gft, Cul-3, guftagu, l(2)br34, l(2)35Cd
Cullen-3 homolog acting in protein degradation - loss of function has pleiotropic effects during development, including defects in external sensory organ development, pattern formation and cell growth and survival - targets Cubitus interruptus
Gene model reviewed during 5.43
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cul3 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cul3 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: gft CG31829
gft plays an essential role in both axonal arborization and proper elaboration of dendrites and may require neddylation for its proper function.
gft mutant axons often stall around branching points, and it is possible that mutant neurites become truncated because of defects in arborization rather than extension.
Perturbation of gft function has pleiotropic effects during development, including defects in external sensory organ development, defects patterning in the wing and notum and defects in cell growth and survival.
New annotation (CG31829) in release 3 of the genome annotation.
1 additional allele is discussed but is not named.
Gene is named "medusa" (in Greek mythology, Medusa represents both life and death) based on the mutant phenotype that affects caspase activation.
The gene is named "guftagu", an Urdu word that means "private conversation", because it appears that the gene product has a "private conversation" with the activated G-sα60A signalling pathway in order to modify the phenotype caused by expression of constitutively activated G-sα60A protein.