FlyBase Gene Report: Dmel\Atg13

General Information

Symbol

Dmel\Atg13

Species

D. melanogaster

Name

Autophagy-related 13

Annotation Symbol

CG7331

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261108

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Autophagy-related 13 (Atg13) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

84F13-84F14

Sequence location

3R:8,349,815..8,352,817 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8349815..8352817

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Atg101; FB:FBgn0030960

(Hegedűs et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein kinase regulator activity

inferred from sequence or structural similarity with SGD:S000006389

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in intestinal epithelial structure maintenance

inferred from mutant phenotype

(Wen et al., 2017)

involved_in larval midgut cell programmed cell death

inferred from mutant phenotype

(Xu et al., 2015, Chang et al., 2013)

involved_in macroautophagy

inferred from mutant phenotype

(Wen et al., 2017, Xu et al., 2015, Chang et al., 2013, Pircs et al., 2012, Barth et al., 2011, Chang and Neufeld, 2009)

inferred from genetic interaction with FLYBASE:Atg1; FB:FBgn0260945

(Zhao et al., 2023)

involved_in positive regulation of nurse cell apoptotic process

inferred from mutant phenotype

(Nezis et al., 2010)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in autophagosome assembly

inferred from electronic annotation with InterPro:IPR040182

(InterPro Project Members, 2004-)

involved_in autophagy

inferred from electronic annotation with InterPro:IPR018731

(InterPro Project Members, 2004-)

involved_in mitophagy

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

involved_in piecemeal microautophagy of the nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

involved_in protein localization to phagophore assembly site

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of Atg1/ULK1 kinase complex

inferred from direct assay

(Nagy et al., 2014, Kim et al., 2013, Chang and Neufeld, 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

part_of Atg1/ULK1 kinase complex

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR018731

(InterPro Project Members, 2004-)

is_active_in autophagosome

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

is_active_in phagophore assembly site

inferred from biological aspect of ancestor with PANTHER:PTN001268151

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES

ATG1 PROTEIN KINASE COMPLEX

Protein Family (UniProt)

Belongs to the ATG13 family. Metazoan subfamily. (Q9VHR6)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Autophagy-related 13 (Atg13) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES -: The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material. It takes place by the assembly of a double membrane vesicle, the autophagosome, which delivers cargo to the lysosome for recycling. (Adapted from FBrf0219844 and FBrf020902).
ATG1 PROTEIN KINASE COMPLEX -: The Atg1 protein kinase complex, is an autophagy-specific complex of the Atg1 Ser/Thr kinase and regulatory subunits. It is required in the early biogenesis of the autophagosome. (Adapted from FBrf0219844 and PMID:23999079).

Protein Function (UniProtKB)

Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1-Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.

(UniProt, Q9VHR6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Atg13 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VHR6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Atg13-RA

FBtr0081843

NM_141539

3003

523

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Atg13-PA

FBpp0081333

56.9

523

6.74

Q9VHR6

NP_649796

AAF54234

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Atg1.

(UniProt, Q9VHR6)

Post Translational Modification

Phosphorylated in a nutrient-, TOR- and Atg1 kinase-dependent manner.

(UniProt, Q9VHR6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg13 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Atg13_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.50

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 13 -- 16

larval foregut atrium

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic foregut sensory structure

(Fisher et al., 2012)

embryonic maxillary sensory complex

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval fat body

(Nagy et al., 2014)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of Atg1/ULK1 kinase complex

inferred from direct assay

(Nagy et al., 2014, Kim et al., 2013, Chang and Neufeld, 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Atg13 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Atg13

View exonic expression by tissue for Dmel\Atg13

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261108

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40998/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261108

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037582

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261108

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7331

Flygut - An atlas of the Drosophila adult midgut

FBgn0261108

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Atg13

Transgenic constructs containing regulatory region of Atg13

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6148

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of P-stage, with Scer\GAL4^Mef2.PU

Atg13^KK100340

lethal - all die before end of pupal stage | recessive

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Atg13^GD12202

viable, with Scer\GAL4^Mef2.PR

Atg13^GD12202

viable, with Scer\GAL4^pnr-MD237

Atg13^GD12202

viable, with Scer\GAL4^tin.CΔ4

Atg13^GD12202

Sterility

Allele

fertile | germline clone (with Atg13^Δ74)

Atg13^Δ81

fertile | germline clone (with Atg13^Δ81)

Atg13^Δ74

Other Phenotypes

Allele

abnormal cell death | germline clone (with Atg13^Δ74)

Atg13^Δ81

abnormal cell death | germline clone (with Atg13^Δ81)

