Gene: Dmel\γTub23C
γ-tubulin, γ tubulin, γTub, γ-Tub, γtubulin
γ Tubulin at 23C - microtubule nucleating factor - critical component of microtubule organizing centers - γ Tubulin ring complex components Grip75 and Grip128 have an essential microtubule-anchoring function in the Drosophila germline
Please see the JBrowse view of Dmel\γTub23C for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
1.875 (longest cDNA)
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with Ote.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\γTub23C using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\γTub23C in GBrowse 22-8
2-6.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: γTub23C l(2)23Ce
The "Pearl-2" allele of "γTub23C" (γTub23CPl-2) maps to the same chromosomal location as the Pl1 mutant allele of the "Pl, Pearl" locus. Both mutations have the same unique combination of mutant phenotypes, but the Pl1 mutation is no longer extant and so the relationship between the "γTub23C" and "Pl" loci cannot be tested.
γTub23C is required for efficient recruitment of pericentriolar material.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of an aberrantly long, monopolar spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
SL2 cells treated with dsRNA against γTub23C show a clear increase in the mitotic index compared to control cells. The treated cells show bipolar monastral and monopolar anastral spindle organisation with metaphase-like chromosome arrangements.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Subcellular localisation of the protein during the cell cycle of cells with and without centrioles is determined. Data suggests centrioles are not essential to the formation of a functional mitotic spindle, but participate in the focal concentration of γTub23C and γTub37C protein during both interphase and mitosis.
γTub23C is required for spermatogenesis.
γTub23C is required for the structure as well as the function of the microtubule organising center MTOC.
Drosophila γ tubulin is part of a complex containing Cp190 and Map60 gene products.
γTub23C has been cloned and sequenced.
Isolated from a D.melanogaster ovary cDNA library using an A.nidulans mipA gene cDNA probe, under low stringency conditions.
A γTub23C cDNA has been cloned and sequenced.
