNA, and the connections between the ovarioles are disorganised and loose. These females lay significantly fewer eggs than controls.
Approximately 65% of beltless RNAi embryos develop cuticular abnormalities, ranging from partially differentiated cuticle to misdirected and only partially-formed denticle belts.
New annotation (CG32589) in release 3 of the genome annotation.
In drd mutants the temporal pattern of expression of three different molecular biomarkers is accelerated.
The expression pattern of drd suggests the gene function is required in specific glial cell types that play a role in the maintenance of brain integrity.
Adult mutants exhibit severe behavioural defects and brain degeneration, these manifest a few days after emergence. Mosaic analysis reveals the drd gene product is non-cell autonomous. Defective glia in the adult brain may disrupt adult nervous system function, contributing to progressive brain degeneration and death. The wild type drd gene product may prevent brain degeneration by providing a necessary glial function.
After normal development and normal behavior of young adults, flies begin to walk in uncoordinated manner and rapidly die (all dead by approximately ten days posteclosion); before death, there are gross holes in brain; mosaic experiment suggests primary defect is in brain. Second allele (drd2) causes similar effects with rapid death of population 9-11 days post-eclosion plus reduced female fertility.
The gene is named "beltless" based on the embryonic loss of function phenotype of missing denticle belts.