Atg13^Δ74

abnormal size | adult stage | somatic clone

Atg13^Δ81

abnormal size | P-stage, with Scer\GAL4^NP0001

Atg13^HMS02028

abnormal size | somatic clone | third instar larval stage

Atg13^Δ81

abnormal starvation stress response | larval stage, with Scer\GAL4^Cg.PU

Atg13^HMS02028

decreased cell death | P-stage, with Scer\GAL4^NP0001

Atg13^HMS02028

increased cell size, with Scer\GAL4^NP0001

Atg13^KK100340

short lived, with Scer\GAL4^Tub.PU

Atg13^KK100340

some die during pupal stage | recessive

visible | adult stage | somatic clone

Atg13^Δ81

Phenotype manifest in

Allele

adult fat body | nutrition conditional, with Scer\GAL4^Tub.PU

Atg13^KK100340

adult midgut epithelium, with Scer\GAL4^NP0001

Atg13^KK100340

adult midgut epithelium, with Scer\GAL4^Tub.PU

Atg13^KK100340

autophagosome | adult stage | nutrition conditional, with Scer\GAL4^Tub.PU

Atg13^KK100340

dorsal appendage | somatic clone

Atg13^Δ81

egg | somatic clone

Atg13^Δ81

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PU

Atg13^HMS02028

embryonic/larval fat body | somatic clone

embryonic/larval fat body | third instar larval stage

Atg13^Δ81

embryonic/larval midgut | P-stage, with Scer\GAL4^NP0001

Atg13^HMS02028

eye | somatic clone

Atg13^Δ81

eye-antennal disc | somatic clone | third instar larval stage

Atg13^Δ81

gastric caecum | P-stage, with Scer\GAL4^NP0001

Atg13^HMS02028

lysosome | adult stage | nutrition conditional, with Scer\GAL4^Tub.PU

Atg13^KK100340

nurse cell | germline clone | oogenesis stage S14

Atg13^Δ81

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\ATG13

11 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Atg13

10 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Atg13

10 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\atg13

8 of 13

Yes

Xtro\scn5a

1 of 13

Danio rerio (Zebrafish) (1)

Drer\atg13

11 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\atg-13

7 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP005715

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\ATG13

3 of 13

Yes

Atha\AT3G18770

2 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ATG13

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\atg13

2 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Atg13. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

Atg13^NIG.7331R

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

Atg13^HMS02028

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

Atg13^UAS.cCa

ameliorates Niemann-Pick disease

modeled by Npc1a^KK101077

(Danielsen et al., 2016)

Atg13^Δ81

ameliorates cancer

modeled by scrib⁶⁷³, Ras85D^V12.UAS

(Katheder et al., 2017)

modeled by Ras85D^V12.cUa.UAS, scrib¹

(Khezri et al., 2021)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^695.UAS

(Zhuang et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATG13; autophagy related 13

11 of 14

615088

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Atg13 - Aduk

anti tag coimmunoprecipitation, western blot

(Braden and Neufeld, 2016)

Atg13 - Atg1

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Braden and Neufeld, 2016, Nagy et al., 2014, Chang and Neufeld, 2009)

Atg13 - Atg101

anti tag coimmunoprecipitation, anti tag western blot

(Hegedűs et al., 2014, Nagy et al., 2014)

Atg13 - Atg17

anti tag coimmunoprecipitation, anti tag western blot

(Nagy et al., 2014, Kim et al., 2013)

Atg13 - ref(2)P

anti tag coimmunoprecipitation, anti tag western blot

(Hegedűs et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Atg13

suppressible

Atg1

(Chang and Neufeld, 2009)

Ras85D|scrib|Atg13

suppressible

Atg8a

(Katheder et al., 2017)

Ras85D|scrib|Atg13

suppressible

Atg14

(Katheder et al., 2017)

suppressible

(Kim et al., 2015)

suppressible

(Cobb et al., 2023)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Aduk

suppressible

Atg13

(Braden and Neufeld, 2016)

Atg1

suppressible

Atg13

(Chang and Neufeld, 2009)

Decay

suppressible

Atg13

(Shinoda et al., 2019)

Ire1

suppressible

Atg13

(Zheng et al., 2023)

Npc1a

suppressible

Atg1|Atg13

(Danielsen et al., 2016)

Ras85D|scrib

suppressible

Atg13

(Katheder et al., 2017)

Ras85D|scrib

suppressible

Atg13|Atg14

(Katheder et al., 2017)

scrib|Ire1

suppressible

Atg13

(Zheng et al., 2023)

scrib|Ire1

suppressible

bsk|Atg13

(Zheng et al., 2023)

External Data

Subunit Structure (UniProtKB)

Interacts with Atg1.

(UniProt, Q9VHR6 )

Linkouts

BioGRID - A database of protein and genetic interactions.

66179

DroID - A comprehensive database of gene and protein interactions.

