embryonic lethal, abnormal vision, embryonic lethal abnormal visual system, EC7, EG:65F1.2 , l(1)G0031
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.46
Multiple (sequential) stage-specific extensions of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Antisense UTR: 3'UTR antisense to arg on opposite strand.
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\elav using the Feature Mapper tool.
elav exhibits exclusive zygotic expression beginning at 2-4 hr after fertilization (AF). It displays sequential, phased lengthening of the 3' UTR during embryogenesis. An initial 3' UTR extension is seen at 4-6 hr, and an even longer extension appears several hours later, between 12 and 14 hr AF. The 3' UTR extension isoforms are highly enriched in nervous system tissues.
The elav protein, which contains RNA-binding motifs, is distributed non-uniformly in the nucleus, and may be part of a larger ribonucleoprotein complex.
elav is used a marker for immature larval photorecetor cells and continues to be expressed in larval photoreceptor cells of the Bolwig organ throughout the larval stages.
Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.
staining is first visible in the R8 cells immediately posterior to the morphogenetic furrow and continues as other photoreceptors are recruited into the cluster.
The localization of elav protein in different developmental stages is consistent with its proposed neuronal housekeeping function. elav protein is first detected after stage 9 of embryogenesis, and is expressed in the CNS during stages 11 to 15. Between stages 13 and 15, elav protein begins to be expressed in the developing PNS. In third instar larvae, elav protein is found in the brain, and in the eye-antennal disc. Twelve hours post-pupariation, elav protein is found in the brain, including the optic lobe, and in the eye-antennal disc. In 72 hour pupae, elav protein continues to be expressed in the brain, including the optic lobe, in the developing eye, and in the cortex of the developing thoracic ganglion. In the adult, elav protein is expressed in the brain, eye, antennae, and the thoracic ganglion. elav protein is not found in neuroblasts, GMCs, glial cells, or in non-neuronal tissues.
GBrowse - Visual display of RNA-Seq signalsView Dmel\elav in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Four EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
Amino acid residues 333 to 374 in the hinge region of elav are necessary for nuclear localisation.
Two distinct temperature-sensitive alleles of elav are suppressed nonsense mutations of the same tryptophan codon.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
Embryonic lethal, or in the case of viable and ostensibly hypomorphic alleles, displays poor jumping and flying ability plus aberrant visual physiology and behavior. No morphological abnormalities visible in sections of dying embryos (elav1, elav2, or elav3). elavts1 allows survival to adult stage at 19oC-25oC but viability is reduced and adults usually die soon after eclosion; viability after rearing at 30oC is very low and newly emerged adults show poor coordination and die soon; this temperature-sensitive allele also causes morphological abnormalities in the brain, especially in the visual system (after postembryonic shift from 19oC to 30oC or even following all development at low-temperature). In studies of viable alleles, elav19 and elav20, both of which are temperature-sensitive, flying and jumping ability shown to be especially aberrant after rearing at 29oC; wing position also aberrant; elavts1 most severe, including having no optomotor response when raised at high (or even low) temperature.
The divergence of the gene sequences in the amino terminal region reflects lowered functional constraint, rather than species-specific functional specification.
Mutations of elav cause abnormalities in the electroretinogram (ERG) and/or prolonged depolarization after potential (PDA).
RNA localisation studies demonstrate that the elav gene product provides a function which is required for the proper development and maintenance of all neurons.
Whole-mount embryos show periodic interruptions in the longitudinal connectives of the CNS and missing commissures especially the posterior ones.
Mosaic analysis of elav1 suggests both directly induced defects in optic lobe development, as well as inductively caused CNS defects mediated through expression of this mutation in the eye (i. e., such that the visual system's ganglia are genotypically normal). Lethal "focusing" in elav1 mosaics suggests influence of gene on derivatives of ventral blastoderm.
elav gene function is autonomously essential in the eye, is essential for normal development of the optic lobes and not necessary in most major imaginal disc cell derivatives with the exception of the eye disc.
"weniger" means "less" in German.