Gene model reviewed during 5.50
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.41
Gene model reviewed during 5.55
Alternative translation stop created by use of multiphasic reading frames within coding region.
Interacts with Dlish (via N-terminus including SH3 domain 1); this leads to palmitoylation of Dlish by app. Interacts with ft; this is likely to interfere with the interaction between app and Dlish, reducing the ability of app to palmitoylate Dlish and tether it to the apical cell cortex.
The DHHC domain is required for palmitoyltransferase activity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\app using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\app in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New annotation (CR32097) in release 3 of the genome annotation.
Candidate gene for tibia length quantitative trait locus.
Mutation analysis suggests app is involved in pattern formation of the wings, legs and thorax.
Mutant alleles have abnormal legs, with reduction of tarsal segments (at least). The wings are reduced in size with the crossveins closer together than in the wild-type. Body size is normally reduced. These phenotypes appear to be due to abnormal apoptosis.
Curry, 25th Jan. 1934.