FBgn0261108

MIST (genetic) - An integrated Molecular Interaction Database

40998

MIST (protein-protein) - An integrated Molecular Interaction Database

40998

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Macroautophagy

Class of Gene

nuclear_gene

protein_coding_gene

(Chang and Neufeld, 2008)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84F13-84F14

Sequence location

3R:8,349,815..8,352,817 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84F13-84F14

Limits computationally determined from genome sequence between P{EP}EP833 and P{lacW}l(3)L4740^L4740

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

81431

y¹ v¹; P{TKO.GS04637}attP40

40861

y¹ v¹; P{TRiP.HMS02028}attP40

56700

y¹ w^*; Mi{MIC}Atg13^MI11954

30169

w¹¹¹⁸; P{EP}Atg13^G6421/TM6C, Sb¹

7331R-3

v103381

v27955

w¹¹¹⁸; P{GD12202}v27955

v27956

w¹¹¹⁸; P{GD12202}v27956

v318571

PBac{fTRG00405.sfGFP-TVPTBF}VK00033

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (149)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD09558

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261108

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261108

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Nagy et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Atg13 CG7331

(Chang and Neufeld, 2009)

Source for merge of: CG7331 BcDNA:HL01508

(FlyBase, 1996-)

Additional comments

Source for merge of CG7331 BcDNA:HL01508 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

ATG13

(Lin et al., 2023, Cox et al., 2021, Song et al., 2020, Barth et al., 2012)

Atg13

(Lee and Kim, 2025, Li et al., 2025, Zhang et al., 2025, Umargamwala et al., 2024, Cobb et al., 2023, Demir and Kacew, 2023, Muita and Baxter, 2023, Sharpe et al., 2023, Tang et al., 2023, Zhao et al., 2023, Zheng et al., 2023, Huang et al., 2022, Ishii et al., 2022, Li et al., 2022, Palozzi et al., 2022, Zhao et al., 2022, Cho and Jiang, 2021, Girard et al., 2021, Jacomin et al., 2021, Barthez et al., 2020, Cunningham et al., 2020, Gohel et al., 2020, Jacomin et al., 2020, Sênos Demarco et al., 2020, Zhuang et al., 2020, Aparicio et al., 2019, Bhattacharjee et al., 2019, Khezri and Rusten, 2019, Meltzer et al., 2019, Xu et al., 2019, Yan et al., 2019, Billes et al., 2018, Liu et al., 2018, O'Keefe and Denton, 2018, Richardson and Portela, 2018, Velentzas et al., 2018, Galluzzi et al., 2017, Kim et al., 2017, Lin et al., 2017, Lo Piccolo et al., 2017, Manent et al., 2017, Péan et al., 2017, Transgenic RNAi Project members, 2017-, Tusco et al., 2017, Wen et al., 2017, Braden and Neufeld, 2016, Danielsen et al., 2016, Kuleesha et al., 2016, Mao et al., 2016, Schmid et al., 2016, Denton et al., 2015, Kim et al., 2015, Kim et al., 2015, Nagy et al., 2015, Xu et al., 2015, Zhang and Baehrecke, 2015, Zirin et al., 2015, Alers et al., 2014, Banreti et al., 2014, Hegedűs et al., 2014, Morelli et al., 2014, Mulakkal et al., 2014, Nagy et al., 2014, Chang et al., 2013, Kim et al., 2013, Moy and Cherry, 2013, Shravage et al., 2013, Érdi et al., 2012, Pircs et al., 2012, Barth et al., 2011, Chang and Neufeld, 2010, Liu and Lu, 2010, Zirin and Perrimon, 2010, Chang and Neufeld, 2009, Chang and Neufeld, 2009, Chang and Neufeld, 2008)

BcDNA:HL01508

CG7331

(Sarov et al., 2016, Érdi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Buszczak et al., 2007, Quinones-Coello, 2007, Betz and Darnell, 2006, Dierick and Greenspan, 2006, Stanyon et al., 2004, FlyBase Curators, 2002-)

DmAtg13

(Tian et al., 2025)

atg13

(Hargitai et al., 2022, Baumgartner et al., 2021, Joy et al., 2021, Khezri et al., 2021, Shinoda et al., 2019, Katheder et al., 2017, Melani et al., 2017, Mukherjee et al., 2016, Jain et al., 2015, Rui et al., 2015, Politi et al., 2014, Nezis et al., 2010)

dAtg13

(Li et al., 2016)

Name Synonyms

Autophagy-related 13

Autophagy-specific gene 13

CG7331

Secondary FlyBase IDs

FBgn0259122
FBgn0037582
FBgn0047245

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40998

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VHR6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VHR6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q95S16

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VHR6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261108

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40998/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261108

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261108

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7331

MARRVEL_MODEL - MARRVEL (model organism gene)

40998

Linkouts

BioGRID - A database of protein and genetic interactions.

66179

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261108

DroID - A comprehensive database of gene and protein interactions.

FBgn0261108

DRSC - Results frm RNAi screens

FBgn0261108

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Atg13_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037582

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261108

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7331

Flygut - An atlas of the Drosophila adult midgut

FBgn0261108

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261108

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001577

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

40998

MIST (protein-protein) - An integrated Molecular Interaction Database

40998

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Macroautophagy

References (138)

The following external sites may use different assemblies or annotations than FlyBase.

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